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The map label for this gene is cutR [H]

Identifier: 213691415

GI number: 213691415

Start: 579015

End: 579677

Strand: Reverse

Name: cutR [H]

Synonym: Blon_0510

Alternate gene names: 213691415

Gene position: 579677-579015 (Counterclockwise)

Preceding gene: 213691429

Following gene: 213691414

Centisome position: 20.46

GC content: 68.78

Gene sequence:

>663_bases
ATGGCGAGGATCCTGATCGTCGAGGACGACGCCGACTTGTCGGCCGTGCTGGACGACTGTCTCAGGCACGAGGGGTACGC
GACCGGACTGGCAGGCACCGGCGTCGAGGCGCTGGACCTGCTCTCACGGGGGGAATACGACGTGATGCTCCTCGACCGTG
ATCTGCCCGTGCTCTCCGGAGACGAGGTCATGCGCACCGCGGACAGGCTGCGCATCCCCGTACGCACGCTCATGCTCACC
GCGGCCGGCAGCATCGAGGACCGCGTGCACGGCCTTGACCTCGGAGCCGACGACTACCTGCCCAAACCGTTCGCCTACCC
CGAACTCCTCGCCCGCATCCGCGCGCTCCTGCGCCGAGGCGACGCCGACGACGCGCCCACCGTGATCTCACGGGGACGGC
TGTCCGTCGATACCGTGAGACGGCTCGCCTACGCGGACGGCCGGCCTCTCGACCTCGCACCCCGCGAATACTCGCTCCTG
GAGGAACTGCTGCGCGCCGACGGCGGGTGGATCAACACCCGCGCCCTTCTCGAATCCCTGTGGCCGTCCGAGGCGCACGA
CCAGCCCGACCTCGTCAAGACCGCCGTCTACTCGCTACGACGCAAACTGCCCGACCCCTCGCTCATCGCCTCGTCGCGCG
GAGAGGGATACCGCATACCATGA

Upstream 100 bases:

>100_bases
TGCGTGTCGCGCTCACCTAACGCACACCCACGCCGACCACAATGGAGAACGCGAAGGCAATCGCATGAAGGCCATGAATC
GGAATCGGAGGCAACGAAAT

Downstream 100 bases:

>100_bases
CCGACACCGACACGACCAACCGGCCGGCCGGGCACGCCGCGCGCCCGCGCAAACCCGCCAGCTTCCGCATCCGCCTCGCC
GTCACCGTCGGACTGCTCCT

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: Defective melC1 suppressor protein [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MARILIVEDDADLSAVLDDCLRHEGYATGLAGTGVEALDLLSRGEYDVMLLDRDLPVLSGDEVMRTADRLRIPVRTLMLT
AAGSIEDRVHGLDLGADDYLPKPFAYPELLARIRALLRRGDADDAPTVISRGRLSVDTVRRLAYADGRPLDLAPREYSLL
EELLRADGGWINTRALLESLWPSEAHDQPDLVKTAVYSLRRKLPDPSLIASSRGEGYRIP

Sequences:

>Translated_220_residues
MARILIVEDDADLSAVLDDCLRHEGYATGLAGTGVEALDLLSRGEYDVMLLDRDLPVLSGDEVMRTADRLRIPVRTLMLT
AAGSIEDRVHGLDLGADDYLPKPFAYPELLARIRALLRRGDADDAPTVISRGRLSVDTVRRLAYADGRPLDLAPREYSLL
EELLRADGGWINTRALLESLWPSEAHDQPDLVKTAVYSLRRKLPDPSLIASSRGEGYRIP
>Mature_219_residues
ARILIVEDDADLSAVLDDCLRHEGYATGLAGTGVEALDLLSRGEYDVMLLDRDLPVLSGDEVMRTADRLRIPVRTLMLTA
AGSIEDRVHGLDLGADDYLPKPFAYPELLARIRALLRRGDADDAPTVISRGRLSVDTVRRLAYADGRPLDLAPREYSLLE
ELLRADGGWINTRALLESLWPSEAHDQPDLVKTAVYSLRRKLPDPSLIASSRGEGYRIP

Specific function: Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=218, Percent_Identity=37.6146788990826, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789402, Length=217, Percent_Identity=35.4838709677419, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1790552, Length=215, Percent_Identity=35.3488372093023, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=36.322869955157, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=35.7466063348416, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=33.7777777777778, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=33.6244541484716, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1789809, Length=168, Percent_Identity=35.1190476190476, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=34.9137931034483, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=31.1926605504587, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=32, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787229, Length=222, Percent_Identity=29.7297297297297, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=31.7796610169492, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1790437, Length=213, Percent_Identity=26.2910798122066, Blast_Score=64, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24316; Mature: 24185

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARILIVEDDADLSAVLDDCLRHEGYATGLAGTGVEALDLLSRGEYDVMLLDRDLPVLSG
CEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCC
DEVMRTADRLRIPVRTLMLTAAGSIEDRVHGLDLGADDYLPKPFAYPELLARIRALLRRG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
DADDAPTVISRGRLSVDTVRRLAYADGRPLDLAPREYSLLEELLRADGGWINTRALLESL
CCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHH
WPSEAHDQPDLVKTAVYSLRRKLPDPSLIASSRGEGYRIP
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
ARILIVEDDADLSAVLDDCLRHEGYATGLAGTGVEALDLLSRGEYDVMLLDRDLPVLSG
EEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCC
DEVMRTADRLRIPVRTLMLTAAGSIEDRVHGLDLGADDYLPKPFAYPELLARIRALLRRG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
DADDAPTVISRGRLSVDTVRRLAYADGRPLDLAPREYSLLEELLRADGGWINTRALLESL
CCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHH
WPSEAHDQPDLVKTAVYSLRRKLPDPSLIASSRGEGYRIP
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]