Click here to switch to the map view.

The map label for this gene is ilvC1 [H]

Identifier: 213691057

GI number: 213691057

Start: 159515

End: 160567

Strand: Direct

Name: ilvC1 [H]

Synonym: Blon_0136

Alternate gene names: 213691057

Gene position: 159515-160567 (Clockwise)

Preceding gene: 213691056

Following gene: 213691061

Centisome position: 5.63

GC content: 62.68

Gene sequence:

>1053_bases
ATGACAGCACAGATCTGGTATGAGAACGACGGTGATCTTTCTGTTCTCGAAGGCAAGAAGGTCGCAATCATCGGCTACGG
CTCCCAGGGCCACGCCCACGCGCTGAACCTGCGCGATTCCGGTGTCGACGTGGTCGTCGGCCTGCGTCCGACCTCCAAGT
CGGTCGACTTCGCCAAGGAGCAGGGCCTCGAGGTCAAGTCCGTGGCCGAGGCTTCCGCCGAGGCCGACGTGATCATGATC
CTGGCCCCCGACCAGTACCAGCGCACCATCTGGGCCAACGACATCGAGCCCAACATCAAGCCGGGTGCTGCCGTCGCCTT
CGCTCATGGCTTCAACATTCACTACGGCTACATCAAGCCGTCTGAGGATCACCCGGTGTTCATGGTTGCCCCGAAGGGCC
CGGGTCACATCGTTCGTCGTGAGTACGCCGCTGGCCGTGGCGTGCCGGTCGTCGTGGCCGTCGAGCAGGATCCGCGTGGC
GATGGTTGGGCTCTGACCCTGGCCTACGCCAAGGCCCTCGGTGCTCTGCGCGCCGGTGCCATCAAGACCACCTTCAAGGA
AGAGACCGAGACCGATCTCTTCGGCGAGCAGAACGTGCTCATGGGTGGCGTGAACAAGCTCGTCGAGATGGGCTTCGAAG
TCCTGACCGACGCCGGCTACCAGCCGGAGATCGCCTACTTCGAGGTCTGCCACGAGCTCAAGATGCTCGTCGATCTGATG
AACGAGGGCGGCCTGAACAAGGCTCGTTGGTCCTGCTCCGACACCGCCCAGTACGGCGACTACGTCAACACCGTCATCAA
CGAGGACTGCCGCAAGCGCATGGAATACCACCTGCAGCGCATCCAGGACGGCTCCTTCGCCAAGGAGTTCATCGACGATC
AGGATGCCGGCGCCCCGCACTTCAAGGAACTGCAGGAGAAGTACTCCAACGAGCGCATCGAGACCGTCGGCCCGAAGCTG
CGCGCCATGTTCTCCTGGAACAAGGATGGCGTCAAGGATGCCGACGAGGCCAACTCCTTCACCGGCAAGATCGCCCGCGC
CCAGGTTCAGTGA

Upstream 100 bases:

>100_bases
TTTGAAGGACACAATCCTCGCAACACAGGACTTATCTGCACACCGTAGATACCCCGGCGCCCGTGGCGCCACACCCCACT
ACTGAAAAGGAGTGCCAATA

Downstream 100 bases:

>100_bases
TTGCCGCTGACTAGCGCATACCACAGGCCGCCGCTCCGATACCTTCGAAGCGGCGGCCTTTCCCATGGTCCCACCGCGTA
GCCAAACCTCCACTACGTGG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase 1; Alpha-keto-beta-hydroxylacil reductoisomerase 1 [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTAQIWYENDGDLSVLEGKKVAIIGYGSQGHAHALNLRDSGVDVVVGLRPTSKSVDFAKEQGLEVKSVAEASAEADVIMI
LAPDQYQRTIWANDIEPNIKPGAAVAFAHGFNIHYGYIKPSEDHPVFMVAPKGPGHIVRREYAAGRGVPVVVAVEQDPRG
DGWALTLAYAKALGALRAGAIKTTFKEETETDLFGEQNVLMGGVNKLVEMGFEVLTDAGYQPEIAYFEVCHELKMLVDLM
NEGGLNKARWSCSDTAQYGDYVNTVINEDCRKRMEYHLQRIQDGSFAKEFIDDQDAGAPHFKELQEKYSNERIETVGPKL
RAMFSWNKDGVKDADEANSFTGKIARAQVQ

Sequences:

>Translated_350_residues
MTAQIWYENDGDLSVLEGKKVAIIGYGSQGHAHALNLRDSGVDVVVGLRPTSKSVDFAKEQGLEVKSVAEASAEADVIMI
LAPDQYQRTIWANDIEPNIKPGAAVAFAHGFNIHYGYIKPSEDHPVFMVAPKGPGHIVRREYAAGRGVPVVVAVEQDPRG
DGWALTLAYAKALGALRAGAIKTTFKEETETDLFGEQNVLMGGVNKLVEMGFEVLTDAGYQPEIAYFEVCHELKMLVDLM
NEGGLNKARWSCSDTAQYGDYVNTVINEDCRKRMEYHLQRIQDGSFAKEFIDDQDAGAPHFKELQEKYSNERIETVGPKL
RAMFSWNKDGVKDADEANSFTGKIARAQVQ
>Mature_349_residues
TAQIWYENDGDLSVLEGKKVAIIGYGSQGHAHALNLRDSGVDVVVGLRPTSKSVDFAKEQGLEVKSVAEASAEADVIMIL
APDQYQRTIWANDIEPNIKPGAAVAFAHGFNIHYGYIKPSEDHPVFMVAPKGPGHIVRREYAAGRGVPVVVAVEQDPRGD
GWALTLAYAKALGALRAGAIKTTFKEETETDLFGEQNVLMGGVNKLVEMGFEVLTDAGYQPEIAYFEVCHELKMLVDLMN
EGGLNKARWSCSDTAQYGDYVNTVINEDCRKRMEYHLQRIQDGSFAKEFIDDQDAGAPHFKELQEKYSNERIETVGPKLR
AMFSWNKDGVKDADEANSFTGKIARAQVQ

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=288, Percent_Identity=34.375, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=255, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 38591; Mature: 38460

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQIWYENDGDLSVLEGKKVAIIGYGSQGHAHALNLRDSGVDVVVGLRPTSKSVDFAKE
CCEEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHH
QGLEVKSVAEASAEADVIMILAPDQYQRTIWANDIEPNIKPGAAVAFAHGFNIHYGYIKP
CCCCHHHHHHCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCEEEEEECCEEEEEEECC
SEDHPVFMVAPKGPGHIVRREYAAGRGVPVVVAVEQDPRGDGWALTLAYAKALGALRAGA
CCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHCCC
IKTTFKEETETDLFGEQNVLMGGVNKLVEMGFEVLTDAGYQPEIAYFEVCHELKMLVDLM
HHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
NEGGLNKARWSCSDTAQYGDYVNTVINEDCRKRMEYHLQRIQDGSFAKEFIDDQDAGAPH
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCH
FKELQEKYSNERIETVGPKLRAMFSWNKDGVKDADEANSFTGKIARAQVQ
HHHHHHHHCCCCCHHCCCHHEEEEECCCCCCCCCHHHCHHHCCCEEEECC
>Mature Secondary Structure 
TAQIWYENDGDLSVLEGKKVAIIGYGSQGHAHALNLRDSGVDVVVGLRPTSKSVDFAKE
CEEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHH
QGLEVKSVAEASAEADVIMILAPDQYQRTIWANDIEPNIKPGAAVAFAHGFNIHYGYIKP
CCCCHHHHHHCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCEEEEEECCEEEEEEECC
SEDHPVFMVAPKGPGHIVRREYAAGRGVPVVVAVEQDPRGDGWALTLAYAKALGALRAGA
CCCCCEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHHCCC
IKTTFKEETETDLFGEQNVLMGGVNKLVEMGFEVLTDAGYQPEIAYFEVCHELKMLVDLM
HHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
NEGGLNKARWSCSDTAQYGDYVNTVINEDCRKRMEYHLQRIQDGSFAKEFIDDQDAGAPH
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCH
FKELQEKYSNERIETVGPKLRAMFSWNKDGVKDADEANSFTGKIARAQVQ
HHHHHHHHCCCCCHHCCCHHEEEEECCCCCCCCCHHHCHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12381787 [H]