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The map label for this gene is gmk [H]

Identifier: 213158926

GI number: 213158926

Start: 3732938

End: 3733567

Strand: Direct

Name: gmk [H]

Synonym: AB57_3627

Alternate gene names: 213158926

Gene position: 3732938-3733567 (Clockwise)

Preceding gene: 213158913

Following gene: 213158927

Centisome position: 92.16

GC content: 39.52

Gene sequence:

>630_bases
ATGTCGGGTCTATTGTTTGTCGTTTCTGCTGCATCAGGAACGGGCAAAACATCTTTGGTGAAAGCCCTACTTGACCGTGT
GAGCAATTTACATGTTTCAGTTTCGCATACTACCCGAGGTCAACGACCAGGTGAGTTAGATGGTGTTCACTATCACTTCA
CAACAAAAGATGAATTTTTAGACCAAGTGAACCAAGGTGGATTTATCGAATATGCTGAAGTATTTGGTAATTACTATGGC
ACTTCGCAAGCAACCGTAAAACAACAGTTAGCTCAAGGACATGATGTCTTGCTTGAAATTGACTGGCAAGGTGCAGAGCA
AGTACGCAAGCTGTTTCCTGAATCTAAACAGATCTTTATTTTACCACCTACTCAATTCGATTTACGTCAGCGTTTATCTA
ACCGTGGTACAGACTCTGTTGAAGTTATTGAACACCGCTTAAGCTGTGCTGTTGAAGACATGCAGCATTATGTAAATTTC
GACTATATCATCATTAATGATGACTTTAATAAAGCCCTACATGAGCTTGAAGCCGTCATTACAGCAAATCGTTTAGTCTT
ATCTCAACAGGCAAAAAGACATCAAAATCTAATTCAAGACTTGATTACTCCACAACCAAAACAGGAATAA

Upstream 100 bases:

>100_bases
CAGGGGAACTTCTCGTAAATATTTGCAGTTAAAACTATTCAGTTTAAACGCACGGTACACTACAATAGCGAAGATATTTT
ATCATATCAGGAAAAATATC

Downstream 100 bases:

>100_bases
CTTGAGTCTGGAACGAAAGCCTTTTATACTATTTAGTCTGTTCAAATTTACCATTCCAAAACGAGAACTTTATGGCACGC
GTCACCGTTGAAGATTGTTT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSGLLFVVSAASGTGKTSLVKALLDRVSNLHVSVSHTTRGQRPGELDGVHYHFTTKDEFLDQVNQGGFIEYAEVFGNYYG
TSQATVKQQLAQGHDVLLEIDWQGAEQVRKLFPESKQIFILPPTQFDLRQRLSNRGTDSVEVIEHRLSCAVEDMQHYVNF
DYIIINDDFNKALHELEAVITANRLVLSQQAKRHQNLIQDLITPQPKQE

Sequences:

>Translated_209_residues
MSGLLFVVSAASGTGKTSLVKALLDRVSNLHVSVSHTTRGQRPGELDGVHYHFTTKDEFLDQVNQGGFIEYAEVFGNYYG
TSQATVKQQLAQGHDVLLEIDWQGAEQVRKLFPESKQIFILPPTQFDLRQRLSNRGTDSVEVIEHRLSCAVEDMQHYVNF
DYIIINDDFNKALHELEAVITANRLVLSQQAKRHQNLIQDLITPQPKQE
>Mature_208_residues
SGLLFVVSAASGTGKTSLVKALLDRVSNLHVSVSHTTRGQRPGELDGVHYHFTTKDEFLDQVNQGGFIEYAEVFGNYYGT
SQATVKQQLAQGHDVLLEIDWQGAEQVRKLFPESKQIFILPPTQFDLRQRLSNRGTDSVEVIEHRLSCAVEDMQHYVNFD
YIIINDDFNKALHELEAVITANRLVLSQQAKRHQNLIQDLITPQPKQE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=186, Percent_Identity=38.7096774193548, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI4504221, Length=186, Percent_Identity=38.7096774193548, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI226874831, Length=186, Percent_Identity=38.7096774193548, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI38570142, Length=182, Percent_Identity=31.8681318681319, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI111154074, Length=177, Percent_Identity=33.8983050847458, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI14780902, Length=189, Percent_Identity=26.984126984127, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI262118263, Length=173, Percent_Identity=30.0578034682081, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI4505237, Length=173, Percent_Identity=30.0578034682081, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI262118259, Length=173, Percent_Identity=30.0578034682081, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI262118255, Length=173, Percent_Identity=30.0578034682081, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790080, Length=203, Percent_Identity=51.7241379310345, Blast_Score=224, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI193203132, Length=175, Percent_Identity=36, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17508835, Length=175, Percent_Identity=36, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17557440, Length=180, Percent_Identity=31.1111111111111, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982296, Length=96, Percent_Identity=34.375, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=40.9836065573771, Blast_Score=135, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21356141, Length=175, Percent_Identity=37.7142857142857, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI116007136, Length=179, Percent_Identity=29.0502793296089, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI85724806, Length=179, Percent_Identity=29.0502793296089, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45554489, Length=179, Percent_Identity=29.0502793296089, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640542, Length=179, Percent_Identity=29.0502793296089, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45554481, Length=179, Percent_Identity=29.0502793296089, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161077626, Length=179, Percent_Identity=29.0502793296089, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23648; Mature: 23517

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLLFVVSAASGTGKTSLVKALLDRVSNLHVSVSHTTRGQRPGELDGVHYHFTTKDEFL
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEEECCHHHHH
DQVNQGGFIEYAEVFGNYYGTSQATVKQQLAQGHDVLLEIDWQGAEQVRKLFPESKQIFI
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCEEEE
LPPTQFDLRQRLSNRGTDSVEVIEHRLSCAVEDMQHYVNFDYIIINDDFNKALHELEAVI
ECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHH
TANRLVLSQQAKRHQNLIQDLITPQPKQE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SGLLFVVSAASGTGKTSLVKALLDRVSNLHVSVSHTTRGQRPGELDGVHYHFTTKDEFL
CCEEEEEEECCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEEECCHHHHH
DQVNQGGFIEYAEVFGNYYGTSQATVKQQLAQGHDVLLEIDWQGAEQVRKLFPESKQIFI
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCEEEE
LPPTQFDLRQRLSNRGTDSVEVIEHRLSCAVEDMQHYVNFDYIIINDDFNKALHELEAVI
ECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHH
TANRLVLSQQAKRHQNLIQDLITPQPKQE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA