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The map label for this gene is hemF [H]

Identifier: 213158863

GI number: 213158863

Start: 3665010

End: 3665960

Strand: Direct

Name: hemF [H]

Synonym: AB57_3560

Alternate gene names: 213158863

Gene position: 3665010-3665960 (Clockwise)

Preceding gene: 213158862

Following gene: 213158864

Centisome position: 90.48

GC content: 43.22

Gene sequence:

>951_bases
ATGCAACATCCGACTTCAACAGATATTCAACGTGTCCGCGAATTTCTCCTCGATTTACAAGCCCGTATTTGTGCCGGTTT
AGAACAACAAGAAAAAGCTGGTGGTGGGACAGCAGAATTTATCATTGATGATTGGGAGCGCCCTGAAGGCGGTGGCGGCC
GTTCACGTGTACTGCAAAATGGTACAGTGATTGAAAAAGGCGGCGTGATGTTTTCACATATCAACATTAGTAAACTGCCT
GCTTCTGCAACAGAACGTCACCCTCAAATTGCAGGGGCAAAAGCTCAAGCGCTAGGTGTGTCTTTAGTCATTCACCCTAA
AAACCCGAATATTCCAACCTCGCATGCGAATGTCCGCTTATTCGTTGCAGAGCGTGAAGATCAAGATCCGATTTGGTGGT
TTGGTGGAGGTTTTGACTTAACGCCATTTTATCCAGATGACCAAGATGTTTTAAATTGGCACCAAGCCGCTTATGACCTC
TGTAAGCCTTTTGGTGACAATGTTTATGCTGAACATAAAAAATGGTGCGATGACTATTTCTATTTAAAGCATCGCGATGA
ACAACGTGGTGTGGGCGGTTTATTCTTTGATGATTTAAATTGCTGGGATTTCGAAACCTGCTTTAAATATATTCAAGCCG
TAGGTAATGGCTATTTAAATGCGATCTTGCCAATTTTCGAAAAACACCGCGAACAGCCTTATACCGAAGCTCAACGCGAA
TTTCAGCTTTATCGCCGTGGCAGATATGTCGAATATAACTTGGTGTATGACCGCGGTACGTTGTTTGGATTACAAACAGG
TGGCCGTATTGAGTCGATTTTAGTTAGCTTACCTAATCTAGCTGCATGGTCTTATCGCCCTGAATGGGATGAAGACTCTC
CAGAGAAGCGTTTAACTGACTACTATTTAAAACCTCGTGATTGGTTAGGTTTAGAAGAAAAAGTCGCCTAA

Upstream 100 bases:

>100_bases
TTTAAGGGATTTTTTCAGGAATTAGAAAAAATCCCTTACTTTTTTTATGGATTTATGTTTTGATGTATCTAATCTATTTC
GATCATCTTTGAGGGTCATT

Downstream 100 bases:

>100_bases
TTTTTTGTTTTGGGGATTCTTTGGCTTCCACCCTAAAGAATCTCCTTTTTTGATTTCCATTTGCCTTCATTCAAATATTT
TTTCTTGTGCTATTTTGACT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MQHPTSTDIQRVREFLLDLQARICAGLEQQEKAGGGTAEFIIDDWERPEGGGGRSRVLQNGTVIEKGGVMFSHINISKLP
ASATERHPQIAGAKAQALGVSLVIHPKNPNIPTSHANVRLFVAEREDQDPIWWFGGGFDLTPFYPDDQDVLNWHQAAYDL
CKPFGDNVYAEHKKWCDDYFYLKHRDEQRGVGGLFFDDLNCWDFETCFKYIQAVGNGYLNAILPIFEKHREQPYTEAQRE
FQLYRRGRYVEYNLVYDRGTLFGLQTGGRIESILVSLPNLAAWSYRPEWDEDSPEKRLTDYYLKPRDWLGLEEKVA

Sequences:

>Translated_316_residues
MQHPTSTDIQRVREFLLDLQARICAGLEQQEKAGGGTAEFIIDDWERPEGGGGRSRVLQNGTVIEKGGVMFSHINISKLP
ASATERHPQIAGAKAQALGVSLVIHPKNPNIPTSHANVRLFVAEREDQDPIWWFGGGFDLTPFYPDDQDVLNWHQAAYDL
CKPFGDNVYAEHKKWCDDYFYLKHRDEQRGVGGLFFDDLNCWDFETCFKYIQAVGNGYLNAILPIFEKHREQPYTEAQRE
FQLYRRGRYVEYNLVYDRGTLFGLQTGGRIESILVSLPNLAAWSYRPEWDEDSPEKRLTDYYLKPRDWLGLEEKVA
>Mature_316_residues
MQHPTSTDIQRVREFLLDLQARICAGLEQQEKAGGGTAEFIIDDWERPEGGGGRSRVLQNGTVIEKGGVMFSHINISKLP
ASATERHPQIAGAKAQALGVSLVIHPKNPNIPTSHANVRLFVAEREDQDPIWWFGGGFDLTPFYPDDQDVLNWHQAAYDL
CKPFGDNVYAEHKKWCDDYFYLKHRDEQRGVGGLFFDDLNCWDFETCFKYIQAVGNGYLNAILPIFEKHREQPYTEAQRE
FQLYRRGRYVEYNLVYDRGTLFGLQTGGRIESILVSLPNLAAWSYRPEWDEDSPEKRLTDYYLKPRDWLGLEEKVA

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=303, Percent_Identity=44.5544554455446, Blast_Score=261, Evalue=7e-70,
Organism=Escherichia coli, GI1788777, Length=302, Percent_Identity=59.6026490066225, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6320249, Length=329, Percent_Identity=41.3373860182371, Blast_Score=231, Evalue=1e-61,
Organism=Drosophila melanogaster, GI17864388, Length=307, Percent_Identity=42.9967426710098, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 36354; Mature: 36354

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHPTSTDIQRVREFLLDLQARICAGLEQQEKAGGGTAEFIIDDWERPEGGGGRSRVLQN
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEECCCCCCCCCCHHHEECC
GTVIEKGGVMFSHINISKLPASATERHPQIAGAKAQALGVSLVIHPKNPNIPTSHANVRL
CCEEECCCEEEEECCHHHCCCCHHHCCCCCCCCCHHEEEEEEEEECCCCCCCCCCCCEEE
FVAEREDQDPIWWFGGGFDLTPFYPDDQDVLNWHQAAYDLCKPFGDNVYAEHKKWCDDYF
EEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
YLKHRDEQRGVGGLFFDDLNCWDFETCFKYIQAVGNGYLNAILPIFEKHREQPYTEAQRE
EEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHH
FQLYRRGRYVEYNLVYDRGTLFGLQTGGRIESILVSLPNLAAWSYRPEWDEDSPEKRLTD
HHHHHCCCEEEEEEEEECCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
YYLKPRDWLGLEEKVA
HHCCCHHHCCCHHHCC
>Mature Secondary Structure
MQHPTSTDIQRVREFLLDLQARICAGLEQQEKAGGGTAEFIIDDWERPEGGGGRSRVLQN
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEECCCCCCCCCCHHHEECC
GTVIEKGGVMFSHINISKLPASATERHPQIAGAKAQALGVSLVIHPKNPNIPTSHANVRL
CCEEECCCEEEEECCHHHCCCCHHHCCCCCCCCCHHEEEEEEEEECCCCCCCCCCCCEEE
FVAEREDQDPIWWFGGGFDLTPFYPDDQDVLNWHQAAYDLCKPFGDNVYAEHKKWCDDYF
EEEECCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
YLKHRDEQRGVGGLFFDDLNCWDFETCFKYIQAVGNGYLNAILPIFEKHREQPYTEAQRE
EEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHH
FQLYRRGRYVEYNLVYDRGTLFGLQTGGRIESILVSLPNLAAWSYRPEWDEDSPEKRLTD
HHHHHCCCEEEEEEEEECCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
YYLKPRDWLGLEEKVA
HHCCCHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA