BacMap

Definition	Acinetobacter baumannii AB0057, complete genome.
Accession	NC_011586
Length	4,050,513

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The map label for this gene is dkgB [H]

Identifier: 213158762

GI number: 213158762

Start: 4017464

End: 4018267

Strand: Direct

Name: dkgB [H]

Synonym: AB57_3896

Alternate gene names: 213158762

Gene position: 4017464-4018267 (Clockwise)

Preceding gene: 213158761

Following gene: 213158763

Centisome position: 99.18

GC content: 40.42

Gene sequence:

>804_bases
ATGAATATCCCACGTTTTGGTCTAGGAACTTTCCGCCTTAAAGAACAAGCTGTGATTGAATCTGTTAAAAATGCGCTAGA
TGTCGGTTATCGTGCAATTGATACTGCTCAAATTTATGAAAATGAAGCGGCAATTGGACAAGCGATTGCTGAAAGTGGTG
TATCACGTCAGGACTTATTTTTAACTACAAAAATTTGGGTAGATAACTTTGCTCAAGAGAAGTTTATTCCAAGCTTAAAA
GAGAGCTTACAAAAGCTTCGTACTGACCATGTCGATTTAACTTTGATTCACTGGCCAGCACCGGATTTAGGCGTTTCAAT
TCCTGAAATCATGCAGCTTTTACTTGAAGCAAAACAACAAGGCTTAACCAAACAAATTGGTATTTCAAACTTCAATATTG
CACTTACCCAACAAGCAATTGACACAATTGGTGTAGAGCATATTGCAACGAACCAGATTGAGCTGAGTCCTTATCTTCAA
AACCATAAACTTGTGAATTTCTTACAAGAGAAGAATATTGATGTCACTTCATACATGACGCTTGCATACGGCAAAGTGCT
TCAAGATCCTGTTTTAGCGGAGATTGCAGCAGCCCATAAAGCAACGACAGCGCAAATTGCATTGGCATGGGCATTGCAGC
GTGGTTTTGCAGTCATTCCATCTTCGACTAAACGTGAAAACCTGATTAGCAATTTAAAAGCACAGGATATCGAGTTAACT
GCGGCTGAAATGCAAATGATTGCCGAACTCGACCGTAACAGTCGTGAAGTTAGCCCAGAGCCATGGGCACCAGTTTGGGA
CTAA

Upstream 100 bases:

>100_bases
AAACATCAAAGATATTTTGCTTATTCATCTATTTTTTCGCAACAATAAAAAAAGCAAAATGCACCTCAAGTTAAACAATT
ATTTAATTTCAGGTGAATAC

Downstream 100 bases:

>100_bases
ACTCATGAACACTCAATCAAATACGGCGTTCTCGTTATTGGCATTGGCAATAGGTGCCTTTGCCATTGGCACCACGGAAT
TTTCTCCAATGGGGTTACTT

Product: 2,5-diketo-D-gluconate reductase B

Products: NA

Alternate protein names: 2,5-DKG reductase B; 2,5-DKGR B; 25DKGR-B; AKR5D [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MNIPRFGLGTFRLKEQAVIESVKNALDVGYRAIDTAQIYENEAAIGQAIAESGVSRQDLFLTTKIWVDNFAQEKFIPSLK
ESLQKLRTDHVDLTLIHWPAPDLGVSIPEIMQLLLEAKQQGLTKQIGISNFNIALTQQAIDTIGVEHIATNQIELSPYLQ
NHKLVNFLQEKNIDVTSYMTLAYGKVLQDPVLAEIAAAHKATTAQIALAWALQRGFAVIPSSTKRENLISNLKAQDIELT
AAEMQMIAELDRNSREVSPEPWAPVWD

Sequences:

>Translated_267_residues
MNIPRFGLGTFRLKEQAVIESVKNALDVGYRAIDTAQIYENEAAIGQAIAESGVSRQDLFLTTKIWVDNFAQEKFIPSLK
ESLQKLRTDHVDLTLIHWPAPDLGVSIPEIMQLLLEAKQQGLTKQIGISNFNIALTQQAIDTIGVEHIATNQIELSPYLQ
NHKLVNFLQEKNIDVTSYMTLAYGKVLQDPVLAEIAAAHKATTAQIALAWALQRGFAVIPSSTKRENLISNLKAQDIELT
AAEMQMIAELDRNSREVSPEPWAPVWD
>Mature_267_residues
MNIPRFGLGTFRLKEQAVIESVKNALDVGYRAIDTAQIYENEAAIGQAIAESGVSRQDLFLTTKIWVDNFAQEKFIPSLK
ESLQKLRTDHVDLTLIHWPAPDLGVSIPEIMQLLLEAKQQGLTKQIGISNFNIALTQQAIDTIGVEHIATNQIELSPYLQ
NHKLVNFLQEKNIDVTSYMTLAYGKVLQDPVLAEIAAAHKATTAQIALAWALQRGFAVIPSSTKRENLISNLKAQDIELT
AAEMQMIAELDRNSREVSPEPWAPVWD

Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) [H]

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase family [H]

Homologues:

Organism=Homo sapiens, GI310109922, Length=275, Percent_Identity=34.5454545454545, Blast_Score=167, Evalue=9e-42,
Organism=Homo sapiens, GI310109920, Length=293, Percent_Identity=33.7883959044369, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI45446745, Length=293, Percent_Identity=33.7883959044369, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI4503285, Length=293, Percent_Identity=33.7883959044369, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI5453543, Length=293, Percent_Identity=33.4470989761092, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI24497585, Length=291, Percent_Identity=32.3024054982818, Blast_Score=158, Evalue=5e-39,
Organism=Homo sapiens, GI223468663, Length=289, Percent_Identity=33.5640138408304, Blast_Score=157, Evalue=7e-39,
Organism=Homo sapiens, GI24497583, Length=287, Percent_Identity=33.7979094076655, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI93277124, Length=299, Percent_Identity=31.438127090301, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI5174695, Length=293, Percent_Identity=34.1296928327645, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI291291012, Length=273, Percent_Identity=33.6996336996337, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI4502049, Length=285, Percent_Identity=35.4385964912281, Blast_Score=147, Evalue=7e-36,
Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=31.6151202749141, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=31.6151202749141, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI300116273, Length=269, Percent_Identity=32.3420074349442, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI300116271, Length=275, Percent_Identity=31.6363636363636, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI310109924, Length=155, Percent_Identity=34.1935483870968, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI310109926, Length=113, Percent_Identity=37.1681415929204, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI207028673, Length=113, Percent_Identity=37.1681415929204, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI1786400, Length=267, Percent_Identity=66.2921348314607, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI87082198, Length=261, Percent_Identity=36.7816091954023, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1788081, Length=263, Percent_Identity=28.1368821292776, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI48994888, Length=272, Percent_Identity=27.2058823529412, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787674, Length=285, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17561298, Length=276, Percent_Identity=31.8840579710145, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17550248, Length=285, Percent_Identity=33.6842105263158, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17537075, Length=292, Percent_Identity=34.2465753424658, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71998625, Length=266, Percent_Identity=32.7067669172932, Blast_Score=139, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17552492, Length=266, Percent_Identity=30.8270676691729, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17537077, Length=288, Percent_Identity=34.0277777777778, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17566692, Length=288, Percent_Identity=31.25, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17564128, Length=290, Percent_Identity=28.2758620689655, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562292, Length=269, Percent_Identity=31.5985130111524, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17561300, Length=275, Percent_Identity=28.7272727272727, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17538386, Length=276, Percent_Identity=28.2608695652174, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17537079, Length=294, Percent_Identity=27.2108843537415, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324694, Length=294, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6320576, Length=262, Percent_Identity=35.1145038167939, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321896, Length=310, Percent_Identity=30.6451612903226, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322556, Length=259, Percent_Identity=26.6409266409266, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319625, Length=287, Percent_Identity=29.2682926829268, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320079, Length=248, Percent_Identity=30.241935483871, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24662789, Length=288, Percent_Identity=31.5972222222222, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24644950, Length=295, Percent_Identity=32.8813559322034, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI221378297, Length=312, Percent_Identity=31.7307692307692, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24663317, Length=285, Percent_Identity=31.9298245614035, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24662785, Length=291, Percent_Identity=35.7388316151203, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24662781, Length=291, Percent_Identity=35.0515463917526, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI20129731, Length=280, Percent_Identity=30, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24657054, Length=287, Percent_Identity=29.616724738676, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21356425, Length=283, Percent_Identity=28.2685512367491, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45553081, Length=283, Percent_Identity=29.6819787985866, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281366140, Length=258, Percent_Identity=28.6821705426357, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: =1.1.1.274 [H]

Molecular weight: Translated: 29742; Mature: 29742

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIPRFGLGTFRLKEQAVIESVKNALDVGYRAIDTAQIYENEAAIGQAIAESGVSRQDLF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEE
LTTKIWVDNFAQEKFIPSLKESLQKLRTDHVDLTLIHWPAPDLGVSIPEIMQLLLEAKQQ
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHC
GLTKQIGISNFNIALTQQAIDTIGVEHIATNQIELSPYLQNHKLVNFLQEKNIDVTSYMT
CCHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHH
LAYGKVLQDPVLAEIAAAHKATTAQIALAWALQRGFAVIPSSTKRENLISNLKAQDIELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCCCCHHHH
AAEMQMIAELDRNSREVSPEPWAPVWD
HHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIPRFGLGTFRLKEQAVIESVKNALDVGYRAIDTAQIYENEAAIGQAIAESGVSRQDLF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEE
LTTKIWVDNFAQEKFIPSLKESLQKLRTDHVDLTLIHWPAPDLGVSIPEIMQLLLEAKQQ
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHC
GLTKQIGISNFNIALTQQAIDTIGVEHIATNQIELSPYLQNHKLVNFLQEKNIDVTSYMT
CCHHHCCCCCCEEEEHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCHHHHHH
LAYGKVLQDPVLAEIAAAHKATTAQIALAWALQRGFAVIPSSTKRENLISNLKAQDIELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCCCCHHHH
AAEMQMIAELDRNSREVSPEPWAPVWD
HHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796; 11108008 [H]