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The map label for this gene is icd [H]

Identifier: 213158202

GI number: 213158202

Start: 3014242

End: 3016479

Strand: Reverse

Name: icd [H]

Synonym: AB57_2921

Alternate gene names: 213158202

Gene position: 3016479-3014242 (Counterclockwise)

Preceding gene: 213158203

Following gene: 213158200

Centisome position: 74.47

GC content: 42.85

Gene sequence:

>2238_bases
ATGGCTGGTGAAAAGTCAACCATCATTTACACACTGACTGACGAGGCGCCATTATTGGCGACTTATTCGCTACTGCCGAT
CATTGAGACCTTTACTAAGCCAGCTGGTATCGAGATTGTTAAAAGTGACATCTCTGTAGCTGCACGTGTGCTCGCAGAAT
TCGCTGACTACCTAAGTGAAGAGCAAAAGGTATCCGACAACCTTGCTGAGCTAGGTCGTCTTACACAAGATCCAGATACT
AACATTATCAAACTCCCAAATATTAGTGCCTCTGTTGCGCAATTGACAGCATGTATTAAAGAACTTCAATCTAAAGGTTA
TGCAATTCCTGACTATCCGGAAAACCCAGCGACTGAAGAAGAAAAAACAATCAAAGCTCGTTATGGCAAATGCCTAGGTT
CAGCAGTAAACCCTGTTCTTCGTGAAGGTAACTCTGACCGTCGTGCTCCTGCTGCCGTTAAAAATTACGCTAAGAAACAC
CCTCACTCAATGAGCGAGTGGAAACAATGGTCGCAAACTCACGTTTCACACATGGAAGAAGGTGACTTCTACCACGGTGA
AAAGTCAATGACACTTGACCGTCCACGCAATGTAAAAATGGAACTTATCACAAACAGTGGTAAGAGCATTGTTCTTAAGC
CAAAAGTTGCGCTTCAAGAAGGCGAAATCATTGACTCAATGTTTATGAGCAAAAAAGCGCTTTGCGACTTCTACGAGAAA
CAACTTGATGACTGCCGCGAAGCAGGAATTTTATTCTCATTACACGTAAAAGCGACAATGATGAAAGTTTCACACCCGAT
CGTTTTCGGTCATTGTGTGAAAATCTACTATAAAGAAGCTTTCGAAAAACACGGTAAGTTGTTTGACGAATTAGGTATTA
ACGTAAATAACGGTATGGCTGGGTTATACGAGAAAATCGAAACTCTTCCAACCTCATTACGTGAAGAAATCATTGAAGAT
TTACATGCTTGCCAAGAACACCGTCCTGCACTTGCGATGGTTGATTCAGCAAAAGGTATCACTAACTTCCATTCACCTAA
TGACATCATCGTAGATGCTTCTATGCCTGCAATGATCCGTGCTGGTGGTAAAATGTGGGGTGCTGATGGTAAGCAATACG
ATGCTAAGGCAGTAATGCCAGAATCAACATTTGCCCGTATTTACCAAGAAATGATCAATTTCTGTAAATGGCATGGTAAC
TTTGATCCAAAAACAATGGGTACAGTACCAAACGTTGGTTTGATGGCTCAAAAAGCTGAAGAATACGGTTCTCACGACAA
GACTTTTGAAATTCCTGAAGCAGGTATTGCAAACATTACTGATTTTGACACTGGTGAAGTGTTATTGACTCAAAATGTTG
AAGAAGGCGATATCTGGCGTATGTGTCAGGTGAAAGACGCTCCGATTCGTGACTGGGTAAAACTTGCAGTAACTCGTGCA
CGTAACTCAGGCATGCCTGCGATCTTCTGGCTTGACCCATACCGTCCACACGAAAATGAATTAATCAAGAAAGTACAGAA
GTACTTAAAAGATCACGATACGACTGGTCTTGATATCCAGATTATGTCTCAAGTACGTGCAATGCGTTACACACTTGAGC
GTGTAGTTCGTGGCCTCGATACAATTTCTGTAACCGGTAACATCTTACGCGACTACTTAACTGACTTGTTCCCAATTATG
GAACTTGGTACTTCTGCAAAAATGTTGTCTATCGTTCCGCTTATGGCGGGTGGTGGCATGTACGAAACTGGTGCGGGTGG
TTCAGCACCTAAACACGTACAACAACTTGTTGAAGAAAACCACTTACGTTGGGATTCGCTTGGTGAGTTCCTTGCGCTTG
CAGTTTCTCTAGAAGAAATGGGTATTAAAGAAAATAATGCTCGTGCGAAGTTACTTGCGAAGACACTTGATGAAGCGACT
GGTAAATTGCTTGACAATGACAAGTCTCCATCACGTCGTACAGGCGAACTTGACAATCGTGGCAGCCACTTCTACTTGTC
ACTTTACTGGGCAGAAGCACTTGCTGCACAGAACGAAGATGCTGAGTTGAAAGCTAAATTTGCTCCACTTGCAAAAGCAT
TAGCTGAAAACGAACAGAAGATCGTTGCTGAGCTTGCTCAAGTACAAGGTAAACCAGCTGATATCGGTGGTTACTATGCA
GTTGACCCAGCGAAAGTAAGCGCTGTAATGCGTCCAAGTGCTACATTTAATGCAGCGCTTTCAACTGTTCAGGCTTAA

Upstream 100 bases:

>100_bases
GAGAGCCGATACTCTCAGGGTTTTATTTAAGCATATCGGTTCGTAGGCACTGGGCCAAAAGCTCGGTCCTCAAAACTCAA
TTCAACGGAAGGGGCTATAT

Downstream 100 bases:

>100_bases
TTACTAATTCATTAGTACATAGCTAAAAGCCGGTGCATAAGCACCGGCTTTTTATTTTTATAAAATAAAAGTTATTAAAA
AAAGCCCACTAACGTGAGCT

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MAGEKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIVKSDISVAARVLAEFADYLSEEQKVSDNLAELGRLTQDPDT
NIIKLPNISASVAQLTACIKELQSKGYAIPDYPENPATEEEKTIKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKH
PHSMSEWKQWSQTHVSHMEEGDFYHGEKSMTLDRPRNVKMELITNSGKSIVLKPKVALQEGEIIDSMFMSKKALCDFYEK
QLDDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMAGLYEKIETLPTSLREEIIED
LHACQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIRAGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGN
FDPKTMGTVPNVGLMAQKAEEYGSHDKTFEIPEAGIANITDFDTGEVLLTQNVEEGDIWRMCQVKDAPIRDWVKLAVTRA
RNSGMPAIFWLDPYRPHENELIKKVQKYLKDHDTTGLDIQIMSQVRAMRYTLERVVRGLDTISVTGNILRDYLTDLFPIM
ELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENHLRWDSLGEFLALAVSLEEMGIKENNARAKLLAKTLDEAT
GKLLDNDKSPSRRTGELDNRGSHFYLSLYWAEALAAQNEDAELKAKFAPLAKALAENEQKIVAELAQVQGKPADIGGYYA
VDPAKVSAVMRPSATFNAALSTVQA

Sequences:

>Translated_745_residues
MAGEKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIVKSDISVAARVLAEFADYLSEEQKVSDNLAELGRLTQDPDT
NIIKLPNISASVAQLTACIKELQSKGYAIPDYPENPATEEEKTIKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKH
PHSMSEWKQWSQTHVSHMEEGDFYHGEKSMTLDRPRNVKMELITNSGKSIVLKPKVALQEGEIIDSMFMSKKALCDFYEK
QLDDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMAGLYEKIETLPTSLREEIIED
LHACQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIRAGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGN
FDPKTMGTVPNVGLMAQKAEEYGSHDKTFEIPEAGIANITDFDTGEVLLTQNVEEGDIWRMCQVKDAPIRDWVKLAVTRA
RNSGMPAIFWLDPYRPHENELIKKVQKYLKDHDTTGLDIQIMSQVRAMRYTLERVVRGLDTISVTGNILRDYLTDLFPIM
ELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENHLRWDSLGEFLALAVSLEEMGIKENNARAKLLAKTLDEAT
GKLLDNDKSPSRRTGELDNRGSHFYLSLYWAEALAAQNEDAELKAKFAPLAKALAENEQKIVAELAQVQGKPADIGGYYA
VDPAKVSAVMRPSATFNAALSTVQA
>Mature_744_residues
AGEKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIVKSDISVAARVLAEFADYLSEEQKVSDNLAELGRLTQDPDTN
IIKLPNISASVAQLTACIKELQSKGYAIPDYPENPATEEEKTIKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKHP
HSMSEWKQWSQTHVSHMEEGDFYHGEKSMTLDRPRNVKMELITNSGKSIVLKPKVALQEGEIIDSMFMSKKALCDFYEKQ
LDDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMAGLYEKIETLPTSLREEIIEDL
HACQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIRAGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGNF
DPKTMGTVPNVGLMAQKAEEYGSHDKTFEIPEAGIANITDFDTGEVLLTQNVEEGDIWRMCQVKDAPIRDWVKLAVTRAR
NSGMPAIFWLDPYRPHENELIKKVQKYLKDHDTTGLDIQIMSQVRAMRYTLERVVRGLDTISVTGNILRDYLTDLFPIME
LGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENHLRWDSLGEFLALAVSLEEMGIKENNARAKLLAKTLDEATG
KLLDNDKSPSRRTGELDNRGSHFYLSLYWAEALAAQNEDAELKAKFAPLAKALAENEQKIVAELAQVQGKPADIGGYYAV
DPAKVSAVMRPSATFNAALSTVQA

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 82674; Mature: 82543

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGEKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIVKSDISVAARVLAEFADYLSE
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
EQKVSDNLAELGRLTQDPDTNIIKLPNISASVAQLTACIKELQSKGYAIPDYPENPATEE
HHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EKTIKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKHPHSMSEWKQWSQTHVSHMEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GDFYHGEKSMTLDRPRNVKMELITNSGKSIVLKPKVALQEGEIIDSMFMSKKALCDFYEK
CCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHH
QLDDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMA
HHHHHHHCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GLYEKIETLPTSLREEIIEDLHACQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHH
AGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGNFDPKTMGTVPNVGLMAQKAE
CCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFEIPEAGIANITDFDTGEVLLTQNVEEGDIWRMCQVKDAPIRDWVKLAVTRA
HHCCCCCEEECCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHH
RNSGMPAIFWLDPYRPHENELIKKVQKYLKDHDTTGLDIQIMSQVRAMRYTLERVVRGLD
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
TISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEEN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALAVSLEEMGIKENNARAKLLAKTLDEATGKLLDNDKSPSRRTGELDNR
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GSHFYLSLYWAEALAAQNEDAELKAKFAPLAKALAENEQKIVAELAQVQGKPADIGGYYA
CCEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEE
VDPAKVSAVMRPSATFNAALSTVQA
ECHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AGEKSTIIYTLTDEAPLLATYSLLPIIETFTKPAGIEIVKSDISVAARVLAEFADYLSE
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
EQKVSDNLAELGRLTQDPDTNIIKLPNISASVAQLTACIKELQSKGYAIPDYPENPATEE
HHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EKTIKARYGKCLGSAVNPVLREGNSDRRAPAAVKNYAKKHPHSMSEWKQWSQTHVSHMEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
GDFYHGEKSMTLDRPRNVKMELITNSGKSIVLKPKVALQEGEIIDSMFMSKKALCDFYEK
CCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHH
QLDDCREAGILFSLHVKATMMKVSHPIVFGHCVKIYYKEAFEKHGKLFDELGINVNNGMA
HHHHHHHCCEEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
GLYEKIETLPTSLREEIIEDLHACQEHRPALAMVDSAKGITNFHSPNDIIVDASMPAMIR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECCCCHHHH
AGGKMWGADGKQYDAKAVMPESTFARIYQEMINFCKWHGNFDPKTMGTVPNVGLMAQKAE
CCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
EYGSHDKTFEIPEAGIANITDFDTGEVLLTQNVEEGDIWRMCQVKDAPIRDWVKLAVTRA
HHCCCCCEEECCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHH
RNSGMPAIFWLDPYRPHENELIKKVQKYLKDHDTTGLDIQIMSQVRAMRYTLERVVRGLD
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCH
TISVTGNILRDYLTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEEN
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHC
HLRWDSLGEFLALAVSLEEMGIKENNARAKLLAKTLDEATGKLLDNDKSPSRRTGELDNR
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GSHFYLSLYWAEALAAQNEDAELKAKFAPLAKALAENEQKIVAELAQVQGKPADIGGYYA
CCEEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEE
VDPAKVSAVMRPSATFNAALSTVQA
ECHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12005040; 4149369; 12467571 [H]