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The map label for this gene is icd [H]

Identifier: 213158200

GI number: 213158200

Start: 3011879

End: 3013135

Strand: Reverse

Name: icd [H]

Synonym: AB57_2919

Alternate gene names: 213158200

Gene position: 3013135-3011879 (Counterclockwise)

Preceding gene: 213158202

Following gene: 213158197

Centisome position: 74.39

GC content: 41.93

Gene sequence:

>1257_bases
ATGGGTTATCAGAAGATCGTGGTTCCTGCCGACGGTGATAAAATTACAGTAAAAGCAGACCTGTCACTGAATGTACCAAA
TCATCCAATTATTCCTTTCATTGAGGGTGACGGTATTGGTGTAGATATTACACCGGCAATGAAAAAAGTTGTTGATGCGG
CAATTTTAAAAGCCTATGGCGGCAAACGCTCTATTGAATGGATGGAAGTGTATTGCGGTGAAAAGGCCAATAAAATTTAC
GGTACCTATATGCCGGAAGAAACCTTTGAAGCGCTGCGTGAATTTGTAGTTTCAATTAAAGGCCCTTTAACTACACCAGT
CGGTGGCGGCATTCGTTCACTCAACGTTGCACTACGCCAAGAACTGGATTTGTATGTATGTGTACGTCCTGTGCGTTGGT
TCCAAGGCGTCCCTTCACCCGTTCAACATCCTGAGTTAACTGACATGGTAATTTTCCGTGAAAACTCGGAAGATATTTAT
GCGGGTATTGAATGGAAAGCAGATTCTGAAGAAGCTAAAAAAGTCATTAAATTCCTTCAAGAAGAAATGGGGGTCACAAA
AATTCGTTTCCCTGAAGGATGTGGTATTGGTATTAAACCTGTTTCTAAAGAAGGAACACAGCGCTTAGTTCGTAAGGCTA
TTCAGTTTGCAATAGATAATGACAAACCTTCGGTGACTCTTGTTCATAAAGGCAACATTATGAAATATACCGAAGGTGCC
TTTAAAGAATGGGGGTATGAGTTAGCGCTAGATCGTTTCGGTGGTGAATTAATCGATGGTGGCCCATGGGTTAAAATTAA
GAACCCTAAAAATGGTAAAGACATCATTATTAAAGACGTGATTGCAGATGCTTTCTTGCAACAAATCTTGATGCGTCCTG
CTGACTACTCTGTAATTGCAACCCTTAATTTAAATGGTGACTATATTTCAGATGCTTTAGCAGCAGAAGTAGGGGGAATC
GGGATTGCACCAGGTGCGAATATTGGTGGAGCTATTGCAGTGTATGAAGCAACGCATGGCACTGCACCTAAATATGCTGG
GCAAGATAAAGTCAACCCGGGTTCAATTATTCTCTCTGCTGAAATGATGCTCCGTGATATGGGGTGGATAGAAGCAGCGG
ACCTGATTATTAAAGGTATTTCAGGAGCGATTGCAGCTAAAACCGTAACTTACGATTTTGAGCGTTTAATGCCGGGAGCG
ACCTTGTTACGTTGCTCAGAATTTGGCGATGCCATAATTCAGCACATGGAAGATTAA

Upstream 100 bases:

>100_bases
TCGATTAAGCTATTATGCGTTAATAAAAGTTGAAAGTATTGTTTATCGATAATTATTTTTGTTTGGTTAGTTAAATATTA
TAAAAGGGAGAATCTACATA

Downstream 100 bases:

>100_bases
ACTTTCATAGAAAAGCCCTCAATTGAGGGCTTTTAAAGTCTTTAGATTTATAATTTTGAAAAATAATAAAAAATAAGAAT
ATTAAACGTTAAAATTTTAG

Product: isocitrate dehydrogenase, NADP-dependent

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MGYQKIVVPADGDKITVKADLSLNVPNHPIIPFIEGDGIGVDITPAMKKVVDAAILKAYGGKRSIEWMEVYCGEKANKIY
GTYMPEETFEALREFVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCVRPVRWFQGVPSPVQHPELTDMVIFRENSEDIY
AGIEWKADSEEAKKVIKFLQEEMGVTKIRFPEGCGIGIKPVSKEGTQRLVRKAIQFAIDNDKPSVTLVHKGNIMKYTEGA
FKEWGYELALDRFGGELIDGGPWVKIKNPKNGKDIIIKDVIADAFLQQILMRPADYSVIATLNLNGDYISDALAAEVGGI
GIAPGANIGGAIAVYEATHGTAPKYAGQDKVNPGSIILSAEMMLRDMGWIEAADLIIKGISGAIAAKTVTYDFERLMPGA
TLLRCSEFGDAIIQHMED

Sequences:

>Translated_418_residues
MGYQKIVVPADGDKITVKADLSLNVPNHPIIPFIEGDGIGVDITPAMKKVVDAAILKAYGGKRSIEWMEVYCGEKANKIY
GTYMPEETFEALREFVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCVRPVRWFQGVPSPVQHPELTDMVIFRENSEDIY
AGIEWKADSEEAKKVIKFLQEEMGVTKIRFPEGCGIGIKPVSKEGTQRLVRKAIQFAIDNDKPSVTLVHKGNIMKYTEGA
FKEWGYELALDRFGGELIDGGPWVKIKNPKNGKDIIIKDVIADAFLQQILMRPADYSVIATLNLNGDYISDALAAEVGGI
GIAPGANIGGAIAVYEATHGTAPKYAGQDKVNPGSIILSAEMMLRDMGWIEAADLIIKGISGAIAAKTVTYDFERLMPGA
TLLRCSEFGDAIIQHMED
>Mature_417_residues
GYQKIVVPADGDKITVKADLSLNVPNHPIIPFIEGDGIGVDITPAMKKVVDAAILKAYGGKRSIEWMEVYCGEKANKIYG
TYMPEETFEALREFVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCVRPVRWFQGVPSPVQHPELTDMVIFRENSEDIYA
GIEWKADSEEAKKVIKFLQEEMGVTKIRFPEGCGIGIKPVSKEGTQRLVRKAIQFAIDNDKPSVTLVHKGNIMKYTEGAF
KEWGYELALDRFGGELIDGGPWVKIKNPKNGKDIIIKDVIADAFLQQILMRPADYSVIATLNLNGDYISDALAAEVGGIG
IAPGANIGGAIAVYEATHGTAPKYAGQDKVNPGSIILSAEMMLRDMGWIEAADLIIKGISGAIAAKTVTYDFERLMPGAT
LLRCSEFGDAIIQHMED

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=394, Percent_Identity=30.9644670050761, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI28178821, Length=350, Percent_Identity=28.8571428571429, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI28178816, Length=350, Percent_Identity=28.8571428571429, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI28178838, Length=366, Percent_Identity=26.5027322404372, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4758582, Length=359, Percent_Identity=27.0194986072423, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=30.939226519337, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1787381, Length=415, Percent_Identity=77.1084337349398, Blast_Score=668, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=375, Percent_Identity=26.9333333333333, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87081683, Length=406, Percent_Identity=23.3990147783251, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71986051, Length=358, Percent_Identity=33.7988826815642, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI25144293, Length=348, Percent_Identity=30.7471264367816, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17505779, Length=282, Percent_Identity=30.4964539007092, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17550882, Length=347, Percent_Identity=24.4956772334294, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324709, Length=392, Percent_Identity=30.8673469387755, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6322097, Length=360, Percent_Identity=30.2777777777778, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324291, Length=365, Percent_Identity=28.7671232876712, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6319830, Length=362, Percent_Identity=24.8618784530387, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24643268, Length=389, Percent_Identity=31.6195372750643, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24643270, Length=389, Percent_Identity=31.6195372750643, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24661184, Length=388, Percent_Identity=30.9278350515464, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI161078635, Length=273, Percent_Identity=28.9377289377289, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI161078639, Length=295, Percent_Identity=28.135593220339, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161078633, Length=273, Percent_Identity=28.9377289377289, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24650122, Length=273, Percent_Identity=28.9377289377289, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161078637, Length=273, Percent_Identity=28.9377289377289, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20130355, Length=384, Percent_Identity=23.9583333333333, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281362242, Length=384, Percent_Identity=25.2604166666667, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24648872, Length=384, Percent_Identity=25.2604166666667, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45635; Mature: 45504

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYQKIVVPADGDKITVKADLSLNVPNHPIIPFIEGDGIGVDITPAMKKVVDAAILKAYG
CCCCEEEEECCCCEEEEEEEEEECCCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHHCC
GKRSIEWMEVYCGEKANKIYGTYMPEETFEALREFVVSIKGPLTTPVGGGIRSLNVALRQ
CCCCCCHHEEECCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ELDLYVCVRPVRWFQGVPSPVQHPELTDMVIFRENSEDIYAGIEWKADSEEAKKVIKFLQ
CCCEEEEEEHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHH
EEMGVTKIRFPEGCGIGIKPVSKEGTQRLVRKAIQFAIDNDKPSVTLVHKGNIMKYTEGA
HHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCH
FKEWGYELALDRFGGELIDGGPWVKIKNPKNGKDIIIKDVIADAFLQQILMRPADYSVIA
HHHCCHHEEHHHCCCEEECCCCEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEE
TLNLNGDYISDALAAEVGGIGIAPGANIGGAIAVYEATHGTAPKYAGQDKVNPGSIILSA
EEECCCCHHHHHHHHHHCCEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEH
EMMLRDMGWIEAADLIIKGISGAIAAKTVTYDFERLMPGATLLRCSEFGDAIIQHMED
HHHHHHCCCHHHHHHHHHCCCCCHHHEEEEEEHHHHCCCHHEEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GYQKIVVPADGDKITVKADLSLNVPNHPIIPFIEGDGIGVDITPAMKKVVDAAILKAYG
CCCEEEEECCCCEEEEEEEEEECCCCCCEEEEECCCCCCEECCHHHHHHHHHHHHHHCC
GKRSIEWMEVYCGEKANKIYGTYMPEETFEALREFVVSIKGPLTTPVGGGIRSLNVALRQ
CCCCCCHHEEECCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ELDLYVCVRPVRWFQGVPSPVQHPELTDMVIFRENSEDIYAGIEWKADSEEAKKVIKFLQ
CCCEEEEEEHHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHH
EEMGVTKIRFPEGCGIGIKPVSKEGTQRLVRKAIQFAIDNDKPSVTLVHKGNIMKYTEGA
HHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCH
FKEWGYELALDRFGGELIDGGPWVKIKNPKNGKDIIIKDVIADAFLQQILMRPADYSVIA
HHHCCHHEEHHHCCCEEECCCCEEEECCCCCCCEEEHHHHHHHHHHHHHHCCCCCCEEEE
TLNLNGDYISDALAAEVGGIGIAPGANIGGAIAVYEATHGTAPKYAGQDKVNPGSIILSA
EEECCCCHHHHHHHHHHCCEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEH
EMMLRDMGWIEAADLIIKGISGAIAAKTVTYDFERLMPGATLLRCSEFGDAIIQHMED
HHHHHHCCCHHHHHHHHHCCCCCHHHEEEEEEHHHHCCCHHEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3112144; 8905232; 9278503; 9352899; 9298646; 2204109; 2682654; 10623532 [H]