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The map label for this gene is accA1 [H]

Identifier: 213157962

GI number: 213157962

Start: 3564941

End: 3566881

Strand: Reverse

Name: accA1 [H]

Synonym: AB57_3456

Alternate gene names: 213157962

Gene position: 3566881-3564941 (Counterclockwise)

Preceding gene: 213157963

Following gene: 213157956

Centisome position: 88.06

GC content: 43.33

Gene sequence:

>1941_bases
ATGAAATTTTCAAAAATACTGGTTGCCAATCGTGGTGAAATTGCAGTTCGAGTTATGCAAACAGCCAAGGCAATGGGTTA
CCAAACCGTCGCAGTTTATTCCGATGCAGACCGTAATGCTCGCCATGTGCAAGAGGCTGATGAAGCTGTTTATATTGGTG
CTTCAAAAGTATCGGAGTCTTATCTCTCCATCGCTAAAATTATTGAAGCTTGCAAAAAAACAGGGGCGGATGCAGTTCAC
CCCGGCTATGGTTTTTTGTCAGAAAATACTGATTTTGCTCAGGCATGTATCGATAATCAGATTACCTTTATTGGGCCTAC
CGCTTCTGCAATTGAGTTAATGGGCAGTAAACGCCTTTCAAAAATCGCCATGATTGAGGCGGGCGTCCCTTGTGTGCCGG
GCTATGAAGGTGACCGACAAGATCTCGAATATTTAGCAACTCAAGCTGAGCAGATTGGCTTTCCAATTATGGTCAAAGCT
TCTGCGGGTGGTGGCGGTCGTGGCATGCGTTTGGTACAGCAAGCATCCGAGTTGTTTGAGGCATTACAAACCGCACGTTC
AGAAGCTGAAAATGCTTTTGGTTCTGGCGAGCTCATTTTAGAAAAAGCAGTCATTGCTCCACGCCATGTCGAAATTCAGG
TTTTTGGTGATACTCACGGCAATTATGTGTATTTGTTTGAACGTGATTGTTCAATTCAGCGCCGTCATCAAAAAGTAGTT
GAAGAAGCTCCATGTCCGGTGATGACGCCTGAACTGCGTCAGAAAATGGGTGAGGCAGCCGTAGCAGCGGCAAAAACATG
TGCTTATGTTGGGGCAGGTACAGTTGAGTTTTTGCTAGATGCATCGGGTGCATTTTACTTTTTGGAGATGAATACCCGTT
TGCAGGTAGAACATCCGGTCACTGAGCTTATTACAGGGTTGGATTTAGTTGAATGGCAGTTACGTGTGGCGAATGGTGAG
CAGTTACCTTTAAAGCAACAGGAATTGACCTTAAATGGACATGCGATCGAAGTGCGTTTGTATGCAGAAGACCCACGTCA
GGATTTTTTGCCACAAACAGGAAAAATTTTACGTTGGAAGCCTGCAGCTTTGCCAAATGTGCGAATCGATCATGGCATGT
TAGCAACTGATGAAGTTAGTCCATTTTACGATCCGATGGTAGCAAAGGTGATTGCCTATGGGAAAACCCGTGAGGATGCG
ATTCGCTTACTGGCTCGTGCAGTCGATGATAGTGTTTTACTTGGAGTGAATAGCAATAAACAGCTCTTGGTCAATTTACT
GCGCCATCCAGTTGTTGTCGCAGGGGATACCAATACAGCATTTATCCAACAGCATTTCAAAAATGATCCGAGCTTACACT
ATCAAGTTTTATCTTTAGAAACCTTAGCGATTGCTGCAGCACTATTTAGCCAAAGTAAAGGTCCTGCAGTATGGCAAACT
GGGCTTGGTGTGCCATTACCGTTAAAATTACAAACTGCCGATCAGCAAATTCAATTACAGCTTTCATCTGTAAATAACAC
GTTTACGGTAGAGCTCTGTGAGCAAACTGTAAGTATTGAGGTTGTTGAAAAAACAGCGGAACAATTAATCTATCTGTTGG
ATGGCGTGCGTCATCGTGTGCAATATGTATTGGATGGCGATCAGCTTTATCTAGATAGAGATAATGGTAATGTTGCAATT
CGCAACGTAACTTATGCCGCCCCAGAGATAGCTGATGTGGCTGGTGATGGCAAAATTCGTGCTCCGATGGATGGTGCGGT
AGTAAATATCTTGGTCAATAAAGGTGATCAAGTCATAAAAGGCCAAACTTTATTAGTGCTTGAAGCCATGAAAATCCAAC
AGCAGATTAAATCGGATGTGGATGGTGTAGTCGATGAAATTTTAGGTCAACAAGGTCAACAAGTGAAAAAACGGCAGATG
TTATTTAGTATCCAAATTTAA

Upstream 100 bases:

>100_bases
AGCGGTTGGTAGTGCTGAAGGACAAGAAGGAACGATGGCTTTTATCCAGAAACGGTTACCAAATTGGGCCGATGAAACAT
AAGAGATAAGGATAAAAATA

Downstream 100 bases:

>100_bases
GAGAAGAGCAATTGTGGTTACTGGTAATCATTATTGATTTATAGAGGATGATTATTTAAATTAAAAAGGGAACATAAGTT
CCCTTTAATTATAAAAAACA

Product: acetyl-/propionyl-coenzyme A carboxylase alpha chain

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MKFSKILVANRGEIAVRVMQTAKAMGYQTVAVYSDADRNARHVQEADEAVYIGASKVSESYLSIAKIIEACKKTGADAVH
PGYGFLSENTDFAQACIDNQITFIGPTASAIELMGSKRLSKIAMIEAGVPCVPGYEGDRQDLEYLATQAEQIGFPIMVKA
SAGGGGRGMRLVQQASELFEALQTARSEAENAFGSGELILEKAVIAPRHVEIQVFGDTHGNYVYLFERDCSIQRRHQKVV
EEAPCPVMTPELRQKMGEAAVAAAKTCAYVGAGTVEFLLDASGAFYFLEMNTRLQVEHPVTELITGLDLVEWQLRVANGE
QLPLKQQELTLNGHAIEVRLYAEDPRQDFLPQTGKILRWKPAALPNVRIDHGMLATDEVSPFYDPMVAKVIAYGKTREDA
IRLLARAVDDSVLLGVNSNKQLLVNLLRHPVVVAGDTNTAFIQQHFKNDPSLHYQVLSLETLAIAAALFSQSKGPAVWQT
GLGVPLPLKLQTADQQIQLQLSSVNNTFTVELCEQTVSIEVVEKTAEQLIYLLDGVRHRVQYVLDGDQLYLDRDNGNVAI
RNVTYAAPEIADVAGDGKIRAPMDGAVVNILVNKGDQVIKGQTLLVLEAMKIQQQIKSDVDGVVDEILGQQGQQVKKRQM
LFSIQI

Sequences:

>Translated_646_residues
MKFSKILVANRGEIAVRVMQTAKAMGYQTVAVYSDADRNARHVQEADEAVYIGASKVSESYLSIAKIIEACKKTGADAVH
PGYGFLSENTDFAQACIDNQITFIGPTASAIELMGSKRLSKIAMIEAGVPCVPGYEGDRQDLEYLATQAEQIGFPIMVKA
SAGGGGRGMRLVQQASELFEALQTARSEAENAFGSGELILEKAVIAPRHVEIQVFGDTHGNYVYLFERDCSIQRRHQKVV
EEAPCPVMTPELRQKMGEAAVAAAKTCAYVGAGTVEFLLDASGAFYFLEMNTRLQVEHPVTELITGLDLVEWQLRVANGE
QLPLKQQELTLNGHAIEVRLYAEDPRQDFLPQTGKILRWKPAALPNVRIDHGMLATDEVSPFYDPMVAKVIAYGKTREDA
IRLLARAVDDSVLLGVNSNKQLLVNLLRHPVVVAGDTNTAFIQQHFKNDPSLHYQVLSLETLAIAAALFSQSKGPAVWQT
GLGVPLPLKLQTADQQIQLQLSSVNNTFTVELCEQTVSIEVVEKTAEQLIYLLDGVRHRVQYVLDGDQLYLDRDNGNVAI
RNVTYAAPEIADVAGDGKIRAPMDGAVVNILVNKGDQVIKGQTLLVLEAMKIQQQIKSDVDGVVDEILGQQGQQVKKRQM
LFSIQI
>Mature_646_residues
MKFSKILVANRGEIAVRVMQTAKAMGYQTVAVYSDADRNARHVQEADEAVYIGASKVSESYLSIAKIIEACKKTGADAVH
PGYGFLSENTDFAQACIDNQITFIGPTASAIELMGSKRLSKIAMIEAGVPCVPGYEGDRQDLEYLATQAEQIGFPIMVKA
SAGGGGRGMRLVQQASELFEALQTARSEAENAFGSGELILEKAVIAPRHVEIQVFGDTHGNYVYLFERDCSIQRRHQKVV
EEAPCPVMTPELRQKMGEAAVAAAKTCAYVGAGTVEFLLDASGAFYFLEMNTRLQVEHPVTELITGLDLVEWQLRVANGE
QLPLKQQELTLNGHAIEVRLYAEDPRQDFLPQTGKILRWKPAALPNVRIDHGMLATDEVSPFYDPMVAKVIAYGKTREDA
IRLLARAVDDSVLLGVNSNKQLLVNLLRHPVVVAGDTNTAFIQQHFKNDPSLHYQVLSLETLAIAAALFSQSKGPAVWQT
GLGVPLPLKLQTADQQIQLQLSSVNNTFTVELCEQTVSIEVVEKTAEQLIYLLDGVRHRVQYVLDGDQLYLDRDNGNVAI
RNVTYAAPEIADVAGDGKIRAPMDGAVVNILVNKGDQVIKGQTLLVLEAMKIQQQIKSDVDGVVDEILGQQGQQVKKRQM
LFSIQI

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=682, Percent_Identity=43.6950146627566, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI189095269, Length=676, Percent_Identity=41.2721893491124, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI65506442, Length=676, Percent_Identity=41.2721893491124, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI295821183, Length=660, Percent_Identity=40.7575757575758, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI106049528, Length=446, Percent_Identity=45.9641255605381, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI106049295, Length=446, Percent_Identity=45.9641255605381, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI106049292, Length=446, Percent_Identity=45.9641255605381, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI38679971, Length=683, Percent_Identity=27.086383601757, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679977, Length=683, Percent_Identity=27.086383601757, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679967, Length=683, Percent_Identity=27.086383601757, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679960, Length=683, Percent_Identity=27.086383601757, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI38679974, Length=683, Percent_Identity=27.086383601757, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI134142062, Length=501, Percent_Identity=30.1397205588822, Blast_Score=229, Evalue=9e-60,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=48.3069977426637, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=671, Percent_Identity=43.5171385991058, Blast_Score=500, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17567343, Length=690, Percent_Identity=37.9710144927536, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17562816, Length=458, Percent_Identity=44.1048034934498, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931226, Length=671, Percent_Identity=28.166915052161, Blast_Score=218, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=551, Percent_Identity=28.6751361161525, Blast_Score=205, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=551, Percent_Identity=28.6751361161525, Blast_Score=205, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=40.4494382022472, Blast_Score=349, Evalue=7e-97,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=42.8251121076233, Blast_Score=340, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=44.1964285714286, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6323863, Length=687, Percent_Identity=27.9475982532751, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6324343, Length=719, Percent_Identity=26.8428372739917, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24651757, Length=664, Percent_Identity=42.4698795180723, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24651759, Length=626, Percent_Identity=41.5335463258786, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI281363050, Length=456, Percent_Identity=46.0526315789474, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=456, Percent_Identity=46.0526315789474, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=456, Percent_Identity=46.0526315789474, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=456, Percent_Identity=46.0526315789474, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=456, Percent_Identity=46.0526315789474, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=456, Percent_Identity=46.0526315789474, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=456, Percent_Identity=46.0526315789474, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=456, Percent_Identity=46.0526315789474, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=456, Percent_Identity=46.0526315789474, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=456, Percent_Identity=46.0526315789474, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24586458, Length=716, Percent_Identity=27.7932960893855, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI161076407, Length=716, Percent_Identity=27.7932960893855, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24586460, Length=716, Percent_Identity=27.7932960893855, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI161076409, Length=716, Percent_Identity=27.7932960893855, Blast_Score=231, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 70786; Mature: 70786

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFSKILVANRGEIAVRVMQTAKAMGYQTVAVYSDADRNARHVQEADEAVYIGASKVSES
CCCCEEEEECCCCEEEHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCEEEEEHHHHHHH
YLSIAKIIEACKKTGADAVHPGYGFLSENTDFAQACIDNQITFIGPTASAIELMGSKRLS
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHH
KIAMIEAGVPCVPGYEGDRQDLEYLATQAEQIGFPIMVKASAGGGGRGMRLVQQASELFE
HEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHH
ALQTARSEAENAFGSGELILEKAVIAPRHVEIQVFGDTHGNYVYLFERDCSIQRRHQKVV
HHHHHHHHHHHCCCCCCEEEEHHHCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
EEAPCPVMTPELRQKMGEAAVAAAKTCAYVGAGTVEFLLDASGAFYFLEMNTRLQVEHPV
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCEEEECCCH
TELITGLDLVEWQLRVANGEQLPLKQQELTLNGHAIEVRLYAEDPRQDFLPQTGKILRWK
HHHHHCCCCEEEEEEECCCCCCCCCHHEEEECCEEEEEEEEECCCCHHCCCCCCCEEEEC
PAALPNVRIDHGMLATDEVSPFYDPMVAKVIAYGKTREDAIRLLARAVDDSVLLGVNSNK
CCCCCCCEECCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCH
QLLVNLLRHPVVVAGDTNTAFIQQHFKNDPSLHYQVLSLETLAIAAALFSQSKGPAVWQT
HHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEC
GLGVPLPLKLQTADQQIQLQLSSVNNTFTVELCEQTVSIEVVEKTAEQLIYLLDGVRHRV
CCCCCCEEEEECCCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
QYVLDGDQLYLDRDNGNVAIRNVTYAAPEIADVAGDGKIRAPMDGAVVNILVNKGDQVIK
EEEECCCEEEEECCCCCEEEEEEEECCCHHHHCCCCCEEECCCCCEEEEEEECCCCCEEC
GQTLLVLEAMKIQQQIKSDVDGVVDEILGQQGQQVKKRQMLFSIQI
CCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEECC
>Mature Secondary Structure
MKFSKILVANRGEIAVRVMQTAKAMGYQTVAVYSDADRNARHVQEADEAVYIGASKVSES
CCCCEEEEECCCCEEEHHHHHHHHCCCEEEEEEECCCCCHHHHHHCCCEEEEEHHHHHHH
YLSIAKIIEACKKTGADAVHPGYGFLSENTDFAQACIDNQITFIGPTASAIELMGSKRLS
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHH
KIAMIEAGVPCVPGYEGDRQDLEYLATQAEQIGFPIMVKASAGGGGRGMRLVQQASELFE
HEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHH
ALQTARSEAENAFGSGELILEKAVIAPRHVEIQVFGDTHGNYVYLFERDCSIQRRHQKVV
HHHHHHHHHHHCCCCCCEEEEHHHCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHHHHH
EEAPCPVMTPELRQKMGEAAVAAAKTCAYVGAGTVEFLLDASGAFYFLEMNTRLQVEHPV
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCEEEECCCH
TELITGLDLVEWQLRVANGEQLPLKQQELTLNGHAIEVRLYAEDPRQDFLPQTGKILRWK
HHHHHCCCCEEEEEEECCCCCCCCCHHEEEECCEEEEEEEEECCCCHHCCCCCCCEEEEC
PAALPNVRIDHGMLATDEVSPFYDPMVAKVIAYGKTREDAIRLLARAVDDSVLLGVNSNK
CCCCCCCEECCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCH
QLLVNLLRHPVVVAGDTNTAFIQQHFKNDPSLHYQVLSLETLAIAAALFSQSKGPAVWQT
HHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEC
GLGVPLPLKLQTADQQIQLQLSSVNNTFTVELCEQTVSIEVVEKTAEQLIYLLDGVRHRV
CCCCCCEEEEECCCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHE
QYVLDGDQLYLDRDNGNVAIRNVTYAAPEIADVAGDGKIRAPMDGAVVNILVNKGDQVIK
EEEECCCEEEEECCCCCEEEEEEEECCCHHHHCCCCCEEECCCCCEEEEEEECCCCCEEC
GQTLLVLEAMKIQQQIKSDVDGVVDEILGQQGQQVKKRQMLFSIQI
CCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]