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The map label for this gene is qor [C]

Identifier: 21245061

GI number: 21245061

Start: 5142252

End: 5143259

Strand: Reverse

Name: qor [C]

Synonym: XAC4349

Alternate gene names: 21245061

Gene position: 5143259-5142252 (Counterclockwise)

Preceding gene: 21245067

Following gene: 77748777

Centisome position: 99.38

GC content: 69.74

Gene sequence:

>1008_bases
ATGAAAGCTATCGCCTATCTCCAACACGGCCTGCCCATCGACGATGCGCGCGCGCTGGTCGAACTCGAGCTGCCGCTGCC
CACCCCCGGCCCGCGCGACCTGCGCGTGCGCATCCACGCCGTGTCGGTCAACCCGGTCGACACCAAGGTGCGTAGCAACG
CCGCGGTGGATGCCCCGCGGGTGCTCGGCTGGGACGCCAGCGGCGTGGTCGATGCGGTCGGCGAGGCGGTCAGCCTGTTC
CGCCCCGGCGATGCGGTGTACTACGCCGGCGCGCTGACCCGCCCGGGCACCAATGCCGAGTTCCACCTGGTCGACGAGCG
CCTGGTCGGGCGCAAGCCGGCCACGCTCGATGACGCTGCGGCTGCGGCGTTGCCGCTGACTGCCATCACCGCCTGGGAAC
TGTTGTTCGACCGGCTCGGCGTTGCCGAAGGTGGCGGCGAAGGCCAGGCGCTGTTGGTGGTCGGTGCGGCCGGTGGCGTC
GGCTCGATGCTGGTGCAGCTGGCGCGCACGCTGACCAAGCTGACCGTGATCGGCACCGCCTCGCGCCCGGAAACCCAGGA
TTGGGTGCATGCACTCGGCGCGCATCACGTGATCGACCACAGCCAGCCGCTGAGCGAGGGCCTGCAGCGGATCGGCATCG
CGCAGGTGCAGCATGTCGCCAGCCTCACCCACACCGACCAGCATTTCGCGCAGCTGGTCGAGGTGCTGGCCCCGCAAGGT
CAGCTGGCGCTGATCGACGACCCGGCCACGCTGGACGCGCTGCCGCTCAAGCGCAAGAGCCTGTCGTTGCACTGGGAGCT
GATGTTCACCCGCTCGTTGTTCGAAACCGAGGACATGATCGCCCAGCACCATCTGCTCAATCGCGTCGCCGAGCTGGTGG
ACACCGGCGTGCTGCGCACCACCCTGGGCGAGCACTACGGCCGCATCACCGCCGACAACCTGCGCCGCGCCCACGCCGCG
CTGGAATCGCACCGCACCCGCGGCAAGCTGGTGCTGGAAGGCTTCTGA

Upstream 100 bases:

>100_bases
CCATCTTCACTCCAATGGTGAAAGTGCTTGCGCAGTTTGCCGGTTTTTCCGTGAATCCGGGTGGCCGACCATGCAACTCC
CTCCCGCACGACGCCCTGCC

Downstream 100 bases:

>100_bases
CCCTACGCCTCAAGCCCAGACAGCGGCCCGCGTCGCCGCTGTCTGGCTGACTCCTGCAGCGCGTGCGCATGATCACGCCG
GCCAGCAGGCGTGACGCAGC

Product: alginate lyase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKAIAYLQHGLPIDDARALVELELPLPTPGPRDLRVRIHAVSVNPVDTKVRSNAAVDAPRVLGWDASGVVDAVGEAVSLF
RPGDAVYYAGALTRPGTNAEFHLVDERLVGRKPATLDDAAAAALPLTAITAWELLFDRLGVAEGGGEGQALLVVGAAGGV
GSMLVQLARTLTKLTVIGTASRPETQDWVHALGAHHVIDHSQPLSEGLQRIGIAQVQHVASLTHTDQHFAQLVEVLAPQG
QLALIDDPATLDALPLKRKSLSLHWELMFTRSLFETEDMIAQHHLLNRVAELVDTGVLRTTLGEHYGRITADNLRRAHAA
LESHRTRGKLVLEGF

Sequences:

>Translated_335_residues
MKAIAYLQHGLPIDDARALVELELPLPTPGPRDLRVRIHAVSVNPVDTKVRSNAAVDAPRVLGWDASGVVDAVGEAVSLF
RPGDAVYYAGALTRPGTNAEFHLVDERLVGRKPATLDDAAAAALPLTAITAWELLFDRLGVAEGGGEGQALLVVGAAGGV
GSMLVQLARTLTKLTVIGTASRPETQDWVHALGAHHVIDHSQPLSEGLQRIGIAQVQHVASLTHTDQHFAQLVEVLAPQG
QLALIDDPATLDALPLKRKSLSLHWELMFTRSLFETEDMIAQHHLLNRVAELVDTGVLRTTLGEHYGRITADNLRRAHAA
LESHRTRGKLVLEGF
>Mature_335_residues
MKAIAYLQHGLPIDDARALVELELPLPTPGPRDLRVRIHAVSVNPVDTKVRSNAAVDAPRVLGWDASGVVDAVGEAVSLF
RPGDAVYYAGALTRPGTNAEFHLVDERLVGRKPATLDDAAAAALPLTAITAWELLFDRLGVAEGGGEGQALLVVGAAGGV
GSMLVQLARTLTKLTVIGTASRPETQDWVHALGAHHVIDHSQPLSEGLQRIGIAQVQHVASLTHTDQHFAQLVEVLAPQG
QLALIDDPATLDALPLKRKSLSLHWELMFTRSLFETEDMIAQHHLLNRVAELVDTGVLRTTLGEHYGRITADNLRRAHAA
LESHRTRGKLVLEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=334, Percent_Identity=27.2455089820359, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI194239674, Length=207, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI13236495, Length=207, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI194239676, Length=207, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI24308257, Length=280, Percent_Identity=26.7857142857143, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI28557745, Length=336, Percent_Identity=28.2738095238095, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1790485, Length=336, Percent_Identity=25.297619047619, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71987554, Length=182, Percent_Identity=34.6153846153846, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17507255, Length=244, Percent_Identity=30.7377049180328, Blast_Score=84, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36017; Mature: 36017

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIAYLQHGLPIDDARALVELELPLPTPGPRDLRVRIHAVSVNPVDTKVRSNAAVDAPR
CCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECCCCCHHHHCCCCCCCCC
VLGWDASGVVDAVGEAVSLFRPGDAVYYAGALTRPGTNAEFHLVDERLVGRKPATLDDAA
EECCCCCHHHHHHHHHHHHCCCCCCEEEECEECCCCCCCEEEEECHHHCCCCCCCCCHHH
AAALPLTAITAWELLFDRLGVAEGGGEGQALLVVGAAGGVGSMLVQLARTLTKLTVIGTA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEECC
SRPETQDWVHALGAHHVIDHSQPLSEGLQRIGIAQVQHVASLTHTDQHFAQLVEVLAPQG
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
QLALIDDPATLDALPLKRKSLSLHWELMFTRSLFETEDMIAQHHLLNRVAELVDTGVLRT
CEEEEECCCCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLGEHYGRITADNLRRAHAALESHRTRGKLVLEGF
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MKAIAYLQHGLPIDDARALVELELPLPTPGPRDLRVRIHAVSVNPVDTKVRSNAAVDAPR
CCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEECCCCCHHHHCCCCCCCCC
VLGWDASGVVDAVGEAVSLFRPGDAVYYAGALTRPGTNAEFHLVDERLVGRKPATLDDAA
EECCCCCHHHHHHHHHHHHCCCCCCEEEECEECCCCCCCEEEEECHHHCCCCCCCCCHHH
AAALPLTAITAWELLFDRLGVAEGGGEGQALLVVGAAGGVGSMLVQLARTLTKLTVIGTA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEECC
SRPETQDWVHALGAHHVIDHSQPLSEGLQRIGIAQVQHVASLTHTDQHFAQLVEVLAPQG
CCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
QLALIDDPATLDALPLKRKSLSLHWELMFTRSLFETEDMIAQHHLLNRVAELVDTGVLRT
CEEEEECCCCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLGEHYGRITADNLRRAHAALESHRTRGKLVLEGF
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA