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The map label for this gene is mutM

Identifier: 21245003

GI number: 21245003

Start: 5064634

End: 5065449

Strand: Reverse

Name: mutM

Synonym: XAC4286

Alternate gene names: 21245003

Gene position: 5065449-5064634 (Counterclockwise)

Preceding gene: 21245005

Following gene: 21245002

Centisome position: 97.87

GC content: 60.91

Gene sequence:

>816_bases
ATGCCTGAGTTGCCCGAGGTCGAAACGACGTTGCGTGGCCTGTCGCCGCATCTGGTTGGGCAGCGGATCCATGGCGTGAT
CCTGCGTCGGCCCGATCTGCGTTGGCCGATTCCCGAGCAGATCGAGCGCTTGCTTCCCGGCGCCACCATTACCAACGTGC
GCCGACGTGCGAAATACTTGCTGATCGATACGGATGCCGGCGGCAGCGTGCTGTTGCATCTGGGGATGTCCGGAAGTCTG
CGGGTGCTGCCTGGCGACACGTTGCCGCGGGCGCACGACCATGTGGATATCAGTCTGCAAAGCGGGCGCTTGCTGCGTTT
CAACGATCCGCGTCGCTTTGGCTGCCTGTTGTGGCAATCCGGCACACAAGCCCATGACTTGCTCGCTGCGCTTGGTCCAG
AACCATTATCGGATGCATTTACTGGCGATTATCTCCACGCGCTGGCACAGGGGCGGCGCGCTGCCGTCAAGACCTTTTTG
ATGGATCAGGCCGTGGTTGTCGGAGTTGGAAATATCTACGCTGCCGAAAGCCTGCATCGGGCGGGAATCAGTCCGTTGCG
CGAGGCGGGGAAGGTCTCGCTGGAGCGTTATCGGCGTCTGGCTGATGCAGTGAAAGACATCCTGGCGTATGCCATCCAGC
GCGGTGGAACCACATTGCGCGACTTCATCAGCCCCGATGGTGCGCCCGGCTATTTCGAGCAGGAACTTTTTGTTTATGGG
CGCGAGGGCGAGGCCTGCAAACAGTGTGGACGGGTCTTGAAACACGCGACGATCGGTCAACGCGCTACGGTGTGGTGCGG
GAGCTGTCAGCGATAA

Upstream 100 bases:

>100_bases
CAGCGATAGCGCGCCGGCAGGGTCGCGTTGATTGTGTTTGAGTGTTTCGACCCCATTAGCTGCTTTGCCGGTGTGTGGCC
GGCGTTTGTTGGATGCGCTG

Downstream 100 bases:

>100_bases
GCGCCATATCAAGCCGGCGCGGTGTTTGACCGCTGACGTTGTCGCGATAGTCTCCAGATCGTTCCAGCGGACGCCACAAC
AATGCGGCTCGGCTAACTCC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPELPEVETTLRGLSPHLVGQRIHGVILRRPDLRWPIPEQIERLLPGATITNVRRRAKYLLIDTDAGGSVLLHLGMSGSL
RVLPGDTLPRAHDHVDISLQSGRLLRFNDPRRFGCLLWQSGTQAHDLLAALGPEPLSDAFTGDYLHALAQGRRAAVKTFL
MDQAVVVGVGNIYAAESLHRAGISPLREAGKVSLERYRRLADAVKDILAYAIQRGGTTLRDFISPDGAPGYFEQELFVYG
REGEACKQCGRVLKHATIGQRATVWCGSCQR

Sequences:

>Translated_271_residues
MPELPEVETTLRGLSPHLVGQRIHGVILRRPDLRWPIPEQIERLLPGATITNVRRRAKYLLIDTDAGGSVLLHLGMSGSL
RVLPGDTLPRAHDHVDISLQSGRLLRFNDPRRFGCLLWQSGTQAHDLLAALGPEPLSDAFTGDYLHALAQGRRAAVKTFL
MDQAVVVGVGNIYAAESLHRAGISPLREAGKVSLERYRRLADAVKDILAYAIQRGGTTLRDFISPDGAPGYFEQELFVYG
REGEACKQCGRVLKHATIGQRATVWCGSCQR
>Mature_270_residues
PELPEVETTLRGLSPHLVGQRIHGVILRRPDLRWPIPEQIERLLPGATITNVRRRAKYLLIDTDAGGSVLLHLGMSGSLR
VLPGDTLPRAHDHVDISLQSGRLLRFNDPRRFGCLLWQSGTQAHDLLAALGPEPLSDAFTGDYLHALAQGRRAAVKTFLM
DQAVVVGVGNIYAAESLHRAGISPLREAGKVSLERYRRLADAVKDILAYAIQRGGTTLRDFISPDGAPGYFEQELFVYGR
EGEACKQCGRVLKHATIGQRATVWCGSCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=271, Percent_Identity=51.6605166051661, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI1786932, Length=274, Percent_Identity=25.5474452554745, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_XANAC (Q8PEQ4)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644585.1
- ProteinModelPortal:   Q8PEQ4
- SMR:   Q8PEQ4
- GeneID:   1158357
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC4286
- NMPDR:   fig|190486.1.peg.4229
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- BioCyc:   XAXO190486:XAC4286-MONOMER
- BRENDA:   3.2.2.23
- BRENDA:   4.2.99.18
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 29828; Mature: 29697

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 261-261 BINDING 92-92 BINDING 111-111 BINDING 152-152

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETTLRGLSPHLVGQRIHGVILRRPDLRWPIPEQIERLLPGATITNVRRRAKYL
CCCCCCHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCHHHHHHHCCCCHHHHHHHCCEEE
LIDTDAGGSVLLHLGMSGSLRVLPGDTLPRAHDHVDISLQSGRLLRFNDPRRFGCLLWQS
EEECCCCCEEEEEECCCCCEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCEEEEEECC
GTQAHDLLAALGPEPLSDAFTGDYLHALAQGRRAAVKTFLMDQAVVVGVGNIYAAESLHR
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCHHEEECCCHHHHHHHHH
AGISPLREAGKVSLERYRRLADAVKDILAYAIQRGGTTLRDFISPDGAPGYFEQELFVYG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEEC
REGEACKQCGRVLKHATIGQRATVWCGSCQR
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCC
>Mature Secondary Structure 
PELPEVETTLRGLSPHLVGQRIHGVILRRPDLRWPIPEQIERLLPGATITNVRRRAKYL
CCCCCHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCHHHHHHHCCCCHHHHHHHCCEEE
LIDTDAGGSVLLHLGMSGSLRVLPGDTLPRAHDHVDISLQSGRLLRFNDPRRFGCLLWQS
EEECCCCCEEEEEECCCCCEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCEEEEEECC
GTQAHDLLAALGPEPLSDAFTGDYLHALAQGRRAAVKTFLMDQAVVVGVGNIYAAESLHR
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHCHHEEECCCHHHHHHHHH
AGISPLREAGKVSLERYRRLADAVKDILAYAIQRGGTTLRDFISPDGAPGYFEQELFVYG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEEC
REGEACKQCGRVLKHATIGQRATVWCGSCQR
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217