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The map label for this gene is trxA [H]

Identifier: 21244554

GI number: 21244554

Start: 4504283

End: 4504624

Strand: Direct

Name: trxA [H]

Synonym: XAC3830

Alternate gene names: 21244554

Gene position: 4504283-4504624 (Clockwise)

Preceding gene: 21244547

Following gene: 21244555

Centisome position: 87.03

GC content: 62.57

Gene sequence:

>342_bases
GTGAGCGATAAGGTTCAACATGTCGGCGATGCCGACTTCGACACAGCTGTACTGCAAGCGGGCGAACCGGTTCTGGTGGA
TTTCTGGGCCGAGTGGTGCGGCCCATGCAAGATGATCGCCCCGGTGCTGGACGATCTGGCCGACACCTATCAGGGCCGCC
TCAAGGTCGCCAAGGTCAATGTGGACCAGAACCGTGCGCTGGCCATCAAGTACCACGTGCGCTCGATTCCGATGCTGTTG
CTGTTCAAGGACGGGCAGGTGCAGGCGACCCAGATCGGTGCCGTCGGCAAGGGCCAGCTGACCCAGATGATCGACAAGAC
CCTGGGTGGCGCGGCCGCCTGA

Upstream 100 bases:

>100_bases
TCAGGACTGACACTTGATTCAGTCGCGCAATGCCCCAGTTTAGCGCAATGTAGCGGCCTGCCCGTTCGGGTGGGCCGTTT
TGGTTTCCAGGAGACCCAAG

Downstream 100 bases:

>100_bases
GCAAGCGGGCGTCCAGCAATGGGCGCCCGATGATGCGCCGGCAGTTAAATCGTGCCCGGCAAGACGCTTGCGCGGCAACG
CGCGGCGGTGATAGTGTCAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 113; Mature: 112

Protein sequence:

>113_residues
MSDKVQHVGDADFDTAVLQAGEPVLVDFWAEWCGPCKMIAPVLDDLADTYQGRLKVAKVNVDQNRALAIKYHVRSIPMLL
LFKDGQVQATQIGAVGKGQLTQMIDKTLGGAAA

Sequences:

>Translated_113_residues
MSDKVQHVGDADFDTAVLQAGEPVLVDFWAEWCGPCKMIAPVLDDLADTYQGRLKVAKVNVDQNRALAIKYHVRSIPMLL
LFKDGQVQATQIGAVGKGQLTQMIDKTLGGAAA
>Mature_112_residues
SDKVQHVGDADFDTAVLQAGEPVLVDFWAEWCGPCKMIAPVLDDLADTYQGRLKVAKVNVDQNRALAIKYHVRSIPMLLL
FKDGQVQATQIGAVGKGQLTQMIDKTLGGAAA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=98, Percent_Identity=37.7551020408163, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=62.037037037037, Blast_Score=149, Evalue=5e-38,
Organism=Escherichia coli, GI1788936, Length=86, Percent_Identity=40.6976744186046, Blast_Score=90, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71998175, Length=106, Percent_Identity=43.3962264150943, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=38.1443298969072, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17509965, Length=100, Percent_Identity=32, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=76, Percent_Identity=40.7894736842105, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=76, Percent_Identity=40.7894736842105, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=103, Percent_Identity=35.9223300970874, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=103, Percent_Identity=35.9223300970874, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=103, Percent_Identity=35.9223300970874, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=111, Percent_Identity=34.2342342342342, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=42.8571428571429, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=38.0952380952381, Blast_Score=69, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24639826, Length=93, Percent_Identity=40.8602150537634, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=35.0515463917526, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664269, Length=101, Percent_Identity=41.5841584158416, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17648013, Length=95, Percent_Identity=35.7894736842105, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583090, Length=95, Percent_Identity=35.7894736842105, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639068, Length=94, Percent_Identity=32.9787234042553, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21358065, Length=60, Percent_Identity=41.6666666666667, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12197; Mature: 12066

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKVQHVGDADFDTAVLQAGEPVLVDFWAEWCGPCKMIAPVLDDLADTYQGRLKVAKVN
CCCCCCCCCCCCCCHHHHHCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEE
VDQNRALAIKYHVRSIPMLLLFKDGQVQATQIGAVGKGQLTQMIDKTLGGAAA
CCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDKVQHVGDADFDTAVLQAGEPVLVDFWAEWCGPCKMIAPVLDDLADTYQGRLKVAKVN
CCCCCCCCCCCCCHHHHHCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEE
VDQNRALAIKYHVRSIPMLLLFKDGQVQATQIGAVGKGQLTQMIDKTLGGAAA
CCCCCEEEEEEECCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]