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The map label for this gene is fmt

Identifier: 21244524

GI number: 21244524

Start: 4470685

End: 4471608

Strand: Reverse

Name: fmt

Synonym: XAC3800

Alternate gene names: 21244524

Gene position: 4471608-4470685 (Counterclockwise)

Preceding gene: 21244525

Following gene: 21244523

Centisome position: 86.4

GC content: 71.1

Gene sequence:

>924_bases
ATGAGAATCATCTTCGCCGGTACGCCGGATTTTGCCGTCCCGTCGCTACGCGCCGCCGCGCAGCGGCATGAGGTGGTGGC
GGTGTACACGCAGCCCGATCGCCCCGCCGGACGTGGTCGCGGGTTGACGCCCTCGCCGGTCAAGCTGGAGGCGATCGCGC
GCGGCATTCCGGTCTTCCAGCCGCAGACGCTGCGTTCGCCCGAAGCATTGGCGACGTTGCGCGCGCTCGATGCGGACCTG
ATGGTGGTGGTGGCGTACGGGTTGATCTTGCCAAAGGCAGTGCTGGCCGCGCCGACGCACGGCTGCTGGAACGTGCATGC
CTCGTTGCTGCCGCGCTGGCGTGGCGCCGCGCCGATCCAGCGTGCGATCGAGGCCGGCGACACCGAGACCGGGGTGTGTC
TGATGCAGATGGAAGCCGGGTTGGACACCGGCCCGGTGCTGCTGTCGCAGCGCATCGAAATTGGCGAGCAGGACACCGGC
GGACAGTTGCACGACCGGCTGGCCGCGCTGGGCGCGCAGGTGCTGTCCGATGGCCTGGGCCTGTTGCGCGCCGGCATCCG
TCCGGTGGCCCAGCCGCAGCCGGCCGACGGGGTGACCTATGCGCACAAGCTGGACAAGGCGCAGGCGCGGCTGGATTGGG
CACAGCCGGCGCAGGAACTGGCGCGACGCGTGCGGGCGTTCAACCCGTGGCCGGTGGCCGAGGCGATCCTGGCGGGCGAG
CGCGTGCGCCTGCATGGCGCGGTGGCGCTTGAACTGGCCCATCAACAGCCGCCGGGCACCCTGCTGGCGGCCAGCAAGCA
GGGCATCGATATCGCCTGCGGTGAGGGTGCGCTGCGGGTGCGCGTGCTCCAGCGCGAGGGCGGCAAGGCGATTACCGCCG
CCGATTACCTCAACGCGCGACGCGACCTGCCGGCGCTGCGCTGA

Upstream 100 bases:

>100_bases
CGCAGATCCCGTTTCCACCTCTCAGCTCCACGCCATTCTCGCCCCGGCCAGCACACCTGCCGTTGCGACTCCCCACTCCC
GAATCCCGAATCCCAGCCCT

Downstream 100 bases:

>100_bases
TGTCGGCCGACACCGCAACCGCCGGCGTCGCCTCGCGCCTGGCTGCCGCACGCGTACTGACGGCGGTGTTCGATCAAGGC
CGGTCGTTGAAGGCCGAACT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRIIFAGTPDFAVPSLRAAAQRHEVVAVYTQPDRPAGRGRGLTPSPVKLEAIARGIPVFQPQTLRSPEALATLRALDADL
MVVVAYGLILPKAVLAAPTHGCWNVHASLLPRWRGAAPIQRAIEAGDTETGVCLMQMEAGLDTGPVLLSQRIEIGEQDTG
GQLHDRLAALGAQVLSDGLGLLRAGIRPVAQPQPADGVTYAHKLDKAQARLDWAQPAQELARRVRAFNPWPVAEAILAGE
RVRLHGAVALELAHQQPPGTLLAASKQGIDIACGEGALRVRVLQREGGKAITAADYLNARRDLPALR

Sequences:

>Translated_307_residues
MRIIFAGTPDFAVPSLRAAAQRHEVVAVYTQPDRPAGRGRGLTPSPVKLEAIARGIPVFQPQTLRSPEALATLRALDADL
MVVVAYGLILPKAVLAAPTHGCWNVHASLLPRWRGAAPIQRAIEAGDTETGVCLMQMEAGLDTGPVLLSQRIEIGEQDTG
GQLHDRLAALGAQVLSDGLGLLRAGIRPVAQPQPADGVTYAHKLDKAQARLDWAQPAQELARRVRAFNPWPVAEAILAGE
RVRLHGAVALELAHQQPPGTLLAASKQGIDIACGEGALRVRVLQREGGKAITAADYLNARRDLPALR
>Mature_307_residues
MRIIFAGTPDFAVPSLRAAAQRHEVVAVYTQPDRPAGRGRGLTPSPVKLEAIARGIPVFQPQTLRSPEALATLRALDADL
MVVVAYGLILPKAVLAAPTHGCWNVHASLLPRWRGAAPIQRAIEAGDTETGVCLMQMEAGLDTGPVLLSQRIEIGEQDTG
GQLHDRLAALGAQVLSDGLGLLRAGIRPVAQPQPADGVTYAHKLDKAQARLDWAQPAQELARRVRAFNPWPVAEAILAGE
RVRLHGAVALELAHQQPPGTLLAASKQGIDIACGEGALRVRVLQREGGKAITAADYLNARRDLPALR

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=292, Percent_Identity=31.1643835616438, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI21614513, Length=296, Percent_Identity=29.3918918918919, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI164663775, Length=314, Percent_Identity=28.343949044586, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1789683, Length=305, Percent_Identity=53.7704918032787, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI1788589, Length=272, Percent_Identity=29.4117647058824, Blast_Score=111, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI133930964, Length=321, Percent_Identity=27.1028037383178, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319458, Length=358, Percent_Identity=24.3016759776536, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550868, Length=309, Percent_Identity=31.7152103559871, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571984, Length=228, Percent_Identity=34.6491228070175, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24585660, Length=261, Percent_Identity=28.735632183908, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_XANAC (Q8PG21)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644106.1
- ProteinModelPortal:   Q8PG21
- SMR:   Q8PG21
- GeneID:   1157871
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3800
- NMPDR:   fig|190486.1.peg.3750
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- ProtClustDB:   PRK00005
- BioCyc:   XAXO190486:XAC3800-MONOMER
- BRENDA:   2.1.2.9
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 32697; Mature: 32697

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIFAGTPDFAVPSLRAAAQRHEVVAVYTQPDRPAGRGRGLTPSPVKLEAIARGIPVFQ
CEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHCCCCCCC
PQTLRSPEALATLRALDADLMVVVAYGLILPKAVLAAPTHGCWNVHASLLPRWRGAAPIQ
CCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHH
RAIEAGDTETGVCLMQMEAGLDTGPVLLSQRIEIGEQDTGGQLHDRLAALGAQVLSDGLG
HHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLRAGIRPVAQPQPADGVTYAHKLDKAQARLDWAQPAQELARRVRAFNPWPVAEAILAGE
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHCCC
RVRLHGAVALELAHQQPPGTLLAASKQGIDIACGEGALRVRVLQREGGKAITAADYLNAR
EEEEEHHEEEEECCCCCCCCEEEECCCCCEEEECCCCEEEEEEECCCCCEEEHHHHHHHH
RDLPALR
CCCCCCC
>Mature Secondary Structure
MRIIFAGTPDFAVPSLRAAAQRHEVVAVYTQPDRPAGRGRGLTPSPVKLEAIARGIPVFQ
CEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHCCCCCCC
PQTLRSPEALATLRALDADLMVVVAYGLILPKAVLAAPTHGCWNVHASLLPRWRGAAPIQ
CCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHH
RAIEAGDTETGVCLMQMEAGLDTGPVLLSQRIEIGEQDTGGQLHDRLAALGAQVLSDGLG
HHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLRAGIRPVAQPQPADGVTYAHKLDKAQARLDWAQPAQELARRVRAFNPWPVAEAILAGE
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHCCC
RVRLHGAVALELAHQQPPGTLLAASKQGIDIACGEGALRVRVLQREGGKAITAADYLNAR
EEEEEHHEEEEECCCCCCCCEEEECCCCCEEEECCCCEEEEEEECCCCCEEEHHHHHHHH
RDLPALR
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217