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The map label for this gene is sun

Identifier: 21244523

GI number: 21244523

Start: 4469375

End: 4470685

Strand: Reverse

Name: sun

Synonym: XAC3799

Alternate gene names: 21244523

Gene position: 4470685-4469375 (Counterclockwise)

Preceding gene: 21244524

Following gene: 21244522

Centisome position: 86.38

GC content: 68.73

Gene sequence:

>1311_bases
ATGTCGGCCGACACCGCAACCGCCGGCGTCGCCTCGCGCCTGGCTGCCGCACGCGTACTGACGGCGGTGTTCGATCAAGG
CCGGTCGTTGAAGGCCGAACTTGCCGCGACCTTGCCCGGCATCGGCGATCCGCGTGATCGCGCGCTGGTGGAGGCGATCT
GCTTTGCGGTCATTCGCCGGCGCCCGGCGTATGAGGTCGCGTTGCGGCAATGGCTGGAACGCGCGTTGCCGCCCCGCGAT
GCCGAACTCAAGGCGCTGCTGATGGTCGGTTTCGCGCAACTCGAGGTGCTGCAACTGCCCGCGCACGCCGCGTTGTCGGC
CACCGTGGATGCGTGTCGCGCACTGGGCCGGCCCCGTCAGGCCGGCATGGTCAACGCGATTCTGCGGCGTGCCCAGCGCG
AAGGATTTCCCGCGGTGGCCGACGATGCCGGTTGGCCGTCTTGGCTGCGCAAGCAGTTGCGCGCGGACTGGGGCGATCGT
GCCGAAGCCATTTTCACCGCAAGTGCGCAGATGGCGCCGATGTGGCTGCGCGTGCAGCGTTCGCGCACCGACCCTGCGAC
ATATGTCGCACGACTGGCCGAACTGGATATCGTCGCGCACACCGATGCTGTATTGCCGGATGCGGTGCGCCTGCACAACG
CCGTGCCGGTGAGCCAGTTGCCGGGCTTCGCCGAAGGCGATGTTTCGGTGCAGGACGGCTCCGCGCAGCAGGTGGCCGAT
GCGTTGACCCTGGCGCCGTCGGCACGCGTGCTCGATGCCTGCGCCGCGCCCGGTGGCAAGGCGGCGCATCTGCTGGAGCG
CCATCCCGGATTGCAGCTCGTGGCGCTGGATGTGGATGCGCGCCGCCTGGAGCGCGTGCAGCAGACCTTGCAGCGCACGG
TCCCCAATGCGCTAGTTGCGTTGCAGGCGGCCGACGCCGCCGATACGGACGCATGGTGGGACGGCCGGCCGTTCGATGCG
GTACTGCTGGACGCGCCATGTTCGGCCACCGGCGTGGTGCGTCGTCAACCGGATGTGCTGCTGCACCGGCGCGCCGACGA
TATCGAGGCGCTGTGTGCGCTGCAGGCGCGGCTACTGGATGCGACCTGGCGCACGCTGCGCCCAGGCGGACAATTGCTGT
ACACCACCTGCTCGCTGTTGGCGCGCGAGAACCAGGCGCAGGTCGAGGCATTCCTGCAGCGCACTCCCGACGCACGCGCG
CAGACCTTGGGTGCGCAGTTCGGGCATGCCGCCGGCGCCGGACGTCAGCGGTTTCCAGGCGAGCAGCACTGCGACGGATT
TTTCTACGCGCTTTTGCTAAAAGCCTCCTGA

Upstream 100 bases:

>100_bases
AGGGTGCGCTGCGGGTGCGCGTGCTCCAGCGCGAGGGCGGCAAGGCGATTACCGCCGCCGATTACCTCAACGCGCGACGC
GACCTGCCGGCGCTGCGCTG

Downstream 100 bases:

>100_bases
TCGCGCGCGAAGTCCAGCGCTCCACCCTCTGCGACCGACTGCCGCCCGACATGTTCAAGAATCGCGCTTCCACCGATGTC
TGGTTGCTGGCCATGACCGC

Product: Sun protein

Products: NA

Alternate protein names: 16S rRNA m5C967 methyltransferase; rRNA (cytosine-C(5)-)-methyltransferase rsmB

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSADTATAGVASRLAAARVLTAVFDQGRSLKAELAATLPGIGDPRDRALVEAICFAVIRRRPAYEVALRQWLERALPPRD
AELKALLMVGFAQLEVLQLPAHAALSATVDACRALGRPRQAGMVNAILRRAQREGFPAVADDAGWPSWLRKQLRADWGDR
AEAIFTASAQMAPMWLRVQRSRTDPATYVARLAELDIVAHTDAVLPDAVRLHNAVPVSQLPGFAEGDVSVQDGSAQQVAD
ALTLAPSARVLDACAAPGGKAAHLLERHPGLQLVALDVDARRLERVQQTLQRTVPNALVALQAADAADTDAWWDGRPFDA
VLLDAPCSATGVVRRQPDVLLHRRADDIEALCALQARLLDATWRTLRPGGQLLYTTCSLLARENQAQVEAFLQRTPDARA
QTLGAQFGHAAGAGRQRFPGEQHCDGFFYALLLKAS

Sequences:

>Translated_436_residues
MSADTATAGVASRLAAARVLTAVFDQGRSLKAELAATLPGIGDPRDRALVEAICFAVIRRRPAYEVALRQWLERALPPRD
AELKALLMVGFAQLEVLQLPAHAALSATVDACRALGRPRQAGMVNAILRRAQREGFPAVADDAGWPSWLRKQLRADWGDR
AEAIFTASAQMAPMWLRVQRSRTDPATYVARLAELDIVAHTDAVLPDAVRLHNAVPVSQLPGFAEGDVSVQDGSAQQVAD
ALTLAPSARVLDACAAPGGKAAHLLERHPGLQLVALDVDARRLERVQQTLQRTVPNALVALQAADAADTDAWWDGRPFDA
VLLDAPCSATGVVRRQPDVLLHRRADDIEALCALQARLLDATWRTLRPGGQLLYTTCSLLARENQAQVEAFLQRTPDARA
QTLGAQFGHAAGAGRQRFPGEQHCDGFFYALLLKAS
>Mature_435_residues
SADTATAGVASRLAAARVLTAVFDQGRSLKAELAATLPGIGDPRDRALVEAICFAVIRRRPAYEVALRQWLERALPPRDA
ELKALLMVGFAQLEVLQLPAHAALSATVDACRALGRPRQAGMVNAILRRAQREGFPAVADDAGWPSWLRKQLRADWGDRA
EAIFTASAQMAPMWLRVQRSRTDPATYVARLAELDIVAHTDAVLPDAVRLHNAVPVSQLPGFAEGDVSVQDGSAQQVADA
LTLAPSARVLDACAAPGGKAAHLLERHPGLQLVALDVDARRLERVQQTLQRTVPNALVALQAADAADTDAWWDGRPFDAV
LLDAPCSATGVVRRQPDVLLHRRADDIEALCALQARLLDATWRTLRPGGQLLYTTCSLLARENQAQVEAFLQRTPDARAQ
TLGAQFGHAAGAGRQRFPGEQHCDGFFYALLLKAS

Specific function: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA

COG id: COG0144

COG function: function code J; tRNA and rRNA cytosine-C5-methylases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmB/NOP family

Homologues:

Organism=Homo sapiens, GI76150625, Length=255, Percent_Identity=31.3725490196078, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI76150623, Length=255, Percent_Identity=31.3725490196078, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI32698918, Length=190, Percent_Identity=31.0526315789474, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI11545785, Length=164, Percent_Identity=35.3658536585366, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI40316918, Length=191, Percent_Identity=29.3193717277487, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI301336155, Length=184, Percent_Identity=28.804347826087, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI39995082, Length=184, Percent_Identity=28.804347826087, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI23199998, Length=260, Percent_Identity=29.2307692307692, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI8922322, Length=260, Percent_Identity=29.2307692307692, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI270288816, Length=260, Percent_Identity=29.2307692307692, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI270288818, Length=260, Percent_Identity=29.2307692307692, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI2367212, Length=428, Percent_Identity=40.1869158878505, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI87081985, Length=235, Percent_Identity=33.6170212765957, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17536757, Length=240, Percent_Identity=30.4166666666667, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25143471, Length=203, Percent_Identity=32.0197044334975, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324268, Length=240, Percent_Identity=27.9166666666667, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319447, Length=188, Percent_Identity=31.9148936170213, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI22024126, Length=250, Percent_Identity=30, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI19920494, Length=174, Percent_Identity=31.6091954022989, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21355201, Length=204, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356513, Length=190, Percent_Identity=30, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24668781, Length=190, Percent_Identity=30, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSMB_XANAC (Q8PG22)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644105.1
- ProteinModelPortal:   Q8PG22
- SMR:   Q8PG22
- GeneID:   1157870
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3799
- NMPDR:   fig|190486.1.peg.3749
- HOGENOM:   HBG726909
- OMA:   ANNAHPP
- ProtClustDB:   PRK10901
- BioCyc:   XAXO190486:XAC3799-MONOMER
- GO:   GO:0005737
- InterPro:   IPR001678
- InterPro:   IPR018314
- InterPro:   IPR006027
- InterPro:   IPR004573
- Gene3D:   G3DSA:1.10.940.10
- TIGRFAMs:   TIGR00563

Pfam domain/function: PF01189 Nol1_Nop2_Fmu; PF01029 NusB; SSF48013 NusB_RsmB_TIM44

EC number: =2.1.1.176

Molecular weight: Translated: 47035; Mature: 46904

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS01153 NOL1_NOP2_SUN

Important sites: ACT_SITE 377-377 BINDING 277-277 BINDING 305-305 BINDING 324-324

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADTATAGVASRLAAARVLTAVFDQGRSLKAELAATLPGIGDPRDRALVEAICFAVIRR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
RPAYEVALRQWLERALPPRDAELKALLMVGFAQLEVLQLPAHAALSATVDACRALGRPRQ
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
AGMVNAILRRAQREGFPAVADDAGWPSWLRKQLRADWGDRAEAIFTASAQMAPMWLRVQR
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHEEEECCCHHCHHHHHHHH
SRTDPATYVARLAELDIVAHTDAVLPDAVRLHNAVPVSQLPGFAEGDVSVQDGSAQQVAD
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCEECCCCHHHHHH
ALTLAPSARVLDACAAPGGKAAHLLERHPGLQLVALDVDARRLERVQQTLQRTVPNALVA
HHHCCCCHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHH
LQAADAADTDAWWDGRPFDAVLLDAPCSATGVVRRQPDVLLHRRADDIEALCALQARLLD
EECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHH
ATWRTLRPGGQLLYTTCSLLARENQAQVEAFLQRTPDARAQTLGAQFGHAAGAGRQRFPG
HHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
EQHCDGFFYALLLKAS
CCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SADTATAGVASRLAAARVLTAVFDQGRSLKAELAATLPGIGDPRDRALVEAICFAVIRR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
RPAYEVALRQWLERALPPRDAELKALLMVGFAQLEVLQLPAHAALSATVDACRALGRPRQ
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
AGMVNAILRRAQREGFPAVADDAGWPSWLRKQLRADWGDRAEAIFTASAQMAPMWLRVQR
CHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHEEEECCCHHCHHHHHHHH
SRTDPATYVARLAELDIVAHTDAVLPDAVRLHNAVPVSQLPGFAEGDVSVQDGSAQQVAD
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCEECCCCHHHHHH
ALTLAPSARVLDACAAPGGKAAHLLERHPGLQLVALDVDARRLERVQQTLQRTVPNALVA
HHHCCCCHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHH
LQAADAADTDAWWDGRPFDAVLLDAPCSATGVVRRQPDVLLHRRADDIEALCALQARLLD
EECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHH
ATWRTLRPGGQLLYTTCSLLARENQAQVEAFLQRTPDARAQTLGAQFGHAAGAGRQRFPG
HHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
EQHCDGFFYALLLKAS
CCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217