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The map label for this gene is cysH

Identifier: 21244057

GI number: 21244057

Start: 3926566

End: 3927291

Strand: Direct

Name: cysH

Synonym: XAC3332

Alternate gene names: 21244057

Gene position: 3926566-3927291 (Clockwise)

Preceding gene: 21244056

Following gene: 21244061

Centisome position: 75.87

GC content: 62.53

Gene sequence:

>726_bases
ATGACCGCGCTGCCTGCTGCATCGATCACTTCTTCCGCGTTCGACGATCTGGACGCGCTCAATGCGCAGCTGGAAGGGCT
GCGTGCCGATCAACGCGTGGCCTGGGCGCTGCAGCACGGCCCGCAGAACGCGGCCTTGTCGTCCAGCTTCGGCGCGCAAT
CGGCGGTTACCTTGCATCTGCTCAGTCAGCAACGTCCGGACATCCCGGTAATCCTGATCGACACCGGTTATCTGTTTCCG
GAAACCTACCGTTTTGCCGATGCCTTGACCGAGCGACTCAAGCTCAATCTCAAGGTCTATCGCCCGCTGGTCAGCCGCGC
CTGGATGGAAGCGCGCCACGGCCGCCTGTGGGAGCAAGGCATGGTCGGCATCGATCAATACAACAATCTGCGCAAGGTCG
AACCGATGCGCCGGGCCTTGAACGAACTCGACGTGGGCACCTGGTTTACCGGCCTGCGCCGCAGCCAGTCCGGCGGCCGC
GCGCAGACGCCGATCATGCAGAAGCGCGGCGAGCGTTACAAAATCAGCCCGATCGCCGACTGGACCGATCGCGATGTGTG
GCAATACCTGCAAGCGCACGACCTGCCGTATCACCCGCTCTGGGAACAAGGCTACGTGTCCATCGGCGATTTCCACACCA
CGCGTCGCTGGGAGCCCGGCATGCGCGAAGAAGACACGCGCTTTTACGGTCTCAAGCGCGAGTGCGGCATCCACGAAGAT
ATCTAG

Upstream 100 bases:

>100_bases
ACGCCAACGATGAAGGCTTCGGCGATTTCCTGCATCGCGCCGGGGTGATCGCATTGCCGCCCTACCCCACGCACCGTCGC
CTCGACCTGGAATTGCTCGC

Downstream 100 bases:

>100_bases
CGTCAGCGGTCCATTGCCAGTTGCGCTTGTACGAGTGACGCTTCACCCGCATGTGCGGCAGCTGCATGCGCATGCTGCAT
CCAGGATGCAACGGCAGTGC

Product: phosphoadenosine phosphosulfate reductase

Products: NA

Alternate protein names: 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MTALPAASITSSAFDDLDALNAQLEGLRADQRVAWALQHGPQNAALSSSFGAQSAVTLHLLSQQRPDIPVILIDTGYLFP
ETYRFADALTERLKLNLKVYRPLVSRAWMEARHGRLWEQGMVGIDQYNNLRKVEPMRRALNELDVGTWFTGLRRSQSGGR
AQTPIMQKRGERYKISPIADWTDRDVWQYLQAHDLPYHPLWEQGYVSIGDFHTTRRWEPGMREEDTRFYGLKRECGIHED
I

Sequences:

>Translated_241_residues
MTALPAASITSSAFDDLDALNAQLEGLRADQRVAWALQHGPQNAALSSSFGAQSAVTLHLLSQQRPDIPVILIDTGYLFP
ETYRFADALTERLKLNLKVYRPLVSRAWMEARHGRLWEQGMVGIDQYNNLRKVEPMRRALNELDVGTWFTGLRRSQSGGR
AQTPIMQKRGERYKISPIADWTDRDVWQYLQAHDLPYHPLWEQGYVSIGDFHTTRRWEPGMREEDTRFYGLKRECGIHED
I
>Mature_240_residues
TALPAASITSSAFDDLDALNAQLEGLRADQRVAWALQHGPQNAALSSSFGAQSAVTLHLLSQQRPDIPVILIDTGYLFPE
TYRFADALTERLKLNLKVYRPLVSRAWMEARHGRLWEQGMVGIDQYNNLRKVEPMRRALNELDVGTWFTGLRRSQSGGRA
QTPIMQKRGERYKISPIADWTDRDVWQYLQAHDLPYHPLWEQGYVSIGDFHTTRRWEPGMREEDTRFYGLKRECGIHEDI

Specific function: Reduction of activated sulfate into sulfite

COG id: COG0175

COG function: function code EH; 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAPS reductase family. CysH subfamily

Homologues:

Organism=Escherichia coli, GI1789121, Length=219, Percent_Identity=64.8401826484018, Blast_Score=310, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6325425, Length=239, Percent_Identity=34.7280334728033, Blast_Score=118, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSH_XANAC (Q8PHC7)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643639.1
- ProteinModelPortal:   Q8PHC7
- SMR:   Q8PHC7
- GeneID:   1157403
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3332
- NMPDR:   fig|190486.1.peg.3283
- HOGENOM:   HBG758022
- OMA:   QVNPSAK
- ProtClustDB:   PRK02090
- BioCyc:   XAXO190486:XAC3332-MONOMER
- BRENDA:   1.8.4.8
- GO:   GO:0005737
- HAMAP:   MF_00063
- InterPro:   IPR004511
- InterPro:   IPR002500
- InterPro:   IPR011800
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00434
- TIGRFAMs:   TIGR02057

Pfam domain/function: PF01507 PAPS_reduct

EC number: =1.8.4.8

Molecular weight: Translated: 27727; Mature: 27595

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALPAASITSSAFDDLDALNAQLEGLRADQRVAWALQHGPQNAALSSSFGAQSAVTLHL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHH
LSQQRPDIPVILIDTGYLFPETYRFADALTERLKLNLKVYRPLVSRAWMEARHGRLWEQG
HHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
MVGIDQYNNLRKVEPMRRALNELDVGTWFTGLRRSQSGGRAQTPIMQKRGERYKISPIAD
CCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHCCCEEEECCCCC
WTDRDVWQYLQAHDLPYHPLWEQGYVSIGDFHTTRRWEPGMREEDTRFYGLKRECGIHED
CCHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCHHCCCHHHCCCCCC
I
C
>Mature Secondary Structure 
TALPAASITSSAFDDLDALNAQLEGLRADQRVAWALQHGPQNAALSSSFGAQSAVTLHL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHH
LSQQRPDIPVILIDTGYLFPETYRFADALTERLKLNLKVYRPLVSRAWMEARHGRLWEQG
HHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHC
MVGIDQYNNLRKVEPMRRALNELDVGTWFTGLRRSQSGGRAQTPIMQKRGERYKISPIAD
CCCHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHHCCCEEEECCCCC
WTDRDVWQYLQAHDLPYHPLWEQGYVSIGDFHTTRRWEPGMREEDTRFYGLKRECGIHED
CCHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCHHCCCHHHCCCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217