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The map label for this gene is cobC [H]

Identifier: 21243915

GI number: 21243915

Start: 3752111

End: 3753094

Strand: Reverse

Name: cobC [H]

Synonym: XAC3189

Alternate gene names: 21243915

Gene position: 3753094-3752111 (Counterclockwise)

Preceding gene: 21243916

Following gene: 21243914

Centisome position: 72.52

GC content: 66.97

Gene sequence:

>984_bases
ATGCTTGAACACGGCGGACGTCTACGCCGCGCTGCGCAGGCCTACAACATTCCGCTCGCGCAGTGGCTGGACCTGTCCAC
TGGCGTGAGCCCGTTTGCATGGCCAGTGCCCGCCATCCCGGAGCATGTGTGGCAGCGCTTGCCCGAAGACGACGATGGCC
TGGCCGAACGCGCGGCTGCATATTACGGCGCGCCGCGGGTACTGCCGGTGGCCGGCTCGCAGGCGGCGATTCAGGCCTTG
CCGCTGCTGCGCGCACCCAGCCGCGTCGGCGTGCTCACGCCTGGCTACGCCGAGCATGCGCAGGCATGGCAGCGTGCCGG
ACATCAGGTCGTGCCGATGAGCGCTGCGCAGTTGCTGCAAGCCGGTGAGACGTTGGATGTGATCGTGCTGATCCACCCCA
ATAACCCATGCGCCGACCGCTTCGATCCCGACACGCTGCTGCAGCTGCATGCGCGGCTTGCAGCACGCGGTGGGTGGCTG
GTGATCGACGAGGCCTTCATGGATGCGACACCGCAACATAGCGTATGCGCCTTCACCCAACGGCCCGGTCTGGTCGTGCT
GCGCTCGGTGGGCAAGTTCTTCGGCATGGCAGGCGCACGTGCGGGATTTGTCTGCGCAGATCGCGCATTGCTGGATGCAG
TGCGCGAACGCTTGGGGCCGTGGACGCTCGGCGGCCCGGCACGCTGGGCCGTGCAACAGGTATTGGCCGATACGCCGTGG
CAGTTGCAGGCATGTGCGCGCCTGCACGCGGCATCGCAGCGGCTTGCGCAGCTGTTGCATGCGCATTCGATCGTACTTAC
CGCAAGCACTGCATTCTTTCAGTGGTGTCGGCGCGAGGACGCCGCCACCTTGCACGTCGCGTTGGCGCAACGCGGCATTT
TGACGCGGCTGTTCGACACACCGTCCAGTCTGCGCTTCGGCCTTCCCCCCGATGCCGCGGGCGAAGCGCGTCTGGATGCG
GCCCTGCGGCAGGTGCTGGCATGA

Upstream 100 bases:

>100_bases
GCGATGATCGGCACGCGGATGGTCTGGTGCTTCACCAACATGCACCGGCGCACCGTGCACGACGGCGCAGGTAGCGCCGC
GCCGCCACCGGGAGTGCGCA

Downstream 100 bases:

>100_bases
GCGCACGCGTGCTGATGGTGCAGGGCTGCACCTCCGATGCGGGCAAGAGCACGCTGGTGGCCGCGCTGTGCCGGTGGCTG
CATCGCCAGGGCATTGCGGT

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MLEHGGRLRRAAQAYNIPLAQWLDLSTGVSPFAWPVPAIPEHVWQRLPEDDDGLAERAAAYYGAPRVLPVAGSQAAIQAL
PLLRAPSRVGVLTPGYAEHAQAWQRAGHQVVPMSAAQLLQAGETLDVIVLIHPNNPCADRFDPDTLLQLHARLAARGGWL
VIDEAFMDATPQHSVCAFTQRPGLVVLRSVGKFFGMAGARAGFVCADRALLDAVRERLGPWTLGGPARWAVQQVLADTPW
QLQACARLHAASQRLAQLLHAHSIVLTASTAFFQWCRREDAATLHVALAQRGILTRLFDTPSSLRFGLPPDAAGEARLDA
ALRQVLA

Sequences:

>Translated_327_residues
MLEHGGRLRRAAQAYNIPLAQWLDLSTGVSPFAWPVPAIPEHVWQRLPEDDDGLAERAAAYYGAPRVLPVAGSQAAIQAL
PLLRAPSRVGVLTPGYAEHAQAWQRAGHQVVPMSAAQLLQAGETLDVIVLIHPNNPCADRFDPDTLLQLHARLAARGGWL
VIDEAFMDATPQHSVCAFTQRPGLVVLRSVGKFFGMAGARAGFVCADRALLDAVRERLGPWTLGGPARWAVQQVLADTPW
QLQACARLHAASQRLAQLLHAHSIVLTASTAFFQWCRREDAATLHVALAQRGILTRLFDTPSSLRFGLPPDAAGEARLDA
ALRQVLA
>Mature_327_residues
MLEHGGRLRRAAQAYNIPLAQWLDLSTGVSPFAWPVPAIPEHVWQRLPEDDDGLAERAAAYYGAPRVLPVAGSQAAIQAL
PLLRAPSRVGVLTPGYAEHAQAWQRAGHQVVPMSAAQLLQAGETLDVIVLIHPNNPCADRFDPDTLLQLHARLAARGGWL
VIDEAFMDATPQHSVCAFTQRPGLVVLRSVGKFFGMAGARAGFVCADRALLDAVRERLGPWTLGGPARWAVQQVLADTPW
QLQACARLHAASQRLAQLLHAHSIVLTASTAFFQWCRREDAATLHVALAQRGILTRLFDTPSSLRFGLPPDAAGEARLDA
ALRQVLA

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 35433; Mature: 35433

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEHGGRLRRAAQAYNIPLAQWLDLSTGVSPFAWPVPAIPEHVWQRLPEDDDGLAERAAA
CCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
YYGAPRVLPVAGSQAAIQALPLLRAPSRVGVLTPGYAEHAQAWQRAGHQVVPMSAAQLLQ
HHCCCCEEEECCCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHCCCEEECHHHHHHHH
AGETLDVIVLIHPNNPCADRFDPDTLLQLHARLAARGGWLVIDEAFMDATPQHSVCAFTQ
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCEEEECC
RPGLVVLRSVGKFFGMAGARAGFVCADRALLDAVRERLGPWTLGGPARWAVQQVLADTPW
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCH
QLQACARLHAASQRLAQLLHAHSIVLTASTAFFQWCRREDAATLHVALAQRGILTRLFDT
HHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
PSSLRFGLPPDAAGEARLDAALRQVLA
CCCCCCCCCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure
MLEHGGRLRRAAQAYNIPLAQWLDLSTGVSPFAWPVPAIPEHVWQRLPEDDDGLAERAAA
CCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHH
YYGAPRVLPVAGSQAAIQALPLLRAPSRVGVLTPGYAEHAQAWQRAGHQVVPMSAAQLLQ
HHCCCCEEEECCCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHCCCEEECHHHHHHHH
AGETLDVIVLIHPNNPCADRFDPDTLLQLHARLAARGGWLVIDEAFMDATPQHSVCAFTQ
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCEEEECC
RPGLVVLRSVGKFFGMAGARAGFVCADRALLDAVRERLGPWTLGGPARWAVQQVLADTPW
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCH
QLQACARLHAASQRLAQLLHAHSIVLTASTAFFQWCRREDAATLHVALAQRGILTRLFDT
HHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
PSSLRFGLPPDAAGEARLDAALRQVLA
CCCCCCCCCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]