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The map label for this gene is cobQ

Identifier: 21243914

GI number: 21243914

Start: 3750639

End: 3752114

Strand: Reverse

Name: cobQ

Synonym: XAC3188

Alternate gene names: 21243914

Gene position: 3752114-3750639 (Counterclockwise)

Preceding gene: 21243915

Following gene: 21243913

Centisome position: 72.5

GC content: 65.72

Gene sequence:

>1476_bases
ATGAGCGCACGCGTGCTGATGGTGCAGGGCTGCACCTCCGATGCGGGCAAGAGCACGCTGGTGGCCGCGCTGTGCCGGTG
GCTGCATCGCCAGGGCATTGCGGTGGCGCCATTCAAGCCGCAGAACATGGCGTTGAATTCGGCAGTGACGGTGGACGGTG
GCGAAATCGGCCGCGCGCAGGCATTGCAGGCACAGGCATGCGGGCTGGATCCGCAGACCGATTTCAATCCGGTATTGCTC
AAGCCCAACAGCGATACTGGTGCGCAGGTGATCGTGCACGGGCAGCCGGTCGCCACGCTGGATGCGGTGGGCTATCACGC
CTACAAGGCAACCGCATTCAAGGCGGTATTGGCCTCGCATGAGCGCCTGGTCGAGCGCTTCGATGTGGTGCTGGTGGAAG
GTGCCGGCAGCCCGGCCGAGATCAATCTGCGCGCCAACGACATCGCCAACATGGGGTATGCCGAAGCGGTGGATTGCGCC
GTCATTCTGGTGGCCGACATCGACCGCGGCGGCGTGTTCGCCCATCTGGTCGGCACGCTGGCGTTGCTTTCGGCCAGCGA
GCGCGCACGCGTTGCAGGTGTTGTGATCAATCGGTTTCGCGGCGATCTTGCGCTGCTTCAGCCCGGCCTGGAATGGCTGG
AGCGCGAAACGGGCAAGCCGGTGCTCGGCGTCTTGCCGTATCTGCACGGCCTGCAGCTGGATGCCGAAGATGCGGTGCCG
CGCAACGCGCCGCAGAAACCGCAGTCGCAATTGCGCGTGGTGGTGCCGGTGCTGCCGCGCATCAGCAATCACACCGACAT
CGACGCGTTGCTGGCGCATCCGCAAGTGGATGTGCGCTTGATCGGTCCTGGGCAGACGCCACCGCCGTGCGATCTGATCC
TGCTGCCGGGCAGCAAATCCACCCGGCACGATCTGCAGTGGCTGCGCACGCATGGGTGGGACGCCGCCATCGCCCGTCAC
CTGCGCTATGGCGGAAAACTGCTTGGCATCTGCGGCGGACTGCAGATGCTGGGCACCCATCTCCACGACCCGGATGGGAT
CGAAGGCGCAGCGGGCAGCAGCCCCGGTCTTGGGTGGCTACCGCTGCAAACCACGCTGCAGCCGCACAAGCAATTGCATC
GCGTGCACGGGCGCCTGCTGCTGGGCGATGCCGGTGTCAGCGGCTATGAAATTCACTGCGGCATCAGCAGCGGAGCTGCG
CTGGCACGGCCATTGCTGCAGCTGGACGATGGGCGTACCGATGGCGCCATCTCCGACGATGGCCAGGTGCTCGGCACCTA
TGTGCATGGTGTGTTCGACCACCCGCAGGCACTGGCTGCATTGCTGGCATGGGCCGGTCTGGCGCAGGCCGCGCCACTGG
ATCTTGCCGCGCTACGCGAAGCCAGCCTGGAACGTCTGGCCGATGCGGTGCACACGCATCTGGATACCGCCGCACTGACA
CGCCTCATCAGCAGGGAGGCGGCATGCAGCACCTGA

Upstream 100 bases:

>100_bases
TGACGCGGCTGTTCGACACACCGTCCAGTCTGCGCTTCGGCCTTCCCCCCGATGCCGCGGGCGAAGCGCGTCTGGATGCG
GCCCTGCGGCAGGTGCTGGC

Downstream 100 bases:

>100_bases
TTCTTGGCGGCGCCCGTTCGGGCAAGAGCGCACTGGCCGAGCGCATCGCGGCAGCGTCCGGGCGCGCAGTGACCTACCTG
GCTACAGCGCAAGCCTTCGA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MSARVLMVQGCTSDAGKSTLVAALCRWLHRQGIAVAPFKPQNMALNSAVTVDGGEIGRAQALQAQACGLDPQTDFNPVLL
KPNSDTGAQVIVHGQPVATLDAVGYHAYKATAFKAVLASHERLVERFDVVLVEGAGSPAEINLRANDIANMGYAEAVDCA
VILVADIDRGGVFAHLVGTLALLSASERARVAGVVINRFRGDLALLQPGLEWLERETGKPVLGVLPYLHGLQLDAEDAVP
RNAPQKPQSQLRVVVPVLPRISNHTDIDALLAHPQVDVRLIGPGQTPPPCDLILLPGSKSTRHDLQWLRTHGWDAAIARH
LRYGGKLLGICGGLQMLGTHLHDPDGIEGAAGSSPGLGWLPLQTTLQPHKQLHRVHGRLLLGDAGVSGYEIHCGISSGAA
LARPLLQLDDGRTDGAISDDGQVLGTYVHGVFDHPQALAALLAWAGLAQAAPLDLAALREASLERLADAVHTHLDTAALT
RLISREAACST

Sequences:

>Translated_491_residues
MSARVLMVQGCTSDAGKSTLVAALCRWLHRQGIAVAPFKPQNMALNSAVTVDGGEIGRAQALQAQACGLDPQTDFNPVLL
KPNSDTGAQVIVHGQPVATLDAVGYHAYKATAFKAVLASHERLVERFDVVLVEGAGSPAEINLRANDIANMGYAEAVDCA
VILVADIDRGGVFAHLVGTLALLSASERARVAGVVINRFRGDLALLQPGLEWLERETGKPVLGVLPYLHGLQLDAEDAVP
RNAPQKPQSQLRVVVPVLPRISNHTDIDALLAHPQVDVRLIGPGQTPPPCDLILLPGSKSTRHDLQWLRTHGWDAAIARH
LRYGGKLLGICGGLQMLGTHLHDPDGIEGAAGSSPGLGWLPLQTTLQPHKQLHRVHGRLLLGDAGVSGYEIHCGISSGAA
LARPLLQLDDGRTDGAISDDGQVLGTYVHGVFDHPQALAALLAWAGLAQAAPLDLAALREASLERLADAVHTHLDTAALT
RLISREAACST
>Mature_490_residues
SARVLMVQGCTSDAGKSTLVAALCRWLHRQGIAVAPFKPQNMALNSAVTVDGGEIGRAQALQAQACGLDPQTDFNPVLLK
PNSDTGAQVIVHGQPVATLDAVGYHAYKATAFKAVLASHERLVERFDVVLVEGAGSPAEINLRANDIANMGYAEAVDCAV
ILVADIDRGGVFAHLVGTLALLSASERARVAGVVINRFRGDLALLQPGLEWLERETGKPVLGVLPYLHGLQLDAEDAVPR
NAPQKPQSQLRVVVPVLPRISNHTDIDALLAHPQVDVRLIGPGQTPPPCDLILLPGSKSTRHDLQWLRTHGWDAAIARHL
RYGGKLLGICGGLQMLGTHLHDPDGIEGAAGSSPGLGWLPLQTTLQPHKQLHRVHGRLLLGDAGVSGYEIHCGISSGAAL
ARPLLQLDDGRTDGAISDDGQVLGTYVHGVFDHPQALAALLAWAGLAQAAPLDLAALREASLERLADAVHTHLDTAALTR
LISREAACST

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_XANAC (Q8PHR1)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643496.1
- ProteinModelPortal:   Q8PHR1
- GeneID:   1157259
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3188
- NMPDR:   fig|190486.1.peg.3140
- HOGENOM:   HBG302271
- OMA:   AHTDLNP
- ProtClustDB:   PRK00784
- BioCyc:   XAXO190486:XAC3188-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 51857; Mature: 51726

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 331-331 ACT_SITE 429-429

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARVLMVQGCTSDAGKSTLVAALCRWLHRQGIAVAPFKPQNMALNSAVTVDGGEIGRAQ
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEECCEEEECCCCCCHHH
ALQAQACGLDPQTDFNPVLLKPNSDTGAQVIVHGQPVATLDAVGYHAYKATAFKAVLASH
HHHHHHCCCCCCCCCCCEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
ERLVERFDVVLVEGAGSPAEINLRANDIANMGYAEAVDCAVILVADIDRGGVFAHLVGTL
HHHHHHHCEEEEECCCCCEEEEEEHHHHCCCCCHHHHCEEEEEEEECCCCCHHHHHHHHH
ALLSASERARVAGVVINRFRGDLALLQPGLEWLERETGKPVLGVLPYLHGLQLDAEDAVP
HHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHCCC
RNAPQKPQSQLRVVVPVLPRISNHTDIDALLAHPQVDVRLIGPGQTPPPCDLILLPGSKS
CCCCCCCHHHHEEEEEHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCC
TRHDLQWLRTHGWDAAIARHLRYGGKLLGICGGLQMLGTHLHDPDGIEGAAGSSPGLGWL
CHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCEEE
PLQTTLQPHKQLHRVHGRLLLGDAGVSGYEIHCGISSGAALARPLLQLDDGRTDGAISDD
ECHHHHHHHHHHHHHHCEEEEECCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCC
GQVLGTYVHGVFDHPQALAALLAWAGLAQAAPLDLAALREASLERLADAVHTHLDTAALT
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLISREAACST
HHHHHHHCCCC
>Mature Secondary Structure 
SARVLMVQGCTSDAGKSTLVAALCRWLHRQGIAVAPFKPQNMALNSAVTVDGGEIGRAQ
CCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEECCEEEECCCCCCHHH
ALQAQACGLDPQTDFNPVLLKPNSDTGAQVIVHGQPVATLDAVGYHAYKATAFKAVLASH
HHHHHHCCCCCCCCCCCEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
ERLVERFDVVLVEGAGSPAEINLRANDIANMGYAEAVDCAVILVADIDRGGVFAHLVGTL
HHHHHHHCEEEEECCCCCEEEEEEHHHHCCCCCHHHHCEEEEEEEECCCCCHHHHHHHHH
ALLSASERARVAGVVINRFRGDLALLQPGLEWLERETGKPVLGVLPYLHGLQLDAEDAVP
HHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHCCC
RNAPQKPQSQLRVVVPVLPRISNHTDIDALLAHPQVDVRLIGPGQTPPPCDLILLPGSKS
CCCCCCCHHHHEEEEEHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCC
TRHDLQWLRTHGWDAAIARHLRYGGKLLGICGGLQMLGTHLHDPDGIEGAAGSSPGLGWL
CHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCEEE
PLQTTLQPHKQLHRVHGRLLLGDAGVSGYEIHCGISSGAALARPLLQLDDGRTDGAISDD
ECHHHHHHHHHHHHHHCEEEEECCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCC
GQVLGTYVHGVFDHPQALAALLAWAGLAQAAPLDLAALREASLERLADAVHTHLDTAALT
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLISREAACST
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217