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The map label for this gene is cobD [H]

Identifier: 21243916

GI number: 21243916

Start: 3753188

End: 3754102

Strand: Reverse

Name: cobD [H]

Synonym: XAC3190

Alternate gene names: 21243916

Gene position: 3754102-3753188 (Counterclockwise)

Preceding gene: 21243917

Following gene: 21243915

Centisome position: 72.54

GC content: 69.07

Gene sequence:

>915_bases
ATGCTGCTGGTGATTGCCACCTCTGCCGTGCTCCTGGATCTGATGCTCGGCGAGCCGCGGCGCGGACATCCGCTGGTGCT
GTTCGGCAACTGGGCCCAACGTGTCGAAGCGCGCCTGCACCGCGACCGTCGCAGCGCCGGCATCCTGGCGTGGTGCGTGA
GCGTGTTGCCGTTGACCTGTGTCGCTGCAGTGGTGCAATGGGGGCTGTGGTGCGTGTCGCCCTGGGCGGCGGCAGGGTTT
GCCGCGATCACGCTGTATTCGGCGCTGGGCCTGCGTAGCCTGGGTGAACACGCGCAAGCGGTGATCGATGCGCTGCAAGT
CACTGATCTGCCTGCCGCCCGCGCTGCAGTGGGCCGTATCGTCAGTCGCGATACGGCCGCACTGGACGCGACCCAGGTCG
CTGCCGCAGCGACCGAGTCGGTACTGGAGAACGGCAGCGATGCCGTCTTCGCCGCGCTGGTCTGGGGCGTCGTGCTGGGC
GCGCCGGGAGCGGTGTTGTATCGGCTATCCAATACGCTGGATGCGATGTGGGGCTATCGCACGCCGCGCTATGTCAACTT
CGGCTGGGCTGCGGCGCGCATCGACGATGCGTTGAACTGGCTGCCGGCGCGGCTGACCGCAGCGACCTATGCGGTGCTGG
GTCGCACCTGCGCGGGCATGCGCTGCGCCTGGCGGCAGGGACGTGGCTGGAAAAGCCCCAATGCCGGTCCCGTGATGGCA
GCGGGTGCAGGCGCGCTGCATGTCCAACTGGGCGGGCCTGCGCCGTACCACAGCCATTGGCAGGCACGCCCCGCGCTGGG
CGAGGGCGCGGCGGCAAGCGCAAATAGCGTGCAACGTGCGTTGCGGCTGGTGCGCGCCGGTGTCGCGTTCTGGCTGCTGC
TGGGCGTGCTGGCAACTGCGCTGGCGATGCGATGA

Upstream 100 bases:

>100_bases
ATCAAGGCGCAACTCGGCATCGAGCTGTAGCCGTGAGCGTGCGCGCGCAACGCCTCGTATGGCTCGGCATGCTGGCTGGC
ATGCGCCGGGACTGCACGCC

Downstream 100 bases:

>100_bases
TCGGCACGCGGATGGTCTGGTGCTTCACCAACATGCACCGGCGCACCGTGCACGACGGCGCAGGTAGCGCCGCGCCGCCA
CCGGGAGTGCGCAATGCTTG

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLLVIATSAVLLDLMLGEPRRGHPLVLFGNWAQRVEARLHRDRRSAGILAWCVSVLPLTCVAAVVQWGLWCVSPWAAAGF
AAITLYSALGLRSLGEHAQAVIDALQVTDLPAARAAVGRIVSRDTAALDATQVAAAATESVLENGSDAVFAALVWGVVLG
APGAVLYRLSNTLDAMWGYRTPRYVNFGWAAARIDDALNWLPARLTAATYAVLGRTCAGMRCAWRQGRGWKSPNAGPVMA
AGAGALHVQLGGPAPYHSHWQARPALGEGAAASANSVQRALRLVRAGVAFWLLLGVLATALAMR

Sequences:

>Translated_304_residues
MLLVIATSAVLLDLMLGEPRRGHPLVLFGNWAQRVEARLHRDRRSAGILAWCVSVLPLTCVAAVVQWGLWCVSPWAAAGF
AAITLYSALGLRSLGEHAQAVIDALQVTDLPAARAAVGRIVSRDTAALDATQVAAAATESVLENGSDAVFAALVWGVVLG
APGAVLYRLSNTLDAMWGYRTPRYVNFGWAAARIDDALNWLPARLTAATYAVLGRTCAGMRCAWRQGRGWKSPNAGPVMA
AGAGALHVQLGGPAPYHSHWQARPALGEGAAASANSVQRALRLVRAGVAFWLLLGVLATALAMR
>Mature_304_residues
MLLVIATSAVLLDLMLGEPRRGHPLVLFGNWAQRVEARLHRDRRSAGILAWCVSVLPLTCVAAVVQWGLWCVSPWAAAGF
AAITLYSALGLRSLGEHAQAVIDALQVTDLPAARAAVGRIVSRDTAALDATQVAAAATESVLENGSDAVFAALVWGVVLG
APGAVLYRLSNTLDAMWGYRTPRYVNFGWAAARIDDALNWLPARLTAATYAVLGRTCAGMRCAWRQGRGWKSPNAGPVMA
AGAGALHVQLGGPAPYHSHWQARPALGEGAAASANSVQRALRLVRAGVAFWLLLGVLATALAMR

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 32071; Mature: 32071

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLVIATSAVLLDLMLGEPRRGHPLVLFGNWAQRVEARLHRDRRSAGILAWCVSVLPLTC
CEEEEEHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAVVQWGLWCVSPWAAAGFAAITLYSALGLRSLGEHAQAVIDALQVTDLPAARAAVGRI
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VSRDTAALDATQVAAAATESVLENGSDAVFAALVWGVVLGAPGAVLYRLSNTLDAMWGYR
HHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
TPRYVNFGWAAARIDDALNWLPARLTAATYAVLGRTCAGMRCAWRQGRGWKSPNAGPVMA
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEE
AGAGALHVQLGGPAPYHSHWQARPALGEGAAASANSVQRALRLVRAGVAFWLLLGVLATA
ECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAMR
HHCC
>Mature Secondary Structure
MLLVIATSAVLLDLMLGEPRRGHPLVLFGNWAQRVEARLHRDRRSAGILAWCVSVLPLTC
CEEEEEHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAAVVQWGLWCVSPWAAAGFAAITLYSALGLRSLGEHAQAVIDALQVTDLPAARAAVGRI
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VSRDTAALDATQVAAAATESVLENGSDAVFAALVWGVVLGAPGAVLYRLSNTLDAMWGYR
HHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
TPRYVNFGWAAARIDDALNWLPARLTAATYAVLGRTCAGMRCAWRQGRGWKSPNAGPVMA
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEE
AGAGALHVQLGGPAPYHSHWQARPALGEGAAASANSVQRALRLVRAGVAFWLLLGVLATA
ECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAMR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA