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The map label for this gene is tolB

Identifier: 21243868

GI number: 21243868

Start: 3692326

End: 3693645

Strand: Reverse

Name: tolB

Synonym: XAC3142

Alternate gene names: 21243868

Gene position: 3693645-3692326 (Counterclockwise)

Preceding gene: 21243869

Following gene: 21243867

Centisome position: 71.37

GC content: 65.45

Gene sequence:

>1320_bases
ATGAAAAAACCGCTGCGTTGGCTAGCTGCCTTGACCGCCCTGTTGTTGCCGCTGAGCGCGCTCGCGCAGCAGCAAGGTCT
CACCATCGATATCGTCGGCGGTAGCGCGTCTGCCACGCCGATCGCCGTCATTCCGATGCCGTATCAGGGCTCGGGCACCG
CGCCGCAGACCGACGTGTCCGCCGTGGTCGGCGCCGACCTGGATCGTTCCGGCCAGTTCCGCACGCTGCCGGCCGCGCAG
ATCGTCGAAAAACCGACCCGTGGCACCGAGGTGCAGTTCCAGACCTGGCGCACCCTCAAGCAGAACTACATCGTGGTCGG
CCGCGTCATGGATGCCGGCGAAGGCGCATACCGGGTCGAATACGAATTGTTCGACGTGGCCAAGGGCGAGCGCATGCTTG
GCCTGGCGATGACGGCGCGTGCCAACGCAATGCGCGATGTTTCGCACCAGATGGCCGATGCCATCTACGAAAAGATCACT
GGCGTACGCGGCGCCTTCTGGACCCGCATTGCCTACGTGACCGCCAGCGGCAAGGGCGGCGCCATGCGCTATGCGCTGAT
GGTGGCCGACTCGGACGGCTACAACCCGCAGACCATCGTGCGTTCGGCCGAGCCGCTGCTGTCGCCGAACTGGAGCCCGG
ACGGCAAGAAGCTGGCCTACGTGAGCTTCGAGCGCGGCAACTCGTCGATCTATCTGCAGGACATCGCCACCGGCGCACGC
GAACTGGTCTCCAGCTTCCGCGGCATCAACGGCGCGCCGTCGTTTTCGCCGGACGGACGTCGCCTGGCGCTGGCGTTGTC
GCGTAGCGGCAACCCGGAAATTTATGTGATGGACCTGGGAAGCAAGCAGCTGACCCAGCTCACCAACCACTTCGGCATCG
ACACCGAGCCGACCTGGGCGCCGGATGGCGGCAGCATCTACTTCACCTCCGATCGCGGCGGTCGTCCGCAGATCTATCAG
GTGGCAGCCAGCGGCGGCAGCGCCAACCGCGTGACCTTCCAGGGTAACTACAATGCCACCGCCAGCGTGTCGTTCGACGG
CAAGAAGATTGCCGTGGCACAGGGCAGCGGCAATACCTACCGCATCGCGATGATGGACCGCAGCCTGGGTTCGCCGAGCT
GGAGCACGCTGTCGCCGGGTTCTCTGGACGAATCGCCGAGCTTTGCGCCCAACGCCAGCATGGTGTTGTACGCCGCACGC
GAAGGTGGCCGTGGCGTGCTGTACGCGGTCTCTTCCGACGCTCGGGTCCGCCAGCGCCTGGTGCTGGCCGACGGCGATGT
GAGAGAACCCGCATGGGGGCCTTACCGAACCGCGCATTAA

Upstream 100 bases:

>100_bases
CGCTCGCTCCGTTTTCACGTCACCTCATTCACGATTGCGAGTATGTTCACTCGTTGATTGCTATCCCTTGCACACTTTTC
CTGCCCGATCCGAGCCGTCC

Downstream 100 bases:

>100_bases
TGTTAATATTTCGCTGCGTTAAACCACTCATTGGCCCAGAGCCTCCATAGGTACCCCATGAACAAGTCCACCCGCGTCTT
GCTTGTCTCCCTGCTGTCCG

Product: translocation protein TolB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKKPLRWLAALTALLLPLSALAQQQGLTIDIVGGSASATPIAVIPMPYQGSGTAPQTDVSAVVGADLDRSGQFRTLPAAQ
IVEKPTRGTEVQFQTWRTLKQNYIVVGRVMDAGEGAYRVEYELFDVAKGERMLGLAMTARANAMRDVSHQMADAIYEKIT
GVRGAFWTRIAYVTASGKGGAMRYALMVADSDGYNPQTIVRSAEPLLSPNWSPDGKKLAYVSFERGNSSIYLQDIATGAR
ELVSSFRGINGAPSFSPDGRRLALALSRSGNPEIYVMDLGSKQLTQLTNHFGIDTEPTWAPDGGSIYFTSDRGGRPQIYQ
VAASGGSANRVTFQGNYNATASVSFDGKKIAVAQGSGNTYRIAMMDRSLGSPSWSTLSPGSLDESPSFAPNASMVLYAAR
EGGRGVLYAVSSDARVRQRLVLADGDVREPAWGPYRTAH

Sequences:

>Translated_439_residues
MKKPLRWLAALTALLLPLSALAQQQGLTIDIVGGSASATPIAVIPMPYQGSGTAPQTDVSAVVGADLDRSGQFRTLPAAQ
IVEKPTRGTEVQFQTWRTLKQNYIVVGRVMDAGEGAYRVEYELFDVAKGERMLGLAMTARANAMRDVSHQMADAIYEKIT
GVRGAFWTRIAYVTASGKGGAMRYALMVADSDGYNPQTIVRSAEPLLSPNWSPDGKKLAYVSFERGNSSIYLQDIATGAR
ELVSSFRGINGAPSFSPDGRRLALALSRSGNPEIYVMDLGSKQLTQLTNHFGIDTEPTWAPDGGSIYFTSDRGGRPQIYQ
VAASGGSANRVTFQGNYNATASVSFDGKKIAVAQGSGNTYRIAMMDRSLGSPSWSTLSPGSLDESPSFAPNASMVLYAAR
EGGRGVLYAVSSDARVRQRLVLADGDVREPAWGPYRTAH
>Mature_439_residues
MKKPLRWLAALTALLLPLSALAQQQGLTIDIVGGSASATPIAVIPMPYQGSGTAPQTDVSAVVGADLDRSGQFRTLPAAQ
IVEKPTRGTEVQFQTWRTLKQNYIVVGRVMDAGEGAYRVEYELFDVAKGERMLGLAMTARANAMRDVSHQMADAIYEKIT
GVRGAFWTRIAYVTASGKGGAMRYALMVADSDGYNPQTIVRSAEPLLSPNWSPDGKKLAYVSFERGNSSIYLQDIATGAR
ELVSSFRGINGAPSFSPDGRRLALALSRSGNPEIYVMDLGSKQLTQLTNHFGIDTEPTWAPDGGSIYFTSDRGGRPQIYQ
VAASGGSANRVTFQGNYNATASVSFDGKKIAVAQGSGNTYRIAMMDRSLGSPSWSTLSPGSLDESPSFAPNASMVLYAAR
EGGRGVLYAVSSDARVRQRLVLADGDVREPAWGPYRTAH

Specific function: Involved in the tonB-independent uptake of proteins

COG id: COG0823

COG function: function code U; Periplasmic component of the Tol biopolymer transport system

Gene ontology:

Cell location: Periplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tolB family

Homologues:

Organism=Escherichia coli, GI1786961, Length=437, Percent_Identity=43.4782608695652, Blast_Score=338, Evalue=4e-94,
Organism=Caenorhabditis elegans, GI32564217, Length=210, Percent_Identity=27.1428571428571, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32564215, Length=210, Percent_Identity=27.1428571428571, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TOLB_XANAC (Q8PHV7)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_643450.1
- ProteinModelPortal:   Q8PHV7
- SMR:   Q8PHV7
- GeneID:   1157213
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC3142
- HOGENOM:   HBG644919
- OMA:   RVADYDG
- ProtClustDB:   PRK04922
- BioCyc:   XAXO190486:XAC3142-MONOMER
- HAMAP:   MF_00671
- InterPro:   IPR011659
- InterPro:   IPR014167
- InterPro:   IPR007195
- InterPro:   IPR015943
- Gene3D:   G3DSA:3.40.50.10070
- Gene3D:   G3DSA:2.130.10.10
- TIGRFAMs:   TIGR02800

Pfam domain/function: PF07676 PD40; PF04052 TolB_N; SSF52964 TolB_N

EC number: NA

Molecular weight: Translated: 47057; Mature: 47057

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPLRWLAALTALLLPLSALAQQQGLTIDIVGGSASATPIAVIPMPYQGSGTAPQTDVS
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCH
AVVGADLDRSGQFRTLPAAQIVEKPTRGTEVQFQTWRTLKQNYIVVGRVMDAGEGAYRVE
HEECCCCCCCCCEEECCHHHHHCCCCCCCEEEEHHHHHHHCCEEEEEEEEECCCCCEEEE
YELFDVAKGERMLGLAMTARANAMRDVSHQMADAIYEKITGVRGAFWTRIAYVTASGKGG
EEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCC
AMRYALMVADSDGYNPQTIVRSAEPLLSPNWSPDGKKLAYVSFERGNSSIYLQDIATGAR
EEEEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEHHHHHHHH
ELVSSFRGINGAPSFSPDGRRLALALSRSGNPEIYVMDLGSKQLTQLTNHFGIDTEPTWA
HHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCC
PDGGSIYFTSDRGGRPQIYQVAASGGSANRVTFQGNYNATASVSFDGKKIAVAQGSGNTY
CCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEECCCCEEEEEEECCCEEEEEECCCCEE
RIAMMDRSLGSPSWSTLSPGSLDESPSFAPNASMVLYAAREGGRGVLYAVSSDARVRQRL
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCHHEEEEE
VLADGDVREPAWGPYRTAH
EEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKPLRWLAALTALLLPLSALAQQQGLTIDIVGGSASATPIAVIPMPYQGSGTAPQTDVS
CCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCH
AVVGADLDRSGQFRTLPAAQIVEKPTRGTEVQFQTWRTLKQNYIVVGRVMDAGEGAYRVE
HEECCCCCCCCCEEECCHHHHHCCCCCCCEEEEHHHHHHHCCEEEEEEEEECCCCCEEEE
YELFDVAKGERMLGLAMTARANAMRDVSHQMADAIYEKITGVRGAFWTRIAYVTASGKGG
EEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCC
AMRYALMVADSDGYNPQTIVRSAEPLLSPNWSPDGKKLAYVSFERGNSSIYLQDIATGAR
EEEEEEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCEEEEHHHHHHHH
ELVSSFRGINGAPSFSPDGRRLALALSRSGNPEIYVMDLGSKQLTQLTNHFGIDTEPTWA
HHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCC
PDGGSIYFTSDRGGRPQIYQVAASGGSANRVTFQGNYNATASVSFDGKKIAVAQGSGNTY
CCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEECCCCEEEEEEECCCEEEEEECCCCEE
RIAMMDRSLGSPSWSTLSPGSLDESPSFAPNASMVLYAAREGGRGVLYAVSSDARVRQRL
EEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCHHEEEEE
VLADGDVREPAWGPYRTAH
EEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217