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The map label for this gene is bioA [H]

Identifier: 21243795

GI number: 21243795

Start: 3588668

End: 3590086

Strand: Direct

Name: bioA [H]

Synonym: XAC3068

Alternate gene names: 21243795

Gene position: 3588668-3590086 (Clockwise)

Preceding gene: 21243784

Following gene: 21243796

Centisome position: 69.34

GC content: 66.24

Gene sequence:

>1419_bases
ATGCATCGACATGTCCATGAACCCGAAATCCTAGCAGACCCTGCAGCCGCACAAACTGCCGAACATTGGCGGCAACGCGA
TCTTGCCGTGGTGTGGCACCCCTGCACGCAGATGCGTGAGCACCCGCACACGCTGCCGCTGGTGCCGATCGTGGGTGGCG
AAGGCGCATGGCTGGTCGGCCATGACGGCCGCCGCTATCTGGACGCGGTGAGCAGCTGGTGGACCAACCTGTTCGGTCAT
ACCGAACCGCGCATCGGCGCGGCCATCGCGCGCCAGGCCGGCGAACTGGAGCAGGTGATGCTGGCCGGCTTCACGCATAC
GCCGGCCGTGCAGCTGGCCGAGCAGTTGCTGGCGATCGCGCCACGCCAGGCCGGGCGCGCGCCGCTGTCCAAGGTGTTCT
ATGCCGACAACGGATCGGCCGGCGTGGAGGTGGCGCTGAAGATGGCCTTTCATTACTTCCACAATCGCGGCGACCACCGG
CGGACGCGGTTCATCGCACTGGAGAATGGTTACCACGGCGAAACCATCGGCGCGCTATCGGTTGGCGATATTCCGCTGTA
CCGGCGCGTGTATGCGCCGCTGTTGCTGGAGGCGATGTTCACGCCCTCGCCCGATGCCTACCTGGCCGAACCGGGGCAAA
GCGCCGAAGACCATGCGCTGCAGGCAGCCGATGCGTTGCAGGCACTGTTCGAACACTCGCCCGGCGAAATCTGTGCACTG
ATCCTGGAGCCGCGCGTGCAATGCGCGGGCGGGATGCGCATGTACCACCCGGCGTATCTGCGCCGCGCGCGCGAATTATG
CGATGCCCATGGTGCATTCTTGATCGCCGACGAGATCGCCACCGGCTTCGGCCGTACCGGCACCCTGTTTGCCTGCGAAC
AGGCCGGCGTGATGCCCGACCTGTTGTGCCTGTCGAAGGGACTGACCGGCGGCTTCCTGCCGCTGTCGGCGGTGTTGGCC
ACGCAGCAGTTGTACGACGCGTTCCTGGACGATTCGCGCGAGCGTGCGTTTCTGCATTCGCACAGTTACACCGGCAACCC
GCTGGCATGTGCCGCGGCGCTGGCGACCTTGAAGATCTTCGCAGACGACGACGTGATTGCGCGTAACCAACCCATCGCCG
CGCGCATGCGCGCGCTCGCTGCGCAGATCGGCGAACACCCGTCCGTGGCGGACGTGCGCCAGGCCGGCATGATCGTGGCC
TTCGAGCTGACCCAGGGCGGTAACAAGCGCACGCCGTTTGCGTCTGCCGCACGCGTCGGCCTGAAGGCGTATCGCGCGGC
GCTCGAAAAAGGCGTGGTGCTGCGCCCGCTTGGCGACGTGCTGTACTGGATGCCGCCGTATTGCGTGGACGAGGCGCAGC
TTGCGTTGTTGGCCGACACCACCCGCCATGCCATCACGGAAGCGGTCGCATGCGCCTGA

Upstream 100 bases:

>100_bases
CGGAACGGCCCGTCGCCCAGATCGGTGATCTTGTGGATGATCGGCAGGCGCGAGCTCATGCGTCGCACGCAGCCGCAAAG
CGGGCCGATAGAATAGGCGG

Downstream 100 bases:

>100_bases
CCCGTTCGCATGTCGCGCTGCCGCTGCACTGCGACCAGGAAGTGACATTGCCGGAAGAGTCGGCCAATCACCTGCTGCGG
GTACTGCGGCTGCGCGAGGG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MHRHVHEPEILADPAAAQTAEHWRQRDLAVVWHPCTQMREHPHTLPLVPIVGGEGAWLVGHDGRRYLDAVSSWWTNLFGH
TEPRIGAAIARQAGELEQVMLAGFTHTPAVQLAEQLLAIAPRQAGRAPLSKVFYADNGSAGVEVALKMAFHYFHNRGDHR
RTRFIALENGYHGETIGALSVGDIPLYRRVYAPLLLEAMFTPSPDAYLAEPGQSAEDHALQAADALQALFEHSPGEICAL
ILEPRVQCAGGMRMYHPAYLRRARELCDAHGAFLIADEIATGFGRTGTLFACEQAGVMPDLLCLSKGLTGGFLPLSAVLA
TQQLYDAFLDDSRERAFLHSHSYTGNPLACAAALATLKIFADDDVIARNQPIAARMRALAAQIGEHPSVADVRQAGMIVA
FELTQGGNKRTPFASAARVGLKAYRAALEKGVVLRPLGDVLYWMPPYCVDEAQLALLADTTRHAITEAVACA

Sequences:

>Translated_472_residues
MHRHVHEPEILADPAAAQTAEHWRQRDLAVVWHPCTQMREHPHTLPLVPIVGGEGAWLVGHDGRRYLDAVSSWWTNLFGH
TEPRIGAAIARQAGELEQVMLAGFTHTPAVQLAEQLLAIAPRQAGRAPLSKVFYADNGSAGVEVALKMAFHYFHNRGDHR
RTRFIALENGYHGETIGALSVGDIPLYRRVYAPLLLEAMFTPSPDAYLAEPGQSAEDHALQAADALQALFEHSPGEICAL
ILEPRVQCAGGMRMYHPAYLRRARELCDAHGAFLIADEIATGFGRTGTLFACEQAGVMPDLLCLSKGLTGGFLPLSAVLA
TQQLYDAFLDDSRERAFLHSHSYTGNPLACAAALATLKIFADDDVIARNQPIAARMRALAAQIGEHPSVADVRQAGMIVA
FELTQGGNKRTPFASAARVGLKAYRAALEKGVVLRPLGDVLYWMPPYCVDEAQLALLADTTRHAITEAVACA
>Mature_472_residues
MHRHVHEPEILADPAAAQTAEHWRQRDLAVVWHPCTQMREHPHTLPLVPIVGGEGAWLVGHDGRRYLDAVSSWWTNLFGH
TEPRIGAAIARQAGELEQVMLAGFTHTPAVQLAEQLLAIAPRQAGRAPLSKVFYADNGSAGVEVALKMAFHYFHNRGDHR
RTRFIALENGYHGETIGALSVGDIPLYRRVYAPLLLEAMFTPSPDAYLAEPGQSAEDHALQAADALQALFEHSPGEICAL
ILEPRVQCAGGMRMYHPAYLRRARELCDAHGAFLIADEIATGFGRTGTLFACEQAGVMPDLLCLSKGLTGGFLPLSAVLA
TQQLYDAFLDDSRERAFLHSHSYTGNPLACAAALATLKIFADDDVIARNQPIAARMRALAAQIGEHPSVADVRQAGMIVA
FELTQGGNKRTPFASAARVGLKAYRAALEKGVVLRPLGDVLYWMPPYCVDEAQLALLADTTRHAITEAVACA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=445, Percent_Identity=26.7415730337079, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI37574042, Length=432, Percent_Identity=26.3888888888889, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI226442705, Length=436, Percent_Identity=25.6880733944954, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI226442709, Length=402, Percent_Identity=26.865671641791, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI4557809, Length=417, Percent_Identity=26.6187050359712, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI24119277, Length=417, Percent_Identity=25.4196642685851, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=26.5432098765432, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1786991, Length=438, Percent_Identity=41.7808219178082, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI145693181, Length=350, Percent_Identity=32.8571428571429, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1789016, Length=410, Percent_Identity=31.4634146341463, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789759, Length=422, Percent_Identity=30.3317535545024, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1788044, Length=420, Percent_Identity=29.2857142857143, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1787560, Length=408, Percent_Identity=30.1470588235294, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI1786349, Length=307, Percent_Identity=29.9674267100977, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=448, Percent_Identity=27.6785714285714, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71992977, Length=419, Percent_Identity=24.582338902148, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25144271, Length=429, Percent_Identity=24.7086247086247, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=307, Percent_Identity=27.0358306188925, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=456, Percent_Identity=32.0175438596491, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323470, Length=462, Percent_Identity=26.4069264069264, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324432, Length=351, Percent_Identity=26.2108262108262, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574759, Length=448, Percent_Identity=28.7946428571429, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI161085790, Length=437, Percent_Identity=28.604118993135, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21357415, Length=430, Percent_Identity=26.9767441860465, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356575, Length=420, Percent_Identity=26.1904761904762, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 51304; Mature: 51304

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRHVHEPEILADPAAAQTAEHWRQRDLAVVWHPCTQMREHPHTLPLVPIVGGEGAWLVG
CCCCCCCCCHHCCCHHHHHHHHHHHCCCEEEECCHHHHHCCCCCCCEEEEECCCCEEEEE
HDGRRYLDAVSSWWTNLFGHTEPRIGAAIARQAGELEQVMLAGFTHTPAVQLAEQLLAIA
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
PRQAGRAPLSKVFYADNGSAGVEVALKMAFHYFHNRGDHRRTRFIALENGYHGETIGALS
CCCCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEECEEE
VGDIPLYRRVYAPLLLEAMFTPSPDAYLAEPGQSAEDHALQAADALQALFEHSPGEICAL
ECCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
ILEPRVQCAGGMRMYHPAYLRRARELCDAHGAFLIADEIATGFGRTGTLFACEQAGVMPD
EECCCHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCEEEECCCCCCHH
LLCLSKGLTGGFLPLSAVLATQQLYDAFLDDSRERAFLHSHSYTGNPLACAAALATLKIF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHEE
ADDDVIARNQPIAARMRALAAQIGEHPSVADVRQAGMIVAFELTQGGNKRTPFASAARVG
ECCCEECCCCCHHHHHHHHHHHHCCCCCHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHH
LKAYRAALEKGVVLRPLGDVLYWMPPYCVDEAQLALLADTTRHAITEAVACA
HHHHHHHHHCCEEEEEHHHHHHHCCCCCCCCHHEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHRHVHEPEILADPAAAQTAEHWRQRDLAVVWHPCTQMREHPHTLPLVPIVGGEGAWLVG
CCCCCCCCCHHCCCHHHHHHHHHHHCCCEEEECCHHHHHCCCCCCCEEEEECCCCEEEEE
HDGRRYLDAVSSWWTNLFGHTEPRIGAAIARQAGELEQVMLAGFTHTPAVQLAEQLLAIA
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
PRQAGRAPLSKVFYADNGSAGVEVALKMAFHYFHNRGDHRRTRFIALENGYHGETIGALS
CCCCCCCCHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCEECEEE
VGDIPLYRRVYAPLLLEAMFTPSPDAYLAEPGQSAEDHALQAADALQALFEHSPGEICAL
ECCCHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
ILEPRVQCAGGMRMYHPAYLRRARELCDAHGAFLIADEIATGFGRTGTLFACEQAGVMPD
EECCCHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHCCCCCCCEEEECCCCCCHH
LLCLSKGLTGGFLPLSAVLATQQLYDAFLDDSRERAFLHSHSYTGNPLACAAALATLKIF
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHEE
ADDDVIARNQPIAARMRALAAQIGEHPSVADVRQAGMIVAFELTQGGNKRTPFASAARVG
ECCCEECCCCCHHHHHHHHHHHHCCCCCHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHH
LKAYRAALEKGVVLRPLGDVLYWMPPYCVDEAQLALLADTTRHAITEAVACA
HHHHHHHHHCCEEEEEHHHHHHHCCCCCCCCHHEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]