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The map label for this gene is bla [H]

Identifier: 21243784

GI number: 21243784

Start: 3579345

End: 3580715

Strand: Direct

Name: bla [H]

Synonym: XAC3057

Alternate gene names: 21243784

Gene position: 3579345-3580715 (Clockwise)

Preceding gene: 21243781

Following gene: 21243795

Centisome position: 69.16

GC content: 67.32

Gene sequence:

>1371_bases
ATGCGCACGCGCCGACGGTTCCGACCGTTGGCTATCGGGCTGTTCGGGGCGTTATTGCCCCTGGCCCTCTCATCCACCGC
GCAGACACCCGCGCCCACCGCCGCTGCGTTGCAGGCGGCCACTGTGGCTCAGTCGCCCACCGCACCGCTGCCCTATCGCA
CCTCGCTGCCGGCCAACCAGGTGTTGGCACCTGCTGCCGGTTTCGATGTGGCGGCATTCGAATCGATGGCCGACCAGCTG
ACCTACGGCAACCGGGTGCCCGGGATGGCGATGGCCATCGTGCAGGGCGGCAAGGTGCTCAGCGCGCGCGGCTATGGCGT
CACCGATGTCAATCATCCGCAGCCGGTCGATGGCCACACGGTGTTTCGCCTGGCCTCGCTTTCCAAAGCCTTCGCCGGCA
CCATGGCCGGCCTGCTGGTCAACGATGGCGTGCTGCGCTGGGACAGCAAGGTGGTCGACTATGTGCCGGGCTTCCAGCTC
AGCGACAACGCGGCCACCCGTCAACTCACCGTGGCCGAAGTGCTCAGCCATCGCGTCGGCCTGACCCGCAACGCCTACGA
CCGCGATATCGAATCCAACGTCGACTACTACTCGCTCAGCCATAAGCTGGCGGCTGCGCCGCTGCGTTGCGCACCGGGCG
ATTGCTACGCGTATCAAAACGTCGCCTTCAGCCTGGTTGGCGATGTGGTGTTCGCCGCATCGGGCAGCTTCTACGAGCAA
TCGGTAGAGCGCCGCATCTTCAAGCCGCTGGGCATGAACGACGCCAGCATGGGGCTGGCCGGTATCCAGGCAAGCCCGCA
CTGGGCACGTCCGCATGTGCGCAGCCGCAATGGCTGGGTCTCGCTGACGCCCAAGCCCACCTACTACCGTCTGGCGCCCG
CTGCGGGCGTCAACGCCAGCGCCAGCGATATGGCGCAGTGGCTGCTCGCGCACACCGGCCATCGCACCGATGTGCTGCCT
GCGCCGCTGTTGGCGACGCTGCACGCGCCGTTGATCTCCACGCCGGGCGAAATGCGTTCGGGCTGGCGCCACGAGCGCGT
GGACGCGGCCAGCTATGCGCTGGGCTGGCGCGTGTTCGATTACGCCGGCCATCAAGTGGTGTTCCATGCCGGCGCGGTGC
AAGGTTATCGCGGTTTGGTCGCACTGCTGCCGGAGCGCGACCTGGGTGTTGCGATCCTGTGGAACGGCGAAAGCGGCCTG
CCCTCGGGCATGCTGCCGACCATCCTGGATCGCGCGCTCGGCCTGCCGGCCAAGCGCTGGCTGGACATCGACGTGGACGG
CGACTTCGGCAGCGAGAACATGCTGGCAGAAAAACCCGACCCGGCTGGCAAGGGTGCGTCTTCCGGCAAGTCGGTGGCCT
CGCCGCGCTGA

Upstream 100 bases:

>100_bases
CAATGCGATGCCCATTCATCTTCCGGCAGTTTGTGCTATTGCAAAGCGCGGCGCTAGAATCGCCGGAGGCAGCGGAACAG
GCGGGACAACCATGACAGAA

Downstream 100 bases:

>100_bases
GTGGACGTCGTGCACTGACCTCGTGTCGGTGACGTCGGCAAAGGCGGCTTCGGCCGCCTTCGTTGTTTCGGTGTCTCCGA
CGCGCGTTGCTCGGCTAGCG

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MRTRRRFRPLAIGLFGALLPLALSSTAQTPAPTAAALQAATVAQSPTAPLPYRTSLPANQVLAPAAGFDVAAFESMADQL
TYGNRVPGMAMAIVQGGKVLSARGYGVTDVNHPQPVDGHTVFRLASLSKAFAGTMAGLLVNDGVLRWDSKVVDYVPGFQL
SDNAATRQLTVAEVLSHRVGLTRNAYDRDIESNVDYYSLSHKLAAAPLRCAPGDCYAYQNVAFSLVGDVVFAASGSFYEQ
SVERRIFKPLGMNDASMGLAGIQASPHWARPHVRSRNGWVSLTPKPTYYRLAPAAGVNASASDMAQWLLAHTGHRTDVLP
APLLATLHAPLISTPGEMRSGWRHERVDAASYALGWRVFDYAGHQVVFHAGAVQGYRGLVALLPERDLGVAILWNGESGL
PSGMLPTILDRALGLPAKRWLDIDVDGDFGSENMLAEKPDPAGKGASSGKSVASPR

Sequences:

>Translated_456_residues
MRTRRRFRPLAIGLFGALLPLALSSTAQTPAPTAAALQAATVAQSPTAPLPYRTSLPANQVLAPAAGFDVAAFESMADQL
TYGNRVPGMAMAIVQGGKVLSARGYGVTDVNHPQPVDGHTVFRLASLSKAFAGTMAGLLVNDGVLRWDSKVVDYVPGFQL
SDNAATRQLTVAEVLSHRVGLTRNAYDRDIESNVDYYSLSHKLAAAPLRCAPGDCYAYQNVAFSLVGDVVFAASGSFYEQ
SVERRIFKPLGMNDASMGLAGIQASPHWARPHVRSRNGWVSLTPKPTYYRLAPAAGVNASASDMAQWLLAHTGHRTDVLP
APLLATLHAPLISTPGEMRSGWRHERVDAASYALGWRVFDYAGHQVVFHAGAVQGYRGLVALLPERDLGVAILWNGESGL
PSGMLPTILDRALGLPAKRWLDIDVDGDFGSENMLAEKPDPAGKGASSGKSVASPR
>Mature_456_residues
MRTRRRFRPLAIGLFGALLPLALSSTAQTPAPTAAALQAATVAQSPTAPLPYRTSLPANQVLAPAAGFDVAAFESMADQL
TYGNRVPGMAMAIVQGGKVLSARGYGVTDVNHPQPVDGHTVFRLASLSKAFAGTMAGLLVNDGVLRWDSKVVDYVPGFQL
SDNAATRQLTVAEVLSHRVGLTRNAYDRDIESNVDYYSLSHKLAAAPLRCAPGDCYAYQNVAFSLVGDVVFAASGSFYEQ
SVERRIFKPLGMNDASMGLAGIQASPHWARPHVRSRNGWVSLTPKPTYYRLAPAAGVNASASDMAQWLLAHTGHRTDVLP
APLLATLHAPLISTPGEMRSGWRHERVDAASYALGWRVFDYAGHQVVFHAGAVQGYRGLVALLPERDLGVAILWNGESGL
PSGMLPTILDRALGLPAKRWLDIDVDGDFGSENMLAEKPDPAGKGASSGKSVASPR

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=384, Percent_Identity=22.3958333333333, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786574, Length=255, Percent_Identity=25.8823529411765, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082101, Length=334, Percent_Identity=22.1556886227545, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17550934, Length=279, Percent_Identity=25.089605734767, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533026, Length=350, Percent_Identity=23.1428571428571, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 48591; Mature: 48591

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTRRRFRPLAIGLFGALLPLALSSTAQTPAPTAAALQAATVAQSPTAPLPYRTSLPANQ
CCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VLAPAAGFDVAAFESMADQLTYGNRVPGMAMAIVQGGKVLSARGYGVTDVNHPQPVDGHT
HCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCHH
VFRLASLSKAFAGTMAGLLVNDGVLRWDSKVVDYVPGFQLSDNAATRQLTVAEVLSHRVG
HHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHCCCCEECCCCCHHHHHHHHHHHHHCC
LTRNAYDRDIESNVDYYSLSHKLAAAPLRCAPGDCYAYQNVAFSLVGDVVFAASGSFYEQ
CCCCCCCCCHHCCCCEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
SVERRIFKPLGMNDASMGLAGIQASPHWARPHVRSRNGWVSLTPKPTYYRLAPAAGVNAS
HHHHHHHHCCCCCCHHCCEECCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCC
ASDMAQWLLAHTGHRTDVLPAPLLATLHAPLISTPGEMRSGWRHERVDAASYALGWRVFD
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHEEEEE
YAGHQVVFHAGAVQGYRGLVALLPERDLGVAILWNGESGLPSGMLPTILDRALGLPAKRW
CCCCEEEEECCCHHCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCHHHE
LDIDVDGDFGSENMLAEKPDPAGKGASSGKSVASPR
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRTRRRFRPLAIGLFGALLPLALSSTAQTPAPTAAALQAATVAQSPTAPLPYRTSLPANQ
CCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VLAPAAGFDVAAFESMADQLTYGNRVPGMAMAIVQGGKVLSARGYGVTDVNHPQPVDGHT
HCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCCCCCCHH
VFRLASLSKAFAGTMAGLLVNDGVLRWDSKVVDYVPGFQLSDNAATRQLTVAEVLSHRVG
HHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHCCCCEECCCCCHHHHHHHHHHHHHCC
LTRNAYDRDIESNVDYYSLSHKLAAAPLRCAPGDCYAYQNVAFSLVGDVVFAASGSFYEQ
CCCCCCCCCHHCCCCEEEHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHH
SVERRIFKPLGMNDASMGLAGIQASPHWARPHVRSRNGWVSLTPKPTYYRLAPAAGVNAS
HHHHHHHHCCCCCCHHCCEECCCCCCCCCCCCCCCCCCEEEECCCCCEEEECCCCCCCCC
ASDMAQWLLAHTGHRTDVLPAPLLATLHAPLISTPGEMRSGWRHERVDAASYALGWRVFD
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHEEEEE
YAGHQVVFHAGAVQGYRGLVALLPERDLGVAILWNGESGLPSGMLPTILDRALGLPAKRW
CCCCEEEEECCCHHCCCCEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCHHHE
LDIDVDGDFGSENMLAEKPDPAGKGASSGKSVASPR
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA