Click here to switch to the map view.

The map label for this gene is virB10 [H]

Identifier: 21243350

GI number: 21243350

Start: 3084400

End: 3085569

Strand: Reverse

Name: virB10 [H]

Synonym: XAC2619

Alternate gene names: 21243350

Gene position: 3085569-3084400 (Counterclockwise)

Preceding gene: 21243351

Following gene: 21243349

Centisome position: 59.62

GC content: 58.97

Gene sequence:

>1170_bases
GTGAATTCGAATATTCCAAACAGCCCTGATGAGCGCATCCAGAACCATGGCGGCGATGAGCAGCACAACGGCGACCACAA
CGAGCGCAACAATCCTTACTTCGCGCGCCAGCAGGCCAGTGCGGAACCGGACCTGGATGCCAATGAGCCGATCTTAAGAT
CGAGCGACATCAAGCGACTTAATCGCAAGGCCCTGGTGTTTCTTGCAGCCATTGCAGCTCTCTTGATTCTCGCCATCTTC
TGGCTAGCGACGCAAAGCGGGGAGGATTCCGCGCCCCCGAAGCCGCGTACCGAGACGGTGGTCGCACCTGCGTTGCCGCA
GAGCATGACTGCGCCGGTTGAGGAAGCGCCAGTCCCGCTAGCTCAGCAGCCCAGTTTGCCGCCACTGCCGCCAATGCCGA
CCGACAATAGCGAAGAGGTCAGCTCCGCACCGGAACGTCAGCGCGGGCCAACGCTGTTGGAGCGTCGCATCCTTGCCGAG
TCTGCTGCAAATGGCGGTGGGGTTCCCGGTCAACTTGGGGCACAGCCTGCGCCTACTCAGGAAGATGGTCCGGTCACGCT
CGCCAAGCCGATCAGCAACCCGGACGGTCTGCTAGTGCGCGGTACCTATATTCGCTGCATCCTGGAGACTCGCATCATCT
CCGATTTCGGCGGCTATACATCGTGCATCGTCACCGAGCCGGTCTACTCCATCAATGGGCACAACCTGCTTCTTCCGAAA
GGGTCCAAGATGCTGGGTCAGTACAGCGCCGGTGAGCCGACCTCTCATCGTCTCCAAGTTGTCTGGGACCGCGTTACTAC
GCCTACCGGTTTGGATGTCACGCTCATGGGTCCAGGCATCGATACGCTCGGGAGCTCCGGTCATCCGGGTAACTACAACG
CACATTGGGGTAACAAAATTGCTTCAGCCCTGTTCATCAGTCTGCTGAGCGACGCATTCAAGTATGCAGCAGCGGAATAT
GGCCCCGAGACCACAACAATTGGCGTGGGCTCCGGCATCGTTACCCAGCAACCGTTTGAGAGTAATACCGCGCGTAGCAT
GCAGCAGCTTGCGGAGCAGGCGGTTGAAAAGTCGGGACGTCGTCCTGCCACACTGACGATCAACCAAGGAACGGTGTTGA
ACGTCTACGTTGCCAAGGACGTCGATTTCTCGGCTGTCCTGCCGAAGTGA

Upstream 100 bases:

>100_bases
CGACGGTGGAGGGAAATACTCTGATCGTGCACGGAACCTACCCTTTCCTGGTGGTTCGTCATGGCGATAACGTCGTCGGT
CTGCGAAGGAACAAGCAAAA

Downstream 100 bases:

>100_bases
ATGAAATGGTTGCCATGACGATCGATGACTCCCCGACAGCGCGTATTTCCAATGACTTTCTGGATTACCAGTACTCCGTG
CTGGGAATTCTGGACTATCT

Product: VirB10 protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNSNIPNSPDERIQNHGGDEQHNGDHNERNNPYFARQQASAEPDLDANEPILRSSDIKRLNRKALVFLAAIAALLILAIF
WLATQSGEDSAPPKPRTETVVAPALPQSMTAPVEEAPVPLAQQPSLPPLPPMPTDNSEEVSSAPERQRGPTLLERRILAE
SAANGGGVPGQLGAQPAPTQEDGPVTLAKPISNPDGLLVRGTYIRCILETRIISDFGGYTSCIVTEPVYSINGHNLLLPK
GSKMLGQYSAGEPTSHRLQVVWDRVTTPTGLDVTLMGPGIDTLGSSGHPGNYNAHWGNKIASALFISLLSDAFKYAAAEY
GPETTTIGVGSGIVTQQPFESNTARSMQQLAEQAVEKSGRRPATLTINQGTVLNVYVAKDVDFSAVLPK

Sequences:

>Translated_389_residues
MNSNIPNSPDERIQNHGGDEQHNGDHNERNNPYFARQQASAEPDLDANEPILRSSDIKRLNRKALVFLAAIAALLILAIF
WLATQSGEDSAPPKPRTETVVAPALPQSMTAPVEEAPVPLAQQPSLPPLPPMPTDNSEEVSSAPERQRGPTLLERRILAE
SAANGGGVPGQLGAQPAPTQEDGPVTLAKPISNPDGLLVRGTYIRCILETRIISDFGGYTSCIVTEPVYSINGHNLLLPK
GSKMLGQYSAGEPTSHRLQVVWDRVTTPTGLDVTLMGPGIDTLGSSGHPGNYNAHWGNKIASALFISLLSDAFKYAAAEY
GPETTTIGVGSGIVTQQPFESNTARSMQQLAEQAVEKSGRRPATLTINQGTVLNVYVAKDVDFSAVLPK
>Mature_389_residues
MNSNIPNSPDERIQNHGGDEQHNGDHNERNNPYFARQQASAEPDLDANEPILRSSDIKRLNRKALVFLAAIAALLILAIF
WLATQSGEDSAPPKPRTETVVAPALPQSMTAPVEEAPVPLAQQPSLPPLPPMPTDNSEEVSSAPERQRGPTLLERRILAE
SAANGGGVPGQLGAQPAPTQEDGPVTLAKPISNPDGLLVRGTYIRCILETRIISDFGGYTSCIVTEPVYSINGHNLLLPK
GSKMLGQYSAGEPTSHRLQVVWDRVTTPTGLDVTLMGPGIDTLGSSGHPGNYNAHWGNKIASALFISLLSDAFKYAAAEY
GPETTTIGVGSGIVTQQPFESNTARSMQQLAEQAVEKSGRRPATLTINQGTVLNVYVAKDVDFSAVLPK

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG2948

COG function: function code U; Type IV secretory pathway, VirB10 components

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbI/virB10 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005498 [H]

Pfam domain/function: PF03743 TrbI [H]

EC number: NA

Molecular weight: Translated: 41530; Mature: 41530

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSNIPNSPDERIQNHGGDEQHNGDHNERNNPYFARQQASAEPDLDANEPILRSSDIKRL
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEHHCCCCCCCCCCCCCCCCCHHHHHH
NRKALVFLAAIAALLILAIFWLATQSGEDSAPPKPRTETVVAPALPQSMTAPVEEAPVPL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCHHCCCHHHCCCCC
AQQPSLPPLPPMPTDNSEEVSSAPERQRGPTLLERRILAESAANGGGVPGQLGAQPAPTQ
CCCCCCCCCCCCCCCCCHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
EDGPVTLAKPISNPDGLLVRGTYIRCILETRIISDFGGYTSCIVTEPVYSINGHNLLLPK
CCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCEEECCC
GSKMLGQYSAGEPTSHRLQVVWDRVTTPTGLDVTLMGPGIDTLGSSGHPGNYNAHWGNKI
CHHHHCCCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCHHHCCCCCCCCCCCCHHHHHH
ASALFISLLSDAFKYAAAEYGPETTTIGVGSGIVTQQPFESNTARSMQQLAEQAVEKSGR
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
RPATLTINQGTVLNVYVAKDVDFSAVLPK
CCEEEEECCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNSNIPNSPDERIQNHGGDEQHNGDHNERNNPYFARQQASAEPDLDANEPILRSSDIKRL
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEHHCCCCCCCCCCCCCCCCCHHHHHH
NRKALVFLAAIAALLILAIFWLATQSGEDSAPPKPRTETVVAPALPQSMTAPVEEAPVPL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCHHCCCHHHCCCCC
AQQPSLPPLPPMPTDNSEEVSSAPERQRGPTLLERRILAESAANGGGVPGQLGAQPAPTQ
CCCCCCCCCCCCCCCCCHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
EDGPVTLAKPISNPDGLLVRGTYIRCILETRIISDFGGYTSCIVTEPVYSINGHNLLLPK
CCCCEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCEEECCC
GSKMLGQYSAGEPTSHRLQVVWDRVTTPTGLDVTLMGPGIDTLGSSGHPGNYNAHWGNKI
CHHHHCCCCCCCCCCCEEEEEEECCCCCCCCEEEEECCCHHHCCCCCCCCCCCCHHHHHH
ASALFISLLSDAFKYAAAEYGPETTTIGVGSGIVTQQPFESNTARSMQQLAEQAVEKSGR
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
RPATLTINQGTVLNVYVAKDVDFSAVLPK
CCEEEEECCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]