Click here to switch to the map view.

The map label for this gene is xseA

Identifier: 21243144

GI number: 21243144

Start: 2807986

End: 2809323

Strand: Direct

Name: xseA

Synonym: XAC2410

Alternate gene names: 21243144

Gene position: 2807986-2809323 (Clockwise)

Preceding gene: 21243143

Following gene: 21243147

Centisome position: 54.25

GC content: 67.94

Gene sequence:

>1338_bases
ATGGCCGACCGCAACGAACAGATCCTCACTCCCAGCCAGCTCAATTCGCTGGCGCGCGACCTGCTGGAAGGCGGTTTCCC
GCTGGTGTGGGTGGAAGCCGAACTGAGCAGCGTCACCCGGCCGGCGTCGGGACATCTGTATTTCACGCTCAAGGACGCGC
GCGCGCAGATCCGCTGCGCGATGTTCAAGCCCAAGAGCACCTGGCTGAAATTCCAGCCGCGCGAAGGCCTGCGCGTGCTC
GCGCGCGGGCGCCTGACCCTATACGAAGCGCGCGGCGACTATCAGCTGGTGCTCGACCATATGGAAGAAGCCGGCGAAGG
CGCCCTGCGTCGCGCCTTCGACGAACTGCGCGCGCGTCTTACCGCCGAAGGCCTGTTCGATGCCGAGCGCAAGCAGGCAC
TGCCTGCGCATGTGCGGCGGCTGGCGGTGATCACCTCGCCCAGCGGCGCGGCGGTGCGCGATGTGCTCAGCGTGCTGGCG
CGGCGTTTTCCGCTGCTCGAAGTGGACCTGCTGCCTTCGCTGGTGCAAGGCGACAGCGCTGCCGCACAGATCACCTCACT
GCTGCAACGCGCCGATGCCTCCGGGCGCTACGACGTTATCCTGATCACCCGCGGTGGCGGCTCGCTGGAAGATCTGTGGG
CCTTCAACGACGAACGCCTGGCGCGCGCGATCGCCGCCGCGCAGACCCCGGTGGTATCTGCAGTCGGCCACGAGACCGAC
TTCAGCCTCAGCGATTTCGTCGCCGATGTCCGCGCACCCACGCCCTCGGTCGCGGCCGAATTGCTGGTGCCCGATCAACG
CGAGCTGGTCGCGCGCGTGCGGCGTGCGCAGGCACGCATGACCCAACTGCAGCAACACGCCTTGGGCAATGCCATGCAAC
GCGCAGACCGGCTGGCCCTGCGGCTGCGTGCGCAGAGCCCGCAGGCGCGCTTGCAACTGCTCCATCGCCGCCAGGAAGAC
GCCGGTCGCCAGCTGCGTGCGCGCATGATGCACGTGCTCGAACGCTTGCAGGCGCGCGTACAGCGTGGGCAAGCACAGCT
GCAATCGCACAACCCGCAACGCCATCTGGCCGGCTTGCAGCAACGCCTGCGGGCACTGCATCCGCAGGCGGCGATGCAAC
GTCGCCTGCAGCATGATCAGCTGCAACTCCGTCGCATTGCACGCTCGCTGGAAGCGGTCAGCCCGCTGGCCACAGTCGCA
CGCGGCTACGCCATCGTGACCCGTCCTGCCAATGGCAGCGTGGTGCGCAGCGCTGCCGAGGTGGTCACGGGCGAACGCCT
GCGCGCGCAGCTGGCCGATGGCAGTATCGAGGTGCGAGTGGAGTCTGGCGAAAGCTGA

Upstream 100 bases:

>100_bases
AACCTGCACGTGCACGCGTTGGCCAACGCTGCGGCTCTGTTGCCATCGGCGTTCGCCGGCCCATCACCCATCACCGTCGT
CGCTACGGGATAATGCAGCG

Downstream 100 bases:

>100_bases
CCGCAAGCCATGCGCGACACCGTGGTTCCTGCAGCAATGCCGGCGCTCCAGCGCTGACATTAACTCTTCGAAGGTGCCCA
TTCCACGGGGCGCCGGAGAG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MADRNEQILTPSQLNSLARDLLEGGFPLVWVEAELSSVTRPASGHLYFTLKDARAQIRCAMFKPKSTWLKFQPREGLRVL
ARGRLTLYEARGDYQLVLDHMEEAGEGALRRAFDELRARLTAEGLFDAERKQALPAHVRRLAVITSPSGAAVRDVLSVLA
RRFPLLEVDLLPSLVQGDSAAAQITSLLQRADASGRYDVILITRGGGSLEDLWAFNDERLARAIAAAQTPVVSAVGHETD
FSLSDFVADVRAPTPSVAAELLVPDQRELVARVRRAQARMTQLQQHALGNAMQRADRLALRLRAQSPQARLQLLHRRQED
AGRQLRARMMHVLERLQARVQRGQAQLQSHNPQRHLAGLQQRLRALHPQAAMQRRLQHDQLQLRRIARSLEAVSPLATVA
RGYAIVTRPANGSVVRSAAEVVTGERLRAQLADGSIEVRVESGES

Sequences:

>Translated_445_residues
MADRNEQILTPSQLNSLARDLLEGGFPLVWVEAELSSVTRPASGHLYFTLKDARAQIRCAMFKPKSTWLKFQPREGLRVL
ARGRLTLYEARGDYQLVLDHMEEAGEGALRRAFDELRARLTAEGLFDAERKQALPAHVRRLAVITSPSGAAVRDVLSVLA
RRFPLLEVDLLPSLVQGDSAAAQITSLLQRADASGRYDVILITRGGGSLEDLWAFNDERLARAIAAAQTPVVSAVGHETD
FSLSDFVADVRAPTPSVAAELLVPDQRELVARVRRAQARMTQLQQHALGNAMQRADRLALRLRAQSPQARLQLLHRRQED
AGRQLRARMMHVLERLQARVQRGQAQLQSHNPQRHLAGLQQRLRALHPQAAMQRRLQHDQLQLRRIARSLEAVSPLATVA
RGYAIVTRPANGSVVRSAAEVVTGERLRAQLADGSIEVRVESGES
>Mature_444_residues
ADRNEQILTPSQLNSLARDLLEGGFPLVWVEAELSSVTRPASGHLYFTLKDARAQIRCAMFKPKSTWLKFQPREGLRVLA
RGRLTLYEARGDYQLVLDHMEEAGEGALRRAFDELRARLTAEGLFDAERKQALPAHVRRLAVITSPSGAAVRDVLSVLAR
RFPLLEVDLLPSLVQGDSAAAQITSLLQRADASGRYDVILITRGGGSLEDLWAFNDERLARAIAAAQTPVVSAVGHETDF
SLSDFVADVRAPTPSVAAELLVPDQRELVARVRRAQARMTQLQQHALGNAMQRADRLALRLRAQSPQARLQLLHRRQEDA
GRQLRARMMHVLERLQARVQRGQAQLQSHNPQRHLAGLQQRLRALHPQAAMQRRLQHDQLQLRRIARSLEAVSPLATVAR
GYAIVTRPANGSVVRSAAEVVTGERLRAQLADGSIEVRVESGES

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=441, Percent_Identity=44.671201814059, Blast_Score=350, Evalue=1e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_XANAC (Q8PJW7)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642726.1
- GeneID:   1156481
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC2410
- NMPDR:   fig|190486.1.peg.2370
- HOGENOM:   HBG634411
- OMA:   EISNFTR
- ProtClustDB:   PRK00286
- BioCyc:   XAXO190486:XAC2410-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 49395; Mature: 49264

Theoretical pI: Translated: 11.40; Mature: 11.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRNEQILTPSQLNSLARDLLEGGFPLVWVEAELSSVTRPASGHLYFTLKDARAQIRCA
CCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCEEEEEEECCCCCEEEE
MFKPKSTWLKFQPREGLRVLARGRLTLYEARGDYQLVLDHMEEAGEGALRRAFDELRARL
EECCCCCCEEECCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
TAEGLFDAERKQALPAHVRRLAVITSPSGAAVRDVLSVLARRFPLLEVDLLPSLVQGDSA
HHHHHHCHHHHHCCHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHH
AAQITSLLQRADASGRYDVILITRGGGSLEDLWAFNDERLARAIAAAQTPVVSAVGHETD
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCCC
FSLSDFVADVRAPTPSVAAELLVPDQRELVARVRRAQARMTQLQQHALGNAMQRADRLAL
CCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRAQSPQARLQLLHRRQEDAGRQLRARMMHVLERLQARVQRGQAQLQSHNPQRHLAGLQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QRLRALHPQAAMQRRLQHDQLQLRRIARSLEAVSPLATVARGYAIVTRPANGSVVRSAAE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHH
VVTGERLRAQLADGSIEVRVESGES
HHHHHHHHHHHCCCCEEEEEECCCC
>Mature Secondary Structure 
ADRNEQILTPSQLNSLARDLLEGGFPLVWVEAELSSVTRPASGHLYFTLKDARAQIRCA
CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCEEEEEEECCCCCEEEE
MFKPKSTWLKFQPREGLRVLARGRLTLYEARGDYQLVLDHMEEAGEGALRRAFDELRARL
EECCCCCCEEECCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
TAEGLFDAERKQALPAHVRRLAVITSPSGAAVRDVLSVLARRFPLLEVDLLPSLVQGDSA
HHHHHHCHHHHHCCHHHHHHEEEEECCCCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHH
AAQITSLLQRADASGRYDVILITRGGGSLEDLWAFNDERLARAIAAAQTPVVSAVGHETD
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCCC
FSLSDFVADVRAPTPSVAAELLVPDQRELVARVRRAQARMTQLQQHALGNAMQRADRLAL
CCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLRAQSPQARLQLLHRRQEDAGRQLRARMMHVLERLQARVQRGQAQLQSHNPQRHLAGLQ
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QRLRALHPQAAMQRRLQHDQLQLRRIARSLEAVSPLATVARGYAIVTRPANGSVVRSAAE
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHH
VVTGERLRAQLADGSIEVRVESGES
HHHHHHHHHHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217