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The map label for this gene is rnD [H]

Identifier: 21243147

GI number: 21243147

Start: 2813482

End: 2814573

Strand: Direct

Name: rnD [H]

Synonym: XAC2413

Alternate gene names: 21243147

Gene position: 2813482-2814573 (Clockwise)

Preceding gene: 21243144

Following gene: 21243150

Centisome position: 54.36

GC content: 67.49

Gene sequence:

>1092_bases
GTGCCCCTTTGGATCACCCACCCCTCCGAGCTGACTGACCGCCTGCAGGCAGCGCGACCATCGCGCATCGGCCTGGATAC
CGAATTCATTCGCGAACGCACCTACTGGCCGCAACTGGCCCTGGTGCAGATGGCCATCGGCGAGGAGATCCTGCTGATCG
ACCCGCTGATCCCCGGCATGAACGCGGCGCTCAAGGAGTGGTTGATCGCCACCGACATCGTCAAGGTGATGCATAGCGCC
AGCGAAGACCTGGTCACGTTCAAATGCGCGTGCGGCGCATTGCCGCGGCCGTTGTTCGACACCCAGATCGCCGCGGCACT
GGCCGGTGTCGGCGGCGGCATGGGATACCAGAAACTGGTGCAGGAAGTCACCGGCACCTTGCTGACCAAGGGCGAAACAC
GCTCGGACTGGATGCGTCGCCCGCTGTCGCCTGCGCAGCTGGAATATGCCGCCGATGACGTGCGCTATCTGTTTGCGATC
CACGACGAGCTCACGCGCCGCCTCGCCGAGCAAGGCCGTCTGGAGTGGCTGGCCGAAGATGCCGACCGCCTGCTCGCCAC
GGTGGAGCACGACGATGGCGAGCGCTGGCCGCATGTGAGCCTGCGCGCAGCACAGTTCCTGGAACCGGCCGCGCAACGAC
GGCTGCTGCGCTTGCTGCGTTGGCGCGACCTGCAGGCGCGGCAGAGCGATCGCCCGCGCAGCTGGATCCTGGAAAACGAA
CTGGCCAGCCAGCTGGCGCGGTTCCCGCCCGCCGACCTGGAGGCCTTGCTGCGCCAGTTCGACAAATTCCCCAAGGCGCC
GCGCAAGCTCGCCAACGCGGTGTGGGATGCACTCAACACCCCGCTGCCGGACGAAGAGCACGCGCCGCTGGCGCAGGCCG
CCACCGACGGCAACAAGGCCGTACTCAAGCGCCTGCAGGACACCGTGGCGCAGCGTAGCCGCGAACTCGGCCTGCCGGAC
GGCCTGCTGGCCTCGCGCCGCCACCTGGAAACCTTGATGGAACAGCGCAGCTGGCCTGCGGCGCTGGGCCAATGGCGCCG
TGCCCTGCTGGAAGCACAGTTGATGCCGCTGCTGGAAGGCACAGCAGCGTAG

Upstream 100 bases:

>100_bases
CACCACCTGCTCCTTCCAGTGCTCTGCCGCACGACAGGCGATCGCGACGTTAGGCTATTCTGCGCGCTCTGCGCAAACCC
TTGCCGCCGACGGAAATCAC

Downstream 100 bases:

>100_bases
GATTGCGGCGGTCATGGCGCCAGCGCCCGCAGCGATGCGGCCCTTCGTCAGGTGCACGCGAGTGGCCCCGCACCGGCGCA
TGCCGCCTCGCAGGCAGTGG

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MPLWITHPSELTDRLQAARPSRIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGMNAALKEWLIATDIVKVMHSA
SEDLVTFKCACGALPRPLFDTQIAAALAGVGGGMGYQKLVQEVTGTLLTKGETRSDWMRRPLSPAQLEYAADDVRYLFAI
HDELTRRLAEQGRLEWLAEDADRLLATVEHDDGERWPHVSLRAAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILENE
LASQLARFPPADLEALLRQFDKFPKAPRKLANAVWDALNTPLPDEEHAPLAQAATDGNKAVLKRLQDTVAQRSRELGLPD
GLLASRRHLETLMEQRSWPAALGQWRRALLEAQLMPLLEGTAA

Sequences:

>Translated_363_residues
MPLWITHPSELTDRLQAARPSRIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGMNAALKEWLIATDIVKVMHSA
SEDLVTFKCACGALPRPLFDTQIAAALAGVGGGMGYQKLVQEVTGTLLTKGETRSDWMRRPLSPAQLEYAADDVRYLFAI
HDELTRRLAEQGRLEWLAEDADRLLATVEHDDGERWPHVSLRAAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILENE
LASQLARFPPADLEALLRQFDKFPKAPRKLANAVWDALNTPLPDEEHAPLAQAATDGNKAVLKRLQDTVAQRSRELGLPD
GLLASRRHLETLMEQRSWPAALGQWRRALLEAQLMPLLEGTAA
>Mature_362_residues
PLWITHPSELTDRLQAARPSRIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGMNAALKEWLIATDIVKVMHSAS
EDLVTFKCACGALPRPLFDTQIAAALAGVGGGMGYQKLVQEVTGTLLTKGETRSDWMRRPLSPAQLEYAADDVRYLFAIH
DELTRRLAEQGRLEWLAEDADRLLATVEHDDGERWPHVSLRAAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILENEL
ASQLARFPPADLEALLRQFDKFPKAPRKLANAVWDALNTPLPDEEHAPLAQAATDGNKAVLKRLQDTVAQRSRELGLPDG
LLASRRHLETLMEQRSWPAALGQWRRALLEAQLMPLLEGTAA

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Escherichia coli, GI1788105, Length=361, Percent_Identity=33.5180055401662, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17531757, Length=251, Percent_Identity=26.6932270916335, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324574, Length=329, Percent_Identity=25.8358662613982, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 40962; Mature: 40830

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLWITHPSELTDRLQAARPSRIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGM
CCEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCH
NAALKEWLIATDIVKVMHSASEDLVTFKCACGALPRPLFDTQIAAALAGVGGGMGYQKLV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
QEVTGTLLTKGETRSDWMRRPLSPAQLEYAADDVRYLFAIHDELTRRLAEQGRLEWLAED
HHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADRLLATVEHDDGERWPHVSLRAAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILENE
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LASQLARFPPADLEALLRQFDKFPKAPRKLANAVWDALNTPLPDEEHAPLAQAATDGNKA
HHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHH
VLKRLQDTVAQRSRELGLPDGLLASRRHLETLMEQRSWPAALGQWRRALLEAQLMPLLEG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
TAA
CCC
>Mature Secondary Structure 
PLWITHPSELTDRLQAARPSRIGLDTEFIRERTYWPQLALVQMAIGEEILLIDPLIPGM
CEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCCH
NAALKEWLIATDIVKVMHSASEDLVTFKCACGALPRPLFDTQIAAALAGVGGGMGYQKLV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
QEVTGTLLTKGETRSDWMRRPLSPAQLEYAADDVRYLFAIHDELTRRLAEQGRLEWLAED
HHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADRLLATVEHDDGERWPHVSLRAAQFLEPAAQRRLLRLLRWRDLQARQSDRPRSWILENE
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
LASQLARFPPADLEALLRQFDKFPKAPRKLANAVWDALNTPLPDEEHAPLAQAATDGNKA
HHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHH
VLKRLQDTVAQRSRELGLPDGLLASRRHLETLMEQRSWPAALGQWRRALLEAQLMPLLEG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
TAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]