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The map label for this gene is Hgd [H]

Identifier: 21243012

GI number: 21243012

Start: 2664701

End: 2665603

Strand: Direct

Name: Hgd [H]

Synonym: XAC2277

Alternate gene names: 21243012

Gene position: 2664701-2665603 (Clockwise)

Preceding gene: 21243011

Following gene: 21243013

Centisome position: 51.49

GC content: 68.44

Gene sequence:

>903_bases
ATGGACATCGGATTGGTCGGCATGGGAAACATCGGGCGTCATTTCGTGGCGCGGTGGCTGGCACAGGGGCATCGCGTCAT
CGTGCACGACACGCGGGCGCAAGCGCTGCAACAGGCAAAGGAGGCGGGAGCGACCACCGCGGCCGGCATGGCCGATGTGC
TGGCGAACGCGGAGGTGATCGCCCTCAGCCTTCCGCTACCGTCGGTGGTGCTGGAGGTGGCCCGGACCCTTGCCGCGGCA
GCCGCTGCGACCGAGATGCGGGACTCGCTGCTCGTCGTGGATCTGTCCACGACGGGCGCCCAAACCACCTCGGAGGTGGG
CCATCTGCTGGAGCGCGCCGATGTGTCATTCCTGAGCGCGCCGGTGAGCGGCGGAACGGCGGCGGCCGCGCAAGGTGTGC
TCACGGTGATGGCCGCGGGACCACTTGCGGCCTACGAGCGGGCAAGGCCCCTGCTCGATGCCGTGGGGCGCCATATCTTC
TACCTGGGCGGGGATGTGCGGCTCGGCCAGACGCTCAAGCTGATCAACAACACCCTGTACGCCAGCGCGATGCTAGCGAG
TTGCGAGGCGCTGGTGTGCGGCGCCAAGGCGGGACTCGACGCACGAACGATGCTTGACGTCATCAACCGCTCCAGCGGCC
GGTGCTTCGCCACGATGGAGCGCCTGCACGGCGCGTTGGATCGGAGTTTCCCGGTCCGCTTCACCACCGAACTGCTGCGC
AAGGACGTGCAACTCGGGCTCATGGCCGCGGACGAACTCGGTGTGCCCATGCACGTCGGCAAGGCAGCGCTGCAGTTGCT
CGACCAGGCCGTCGCCGATGGCCTCGGCGAGGCGGACAACATCGCCGCGATCCAGTCTATCGAACGGCAGGCCGGCGCCG
TGTTCGGAGCCGCGGCGCACTGA

Upstream 100 bases:

>100_bases
GATTGACGAAACCGCAAGCGCCTCGGCGGATTTCGCAATCGCCAACGGCGCCCTCTGTTCCTAGCATCCGATCCATTGTT
GTCGAGACAGGGAGCGGTAC

Downstream 100 bases:

>100_bases
TCGAGCACCCGCCGGCCGCTTTGCACTGCCGGCGGCGACAGCACAACAACCAACGACACCCGAGGAGAAACCATGAAACG
AAGAATCATCGCATCGCTCA

Product: 3-hydroxyisobutirate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MDIGLVGMGNIGRHFVARWLAQGHRVIVHDTRAQALQQAKEAGATTAAGMADVLANAEVIALSLPLPSVVLEVARTLAAA
AAATEMRDSLLVVDLSTTGAQTTSEVGHLLERADVSFLSAPVSGGTAAAAQGVLTVMAAGPLAAYERARPLLDAVGRHIF
YLGGDVRLGQTLKLINNTLYASAMLASCEALVCGAKAGLDARTMLDVINRSSGRCFATMERLHGALDRSFPVRFTTELLR
KDVQLGLMAADELGVPMHVGKAALQLLDQAVADGLGEADNIAAIQSIERQAGAVFGAAAH

Sequences:

>Translated_300_residues
MDIGLVGMGNIGRHFVARWLAQGHRVIVHDTRAQALQQAKEAGATTAAGMADVLANAEVIALSLPLPSVVLEVARTLAAA
AAATEMRDSLLVVDLSTTGAQTTSEVGHLLERADVSFLSAPVSGGTAAAAQGVLTVMAAGPLAAYERARPLLDAVGRHIF
YLGGDVRLGQTLKLINNTLYASAMLASCEALVCGAKAGLDARTMLDVINRSSGRCFATMERLHGALDRSFPVRFTTELLR
KDVQLGLMAADELGVPMHVGKAALQLLDQAVADGLGEADNIAAIQSIERQAGAVFGAAAH
>Mature_300_residues
MDIGLVGMGNIGRHFVARWLAQGHRVIVHDTRAQALQQAKEAGATTAAGMADVLANAEVIALSLPLPSVVLEVARTLAAA
AAATEMRDSLLVVDLSTTGAQTTSEVGHLLERADVSFLSAPVSGGTAAAAQGVLTVMAAGPLAAYERARPLLDAVGRHIF
YLGGDVRLGQTLKLINNTLYASAMLASCEALVCGAKAGLDARTMLDVINRSSGRCFATMERLHGALDRSFPVRFTTELLR
KDVQLGLMAADELGVPMHVGKAALQLLDQAVADGLGEADNIAAIQSIERQAGAVFGAAAH

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=295, Percent_Identity=28.8135593220339, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI40556376, Length=278, Percent_Identity=26.2589928057554, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1790315, Length=291, Percent_Identity=29.2096219931272, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693186, Length=291, Percent_Identity=26.8041237113402, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1789092, Length=288, Percent_Identity=29.1666666666667, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1786719, Length=293, Percent_Identity=26.6211604095563, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17557316, Length=296, Percent_Identity=29.7297297297297, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24655230, Length=285, Percent_Identity=28.0701754385965, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19922568, Length=285, Percent_Identity=28.0701754385965, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574115, Length=286, Percent_Identity=21.3286713286713, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 31111; Mature: 31111

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIGLVGMGNIGRHFVARWLAQGHRVIVHDTRAQALQQAKEAGATTAAGMADVLANAEVI
CCEEEECCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHCCCEEE
ALSLPLPSVVLEVARTLAAAAAATEMRDSLLVVDLSTTGAQTTSEVGHLLERADVSFLSA
EEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHCC
PVSGGTAAAAQGVLTVMAAGPLAAYERARPLLDAVGRHIFYLGGDVRLGQTLKLINNTLY
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHHHHHHHH
ASAMLASCEALVCGAKAGLDARTMLDVINRSSGRCFATMERLHGALDRSFPVRFTTELLR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
KDVQLGLMAADELGVPMHVGKAALQLLDQAVADGLGEADNIAAIQSIERQAGAVFGAAAH
HHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDIGLVGMGNIGRHFVARWLAQGHRVIVHDTRAQALQQAKEAGATTAAGMADVLANAEVI
CCEEEECCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHCCCEEE
ALSLPLPSVVLEVARTLAAAAAATEMRDSLLVVDLSTTGAQTTSEVGHLLERADVSFLSA
EEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCHHHHCC
PVSGGTAAAAQGVLTVMAAGPLAAYERARPLLDAVGRHIFYLGGDVRLGQTLKLINNTLY
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCEEHHHHHHHHHHHHH
ASAMLASCEALVCGAKAGLDARTMLDVINRSSGRCFATMERLHGALDRSFPVRFTTELLR
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
KDVQLGLMAADELGVPMHVGKAALQLLDQAVADGLGEADNIAAIQSIERQAGAVFGAAAH
HHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA