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The map label for this gene is hisB

Identifier: 21242575

GI number: 21242575

Start: 2126850

End: 2127977

Strand: Direct

Name: hisB

Synonym: XAC1831

Alternate gene names: 21242575

Gene position: 2126850-2127977 (Clockwise)

Preceding gene: 21242574

Following gene: 21242576

Centisome position: 41.09

GC content: 62.23

Gene sequence:

>1128_bases
ATGACCCCGATTCTTTTTGTCGACCGCGACGGCACGCTGATCGTCGAGCCGGCCGATTACCAGATCGACGCCTACGAAAA
ATTGCGCTTGGTCGATCACGTGATTCCGGCGATGCTCAAGCTGCGCGATGCCGGCTATCAGTTCGTCATCGTCAGCAACC
AGGATGGGTTGGGCAGCGAGAGCTACCCACGCGCGTCCTTCGACGGCCCGAACAATCTGATGCTGCAGATCTTCGCCAGC
CAGGGCATCGAATTTCGCGAAGTGCTGATCGATTGCAGCTGGCCTGCCGACAATGCGCCCACGCGCAAGCCCGGTATCGG
CCTGATGGTGCCGTATCTGCAGGACCGCACCATCGACTGGGCACGCTCGGCGATGGTGGGCGACCGCATCACCGACATCC
AGTTCGCGCAGAATCTGAATATCCGCGGGTTTCAGCTGCGCACCGATGAGTTCGGCGGCGAGTGGGACTGGTCCGGCATC
GCCCACGAGCTGGCCGATGCGCCACGCCGTGCGCTGGTCCAGCGCAATACCAAGGAAACCAGGATCCGCGTCGAACTGGA
TCTGGATCGTGTCGCCGAGCCGAAGACTGCCACCGGTCTGCCGTTCTTCGACCACATGCTGGAACAGATCGGCAAGCATG
GCGGTTTTGCGCTGGAGATCCGTGCCGAAGGCGATCTGCATATCGATGAGCACCACACCATCGAAGACACCGGCCTTGCG
CTGGGCCAAGCGCTGCGTGAAGCGCTGGGCGATAAACGCGGCATCGGCCGTTACGGCTTCGATCCGGAAAGCAGCCCCTG
GCGTGTCGCTGGCGACACGCCGCAGCACGGCTTCACGTTGCCGATGGACGAAACCATCGCAAGTGCGGCGCTGGATTTCA
GTGGCCGCCCGTATTTCGTCTTCGAGGGCGAATTCAAGCGCGAGCGCGTCGGCGACATGCCCACCGAACTGGTGCCGCAT
TTCTTCCGTTCGATCTGCGATGCGTCCGGCTTGAATCTGCATCTGACCGTGCGTGGCGAGAACGATCACCACAAGGTGGA
AGCCTGCTTCAAGGCCTTGGCGCGGGCATTGCGTCAGGCGATTCGCCGTGAGGGCACCGCGTTGCCGACCACCAAGGGCA
CGCTATGA

Upstream 100 bases:

>100_bases
CAGTGCCGCGCCTGGCCGACGCGTTGCGGATCACGCTGGGCACGAACGAACAGAACCAGCGCGTGCTGAGCGCGCTGCAA
CGCACGCAGGAGGCCGCCGC

Downstream 100 bases:

>100_bases
CCGACGTTGCGCTGATCGATGCCGGTGGCGCCAACCTGGGCTCGGTGCGCTATGCATTGGAGCGCTTGGGCGTCGACGCA
CGCTTGGTGCGCGATGCGGC

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTPILFVDRDGTLIVEPADYQIDAYEKLRLVDHVIPAMLKLRDAGYQFVIVSNQDGLGSESYPRASFDGPNNLMLQIFAS
QGIEFREVLIDCSWPADNAPTRKPGIGLMVPYLQDRTIDWARSAMVGDRITDIQFAQNLNIRGFQLRTDEFGGEWDWSGI
AHELADAPRRALVQRNTKETRIRVELDLDRVAEPKTATGLPFFDHMLEQIGKHGGFALEIRAEGDLHIDEHHTIEDTGLA
LGQALREALGDKRGIGRYGFDPESSPWRVAGDTPQHGFTLPMDETIASAALDFSGRPYFVFEGEFKRERVGDMPTELVPH
FFRSICDASGLNLHLTVRGENDHHKVEACFKALARALRQAIRREGTALPTTKGTL

Sequences:

>Translated_375_residues
MTPILFVDRDGTLIVEPADYQIDAYEKLRLVDHVIPAMLKLRDAGYQFVIVSNQDGLGSESYPRASFDGPNNLMLQIFAS
QGIEFREVLIDCSWPADNAPTRKPGIGLMVPYLQDRTIDWARSAMVGDRITDIQFAQNLNIRGFQLRTDEFGGEWDWSGI
AHELADAPRRALVQRNTKETRIRVELDLDRVAEPKTATGLPFFDHMLEQIGKHGGFALEIRAEGDLHIDEHHTIEDTGLA
LGQALREALGDKRGIGRYGFDPESSPWRVAGDTPQHGFTLPMDETIASAALDFSGRPYFVFEGEFKRERVGDMPTELVPH
FFRSICDASGLNLHLTVRGENDHHKVEACFKALARALRQAIRREGTALPTTKGTL
>Mature_374_residues
TPILFVDRDGTLIVEPADYQIDAYEKLRLVDHVIPAMLKLRDAGYQFVIVSNQDGLGSESYPRASFDGPNNLMLQIFASQ
GIEFREVLIDCSWPADNAPTRKPGIGLMVPYLQDRTIDWARSAMVGDRITDIQFAQNLNIRGFQLRTDEFGGEWDWSGIA
HELADAPRRALVQRNTKETRIRVELDLDRVAEPKTATGLPFFDHMLEQIGKHGGFALEIRAEGDLHIDEHHTIEDTGLAL
GQALREALGDKRGIGRYGFDPESSPWRVAGDTPQHGFTLPMDETIASAALDFSGRPYFVFEGEFKRERVGDMPTELVPHF
FRSICDASGLNLHLTVRGENDHHKVEACFKALARALRQAIRREGTALPTTKGTL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=372, Percent_Identity=52.6881720430108, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1786399, Length=192, Percent_Identity=30.2083333333333, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324776, Length=233, Percent_Identity=41.6309012875536, Blast_Score=173, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_XANAC (P58881)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642157.1
- ProteinModelPortal:   P58881
- SMR:   P58881
- GeneID:   1155902
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1831
- NMPDR:   fig|190486.1.peg.1801
- HOGENOM:   HBG289010
- OMA:   QDGLGTP
- ProtClustDB:   PRK05446
- BioCyc:   XAXO190486:XAC1831-MONOMER
- BRENDA:   3.1.3.15
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_01022
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.40.50.1000
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01261
- TIGRFAMs:   TIGR01656

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P; SSF54211 Ribosomal_S5_D2-typ_fold; SSF56784 SSF56784

EC number: =3.1.3.15; =4.2.1.19

Molecular weight: Translated: 42011; Mature: 41880

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPILFVDRDGTLIVEPADYQIDAYEKLRLVDHVIPAMLKLRDAGYQFVIVSNQDGLGSE
CCCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
SYPRASFDGPNNLMLQIFASQGIEFREVLIDCSWPADNAPTRKPGIGLMVPYLQDRTIDW
CCCCCCCCCCCCEEEEEEHHCCCEEEHEEEECCCCCCCCCCCCCCCEEEECCCCCCCHHH
ARSAMVGDRITDIQFAQNLNIRGFQLRTDEFGGEWDWSGIAHELADAPRRALVQRNTKET
HHHHHHCCCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
RIRVELDLDRVAEPKTATGLPFFDHMLEQIGKHGGFALEIRAEGDLHIDEHHTIEDTGLA
EEEEEECHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHH
LGQALREALGDKRGIGRYGFDPESSPWRVAGDTPQHGFTLPMDETIASAALDFSGRPYFV
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCEECCHHHHHHHHHHCCCCCEEEE
FEGEFKRERVGDMPTELVPHFFRSICDASGLNLHLTVRGENDHHKVEACFKALARALRQA
ECCCCCHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
IRREGTALPTTKGTL
HHHCCCCCCCCCCCC
>Mature Secondary Structure 
TPILFVDRDGTLIVEPADYQIDAYEKLRLVDHVIPAMLKLRDAGYQFVIVSNQDGLGSE
CCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
SYPRASFDGPNNLMLQIFASQGIEFREVLIDCSWPADNAPTRKPGIGLMVPYLQDRTIDW
CCCCCCCCCCCCEEEEEEHHCCCEEEHEEEECCCCCCCCCCCCCCCEEEECCCCCCCHHH
ARSAMVGDRITDIQFAQNLNIRGFQLRTDEFGGEWDWSGIAHELADAPRRALVQRNTKET
HHHHHHCCCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
RIRVELDLDRVAEPKTATGLPFFDHMLEQIGKHGGFALEIRAEGDLHIDEHHTIEDTGLA
EEEEEECHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCEEECCCCCCHHHHHH
LGQALREALGDKRGIGRYGFDPESSPWRVAGDTPQHGFTLPMDETIASAALDFSGRPYFV
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCEECCHHHHHHHHHHCCCCCEEEE
FEGEFKRERVGDMPTELVPHFFRSICDASGLNLHLTVRGENDHHKVEACFKALARALRQA
ECCCCCHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
IRREGTALPTTKGTL
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217