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The map label for this gene is dapA

Identifier: 21242506

GI number: 21242506

Start: 2017561

End: 2018469

Strand: Direct

Name: dapA

Synonym: XAC1760

Alternate gene names: 21242506

Gene position: 2017561-2018469 (Clockwise)

Preceding gene: 21242497

Following gene: 21242507

Centisome position: 38.98

GC content: 70.19

Gene sequence:

>909_bases
TTGTCCCTTTCCGGCATCATCACCGCGCTGGCGACCCCCTTCGGTCCCGATGGCGCACTCGACCTGGATGCCTGGCGGCG
GCTGCTGGAGCAGCAGTTGCACGGTGGCGTGCAGGGACTCGTGGTTGCCGGCTCCACCGGCGAAGCGGCGGCATTGAGCG
ACGACGAATACGACACCCTACTGCGCGCTGCCGCGGCGCAGGTGGCCGGTCGCGTGCCGGTGCTGGCCGGCACCGGCTTG
TCCGGGACGGCAAAGACCATTGCGCAGACCCGTCGCGCTGCAGCGCTGGGCGCGCAGTACGCGCTGGTGGTGACGCCGCC
CTACGTGCGTCCGACCCAGGCCGGGTTGAAGGCACACTTTCTGGCGGTGGCCGATGAAGGTGGCCTGCCGGTGGTGCTGT
ACAACGTGCCGGGCCGCACCGGCTGCGACCTGCTGCCGGAGACGGTGGCCGAGCTGGTGGGCCATCCGAACATCGTCGGT
ATCAAGGAAGCGCGTAGCGAACCCGAGCGCGTCGCCGCGTTGGTGGCCTTGCGCAGCGACAGTTTTGTGGTGCTCAGCGG
CGACGACGGCAGCGCGGCGCACGCGATGCTGTCCGGCGCTGCCGGGCTGATCTCGGTCGCCTCCAACGCCTTGCCGGCGG
CGTACCGGCGCCTGTGCGATCTGGCCCGCGATGGCCAGCGCGATGCTGCCGCTGCCTGGGACGCGCGGCTGAGCGAATAC
CACAACTTCTGCGGCATCGAATCCAATCCCATCCCGGTCAAGGCGCTGCTGCAGCGCGCCGGGATCGGCCACGGCCTGCG
CTTGCCGCTGCTGCCTCTTTCTGCGGCGCACCAGCCTGCCGCCGACCGCCTTGCCGCCGACGCCATTGCGTTGGAAGCGC
TTTCCAGCCGCGAAATGCTCGCGGCCTGA

Upstream 100 bases:

>100_bases
CCAGCATACTTGCCCGTGGTTTCGCGCCGCAAGTAACATGCAGGCGGTCGCAACCCGCGCGTGCGCGGGCCTTTTCCTGT
CACGTAAGAGCAGCAGAATC

Downstream 100 bases:

>100_bases
CCCAGGAGATCTATCGATGCGTCATTCCGTTTCCCCCGTCCGCGTGCTGTCGCTCGCGTTGCTGGCGACCGCCACCGTCG
CTGCCACGAGCGGTTGCAGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSLSGIITALATPFGPDGALDLDAWRRLLEQQLHGGVQGLVVAGSTGEAAALSDDEYDTLLRAAAAQVAGRVPVLAGTGL
SGTAKTIAQTRRAAALGAQYALVVTPPYVRPTQAGLKAHFLAVADEGGLPVVLYNVPGRTGCDLLPETVAELVGHPNIVG
IKEARSEPERVAALVALRSDSFVVLSGDDGSAAHAMLSGAAGLISVASNALPAAYRRLCDLARDGQRDAAAAWDARLSEY
HNFCGIESNPIPVKALLQRAGIGHGLRLPLLPLSAAHQPAADRLAADAIALEALSSREMLAA

Sequences:

>Translated_302_residues
MSLSGIITALATPFGPDGALDLDAWRRLLEQQLHGGVQGLVVAGSTGEAAALSDDEYDTLLRAAAAQVAGRVPVLAGTGL
SGTAKTIAQTRRAAALGAQYALVVTPPYVRPTQAGLKAHFLAVADEGGLPVVLYNVPGRTGCDLLPETVAELVGHPNIVG
IKEARSEPERVAALVALRSDSFVVLSGDDGSAAHAMLSGAAGLISVASNALPAAYRRLCDLARDGQRDAAAAWDARLSEY
HNFCGIESNPIPVKALLQRAGIGHGLRLPLLPLSAAHQPAADRLAADAIALEALSSREMLAA
>Mature_301_residues
SLSGIITALATPFGPDGALDLDAWRRLLEQQLHGGVQGLVVAGSTGEAAALSDDEYDTLLRAAAAQVAGRVPVLAGTGLS
GTAKTIAQTRRAAALGAQYALVVTPPYVRPTQAGLKAHFLAVADEGGLPVVLYNVPGRTGCDLLPETVAELVGHPNIVGI
KEARSEPERVAALVALRSDSFVVLSGDDGSAAHAMLSGAAGLISVASNALPAAYRRLCDLARDGQRDAAAAWDARLSEYH
NFCGIESNPIPVKALLQRAGIGHGLRLPLLPLSAAHQPAADRLAADAIALEALSSREMLAA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=290, Percent_Identity=34.4827586206897, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1788823, Length=274, Percent_Identity=41.6058394160584, Blast_Score=204, Evalue=5e-54,
Organism=Escherichia coli, GI1786463, Length=239, Percent_Identity=34.7280334728033, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082415, Length=290, Percent_Identity=30, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1789620, Length=279, Percent_Identity=27.2401433691756, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_XANAC (Q8PLN5)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_642088.1
- ProteinModelPortal:   Q8PLN5
- SMR:   Q8PLN5
- GeneID:   1155831
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1760
- NMPDR:   fig|190486.1.peg.1732
- HOGENOM:   HBG358848
- OMA:   AVKDCAY
- ProtClustDB:   PRK03170
- BioCyc:   XAXO190486:XAC1760-MONOMER
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31019; Mature: 30887

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 162-162

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSGIITALATPFGPDGALDLDAWRRLLEQQLHGGVQGLVVAGSTGEAAALSDDEYDTL
CCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHH
LRAAAAQVAGRVPVLAGTGLSGTAKTIAQTRRAAALGAQYALVVTPPYVRPTQAGLKAHF
HHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHCCEEEE
LAVADEGGLPVVLYNVPGRTGCDLLPETVAELVGHPNIVGIKEARSEPERVAALVALRSD
EEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECHHHCCCHHHHHHHHEECCC
SFVVLSGDDGSAAHAMLSGAAGLISVASNALPAAYRRLCDLARDGQRDAAAAWDARLSEY
CEEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HNFCGIESNPIPVKALLQRAGIGHGLRLPLLPLSAAHQPAADRLAADAIALEALSSREML
HHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHH
AA
CC
>Mature Secondary Structure 
SLSGIITALATPFGPDGALDLDAWRRLLEQQLHGGVQGLVVAGSTGEAAALSDDEYDTL
CCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHH
LRAAAAQVAGRVPVLAGTGLSGTAKTIAQTRRAAALGAQYALVVTPPYVRPTQAGLKAHF
HHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHCCEEEE
LAVADEGGLPVVLYNVPGRTGCDLLPETVAELVGHPNIVGIKEARSEPERVAALVALRSD
EEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECHHHCCCHHHHHHHHEECCC
SFVVLSGDDGSAAHAMLSGAAGLISVASNALPAAYRRLCDLARDGQRDAAAAWDARLSEY
CEEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HNFCGIESNPIPVKALLQRAGIGHGLRLPLLPLSAAHQPAADRLAADAIALEALSSREML
HHHCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHH
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217