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The map label for this gene is fkpA [H]

Identifier: 21242301

GI number: 21242301

Start: 1790890

End: 1791792

Strand: Direct

Name: fkpA [H]

Synonym: XAC1550

Alternate gene names: 21242301

Gene position: 1790890-1791792 (Clockwise)

Preceding gene: 21242300

Following gene: 21242302

Centisome position: 34.6

GC content: 62.46

Gene sequence:

>903_bases
ATGTCGCAGCAACCGGCCGCAGCGGCCACCAAGGAGAAGCCAGCTTTGAATGCATCGTCTGATAAGAGCACGCGCGACAA
CGTCAGCTACGCCATCGGTATGGACGTGGCACGTTCGTTCGAGCCGATCGCTCAGGACATCGATGTGAACGCGATGCAAC
GCGCCATCGAAAATGCATTCAAGGGCGGCAAGCCGCTGTTGTCGGATGAGCAGACCCAGGCCACCGATACTGCATTGCGT
ACCGCGCTCGCTGCCCGCAACGGCCAGCAGGTGCCAGGCATGGCGCCGGGCGCCGCGCCGGCTGCACCGTCCAAGGAAAA
TGTCGGCCTGATGCTCGGCGATCGCGCGGTTGGTCCGTCGCTGGCCGGTATCAAGGACGAGATCGATCTGTCGATCCTGA
TGGAAGCGGTGCGTACCGTGTTCGCCAAGGGCACCACGCGTCTGACCCAGCAGGAGGCCGCAGCCACCATGCAGGCATTC
GCCTCTGCCAAGCAGGGCGCTGCCGCTGCCAACAATCGCCAGCAGGGCAATGAATTCCTTGCCAAGAACAAGACCGAGAC
GGGCGTGATCACCACCGCGTCCGGCCTGCAGTACATGGTGTTGCGCCAGGGTAGCGGCGAGCGCCCGATGCGGACCAGCA
AGGTGCGTGTGAACTACGAAGGCAAGCTGCTCAACGGGCAGGTCTTCGACAGTTCCTACCAGCGCGGCCAGCCGGCGGAG
TTCGGTCTGGATCAAGTCATTCCCGGTTGGACCGAGGGCGTGGCGTTGATGCCGGTCGGTTCGAAATACCGTTTCTGGAT
TCCATCCAACTTGGCCTATGGCCCGAACGGCACGCAAGGAGGGCCGATCGGACCTGACGCAACGTTGACGTTCGATGTCG
AACTGATGGGTATCCTTCCCTGA

Upstream 100 bases:

>100_bases
CGTGTCTTTTCACTTTTGGGAAGTGCATCGAATGAAGATGGGAAAGCGCGGCGCGGCGGCGTCGTTACTGATGGTGGCAA
TGGCGGCGTCGATGCCGGCG

Downstream 100 bases:

>100_bases
TCTTCCGCAGGAGGCAGTTCATTCCATGCGCGTTGCGATCTTCGGCACCGGCTACGTGGGTCTTGTGACCGGTGCCTGCC
TGGCGGAAGTGGGGCATCAG

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MSQQPAAAATKEKPALNASSDKSTRDNVSYAIGMDVARSFEPIAQDIDVNAMQRAIENAFKGGKPLLSDEQTQATDTALR
TALAARNGQQVPGMAPGAAPAAPSKENVGLMLGDRAVGPSLAGIKDEIDLSILMEAVRTVFAKGTTRLTQQEAAATMQAF
ASAKQGAAAANNRQQGNEFLAKNKTETGVITTASGLQYMVLRQGSGERPMRTSKVRVNYEGKLLNGQVFDSSYQRGQPAE
FGLDQVIPGWTEGVALMPVGSKYRFWIPSNLAYGPNGTQGGPIGPDATLTFDVELMGILP

Sequences:

>Translated_300_residues
MSQQPAAAATKEKPALNASSDKSTRDNVSYAIGMDVARSFEPIAQDIDVNAMQRAIENAFKGGKPLLSDEQTQATDTALR
TALAARNGQQVPGMAPGAAPAAPSKENVGLMLGDRAVGPSLAGIKDEIDLSILMEAVRTVFAKGTTRLTQQEAAATMQAF
ASAKQGAAAANNRQQGNEFLAKNKTETGVITTASGLQYMVLRQGSGERPMRTSKVRVNYEGKLLNGQVFDSSYQRGQPAE
FGLDQVIPGWTEGVALMPVGSKYRFWIPSNLAYGPNGTQGGPIGPDATLTFDVELMGILP
>Mature_299_residues
SQQPAAAATKEKPALNASSDKSTRDNVSYAIGMDVARSFEPIAQDIDVNAMQRAIENAFKGGKPLLSDEQTQATDTALRT
ALAARNGQQVPGMAPGAAPAAPSKENVGLMLGDRAVGPSLAGIKDEIDLSILMEAVRTVFAKGTTRLTQQEAAATMQAFA
SAKQGAAAANNRQQGNEFLAKNKTETGVITTASGLQYMVLRQGSGERPMRTSKVRVNYEGKLLNGQVFDSSYQRGQPAEF
GLDQVIPGWTEGVALMPVGSKYRFWIPSNLAYGPNGTQGGPIGPDATLTFDVELMGILP

Specific function: Ppiases Accelerate The Folding Of Proteins. It Catalyzes The Cis-Trans Isomerization Of Proline Imidic Peptide Bonds In Oligopeptides. [C]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=42.9906542056075, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=42.9906542056075, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI224809329, Length=130, Percent_Identity=39.2307692307692, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI224809327, Length=130, Percent_Identity=39.2307692307692, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI4758384, Length=130, Percent_Identity=39.2307692307692, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI224809331, Length=130, Percent_Identity=39.2307692307692, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=38.3177570093458, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1789745, Length=185, Percent_Identity=43.7837837837838, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI87082390, Length=125, Percent_Identity=53.6, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71993519, Length=109, Percent_Identity=40.3669724770642, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=52.1276595744681, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=86, Percent_Identity=48.8372093023256, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323482, Length=97, Percent_Identity=42.2680412371134, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323566, Length=138, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=42.0560747663551, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281363946, Length=87, Percent_Identity=47.1264367816092, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17352457, Length=87, Percent_Identity=47.1264367816092, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=38.6792452830189, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356629, Length=88, Percent_Identity=47.7272727272727, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 31678; Mature: 31547

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQPAAAATKEKPALNASSDKSTRDNVSYAIGMDVARSFEPIAQDIDVNAMQRAIENAF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHH
KGGKPLLSDEQTQATDTALRTALAARNGQQVPGMAPGAAPAAPSKENVGLMLGDRAVGPS
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
LAGIKDEIDLSILMEAVRTVFAKGTTRLTQQEAAATMQAFASAKQGAAAANNRQQGNEFL
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCHHHH
AKNKTETGVITTASGLQYMVLRQGSGERPMRTSKVRVNYEGKLLNGQVFDSSYQRGQPAE
HCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCEEEEEECCEEECCEEECCCCCCCCCHH
FGLDQVIPGWTEGVALMPVGSKYRFWIPSNLAYGPNGTQGGPIGPDATLTFDVELMGILP
CCHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCC
>Mature Secondary Structure 
SQQPAAAATKEKPALNASSDKSTRDNVSYAIGMDVARSFEPIAQDIDVNAMQRAIENAF
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHH
KGGKPLLSDEQTQATDTALRTALAARNGQQVPGMAPGAAPAAPSKENVGLMLGDRAVGPS
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCC
LAGIKDEIDLSILMEAVRTVFAKGTTRLTQQEAAATMQAFASAKQGAAAANNRQQGNEFL
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCHHHH
AKNKTETGVITTASGLQYMVLRQGSGERPMRTSKVRVNYEGKLLNGQVFDSSYQRGQPAE
HCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCEEEEEECCEEECCEEECCCCCCCCCHH
FGLDQVIPGWTEGVALMPVGSKYRFWIPSNLAYGPNGTQGGPIGPDATLTFDVELMGILP
CCHHHCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]