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The map label for this gene is tyrA [C]

Identifier: 21242276

GI number: 21242276

Start: 1759814

End: 1760935

Strand: Direct

Name: tyrA [C]

Synonym: XAC1525

Alternate gene names: 21242276

Gene position: 1759814-1760935 (Clockwise)

Preceding gene: 21242275

Following gene: 21242291

Centisome position: 34.0

GC content: 64.88

Gene sequence:

>1122_bases
ATGATCGCACAGCCGGTGGTCGGCATCGTCGGCATCGCCGGTGCGTACGGGCGCTGGCTGGCACAGTTCCTGCGCACGCG
CATGCAGCTGGAAGTGATCGGGTCCGATCCGGCCGACAGCGACAGCATGGATGAGGCCACGCTGGCGCAGCGTGCCGACG
TGCTGATGTTCGCCGCGCCGATTCGCCATACTGCCGCATTGATCGAGCGGTATGTGGAACTCACCGGCGCACGCGCTGCA
GCGCAGCTGTGGCTGGATGTCACCTCGATCAAACAGGCACCGGTCGCTGCAATGCTGACCTCGCAGGCGGACGTGGTCGG
CCTGCATCCGATGACCGCACCGCCAAAATCGCCGACCTTGAAAGGGCGCGTGATGGTGGTCTGCCAAGCGCGGCTGCGAC
ACTGGTCGGGATGGGTGCAGAGCTTGTGCAGCGCGCTGCAGGCCGAATGCGTGTACGCAACGCCAGAGCACCACGACCGC
GTGATGGCGCTGGTGCAGGCGATGGTGCACGCCACTCACCTGGCGCAGGCCGGCACCTTGCGCGACTACGCACCGCTGCT
GGGCGAGCTGCGCGCGCTGATGCCGTACCGCTCGGCGTCGTTCGAACTGGATACCGCAGTGATCGCGCGTATTCTTTCGC
TCAATCCCTCGATCTACGAAGACATCCAGTTCGGTAACCCGTATGTGGGCGAGATGCTCGACCGGTTGCTGCTGCAGTTG
CAGCAGCTGCGTGCCCTGGTCGGGCAGGGCGACGATGCCGCGCGTGCGCAGTTCCGCACCCAATTCCTGCACGACAACGC
GCAAGCCCTGCAGCACGACGCGCTTGCGGCAGGCAATTACACCTACGAGCGCGTGGGCTATCTGCTGGCCGATCTCACCG
AACCGCTGACTTTGAGCGTGTATCTGCCCGAAGACCAGCCCGGCTCGCTGCGTGCCTTGTTGCATGTGTTCGAGCGGCAT
GGGGTGAACCTGTCGTCGATCCACTCATCGCGCACGCCGGTTGGCGAGCTGCATTTCCGTATCGGCTTCGAGGTGGCAAG
CGATCGTGCGGCATTGGCGCAAGCAGCGAGCGAGATCGATCGCAGTGGGATCGGTCGGGTGCTGGAGCGTTCCGGTGACT
AG

Upstream 100 bases:

>100_bases
TGGAAGCGACCCTGGCTGCGGGGTTCGAGGAGTTCGACGTGCTGGCAGCGGCGCCGGCCGCACTTGCCGCAACGCCACGA
TTTGCCGTCGAGCGCTTGGC

Downstream 100 bases:

>100_bases
TGGCGCAACGAAGCCCGTTCCCGTCGCCATCGTTTCATCCACACAAGGTGTGGATGAAACTTGCACAAGCATGTGGATAA
CTGCGCGCAGCCCTTGCAGC

Product: prephenate dehydrogenase

Products: 4-hydroxyphenylpyruvate; CO2; NADH

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MIAQPVVGIVGIAGAYGRWLAQFLRTRMQLEVIGSDPADSDSMDEATLAQRADVLMFAAPIRHTAALIERYVELTGARAA
AQLWLDVTSIKQAPVAAMLTSQADVVGLHPMTAPPKSPTLKGRVMVVCQARLRHWSGWVQSLCSALQAECVYATPEHHDR
VMALVQAMVHATHLAQAGTLRDYAPLLGELRALMPYRSASFELDTAVIARILSLNPSIYEDIQFGNPYVGEMLDRLLLQL
QQLRALVGQGDDAARAQFRTQFLHDNAQALQHDALAAGNYTYERVGYLLADLTEPLTLSVYLPEDQPGSLRALLHVFERH
GVNLSSIHSSRTPVGELHFRIGFEVASDRAALAQAASEIDRSGIGRVLERSGD

Sequences:

>Translated_373_residues
MIAQPVVGIVGIAGAYGRWLAQFLRTRMQLEVIGSDPADSDSMDEATLAQRADVLMFAAPIRHTAALIERYVELTGARAA
AQLWLDVTSIKQAPVAAMLTSQADVVGLHPMTAPPKSPTLKGRVMVVCQARLRHWSGWVQSLCSALQAECVYATPEHHDR
VMALVQAMVHATHLAQAGTLRDYAPLLGELRALMPYRSASFELDTAVIARILSLNPSIYEDIQFGNPYVGEMLDRLLLQL
QQLRALVGQGDDAARAQFRTQFLHDNAQALQHDALAAGNYTYERVGYLLADLTEPLTLSVYLPEDQPGSLRALLHVFERH
GVNLSSIHSSRTPVGELHFRIGFEVASDRAALAQAASEIDRSGIGRVLERSGD
>Mature_373_residues
MIAQPVVGIVGIAGAYGRWLAQFLRTRMQLEVIGSDPADSDSMDEATLAQRADVLMFAAPIRHTAALIERYVELTGARAA
AQLWLDVTSIKQAPVAAMLTSQADVVGLHPMTAPPKSPTLKGRVMVVCQARLRHWSGWVQSLCSALQAECVYATPEHHDR
VMALVQAMVHATHLAQAGTLRDYAPLLGELRALMPYRSASFELDTAVIARILSLNPSIYEDIQFGNPYVGEMLDRLLLQL
QQLRALVGQGDDAARAQFRTQFLHDNAQALQHDALAAGNYTYERVGYLLADLTEPLTLSVYLPEDQPGSLRALLHVFERH
GVNLSSIHSSRTPVGELHFRIGFEVASDRAALAQAASEIDRSGIGRVLERSGD

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=276, Percent_Identity=26.8115942028986, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR005121
- InterPro:   IPR008299
- InterPro:   IPR003099 [H]

Pfam domain/function: PF03147 FDX-ACB; PF02153 PDH [H]

EC number: 1.3.1.12

Molecular weight: Translated: 40777; Mature: 40777

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQPVVGIVGIAGAYGRWLAQFLRTRMQLEVIGSDPADSDSMDEATLAQRADVLMFAAP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
IRHTAALIERYVELTGARAAAQLWLDVTSIKQAPVAAMLTSQADVVGLHPMTAPPKSPTL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEECCCCCCCCCCCCC
KGRVMVVCQARLRHWSGWVQSLCSALQAECVYATPEHHDRVMALVQAMVHATHLAQAGTL
CCCEEEEHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCH
RDYAPLLGELRALMPYRSASFELDTAVIARILSLNPSIYEDIQFGNPYVGEMLDRLLLQL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHH
QQLRALVGQGDDAARAQFRTQFLHDNAQALQHDALAAGNYTYERVGYLLADLTEPLTLSV
HHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEE
YLPEDQPGSLRALLHVFERHGVNLSSIHSSRTPVGELHFRIGFEVASDRAALAQAASEID
EECCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCHHHEEEEEEEEEHHHHHHHHHHHHHHH
RSGIGRVLERSGD
HHHHHHHHHCCCC
>Mature Secondary Structure
MIAQPVVGIVGIAGAYGRWLAQFLRTRMQLEVIGSDPADSDSMDEATLAQRADVLMFAAP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
IRHTAALIERYVELTGARAAAQLWLDVTSIKQAPVAAMLTSQADVVGLHPMTAPPKSPTL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEECCCCCCCCCCCCC
KGRVMVVCQARLRHWSGWVQSLCSALQAECVYATPEHHDRVMALVQAMVHATHLAQAGTL
CCCEEEEHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCH
RDYAPLLGELRALMPYRSASFELDTAVIARILSLNPSIYEDIQFGNPYVGEMLDRLLLQL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHH
QQLRALVGQGDDAARAQFRTQFLHDNAQALQHDALAAGNYTYERVGYLLADLTEPLTLSV
HHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEE
YLPEDQPGSLRALLHVFERHGVNLSSIHSSRTPVGELHFRIGFEVASDRAALAQAASEID
EECCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCHHHEEEEEEEEEHHHHHHHHHHHHHHH
RSGIGRVLERSGD
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: prephenate; NAD+

Specific reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]