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The map label for this gene is pdxY [H]

Identifier: 21242275

GI number: 21242275

Start: 1758909

End: 1759817

Strand: Direct

Name: pdxY [H]

Synonym: XAC1524

Alternate gene names: 21242275

Gene position: 1758909-1759817 (Clockwise)

Preceding gene: 21242274

Following gene: 21242276

Centisome position: 33.98

GC content: 69.09

Gene sequence:

>909_bases
ATGAGCGATGCAACCGACAGCCACCTCGTCCATGGTCGCCGCCAGCGTCCGGATGGCCCTTCGCCGATCGACGTGATCTC
GGTGCAATCGCAATTGGTCTATGGCCATGCCGGCAACAGCGCTGCGGTGCCGCCGCTGCGCGCGCTGGGACTGCGTGTGG
CCGAAGTGCCCACCACATTGCTGAGCAACGCGCCGTTCTACGCGACCCTGCGCGGGCGCATCCTGCCGGCCGACTGGCTG
GCGGATTTGCTGCTGGGCGCCACCGAACGTGGCCTGCCGCAGCGTGCACGCATGCTGGTGTCCGGCTATTTCGGCAGCCT
GGCCAACGGCGAAGCCTTCGCCGACTGGCTGGCGCAGACCTTGCCGCAGGCCCCGCAGCTGCGCTACTGCCTGGACCCGG
TGATTGGCGACACGCACACCGGCCCATATGTGGAACCCGGGCTGGAGCGCGTGTTCGCCGAGCGTTTGCTGCCGCACGCC
TGGCTGGTGACGCCCAACGCATTCGAGTTGGGGCGGTTGACCGGCTTGCCGAGCCTGCAGCAGGACGATGCCATCGTCGC
CGCGCGCGCATTGCTGGCACGTGGACCGCAGTGGGTGCTTGCGCACAGCGTGGCCGGTGCCGCGGGCGAGCTGGTGACGT
TGGCGGTCAGCGACACGGCGGTGTATCGCTGGGCCAGCCCGCACCTGCCGGTGGATGTTGCCGGTACCGGCGATGTGCTG
ATGGCGCTGCTGATCGGCCTGCTGTTGCGCGACGTGCCATTCGAGCAGGCGGTGGGCCACGCACTCAGCGGCGTGCATAG
CGCGCTGGAAGCGACCCTGGCTGCGGGGTTCGAGGAGTTCGACGTGCTGGCAGCGGCGCCGGCCGCACTTGCCGCAACGC
CACGATTTGCCGTCGAGCGCTTGGCATGA

Upstream 100 bases:

>100_bases
CGACGGTATTGCCAAAACTGCCGGTGACGTCGTTCATCCACGACATCCTTGCAAGGTTACGCGGATAATCGGTGCCCTCT
TTTCCAGCACGGCCGCCCGC

Downstream 100 bases:

>100_bases
TCGCACAGCCGGTGGTCGGCATCGTCGGCATCGCCGGTGCGTACGGGCGCTGGCTGGCACAGTTCCTGCGCACGCGCATG
CAGCTGGAAGTGATCGGGTC

Product: pyridoxine kinase

Products: NA

Alternate protein names: PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSDATDSHLVHGRRQRPDGPSPIDVISVQSQLVYGHAGNSAAVPPLRALGLRVAEVPTTLLSNAPFYATLRGRILPADWL
ADLLLGATERGLPQRARMLVSGYFGSLANGEAFADWLAQTLPQAPQLRYCLDPVIGDTHTGPYVEPGLERVFAERLLPHA
WLVTPNAFELGRLTGLPSLQQDDAIVAARALLARGPQWVLAHSVAGAAGELVTLAVSDTAVYRWASPHLPVDVAGTGDVL
MALLIGLLLRDVPFEQAVGHALSGVHSALEATLAAGFEEFDVLAAAPAALAATPRFAVERLA

Sequences:

>Translated_302_residues
MSDATDSHLVHGRRQRPDGPSPIDVISVQSQLVYGHAGNSAAVPPLRALGLRVAEVPTTLLSNAPFYATLRGRILPADWL
ADLLLGATERGLPQRARMLVSGYFGSLANGEAFADWLAQTLPQAPQLRYCLDPVIGDTHTGPYVEPGLERVFAERLLPHA
WLVTPNAFELGRLTGLPSLQQDDAIVAARALLARGPQWVLAHSVAGAAGELVTLAVSDTAVYRWASPHLPVDVAGTGDVL
MALLIGLLLRDVPFEQAVGHALSGVHSALEATLAAGFEEFDVLAAAPAALAATPRFAVERLA
>Mature_301_residues
SDATDSHLVHGRRQRPDGPSPIDVISVQSQLVYGHAGNSAAVPPLRALGLRVAEVPTTLLSNAPFYATLRGRILPADWLA
DLLLGATERGLPQRARMLVSGYFGSLANGEAFADWLAQTLPQAPQLRYCLDPVIGDTHTGPYVEPGLERVFAERLLPHAW
LVTPNAFELGRLTGLPSLQQDDAIVAARALLARGPQWVLAHSVAGAAGELVTLAVSDTAVYRWASPHLPVDVAGTGDVLM
ALLIGLLLRDVPFEQAVGHALSGVHSALEATLAAGFEEFDVLAAAPAALAATPRFAVERLA

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates [H]

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505701, Length=182, Percent_Identity=31.8681318681319, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788758, Length=240, Percent_Identity=38.75, Blast_Score=161, Evalue=4e-41,
Organism=Escherichia coli, GI1787924, Length=268, Percent_Identity=31.3432835820896, Blast_Score=120, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17507759, Length=226, Percent_Identity=33.1858407079646, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17507757, Length=236, Percent_Identity=31.7796610169492, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324354, Length=277, Percent_Identity=27.0758122743682, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45553007, Length=264, Percent_Identity=26.1363636363636, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004625 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 31921; Mature: 31790

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDATDSHLVHGRRQRPDGPSPIDVISVQSQLVYGHAGNSAAVPPLRALGLRVAEVPTTL
CCCCCCCHHHCCCCCCCCCCCCCCEEEHHHHEEEEECCCCCCCCCHHHHCCHHHHHHHHH
LSNAPFYATLRGRILPADWLADLLLGATERGLPQRARMLVSGYFGSLANGEAFADWLAQT
HCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LPQAPQLRYCLDPVIGDTHTGPYVEPGLERVFAERLLPHAWLVTPNAFELGRLTGLPSLQ
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHCCCCCCC
QDDAIVAARALLARGPQWVLAHSVAGAAGELVTLAVSDTAVYRWASPHLPVDVAGTGDVL
CCHHHHHHHHHHHCCCCCEEHHHHCCCCCCEEEEEECCCEEEEECCCCCCEEECCCHHHH
MALLIGLLLRDVPFEQAVGHALSGVHSALEATLAAGFEEFDVLAAAPAALAATPRFAVER
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHCCHHHHHHH
LA
CC
>Mature Secondary Structure 
SDATDSHLVHGRRQRPDGPSPIDVISVQSQLVYGHAGNSAAVPPLRALGLRVAEVPTTL
CCCCCCHHHCCCCCCCCCCCCCCEEEHHHHEEEEECCCCCCCCCHHHHCCHHHHHHHHH
LSNAPFYATLRGRILPADWLADLLLGATERGLPQRARMLVSGYFGSLANGEAFADWLAQT
HCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LPQAPQLRYCLDPVIGDTHTGPYVEPGLERVFAERLLPHAWLVTPNAFELGRLTGLPSLQ
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHCCCCCCC
QDDAIVAARALLARGPQWVLAHSVAGAAGELVTLAVSDTAVYRWASPHLPVDVAGTGDVL
CCHHHHHHHHHHHCCCCCEEHHHHCCCCCCEEEEEECCCEEEEECCCCCCEEECCCHHHH
MALLIGLLLRDVPFEQAVGHALSGVHSALEATLAAGFEEFDVLAAAPAALAATPRFAVER
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHCCHHHHHHH
LA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]