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The map label for this gene is pmrA [H]

Identifier: 21242198

GI number: 21242198

Start: 1667934

End: 1669127

Strand: Direct

Name: pmrA [H]

Synonym: XAC1445

Alternate gene names: 21242198

Gene position: 1667934-1669127 (Clockwise)

Preceding gene: 21242197

Following gene: 21242199

Centisome position: 32.23

GC content: 65.91

Gene sequence:

>1194_bases
ATGAGCCAGACGACTTCAACTTCTCCTCAACCCGCACCGGCCGCGCCCAGCAAGCGCCGTGCTGCGCTGCGCATCGTGGC
CATTGTGGCGATCCTGGCGATCATCGGCCTGGTGGTGTGGTACTTCCTGGTCGGCCGTTGGCACGAAGACACCGACGATG
CGTATGTGCAGGGCAACCAGGTGCAGATCACCCCGATGGTGGGCGGTACCGTGGTCAGCATCGGCGCCGAAGACGGCATG
CGCGTGGAGCGCGGCCAGTTGCTGGTGCAGCTGGATCCGGCCGACACCGAGGTGGCCTTGCAGCAGGCCGAAGCCAACCT
GGCCAAGACCGTGCGTCAGGTGCGCGGTCTGTATCGCACCGTGGAAGGTGCGCAAGCCGAATTGTCCGCACGCGAAGTCA
CGTTGCGCAGCGCGCGCTCGGACTTCGCGCGGCGTAAGGATCTGGCCGCCACCGGCGCGATCTCCAACGAAGAACTGGCC
CATGCCCGCGACGAACTGGCCGCCGCCGAAGCGGCCGTGAGCGGCTCGCGCGAGAGCCTGGAGCGTAACCGTGCGTTGGT
GGACGACAGCGCGGTGGCCAACCAGCCGGACGTGCAGACCGCCGCCGCACAGCTGCGTCAGGCGTATTTGAATCATGCGC
GCACCGGCGTGGTGGCGCCGGTGTCCGGCTATGTCGCACGGCGCTCGGCCCAGGTGGGTCAGCGCGTGCAGCCGGGCAGC
GTGTTGATGGCGGTGGTGCCGCTGGAGCAGGTGTGGGTGGAAGCCAATTTCAAGGAAACCCAGCTCAAGCACATGCGCCT
GGGCCAGGAAGTGGAACTGCATTCTGATCTGTACGGCGGCGGCGTGAGCTACACCGGCCGTATCCAGAGCCTGGGCCTGG
GCACCGGCAGCGCGTTCTCTCTATTGCCGGCGCAAAACGCCAGCGGTAACTGGATCAAGATCGTGCAGCGCGTGCCGGTG
CGCATTGCGGTGGATTCCAAGCAGCTTGCCAGCAATCCGCTGCGGATTGGTCTGTCGATGAAGGTGGATGTAAACCTGCA
CGATCAGCAGGGCAGTGTGCTGCCGACCAAGGTCGCCAACGGCGCGGTGTTCGCCACCGACGTGTATGCGCAGCAGCTCA
AGGCTGCCGACGCCGACATCCAACGCATCATCCAGGACAACCTGCCGTCGCAGGCTGCCAGCAAGGCGGGCTAA

Upstream 100 bases:

>100_bases
TTGCAGCGTGCGCTGGGCGGCGGATTCACGCCGGAGCCCGCACGCGATACCGCACGCACCGCGCCCACTTCCGCACAACC
GAATTCCTGAGACATCGACG

Downstream 100 bases:

>100_bases
GCCACCATGTCTTCGCAAGCTCCCACCGCGTCCGGCGGCCCGGCGGCACCGGCGCCAGCGGCCGGTTTTCGCCCGGCCAG
CGTGGCGTTGTGCACCGTGG

Product: multidrug resistance efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSQTTSTSPQPAPAAPSKRRAALRIVAIVAILAIIGLVVWYFLVGRWHEDTDDAYVQGNQVQITPMVGGTVVSIGAEDGM
RVERGQLLVQLDPADTEVALQQAEANLAKTVRQVRGLYRTVEGAQAELSAREVTLRSARSDFARRKDLAATGAISNEELA
HARDELAAAEAAVSGSRESLERNRALVDDSAVANQPDVQTAAAQLRQAYLNHARTGVVAPVSGYVARRSAQVGQRVQPGS
VLMAVVPLEQVWVEANFKETQLKHMRLGQEVELHSDLYGGGVSYTGRIQSLGLGTGSAFSLLPAQNASGNWIKIVQRVPV
RIAVDSKQLASNPLRIGLSMKVDVNLHDQQGSVLPTKVANGAVFATDVYAQQLKAADADIQRIIQDNLPSQAASKAG

Sequences:

>Translated_397_residues
MSQTTSTSPQPAPAAPSKRRAALRIVAIVAILAIIGLVVWYFLVGRWHEDTDDAYVQGNQVQITPMVGGTVVSIGAEDGM
RVERGQLLVQLDPADTEVALQQAEANLAKTVRQVRGLYRTVEGAQAELSAREVTLRSARSDFARRKDLAATGAISNEELA
HARDELAAAEAAVSGSRESLERNRALVDDSAVANQPDVQTAAAQLRQAYLNHARTGVVAPVSGYVARRSAQVGQRVQPGS
VLMAVVPLEQVWVEANFKETQLKHMRLGQEVELHSDLYGGGVSYTGRIQSLGLGTGSAFSLLPAQNASGNWIKIVQRVPV
RIAVDSKQLASNPLRIGLSMKVDVNLHDQQGSVLPTKVANGAVFATDVYAQQLKAADADIQRIIQDNLPSQAASKAG
>Mature_396_residues
SQTTSTSPQPAPAAPSKRRAALRIVAIVAILAIIGLVVWYFLVGRWHEDTDDAYVQGNQVQITPMVGGTVVSIGAEDGMR
VERGQLLVQLDPADTEVALQQAEANLAKTVRQVRGLYRTVEGAQAELSAREVTLRSARSDFARRKDLAATGAISNEELAH
ARDELAAAEAAVSGSRESLERNRALVDDSAVANQPDVQTAAAQLRQAYLNHARTGVVAPVSGYVARRSAQVGQRVQPGSV
LMAVVPLEQVWVEANFKETQLKHMRLGQEVELHSDLYGGGVSYTGRIQSLGLGTGSAFSLLPAQNASGNWIKIVQRVPVR
IAVDSKQLASNPLRIGLSMKVDVNLHDQQGSVLPTKVANGAVFATDVYAQQLKAADADIQRIIQDNLPSQAASKAG

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=383, Percent_Identity=42.5587467362924, Blast_Score=307, Evalue=8e-85,
Organism=Escherichia coli, GI1788711, Length=339, Percent_Identity=43.3628318584071, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI87081951, Length=307, Percent_Identity=30.2931596091205, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790519, Length=313, Percent_Identity=30.6709265175719, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1789637, Length=311, Percent_Identity=25.7234726688103, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790024, Length=235, Percent_Identity=22.9787234042553, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42431; Mature: 42299

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTTSTSPQPAPAAPSKRRAALRIVAIVAILAIIGLVVWYFLVGRWHEDTDDAYVQGNQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCE
VQITPMVGGTVVSIGAEDGMRVERGQLLVQLDPADTEVALQQAEANLAKTVRQVRGLYRT
EEEEEEECCEEEEECCCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VEGAQAELSAREVTLRSARSDFARRKDLAATGAISNEELAHARDELAAAEAAVSGSRESL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
ERNRALVDDSAVANQPDVQTAAAQLRQAYLNHARTGVVAPVSGYVARRSAQVGQRVQPGS
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHCCCCCCCC
VLMAVVPLEQVWVEANFKETQLKHMRLGQEVELHSDLYGGGVSYTGRIQSLGLGTGSAFS
EEEEEECHHHHHEECCCHHHHHHHHHCCCCEEHHHHHCCCCCCCCCEEEEECCCCCCCEE
LLPAQNASGNWIKIVQRVPVRIAVDSKQLASNPLRIGLSMKVDVNLHDQQGSVLPTKVAN
EEECCCCCCCCEEHEECCCEEEEECCHHHHCCCEEEEEEEEEEEEEECCCCCCCCHHHCC
GAVFATDVYAQQLKAADADIQRIIQDNLPSQAASKAG
CEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure 
SQTTSTSPQPAPAAPSKRRAALRIVAIVAILAIIGLVVWYFLVGRWHEDTDDAYVQGNQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCE
VQITPMVGGTVVSIGAEDGMRVERGQLLVQLDPADTEVALQQAEANLAKTVRQVRGLYRT
EEEEEEECCEEEEECCCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VEGAQAELSAREVTLRSARSDFARRKDLAATGAISNEELAHARDELAAAEAAVSGSRESL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
ERNRALVDDSAVANQPDVQTAAAQLRQAYLNHARTGVVAPVSGYVARRSAQVGQRVQPGS
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHCCCCCCCC
VLMAVVPLEQVWVEANFKETQLKHMRLGQEVELHSDLYGGGVSYTGRIQSLGLGTGSAFS
EEEEEECHHHHHEECCCHHHHHHHHHCCCCEEHHHHHCCCCCCCCCEEEEECCCCCCCEE
LLPAQNASGNWIKIVQRVPVRIAVDSKQLASNPLRIGLSMKVDVNLHDQQGSVLPTKVAN
EEECCCCCCCCEEHEECCCEEEEECCHHHHCCCEEEEEEEEEEEEEECCCCCCCCHHHCC
GAVFATDVYAQQLKAADADIQRIIQDNLPSQAASKAG
CEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]