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The map label for this gene is yjcP [H]

Identifier: 21242197

GI number: 21242197

Start: 1666433

End: 1667923

Strand: Direct

Name: yjcP [H]

Synonym: XAC1444

Alternate gene names: 21242197

Gene position: 1666433-1667923 (Clockwise)

Preceding gene: 21242196

Following gene: 21242198

Centisome position: 32.2

GC content: 69.15

Gene sequence:

>1491_bases
ATGCTGCGCCCGCGCTCGATGCGCCTGGCACAGCCGCTCGTCATCACCGCCCTGGCACTGGCGTTGGCCGCCTGCGCCAG
CAGCCGTGGCCTGAATCCGCAAGGCACCGTGCTGGATCCGAGCACGCTGCATGCAGAGCGCACCCTGGCGCAGCAAACCA
CGCTGAGTCCGGCCGCATGGCCGGCCAGCGATTGGTGGCGCGCGCTGGGCGATGCGCAGCTGGACGCGCTGATCGCCGAA
GGCCTGCAGCACAGCCCCAGCCTCGCGGCGGCCGATGCGCGCCTACACCAGGCGCAGGCACGTATCGGCAGTGCGCAGGC
CGAGCGCGGCCCCAGCCTCTCGGTGTCCGGTGGCTACACCGGCCTGCAGCTACCTGAATCCATGGTCGGCGAAGAGCTCG
GCGGCAGCTATGGCGGCAGCGCGCAGGTCGTGCTGGATTTCCGCTACGGCGTCGATCTGTGGGGCGGCAAGCGCAGCGCG
TGGGAAGCGGCAGTCGACCAGGCGCATGCGGCCGAAGTGGATGCGCAGGCGGCACGATTGAACCTGTCGTCGGCGATTGC
CGAAGGCTATGCGCAGCTTGCGTACGCGTGGAGCCTGCACGACCTGGCCAACGACGAATTGAGCCGTGCGCAGAAGACCC
TGGAGCTGACCCGGCAACGCCGCAGCGCCGGCATCGACAGCGAGTTGCAGGTGCGTCAGGCGCAAGCGCGCGTACCGGCT
GCGCAGCAGCAGTTGCAATCGGCGCAGCAGCAGATCGACGAAGCCCGCACCGCGCTGGCCGCCTTGGTCGGGCAGGGCCC
GGATCGCGGTTTGGGCATTGCCCGGCCTGTATTCGGTGCGGGCATCGCCACGCAGTTGCCGAGCATGCTGCCGGCCGATC
TGCTGGGCCGTCGCCCCGACGTGGTGGCGGCACGCTGGCGCGTGGAGGCGGCCGACAAGGACATCGCAGTCGCCAAGACC
CGCTTCTATCCCAGCCTCAACCTCACCACGCTGGGCGGTGTGATCAACCCGGATGTCGGCAAGTTGCTGGAAAGCGGCTC
GGTGTTCGGACTGGTCGCGCCGGCGTTGAGCCTGCCGATCTTCGACGGCGGCAAGCTGCGCGCCAATCTGGCCGGCAGCG
ATGCGCAATACGACCTGGCCGTGGCCGACTACAACCAGAAAGTGATCTCCGCGCTGCGCGAGGTGGCCGACCAGGTCACC
GCCGTGCGTTCGCTGGAGCTACGCGCGCAGGCGCAGAACGACGCCGTGCAGACAGCCACGGCCGCTTTCGATCTGGCGCA
GCAGCGCTACCGCGCCGGCATCGGCAGCTATCTGGACGTGCTCAGCGTGCAGGAGCAGTTGCTCGTCGCACGCCAACGCA
TGGCCGGGCTGCAGTCGCAACAACTTCTGGCCTCGGTGAGGTTGCAGCGTGCGCTGGGCGGCGGATTCACGCCGGAGCCC
GCACGCGATACCGCACGCACCGCGCCCACTTCCGCACAACCGAATTCCTGA

Upstream 100 bases:

>100_bases
TGCGCGACCTGTCCGCGGTCGAGCGCGAACTTCTCACCTCACTCCTTATCCGTGTCCGCGATGCACTCAACTCATGAACG
TTGCTAGTTCTTCGACCCAG

Downstream 100 bases:

>100_bases
GACATCGACGATGAGCCAGACGACTTCAACTTCTCCTCAACCCGCACCGGCCGCGCCCAGCAAGCGCCGTGCTGCGCTGC
GCATCGTGGCCATTGTGGCG

Product: outer membrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MLRPRSMRLAQPLVITALALALAACASSRGLNPQGTVLDPSTLHAERTLAQQTTLSPAAWPASDWWRALGDAQLDALIAE
GLQHSPSLAAADARLHQAQARIGSAQAERGPSLSVSGGYTGLQLPESMVGEELGGSYGGSAQVVLDFRYGVDLWGGKRSA
WEAAVDQAHAAEVDAQAARLNLSSAIAEGYAQLAYAWSLHDLANDELSRAQKTLELTRQRRSAGIDSELQVRQAQARVPA
AQQQLQSAQQQIDEARTALAALVGQGPDRGLGIARPVFGAGIATQLPSMLPADLLGRRPDVVAARWRVEAADKDIAVAKT
RFYPSLNLTTLGGVINPDVGKLLESGSVFGLVAPALSLPIFDGGKLRANLAGSDAQYDLAVADYNQKVISALREVADQVT
AVRSLELRAQAQNDAVQTATAAFDLAQQRYRAGIGSYLDVLSVQEQLLVARQRMAGLQSQQLLASVRLQRALGGGFTPEP
ARDTARTAPTSAQPNS

Sequences:

>Translated_496_residues
MLRPRSMRLAQPLVITALALALAACASSRGLNPQGTVLDPSTLHAERTLAQQTTLSPAAWPASDWWRALGDAQLDALIAE
GLQHSPSLAAADARLHQAQARIGSAQAERGPSLSVSGGYTGLQLPESMVGEELGGSYGGSAQVVLDFRYGVDLWGGKRSA
WEAAVDQAHAAEVDAQAARLNLSSAIAEGYAQLAYAWSLHDLANDELSRAQKTLELTRQRRSAGIDSELQVRQAQARVPA
AQQQLQSAQQQIDEARTALAALVGQGPDRGLGIARPVFGAGIATQLPSMLPADLLGRRPDVVAARWRVEAADKDIAVAKT
RFYPSLNLTTLGGVINPDVGKLLESGSVFGLVAPALSLPIFDGGKLRANLAGSDAQYDLAVADYNQKVISALREVADQVT
AVRSLELRAQAQNDAVQTATAAFDLAQQRYRAGIGSYLDVLSVQEQLLVARQRMAGLQSQQLLASVRLQRALGGGFTPEP
ARDTARTAPTSAQPNS
>Mature_496_residues
MLRPRSMRLAQPLVITALALALAACASSRGLNPQGTVLDPSTLHAERTLAQQTTLSPAAWPASDWWRALGDAQLDALIAE
GLQHSPSLAAADARLHQAQARIGSAQAERGPSLSVSGGYTGLQLPESMVGEELGGSYGGSAQVVLDFRYGVDLWGGKRSA
WEAAVDQAHAAEVDAQAARLNLSSAIAEGYAQLAYAWSLHDLANDELSRAQKTLELTRQRRSAGIDSELQVRQAQARVPA
AQQQLQSAQQQIDEARTALAALVGQGPDRGLGIARPVFGAGIATQLPSMLPADLLGRRPDVVAARWRVEAADKDIAVAKT
RFYPSLNLTTLGGVINPDVGKLLESGSVFGLVAPALSLPIFDGGKLRANLAGSDAQYDLAVADYNQKVISALREVADQVT
AVRSLELRAQAQNDAVQTATAAFDLAQQRYRAGIGSYLDVLSVQEQLLVARQRMAGLQSQQLLASVRLQRALGGGFTPEP
ARDTARTAPTSAQPNS

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI2367348, Length=470, Percent_Identity=30.2127659574468, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1786785, Length=414, Percent_Identity=25.8454106280193, Blast_Score=129, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 52433; Mature: 52433

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRPRSMRLAQPLVITALALALAACASSRGLNPQGTVLDPSTLHAERTLAQQTTLSPAAW
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCC
PASDWWRALGDAQLDALIAEGLQHSPSLAAADARLHQAQARIGSAQAERGPSLSVSGGYT
CHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCEEECCCCC
GLQLPESMVGEELGGSYGGSAQVVLDFRYGVDLWGGKRSAWEAAVDQAHAAEVDAQAARL
CCCCCHHHHHHHHCCCCCCCEEEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NLSSAIAEGYAQLAYAWSLHDLANDELSRAQKTLELTRQRRSAGIDSELQVRQAQARVPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCH
AQQQLQSAQQQIDEARTALAALVGQGPDRGLGIARPVFGAGIATQLPSMLPADLLGRRPD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHCCCHHHHCCCCC
VVAARWRVEAADKDIAVAKTRFYPSLNLTTLGGVINPDVGKLLESGSVFGLVAPALSLPI
CEEHHEEEECCCCCCEEHHHHCCCCCCCHHCCCCCCCCHHHHHHCCCCCEEHHHHHHCCC
FDGGKLRANLAGSDAQYDLAVADYNQKVISALREVADQVTAVRSLELRAQAQNDAVQTAT
CCCCCEEEEECCCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAFDLAQQRYRAGIGSYLDVLSVQEQLLVARQRMAGLQSQQLLASVRLQRALGGGFTPEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCC
ARDTARTAPTSAQPNS
CCHHHHCCCCCCCCCC
>Mature Secondary Structure
MLRPRSMRLAQPLVITALALALAACASSRGLNPQGTVLDPSTLHAERTLAQQTTLSPAAW
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCC
PASDWWRALGDAQLDALIAEGLQHSPSLAAADARLHQAQARIGSAQAERGPSLSVSGGYT
CHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCEEECCCCC
GLQLPESMVGEELGGSYGGSAQVVLDFRYGVDLWGGKRSAWEAAVDQAHAAEVDAQAARL
CCCCCHHHHHHHHCCCCCCCEEEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NLSSAIAEGYAQLAYAWSLHDLANDELSRAQKTLELTRQRRSAGIDSELQVRQAQARVPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCH
AQQQLQSAQQQIDEARTALAALVGQGPDRGLGIARPVFGAGIATQLPSMLPADLLGRRPD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHCCCHHHHCCCCC
VVAARWRVEAADKDIAVAKTRFYPSLNLTTLGGVINPDVGKLLESGSVFGLVAPALSLPI
CEEHHEEEECCCCCCEEHHHHCCCCCCCHHCCCCCCCCHHHHHHCCCCCEEHHHHHHCCC
FDGGKLRANLAGSDAQYDLAVADYNQKVISALREVADQVTAVRSLELRAQAQNDAVQTAT
CCCCCEEEEECCCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAFDLAQQRYRAGIGSYLDVLSVQEQLLVARQRMAGLQSQQLLASVRLQRALGGGFTPEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCC
ARDTARTAPTSAQPNS
CCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]