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The map label for this gene is folC [H]

Identifier: 21241794

GI number: 21241794

Start: 1186466

End: 1187764

Strand: Direct

Name: folC [H]

Synonym: XAC1029

Alternate gene names: 21241794

Gene position: 1186466-1187764 (Clockwise)

Preceding gene: 21241793

Following gene: 21241795

Centisome position: 22.92

GC content: 68.28

Gene sequence:

>1299_bases
ATGAACGCAACCGACTCCCTCTCCGCCTGGCTCGCCTATATCGAGCAGCAGCATCCCAGCGCTATTGCCATGGGCCTGGA
GCGCGTGCGCGAGGTTGCGGTGCGGTTGCAGATCGCCGCGCCGGCCAAGCACGTCATCGTCGTAGGCGGGACCAATGGCA
AGGGTTCGACGGTGGCCTTCATCGAGGCGATCGGGCGTGCCGCCGGCTGGAAGGTGGGTGCCTACACCTCGCCGCACCTG
CTGCGCTACAACGAGCGCGTGCGCATCGATGGCCAAGAGGCCAGCGACGCCCAGCTGGTCGACGCGTTTGCGGCGGTCGA
AGCAGCACGCGGCGACACCGCGTTGACCTATTTCGAGTTCGGTACGCTGGCGGCGCTGTGGTTGTTTCAGCAGTCGGCGC
TGGAGTTGGCGGTGCTGGAAATCGGCCTGGGCGGGCGTCTGGATGCGGTCAACATCGTCGATTCGGATGTGGCGGTGATT
ACCACTGTCGATCTCGACCACACCGATTGGCTGGGCGACGACCGCGAGGCCATCGGCGCCGAGAAGGCCGGCATCATCCG
CGCCTGGAAGCCGGTGGTGCTGGGCGAGATCGACCCGCCGTCCAGCGTGCTGCGTCGCGCCTACCAGTTGGGCGCCAATG
CCATCCGTGCCGGCAGCGATTATTTCTTCGAGCCGATCGACACACAGCACGCCGAGAGCCCGCAATCCGATGCGCCGCGC
TGGCGCTGGCGCGATGTGGCGGTGACGCTGGAATTGCCGATGCCGGCATTGCACGCGCCGGTGCAGCTGGCCAACGCCGC
TGCCGCGATCGCCGCATTGCAGGCATTGCCGGTGGAGGTGCCCGACGCGGCCTGGGCGCAAGGCATCGGTAACGCGCAAG
TGGCCGGACGACTGCAGCGGCTTGAGGTCGATGGCGTGCAGGTATTGCTGGATGTCGGCCACAACCCGCAGGCCGCGCGG
GCGCTGGCTGCCGCGCTCGATGCGCAGGCGCATGCCGGCAGCACCTATGCGATCTACGCTGCATTGGCCGACAAGGATGT
GTTGGGCGTGGTGGAGGCAGTCGCTGCGCAGATCGACCGCTGGGCGCTGGCGGGGCTGGAAGGCGCTCGCGGCCAATCGG
CGCAGGCGTTGCAGGCCCGCCTGCAAGGCAGTGCCGCCGCGCAGGCGCCGTGTCATCGCGATGTTGCCAGTGCGGTGCGT
GCGGTCCTGGACGCGGCCAGCCCCGGCGACCGTGTGCTGGTCTTCGGCTCGTTTCACACCGTGGCCGACGCGCTTGGCGC
ACTTCGTTCAGCCCGCTGA

Upstream 100 bases:

>100_bases
GCTGCTTCGGTCTGGCCAAGCAATTGCGAGAGCACCGACGTGGCGTGCGACGCGCAAGCGCAAATGGCGATAATGTGCCC
CTCTCTGCGCAGCCCTCCCC

Downstream 100 bases:

>100_bases
GGTCGTCGGGGTGGCGCCGGCCTTATAATCGCCGCGGCACCCCGCCACGCCGCCTCTCGTCTCTTCCGTGGATACTGCTC
TGAAACAGCGACTGATTGGC

Product: dihydrofolate synthase

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNATDSLSAWLAYIEQQHPSAIAMGLERVREVAVRLQIAAPAKHVIVVGGTNGKGSTVAFIEAIGRAAGWKVGAYTSPHL
LRYNERVRIDGQEASDAQLVDAFAAVEAARGDTALTYFEFGTLAALWLFQQSALELAVLEIGLGGRLDAVNIVDSDVAVI
TTVDLDHTDWLGDDREAIGAEKAGIIRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIDTQHAESPQSDAPR
WRWRDVAVTLELPMPALHAPVQLANAAAAIAALQALPVEVPDAAWAQGIGNAQVAGRLQRLEVDGVQVLLDVGHNPQAAR
ALAAALDAQAHAGSTYAIYAALADKDVLGVVEAVAAQIDRWALAGLEGARGQSAQALQARLQGSAAAQAPCHRDVASAVR
AVLDAASPGDRVLVFGSFHTVADALGALRSAR

Sequences:

>Translated_432_residues
MNATDSLSAWLAYIEQQHPSAIAMGLERVREVAVRLQIAAPAKHVIVVGGTNGKGSTVAFIEAIGRAAGWKVGAYTSPHL
LRYNERVRIDGQEASDAQLVDAFAAVEAARGDTALTYFEFGTLAALWLFQQSALELAVLEIGLGGRLDAVNIVDSDVAVI
TTVDLDHTDWLGDDREAIGAEKAGIIRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIDTQHAESPQSDAPR
WRWRDVAVTLELPMPALHAPVQLANAAAAIAALQALPVEVPDAAWAQGIGNAQVAGRLQRLEVDGVQVLLDVGHNPQAAR
ALAAALDAQAHAGSTYAIYAALADKDVLGVVEAVAAQIDRWALAGLEGARGQSAQALQARLQGSAAAQAPCHRDVASAVR
AVLDAASPGDRVLVFGSFHTVADALGALRSAR
>Mature_432_residues
MNATDSLSAWLAYIEQQHPSAIAMGLERVREVAVRLQIAAPAKHVIVVGGTNGKGSTVAFIEAIGRAAGWKVGAYTSPHL
LRYNERVRIDGQEASDAQLVDAFAAVEAARGDTALTYFEFGTLAALWLFQQSALELAVLEIGLGGRLDAVNIVDSDVAVI
TTVDLDHTDWLGDDREAIGAEKAGIIRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIDTQHAESPQSDAPR
WRWRDVAVTLELPMPALHAPVQLANAAAAIAALQALPVEVPDAAWAQGIGNAQVAGRLQRLEVDGVQVLLDVGHNPQAAR
ALAAALDAQAHAGSTYAIYAALADKDVLGVVEAVAAQIDRWALAGLEGARGQSAQALQARLQGSAAAQAPCHRDVASAVR
AVLDAASPGDRVLVFGSFHTVADALGALRSAR

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932990, Length=179, Percent_Identity=37.9888268156425, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI66932984, Length=179, Percent_Identity=37.9888268156425, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1788654, Length=432, Percent_Identity=44.6759259259259, Blast_Score=325, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17553148, Length=199, Percent_Identity=34.6733668341709, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI71984923, Length=199, Percent_Identity=34.6733668341709, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17553150, Length=199, Percent_Identity=34.6733668341709, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323760, Length=371, Percent_Identity=25.3369272237197, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324815, Length=222, Percent_Identity=31.0810810810811, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24641571, Length=279, Percent_Identity=31.1827956989247, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24581568, Length=146, Percent_Identity=36.986301369863, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 45411; Mature: 45411

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATDSLSAWLAYIEQQHPSAIAMGLERVREVAVRLQIAAPAKHVIVVGGTNGKGSTVAF
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCCHHHH
IEAIGRAAGWKVGAYTSPHLLRYNERVRIDGQEASDAQLVDAFAAVEAARGDTALTYFEF
HHHHHHHCCCEECCCCCCCEEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEHH
GTLAALWLFQQSALELAVLEIGLGGRLDAVNIVDSDVAVITTVDLDHTDWLGDDREAIGA
HHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEECCCEEEEEEEECCCCCCCCCCHHHHCC
EKAGIIRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIDTQHAESPQSDAPR
CCCCHHEECCCEEEECCCCHHHHHHHHHHHCCHHEECCCCCCCCCCCCCCCCCCCCCCCC
WRWRDVAVTLELPMPALHAPVQLANAAAAIAALQALPVEVPDAAWAQGIGNAQVAGRLQR
CEEEEEEEEEECCCCHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHH
LEVDGVQVLLDVGHNPQAARALAAALDAQAHAGSTYAIYAALADKDVLGVVEAVAAQIDR
EECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
WALAGLEGARGQSAQALQARLQGSAAAQAPCHRDVASAVRAVLDAASPGDRVLVFGSFHT
HHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECHHH
VADALGALRSAR
HHHHHHHHHCCC
>Mature Secondary Structure
MNATDSLSAWLAYIEQQHPSAIAMGLERVREVAVRLQIAAPAKHVIVVGGTNGKGSTVAF
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCCHHHH
IEAIGRAAGWKVGAYTSPHLLRYNERVRIDGQEASDAQLVDAFAAVEAARGDTALTYFEF
HHHHHHHCCCEECCCCCCCEEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEHH
GTLAALWLFQQSALELAVLEIGLGGRLDAVNIVDSDVAVITTVDLDHTDWLGDDREAIGA
HHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEECCCEEEEEEEECCCCCCCCCCHHHHCC
EKAGIIRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIDTQHAESPQSDAPR
CCCCHHEECCCEEEECCCCHHHHHHHHHHHCCHHEECCCCCCCCCCCCCCCCCCCCCCCC
WRWRDVAVTLELPMPALHAPVQLANAAAAIAALQALPVEVPDAAWAQGIGNAQVAGRLQR
CEEEEEEEEEECCCCHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHHHH
LEVDGVQVLLDVGHNPQAARALAAALDAQAHAGSTYAIYAALADKDVLGVVEAVAAQIDR
EECCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
WALAGLEGARGQSAQALQARLQGSAAAQAPCHRDVASAVRAVLDAASPGDRVLVFGSFHT
HHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECHHH
VADALGALRSAR
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]