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The map label for this gene is yogA [H]

Identifier: 21241564

GI number: 21241564

Start: 941866

End: 942843

Strand: Direct

Name: yogA [H]

Synonym: XAC0794

Alternate gene names: 21241564

Gene position: 941866-942843 (Clockwise)

Preceding gene: 21241559

Following gene: 21241565

Centisome position: 18.2

GC content: 68.81

Gene sequence:

>978_bases
ATGAGCGATACCACGATGACCGCCATCGCCATCCGCGACGGCAAGGGCGACGCCGACGCGCTGTACGCCACCGAGCAACC
GCGCCCGCGTCCTGCGCCGGGGCAGGTGCTGATCCGCGTGCATGCTGCCGGCATCAATCGCCCCGATCTGCTGCAACGCG
CCGGGCACTATCCGCCGCCGCCTGGCGCGCCGGAAACACTGGGGCTGGAAATCGCCGGCGAAATCGTCGAGCCGGCCGGT
CGCTGGAAGGTCGGCGACCGCGTGTGCGCACTGCTGGGTGGCGGCGGTTACGCGCAATACGCCGCCGTCGATGCGCGTCA
CGTCCTGCCGATCCCCGCCGGCATGGATCTGGTGCACGCGGCGGCGTTGCCGGAAACCATCTTCACTGCCTACGCCAATC
TGTTCGAACACGGTCGGCTCGCGGCGGGCCAATGGCTGCTGTTGCATGGTGCGACCTCGGGCATCGGCGTCACGGCGATC
CAGATGGCCAAGGCGGCGGGCGCGCACGTGCTGGCCACCGCGCGCTCGGCCGTCAAGGCGGCACAGGCACGCGAGTTGGG
CGCCGATGTGGCGATCGATTCCACCACTGCGTCGTTTGTCGAGGTGGCCAAGGCGCATGGCGGTGTGGACGTTGCGCTCG
ACATGGTGGGCGCTGCGGTATTCGCCGACACCCTGGAAGCGCTCAACCCGCACGGACGCATCGTCTACATCGCCTCGCAG
GCCGGCGCCACCATCGAGGTGCCGATCCCGGTGCTGATGCGCAAGCAGGCGGTCATCACCGGCTCGACGCTACGCCCACG
CAGTGCAGACGAAAAAGCCCGGCTGGCCGCGGAAGTGGAACGCGTGGTGTGGCCCTGGATCGAGCAGGGCAAGCTGCGCG
TGCTGCTCGACAAGCGCTTCCCGCTGCGCGAAGCGGCTGCGGCACATCGTTACCTGGAGCAGGGCAGTCACCTGGGCAAG
GTGGTGCTGGAGATGTAG

Upstream 100 bases:

>100_bases
TGCTGCTGCGGCAATGCCTGCTGGCAACCGTGGGGTGCATCTGCGCCAGGCGTTGACGTCTGCACGCCTACACTGGGCGC
ACTTTCCATGGAGCGCTTTC

Downstream 100 bases:

>100_bases
AACGAGCCACTCGCCGCATCACCAAGATCGGCGCCAGCGGCTGCAGGGGCCGCGCGCCCGGCGATCGACAAGTGCCGGGC
GCACCACCGCCCAACCGCAT

Product: quinone reductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSDTTMTAIAIRDGKGDADALYATEQPRPRPAPGQVLIRVHAAGINRPDLLQRAGHYPPPPGAPETLGLEIAGEIVEPAG
RWKVGDRVCALLGGGGYAQYAAVDARHVLPIPAGMDLVHAAALPETIFTAYANLFEHGRLAAGQWLLLHGATSGIGVTAI
QMAKAAGAHVLATARSAVKAAQARELGADVAIDSTTASFVEVAKAHGGVDVALDMVGAAVFADTLEALNPHGRIVYIASQ
AGATIEVPIPVLMRKQAVITGSTLRPRSADEKARLAAEVERVVWPWIEQGKLRVLLDKRFPLREAAAAHRYLEQGSHLGK
VVLEM

Sequences:

>Translated_325_residues
MSDTTMTAIAIRDGKGDADALYATEQPRPRPAPGQVLIRVHAAGINRPDLLQRAGHYPPPPGAPETLGLEIAGEIVEPAG
RWKVGDRVCALLGGGGYAQYAAVDARHVLPIPAGMDLVHAAALPETIFTAYANLFEHGRLAAGQWLLLHGATSGIGVTAI
QMAKAAGAHVLATARSAVKAAQARELGADVAIDSTTASFVEVAKAHGGVDVALDMVGAAVFADTLEALNPHGRIVYIASQ
AGATIEVPIPVLMRKQAVITGSTLRPRSADEKARLAAEVERVVWPWIEQGKLRVLLDKRFPLREAAAAHRYLEQGSHLGK
VVLEM
>Mature_324_residues
SDTTMTAIAIRDGKGDADALYATEQPRPRPAPGQVLIRVHAAGINRPDLLQRAGHYPPPPGAPETLGLEIAGEIVEPAGR
WKVGDRVCALLGGGGYAQYAAVDARHVLPIPAGMDLVHAAALPETIFTAYANLFEHGRLAAGQWLLLHGATSGIGVTAIQ
MAKAAGAHVLATARSAVKAAQARELGADVAIDSTTASFVEVAKAHGGVDVALDMVGAAVFADTLEALNPHGRIVYIASQA
GATIEVPIPVLMRKQAVITGSTLRPRSADEKARLAAEVERVVWPWIEQGKLRVLLDKRFPLREAAAAHRYLEQGSHLGKV
VLEM

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=325, Percent_Identity=37.8461538461538, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI22538444, Length=325, Percent_Identity=37.8461538461538, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI194239674, Length=304, Percent_Identity=31.25, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI13236495, Length=304, Percent_Identity=31.25, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI28557745, Length=321, Percent_Identity=30.2180685358255, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI194239676, Length=300, Percent_Identity=29.3333333333333, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI18379349, Length=308, Percent_Identity=29.2207792207792, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI24308257, Length=336, Percent_Identity=26.7857142857143, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI41872631, Length=307, Percent_Identity=28.6644951140065, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI47519420, Length=341, Percent_Identity=26.3929618768328, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI197927207, Length=195, Percent_Identity=27.1794871794872, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1790485, Length=318, Percent_Identity=31.4465408805031, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI226510941, Length=323, Percent_Identity=27.2445820433437, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17507255, Length=314, Percent_Identity=28.9808917197452, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI212642053, Length=334, Percent_Identity=26.9461077844311, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17536829, Length=242, Percent_Identity=27.6859504132231, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319520, Length=329, Percent_Identity=27.355623100304, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6323729, Length=358, Percent_Identity=27.9329608938547, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=307, Percent_Identity=29.3159609120521, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=285, Percent_Identity=29.8245614035088, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=283, Percent_Identity=26.8551236749117, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581345, Length=323, Percent_Identity=24.4582043343653, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 34205; Mature: 34074

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTTMTAIAIRDGKGDADALYATEQPRPRPAPGQVLIRVHAAGINRPDLLQRAGHYPPP
CCCCEEEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHCCCCCCC
PGAPETLGLEIAGEIVEPAGRWKVGDRVCALLGGGGYAQYAAVDARHVLPIPAGMDLVHA
CCCCCCCCCEEHHHHHCCCCCCCCCCCEEEEECCCCCEEHEEECCCEEEECCCCHHHHHH
AALPETIFTAYANLFEHGRLAAGQWLLLHGATSGIGVTAIQMAKAAGAHVLATARSAVKA
HHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
AQARELGADVAIDSTTASFVEVAKAHGGVDVALDMVGAAVFADTLEALNPHGRIVYIASQ
HHHHHCCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
AGATIEVPIPVLMRKQAVITGSTLRPRSADEKARLAAEVERVVWPWIEQGKLRVLLDKRF
CCCEEEECCHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHCCCCEEEEEECCC
PLREAAAAHRYLEQGSHLGKVVLEM
CHHHHHHHHHHHHCCCCHHHHEECC
>Mature Secondary Structure 
SDTTMTAIAIRDGKGDADALYATEQPRPRPAPGQVLIRVHAAGINRPDLLQRAGHYPPP
CCCEEEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHCCCCCCC
PGAPETLGLEIAGEIVEPAGRWKVGDRVCALLGGGGYAQYAAVDARHVLPIPAGMDLVHA
CCCCCCCCCEEHHHHHCCCCCCCCCCCEEEEECCCCCEEHEEECCCEEEECCCCHHHHHH
AALPETIFTAYANLFEHGRLAAGQWLLLHGATSGIGVTAIQMAKAAGAHVLATARSAVKA
HHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
AQARELGADVAIDSTTASFVEVAKAHGGVDVALDMVGAAVFADTLEALNPHGRIVYIASQ
HHHHHCCCCEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
AGATIEVPIPVLMRKQAVITGSTLRPRSADEKARLAAEVERVVWPWIEQGKLRVLLDKRF
CCCEEEECCHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHCCCCEEEEEECCC
PLREAAAAHRYLEQGSHLGKVVLEM
CHHHHHHHHHHHHCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]