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The map label for this gene is folK [H]

Identifier: 21241457

GI number: 21241457

Start: 812621

End: 813136

Strand: Direct

Name: folK [H]

Synonym: XAC0686

Alternate gene names: 21241457

Gene position: 812621-813136 (Clockwise)

Preceding gene: 21241456

Following gene: 77748546

Centisome position: 15.7

GC content: 66.28

Gene sequence:

>516_bases
ATGACCACCGTGCTTCTCAGCCTCGGCAGCAACGTCCAGCCGACCCACTACCTGCGCTTGGCTGTCGCCGCCCTGCGCGC
GCGCTTCGGCCAGGTTGTCGTGTCACCCGCGTACCGCACGCCCGCGGTGGGCTTCGATGGGCCGGACTTCGTCAACAATG
CGGCGGTATTGCAGACCGATCTGGATCTGGACGCGCTGGATCACTGGCTGCATGCGCTGGAAGATGCGCATGGGCGCGAT
CGCAGCGGCCCGCGTTTCAGCGACCGCACCCTGGATCTGGACGTGGTGTTCTTCGGCGACCGTATCGTCGAAGGCCCCGG
GCATCTGCGCATCCCGCGGCCCGAACTCAAACATGCATTCGTGCTCAAGCCGCTGGCCGACATCGCGCCGGACTTCATCG
ACCCGCTGAGCGGGCAGACATTGGCAACCCTGTGGCAGGCGCATCCGCAGTACGGCAGCGCGTTTGCCACGGTGGAGCTG
GATGCGGCTGCGCCGGAGTTGAGCGTCACGCAATAG

Upstream 100 bases:

>100_bases
GTGGCCTGAGATCACGTTTGCGCGCAGCCGGCGCATGCGTCGACGGTGCAACGCGATTGCAACAGTTGACGTCCACGCCG
GCCGCATGCGCGAATAACGT

Downstream 100 bases:

>100_bases
CGCTGTTCTGGCAGCGCGGTTGAACGCGGCCGAGCAAACATGCACCTAGCGCGACGGCGTGCGGACTGTCTGGCAGTGCC
GCACGCGCCGAGGCGGCAGC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTTVLLSLGSNVQPTHYLRLAVAALRARFGQVVVSPAYRTPAVGFDGPDFVNNAAVLQTDLDLDALDHWLHALEDAHGRD
RSGPRFSDRTLDLDVVFFGDRIVEGPGHLRIPRPELKHAFVLKPLADIAPDFIDPLSGQTLATLWQAHPQYGSAFATVEL
DAAAPELSVTQ

Sequences:

>Translated_171_residues
MTTVLLSLGSNVQPTHYLRLAVAALRARFGQVVVSPAYRTPAVGFDGPDFVNNAAVLQTDLDLDALDHWLHALEDAHGRD
RSGPRFSDRTLDLDVVFFGDRIVEGPGHLRIPRPELKHAFVLKPLADIAPDFIDPLSGQTLATLWQAHPQYGSAFATVEL
DAAAPELSVTQ
>Mature_170_residues
TTVLLSLGSNVQPTHYLRLAVAALRARFGQVVVSPAYRTPAVGFDGPDFVNNAAVLQTDLDLDALDHWLHALEDAHGRDR
SGPRFSDRTLDLDVVFFGDRIVEGPGHLRIPRPELKHAFVLKPLADIAPDFIDPLSGQTLATLWQAHPQYGSAFATVELD
AAAPELSVTQ

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=140, Percent_Identity=35, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18629; Mature: 18498

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVLLSLGSNVQPTHYLRLAVAALRARFGQVVVSPAYRTPAVGFDGPDFVNNAAVLQTD
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHCCCEEEEEC
LDLDALDHWLHALEDAHGRDRSGPRFSDRTLDLDVVFFGDRIVEGPGHLRIPRPELKHAF
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCEEECCCCCEECCCHHHHHHH
VLKPLADIAPDFIDPLSGQTLATLWQAHPQYGSAFATVELDAAAPELSVTQ
HCCCHHHHCHHHHCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TTVLLSLGSNVQPTHYLRLAVAALRARFGQVVVSPAYRTPAVGFDGPDFVNNAAVLQTD
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHCCCEEEEEC
LDLDALDHWLHALEDAHGRDRSGPRFSDRTLDLDVVFFGDRIVEGPGHLRIPRPELKHAF
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCEEECCCCCEECCCHHHHHHH
VLKPLADIAPDFIDPLSGQTLATLWQAHPQYGSAFATVELDAAAPELSVTQ
HCCCHHHHCHHHHCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]