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The map label for this gene is metR [H]

Identifier: 21241107

GI number: 21241107

Start: 398525

End: 399439

Strand: Reverse

Name: metR [H]

Synonym: XAC0333

Alternate gene names: 21241107

Gene position: 399439-398525 (Counterclockwise)

Preceding gene: 21241111

Following gene: 21241106

Centisome position: 7.72

GC content: 64.92

Gene sequence:

>915_bases
ATGCTTGAGCGCATCCATCTCACCATCGTCCAGCAGGTCGAGCAGCAAGGCTCGCTGACCGCCGCCGCAGGCGTGTTGAA
TCTGACCCAGTCGGCGCTGAGCCACAGCATGAAGAAGCTGGAACAGCAGCTGGGCACCGACATCTGGTTGCGCGAGGGGC
GCAGCCTGCGCCTGACCCAGGCCGGCCAGTACCTGCTGGCGGTGGCAAACCGGGTGCTACCGCAACTGGACCTGGCCGAA
GAGCGGCTGGGGCAGTTCGCCCAAGGCGAGCGCGGTGCGCTACGCATCGGCATGGAATGCCATCCCTGCTACCAGTGGCT
GCTCAAGTTGGTGGCGCCGTATCTGGCCACGTGGCCGGATGTGGATGTGGATGTGAAACAGAAGTTCCAGTTCGGCGGCA
TCGGCGCGTTGTTCGGCTACGAGATCGATCTGCTGGTCACGCCCGACCCGCTGTTCAAGCCAGGACTCAGGTTCGAGCCG
GTGTTCCACTATGAGCAGGTGCTGGTCGTGGCCAAGCGCCATGCGTTGGCGTCGGCGGCCTACGTCAAGCCACAGCAGCT
CACACGCGAGGTGCTGATCAGCTACCCGGTGGATCTTGAGCGCCTGGATATCTACAGCCAATTCCTGTTGCCGGCCGGCG
TCACGCCGCGGCGCCACAAGGCCATCGAAACCACCGACATCATGATGCAGATGGTGGCCAGCGGCCGCGGCGTGGCCGCC
ATGCCGCGCTGGCTGGTCGAGGAATATGCGGCCAGAATGGACGTGGTGCCGGTGCGGCTGGGTGCGCGCGGCATCCCCAA
GCAGATCTATCTGGGCGCGCGCGAGGCGGACATCGCAATCGATTACCTGCGCGCCTTCATCGAACTGGCGCGTGCGCCGG
CCAATGCCACTGCCTATCCGCAAGGACCCCACTGA

Upstream 100 bases:

>100_bases
TCGCACGGCAGCGACTGAACAACGAGTCCCGATGCTAGGGCTGGCATTCAATGAAGTAAAATGGTGTTATTTCAACAATC
CATGAATTCGGATCATTTGA

Downstream 100 bases:

>100_bases
TGGACGCCACTGCCCAACGCATGCCACTTCCACTGCCTGACGGCCACGCCAAGGTCTTGCTGCATTCGTGCTGCGCGCCG
TGCTCTGGCGAGGTCATGGA

Product: MetE/MetH family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLERIHLTIVQQVEQQGSLTAAAGVLNLTQSALSHSMKKLEQQLGTDIWLREGRSLRLTQAGQYLLAVANRVLPQLDLAE
ERLGQFAQGERGALRIGMECHPCYQWLLKLVAPYLATWPDVDVDVKQKFQFGGIGALFGYEIDLLVTPDPLFKPGLRFEP
VFHYEQVLVVAKRHALASAAYVKPQQLTREVLISYPVDLERLDIYSQFLLPAGVTPRRHKAIETTDIMMQMVASGRGVAA
MPRWLVEEYAARMDVVPVRLGARGIPKQIYLGAREADIAIDYLRAFIELARAPANATAYPQGPH

Sequences:

>Translated_304_residues
MLERIHLTIVQQVEQQGSLTAAAGVLNLTQSALSHSMKKLEQQLGTDIWLREGRSLRLTQAGQYLLAVANRVLPQLDLAE
ERLGQFAQGERGALRIGMECHPCYQWLLKLVAPYLATWPDVDVDVKQKFQFGGIGALFGYEIDLLVTPDPLFKPGLRFEP
VFHYEQVLVVAKRHALASAAYVKPQQLTREVLISYPVDLERLDIYSQFLLPAGVTPRRHKAIETTDIMMQMVASGRGVAA
MPRWLVEEYAARMDVVPVRLGARGIPKQIYLGAREADIAIDYLRAFIELARAPANATAYPQGPH
>Mature_304_residues
MLERIHLTIVQQVEQQGSLTAAAGVLNLTQSALSHSMKKLEQQLGTDIWLREGRSLRLTQAGQYLLAVANRVLPQLDLAE
ERLGQFAQGERGALRIGMECHPCYQWLLKLVAPYLATWPDVDVDVKQKFQFGGIGALFGYEIDLLVTPDPLFKPGLRFEP
VFHYEQVLVVAKRHALASAAYVKPQQLTREVLISYPVDLERLDIYSQFLLPAGVTPRRHKAIETTDIMMQMVASGRGVAA
MPRWLVEEYAARMDVVPVRLGARGIPKQIYLGAREADIAIDYLRAFIELARAPANATAYPQGPH

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=291, Percent_Identity=40.2061855670103, Blast_Score=204, Evalue=4e-54,
Organism=Escherichia coli, GI157672245, Length=217, Percent_Identity=29.0322580645161, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI2367136, Length=224, Percent_Identity=26.7857142857143, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787879, Length=260, Percent_Identity=24.6153846153846, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786401, Length=303, Percent_Identity=23.7623762376238, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787530, Length=284, Percent_Identity=23.5915492957746, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789639, Length=255, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787589, Length=138, Percent_Identity=28.9855072463768, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33995; Mature: 33995

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERIHLTIVQQVEQQGSLTAAAGVLNLTQSALSHSMKKLEQQLGTDIWLREGRSLRLTQ
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEHH
AGQYLLAVANRVLPQLDLAEERLGQFAQGERGALRIGMECHPCYQWLLKLVAPYLATWPD
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCC
VDVDVKQKFQFGGIGALFGYEIDLLVTPDPLFKPGLRFEPVFHYEQVLVVAKRHALASAA
CCCCHHHHHCCCCEEEEECEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YVKPQQLTREVLISYPVDLERLDIYSQFLLPAGVTPRRHKAIETTDIMMQMVASGRGVAA
HCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHH
MPRWLVEEYAARMDVVPVRLGARGIPKQIYLGAREADIAIDYLRAFIELARAPANATAYP
HHHHHHHHHHHHCCCEEEECCCCCCCHHHEECCCHHHHHHHHHHHHHHHHHCCCCCCCCC
QGPH
CCCC
>Mature Secondary Structure
MLERIHLTIVQQVEQQGSLTAAAGVLNLTQSALSHSMKKLEQQLGTDIWLREGRSLRLTQ
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEHH
AGQYLLAVANRVLPQLDLAEERLGQFAQGERGALRIGMECHPCYQWLLKLVAPYLATWPD
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCC
VDVDVKQKFQFGGIGALFGYEIDLLVTPDPLFKPGLRFEPVFHYEQVLVVAKRHALASAA
CCCCHHHHHCCCCEEEEECEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YVKPQQLTREVLISYPVDLERLDIYSQFLLPAGVTPRRHKAIETTDIMMQMVASGRGVAA
HCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHH
MPRWLVEEYAARMDVVPVRLGARGIPKQIYLGAREADIAIDYLRAFIELARAPANATAYP
HHHHHHHHHHHHCCCEEEECCCCCCCHHHEECCCHHHHHHHHHHHHHHHHHCCCCCCCCC
QGPH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]