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The map label for this gene is gltC [H]

Identifier: 21241086

GI number: 21241086

Start: 373182

End: 374099

Strand: Direct

Name: gltC [H]

Synonym: XAC0312

Alternate gene names: 21241086

Gene position: 373182-374099 (Clockwise)

Preceding gene: 21241077

Following gene: 21241087

Centisome position: 7.21

GC content: 67.86

Gene sequence:

>918_bases
ATGCTGACCTTCTCGCGCTTCACCCGGTATTTCATCGAAGTGGCACGCTGCGGCAGCATCCGCAAGGCCTCCGAGGTACT
ACACGTCTCGGCGTCGGCGATCGACCGGCAGATCCTCAAGGCCGAGGAAGAACTGGGGGCGCAGCTGTTCGAACGCCTGC
CTGGCCGGTTGCGGCTCACCGCTGCGGGCGAGCTGTTGCTGGTGGACGTGCGCGGCTGGGAGAAGGCCTACGCGCGCACG
CTGGAGCGCTTCGACGAGCTCAAGGGCCTGCGCCGCGGGCATGTGGAGATCGCCATGATCGACGCGCTCAGCGAGGGCCT
GGTGCCGGCGGCGGTGGCGGCGCTGGTGCAGGAGTACCCGGGCATCACCTTCAACCTCTCCACCGCGCGCAACCAGCGGG
TGATGGAGATGGTGACCTCGGCCGATGTGGATATCGGCCTGCTGCTGGACCCGGTCAGCAGCGTGGACCTGGAGGTGCGC
GCGTTTGCGGACATTCCGCTAGGCATTGCGATGCCGGTGGGGCATCCGTTGAGCACCCGCACCGAGCTGCAGCTGAGCGA
GACGCTGGAGCATCGTCTGTTGCTGCCCGCCGCCCCGTTGATCGTCGGCGAGCACGCCAAGGTGCTGTACCAGCGCCAGC
ACATCGACGTGAAACGGCTCACCCACTGCAACGACGTGCGTACGCTGCGCGGGTTGGTGCGCGCCGGCGCCGGCGTTGGG
TTGATGTCGTGGCTGGATGCCGCCCCGGACGTGGCCGACGGACGTCTGGCTTTCGTGCCGTTTCGCCAGCACCTGACCAA
GCCGATGACGCTGGCGCTGTGCGTGGCGCCGCAGCGCCAACTGTCACGTTCGGCGCAACTGGCGATCCAGGCGCTGGCAG
CGAAGATCGATGCGATGGCGGTGCCGGCGGTGGAGTAG

Upstream 100 bases:

>100_bases
AGCGGTGCCGATTGACTCTAGGAAGCCGGGGGTGTGTGATCAAACATCGATTTTCAGCCAAGCCATTGCAAAAAATGCAA
CGTCAACCGAGCCCCGCCGC

Downstream 100 bases:

>100_bases
CCCTCATCCGGCGCTGAGCGCCACCTTACTCCCGCCAGTGGGAGAAGGGAGATCGTCAATGCCGCCTGCCTTCCCCCGCC
TGCGGGGGAAGGTGCCCGAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MLTFSRFTRYFIEVARCGSIRKASEVLHVSASAIDRQILKAEEELGAQLFERLPGRLRLTAAGELLLVDVRGWEKAYART
LERFDELKGLRRGHVEIAMIDALSEGLVPAAVAALVQEYPGITFNLSTARNQRVMEMVTSADVDIGLLLDPVSSVDLEVR
AFADIPLGIAMPVGHPLSTRTELQLSETLEHRLLLPAAPLIVGEHAKVLYQRQHIDVKRLTHCNDVRTLRGLVRAGAGVG
LMSWLDAAPDVADGRLAFVPFRQHLTKPMTLALCVAPQRQLSRSAQLAIQALAAKIDAMAVPAVE

Sequences:

>Translated_305_residues
MLTFSRFTRYFIEVARCGSIRKASEVLHVSASAIDRQILKAEEELGAQLFERLPGRLRLTAAGELLLVDVRGWEKAYART
LERFDELKGLRRGHVEIAMIDALSEGLVPAAVAALVQEYPGITFNLSTARNQRVMEMVTSADVDIGLLLDPVSSVDLEVR
AFADIPLGIAMPVGHPLSTRTELQLSETLEHRLLLPAAPLIVGEHAKVLYQRQHIDVKRLTHCNDVRTLRGLVRAGAGVG
LMSWLDAAPDVADGRLAFVPFRQHLTKPMTLALCVAPQRQLSRSAQLAIQALAAKIDAMAVPAVE
>Mature_305_residues
MLTFSRFTRYFIEVARCGSIRKASEVLHVSASAIDRQILKAEEELGAQLFERLPGRLRLTAAGELLLVDVRGWEKAYART
LERFDELKGLRRGHVEIAMIDALSEGLVPAAVAALVQEYPGITFNLSTARNQRVMEMVTSADVDIGLLLDPVSSVDLEVR
AFADIPLGIAMPVGHPLSTRTELQLSETLEHRLLLPAAPLIVGEHAKVLYQRQHIDVKRLTHCNDVRTLRGLVRAGAGVG
LMSWLDAAPDVADGRLAFVPFRQHLTKPMTLALCVAPQRQLSRSAQLAIQALAAKIDAMAVPAVE

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=238, Percent_Identity=26.890756302521, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI145693105, Length=234, Percent_Identity=26.4957264957265, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789204, Length=308, Percent_Identity=24.3506493506494, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790399, Length=298, Percent_Identity=26.1744966442953, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788887, Length=264, Percent_Identity=25.3787878787879, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788481, Length=245, Percent_Identity=28.1632653061224, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788748, Length=159, Percent_Identity=28.9308176100629, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787601, Length=121, Percent_Identity=35.5371900826446, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787879, Length=284, Percent_Identity=25.7042253521127, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33446; Mature: 33446

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTFSRFTRYFIEVARCGSIRKASEVLHVSASAIDRQILKAEEELGAQLFERLPGRLRLT
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
AAGELLLVDVRGWEKAYARTLERFDELKGLRRGHVEIAMIDALSEGLVPAAVAALVQEYP
ECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCHHHHHHHHHHHCC
GITFNLSTARNQRVMEMVTSADVDIGLLLDPVSSVDLEVRAFADIPLGIAMPVGHPLSTR
CCEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCEEECCCCCCCCCC
TELQLSETLEHRLLLPAAPLIVGEHAKVLYQRQHIDVKRLTHCNDVRTLRGLVRAGAGVG
HHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCH
LMSWLDAAPDVADGRLAFVPFRQHLTKPMTLALCVAPQRQLSRSAQLAIQALAAKIDAMA
HHHHHHCCCCCCCCCEEEEEHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHC
VPAVE
CCCCC
>Mature Secondary Structure
MLTFSRFTRYFIEVARCGSIRKASEVLHVSASAIDRQILKAEEELGAQLFERLPGRLRLT
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
AAGELLLVDVRGWEKAYARTLERFDELKGLRRGHVEIAMIDALSEGLVPAAVAALVQEYP
ECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCHHHHHHHHHHHCC
GITFNLSTARNQRVMEMVTSADVDIGLLLDPVSSVDLEVRAFADIPLGIAMPVGHPLSTR
CCEEEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCEEECCCCCCCCCC
TELQLSETLEHRLLLPAAPLIVGEHAKVLYQRQHIDVKRLTHCNDVRTLRGLVRAGAGVG
HHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCH
LMSWLDAAPDVADGRLAFVPFRQHLTKPMTLALCVAPQRQLSRSAQLAIQALAAKIDAMA
HHHHHHCCCCCCCCCEEEEEHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHC
VPAVE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]