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The map label for this gene is flp [H]

Identifier: 21240908

GI number: 21240908

Start: 157496

End: 158680

Strand: Direct

Name: flp [H]

Synonym: XAC0134

Alternate gene names: 21240908

Gene position: 157496-158680 (Clockwise)

Preceding gene: 21240906

Following gene: 21240909

Centisome position: 3.04

GC content: 67.59

Gene sequence:

>1185_bases
GTGCTTTGCAGTGGTCAGGCGTGGGCGGGCGGGCCGGGTCGGCCGCCCGCGCCGGACGCCATCACACGCACACTCCAGCA
ACACATGGACGCCGCCGGCATCGTCGGCCTGGGCGCGGCGATCATCCGCGACCGCAAGGTGGTCTGGACCGGCGGCGTCG
GTTTTGCCGACCGTGCGCGCGGCACGCCATTCACGCCCGACACCGTCATGAACATCGGCTCGATCAGCAAGACCGTGACC
GGCGTGGCGCTGATGCAGGCGGTGCAGGACGGCAAGCTGGCGCTGGATGCGGACATCAACACCTATCTGCCGTTCGCCGT
GCGCAACCCGCAGTTTCCGCAGGTGCCGATCACCCTGCGGCAACTGGCCACGCACACCTCCAGCCTGACCGACCGCTGGG
AGGTCTACCGCGACACCTATCGCTGGCAAGGCCTGCCGGTCGCGCCGTTGGGCGACTTCTTGCGCGGCTATCTGGCGCCC
GGCGGGCGCGACTACCAGGCGCAGAACTACCTGCCGGTCAAACCCGGCACGCATCGCGAATACTCCAACATCGGTGCCGG
CCTGGTGGGCTACATCGTCGCGCGCGCGGTGGGCCAGTCGCTGGAGCGCTACACGCACACGCGCATCTTCGCGCCACTGG
GCATGCAGCACACTGCCTGGCATGCGGCCGATCTGCCGGCCGCCGCCCAGGCCACGCTGTATGTGAGCCAGTTCGGTGTG
AGCGTGCCGATCCCGCCGTACGAACTCACCACCTACCCCGACGGCGGCGTGCGCACCAGCGTCAACGACCTCTCCAGGCT
GTTCATCGCCCTGCTCGATGGCGGGCAGTACCAGGGCGTGCGTATTCTGGATACCACCACCACCGCGCAGATGCTGCGTT
TCCAGTACACCGCCGCCAACACGCCCGACAATGTCGCCTTGAACGAGAAGAACTCCGGCATCTTCTGGTCCACCAAGTAC
AACGTCACCCGCATCGGCCACGGCGGCTCGGACCCGGGCGTGCACACCGAGATGCTGTCGGACCTGGCGCACGACAATGC
GGTAGTGCTGATCAGCAACACCTCCTTGGACAGCAGCGATGCCAGGGTCAATGCGCAGCTCTTCGACGATCTGTGGGCGT
ATGCCGTGGAGCTCAGGCAGCAAGCGGCCTCCGCTGCCGGCCGTCGCCGCCCCGCACCGGATTGA

Upstream 100 bases:

>100_bases
CCCACGTGGGGCATCTGCAGCAACCACATCACGGACGGAGGGCGCCATGCGTGCAGGCACAGCAGCGGGATGGACGGTAA
AGATCGGGCTGGCGATCGGT

Downstream 100 bases:

>100_bases
GCGCAGCCAGCAGAACGGAAGCGGACCGGGCATGACCTGCGGCCCCGGGGTGGTGTGCCGGTGTGCGCACGCGCTGCAGC
CGCGACAGGGGCCGCAGGTC

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MLCSGQAWAGGPGRPPAPDAITRTLQQHMDAAGIVGLGAAIIRDRKVVWTGGVGFADRARGTPFTPDTVMNIGSISKTVT
GVALMQAVQDGKLALDADINTYLPFAVRNPQFPQVPITLRQLATHTSSLTDRWEVYRDTYRWQGLPVAPLGDFLRGYLAP
GGRDYQAQNYLPVKPGTHREYSNIGAGLVGYIVARAVGQSLERYTHTRIFAPLGMQHTAWHAADLPAAAQATLYVSQFGV
SVPIPPYELTTYPDGGVRTSVNDLSRLFIALLDGGQYQGVRILDTTTTAQMLRFQYTAANTPDNVALNEKNSGIFWSTKY
NVTRIGHGGSDPGVHTEMLSDLAHDNAVVLISNTSLDSSDARVNAQLFDDLWAYAVELRQQAASAAGRRRPAPD

Sequences:

>Translated_394_residues
MLCSGQAWAGGPGRPPAPDAITRTLQQHMDAAGIVGLGAAIIRDRKVVWTGGVGFADRARGTPFTPDTVMNIGSISKTVT
GVALMQAVQDGKLALDADINTYLPFAVRNPQFPQVPITLRQLATHTSSLTDRWEVYRDTYRWQGLPVAPLGDFLRGYLAP
GGRDYQAQNYLPVKPGTHREYSNIGAGLVGYIVARAVGQSLERYTHTRIFAPLGMQHTAWHAADLPAAAQATLYVSQFGV
SVPIPPYELTTYPDGGVRTSVNDLSRLFIALLDGGQYQGVRILDTTTTAQMLRFQYTAANTPDNVALNEKNSGIFWSTKY
NVTRIGHGGSDPGVHTEMLSDLAHDNAVVLISNTSLDSSDARVNAQLFDDLWAYAVELRQQAASAAGRRRPAPD
>Mature_394_residues
MLCSGQAWAGGPGRPPAPDAITRTLQQHMDAAGIVGLGAAIIRDRKVVWTGGVGFADRARGTPFTPDTVMNIGSISKTVT
GVALMQAVQDGKLALDADINTYLPFAVRNPQFPQVPITLRQLATHTSSLTDRWEVYRDTYRWQGLPVAPLGDFLRGYLAP
GGRDYQAQNYLPVKPGTHREYSNIGAGLVGYIVARAVGQSLERYTHTRIFAPLGMQHTAWHAADLPAAAQATLYVSQFGV
SVPIPPYELTTYPDGGVRTSVNDLSRLFIALLDGGQYQGVRILDTTTTAQMLRFQYTAANTPDNVALNEKNSGIFWSTKY
NVTRIGHGGSDPGVHTEMLSDLAHDNAVVLISNTSLDSSDARVNAQLFDDLWAYAVELRQQAASAAGRRRPAPD

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI239747261, Length=290, Percent_Identity=27.9310344827586, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI239752721, Length=290, Percent_Identity=27.9310344827586, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI239741085, Length=290, Percent_Identity=27.9310344827586, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI26051231, Length=130, Percent_Identity=33.0769230769231, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI26051233, Length=130, Percent_Identity=33.0769230769231, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790593, Length=258, Percent_Identity=29.8449612403101, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786574, Length=289, Percent_Identity=25.9515570934256, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115533026, Length=260, Percent_Identity=28.4615384615385, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17550934, Length=203, Percent_Identity=27.0935960591133, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 42651; Mature: 42651

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCSGQAWAGGPGRPPAPDAITRTLQQHMDAAGIVGLGAAIIRDRKVVWTGGVGFADRAR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCHHCCC
GTPFTPDTVMNIGSISKTVTGVALMQAVQDGKLALDADINTYLPFAVRNPQFPQVPITLR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEECCCCCCCCCHHHH
QLATHTSSLTDRWEVYRDTYRWQGLPVAPLGDFLRGYLAPGGRDYQAQNYLPVKPGTHRE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCC
YSNIGAGLVGYIVARAVGQSLERYTHTRIFAPLGMQHTAWHAADLPAAAQATLYVSQFGV
HHHCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHHHHEEEHHHCCC
SVPIPPYELTTYPDGGVRTSVNDLSRLFIALLDGGQYQGVRILDTTTTAQMLRFQYTAAN
CCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHEEEEECCC
TPDNVALNEKNSGIFWSTKYNVTRIGHGGSDPGVHTEMLSDLAHDNAVVLISNTSLDSSD
CCCCEEEECCCCCEEEEECCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
ARVNAQLFDDLWAYAVELRQQAASAAGRRRPAPD
CEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLCSGQAWAGGPGRPPAPDAITRTLQQHMDAAGIVGLGAAIIRDRKVVWTGGVGFADRAR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCHHCCC
GTPFTPDTVMNIGSISKTVTGVALMQAVQDGKLALDADINTYLPFAVRNPQFPQVPITLR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEECCCCCCCCCHHHH
QLATHTSSLTDRWEVYRDTYRWQGLPVAPLGDFLRGYLAPGGRDYQAQNYLPVKPGTHRE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCC
YSNIGAGLVGYIVARAVGQSLERYTHTRIFAPLGMQHTAWHAADLPAAAQATLYVSQFGV
HHHCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHHHHEEEHHHCCC
SVPIPPYELTTYPDGGVRTSVNDLSRLFIALLDGGQYQGVRILDTTTTAQMLRFQYTAAN
CCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHEEEEECCC
TPDNVALNEKNSGIFWSTKYNVTRIGHGGSDPGVHTEMLSDLAHDNAVVLISNTSLDSSD
CCCCEEEECCCCCEEEEECCCEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
ARVNAQLFDDLWAYAVELRQQAASAAGRRRPAPD
CEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA