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The map label for this gene is tyrB [H]

Identifier: 21240899

GI number: 21240899

Start: 147156

End: 148358

Strand: Reverse

Name: tyrB [H]

Synonym: XAC0125

Alternate gene names: 21240899

Gene position: 148358-147156 (Counterclockwise)

Preceding gene: 21240907

Following gene: 21240898

Centisome position: 2.87

GC content: 66.58

Gene sequence:

>1203_bases
GTGTCCTTCTTTGCAAACGTGGAACAGGTTCCAGGCGACCCCATCCTGGGCCTGACCGAGGCCTACAACGCCGACAGCCG
CCCCAACAAGGTCAACCTGGGCGTGGGCATCTATTACGACGAAAACGGGCGCATCCCGCTGTTGCGCGCCGTGCACAAGA
TCGAGCAGCAGCTCGCGCAGGACGCCAAACCGCGGGGTTATCTGCCCATCGACGGCCTGGCCGCGTACGACAAGGCCACC
CAGGAGCTGCTGTTTGGCGCCGACTCTGCGCTGGTGACCTCCGGCCGCGTGGCGACCTCGCAGACCGTCGGCGGCAGCGG
CGCATTGCGCGTGGGCGCGGACCTGCTCAAGAAGCTGCTGCCCACCGCCACCATCGCCATCAGCAACCCCAGCTGGGAAA
ACCATCGCGCGGTGTTCGGCGCGGCCGGCTTCGAGGTTGTCGATTACACCTACTTCGATGCCGCCATCCATGGCCTGAAC
TTCGACGGCATGCTCGCCGACCTGGCCAAGCTCGAACCGGGCACCGTGGTGCTGCTGCACGCCTGCTGCCACAACCCCAC
CGGCGCCGACCTGAGCAAGGAACAGTGGAAGCAGGTGGCCGGCCTGTTGAAGGAACGCAACCTGTTCCCGTTCGTCGACA
TCGCCTACCAGGGCTTCGACAAGGGCATCGAGGCCGATGCCTATGCGGTGCGCCTGCTGGCTGCCGAAGGCATCGACAGC
TACGTGGTCGCCAGTTCCTATTCCAAGTCGTTCTCGCTGTATGGCGAGCGCGTGGGCGCGCTGTCGGTGGTCTCGGCCAC
CGCCGCCGAAGCCAAGGCGGTGCAGTCGCAGGTCAAGCGCATCATCCGCACGATCTACTCCAGCCCGTCCACGCACGGCG
CCGCCCTGGTGGCCGGCGTGCTGACCAGCCCGGAGCTGCGCGATCTGTGGGAGCAGGAACTGACCGAGATGCGCGAGCGC
ATCCATTCCCTGCGCGCCGGGCTGGTGGAAAAACTCGCCACGCTGGGTGCGCCGGAGTTCGACTTCATCCAGCGCCAGGC
CGGCATGTTCTCGTACTCGGGCCTGACCAAGACCCAGGTGGACCGCCTGCGCGACGAGTTCGCGATCTACGCGGTCGGCA
CCGGCCGCATCTGCGTGGCAGCACTGAGCCAGCGTAACCTGGACTACGTGGCCCAGGCCGTGGCCACTGTCAGCCGGGTG
TAG

Upstream 100 bases:

>100_bases
TGCTACGCCGGCCATGGGCTGCTACGATGAAGTGGTTTGGCCCAGCAGCGGTCAACGATCCGGAAGTACCCCACTCTTTC
GTCCTTCAGCGAGTCATGCC

Downstream 100 bases:

>100_bases
TGCAGCGGAGCTTCATCGGCTACATCGGCTGACGCGATCAAGCCGGGAGCGCGCAAGCCTCCCGGTTTTTTGCTTGCTGT
TGCCTTGCCCCCGCCGACGT

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSFFANVEQVPGDPILGLTEAYNADSRPNKVNLGVGIYYDENGRIPLLRAVHKIEQQLAQDAKPRGYLPIDGLAAYDKAT
QELLFGADSALVTSGRVATSQTVGGSGALRVGADLLKKLLPTATIAISNPSWENHRAVFGAAGFEVVDYTYFDAAIHGLN
FDGMLADLAKLEPGTVVLLHACCHNPTGADLSKEQWKQVAGLLKERNLFPFVDIAYQGFDKGIEADAYAVRLLAAEGIDS
YVVASSYSKSFSLYGERVGALSVVSATAAEAKAVQSQVKRIIRTIYSSPSTHGAALVAGVLTSPELRDLWEQELTEMRER
IHSLRAGLVEKLATLGAPEFDFIQRQAGMFSYSGLTKTQVDRLRDEFAIYAVGTGRICVAALSQRNLDYVAQAVATVSRV

Sequences:

>Translated_400_residues
MSFFANVEQVPGDPILGLTEAYNADSRPNKVNLGVGIYYDENGRIPLLRAVHKIEQQLAQDAKPRGYLPIDGLAAYDKAT
QELLFGADSALVTSGRVATSQTVGGSGALRVGADLLKKLLPTATIAISNPSWENHRAVFGAAGFEVVDYTYFDAAIHGLN
FDGMLADLAKLEPGTVVLLHACCHNPTGADLSKEQWKQVAGLLKERNLFPFVDIAYQGFDKGIEADAYAVRLLAAEGIDS
YVVASSYSKSFSLYGERVGALSVVSATAAEAKAVQSQVKRIIRTIYSSPSTHGAALVAGVLTSPELRDLWEQELTEMRER
IHSLRAGLVEKLATLGAPEFDFIQRQAGMFSYSGLTKTQVDRLRDEFAIYAVGTGRICVAALSQRNLDYVAQAVATVSRV
>Mature_399_residues
SFFANVEQVPGDPILGLTEAYNADSRPNKVNLGVGIYYDENGRIPLLRAVHKIEQQLAQDAKPRGYLPIDGLAAYDKATQ
ELLFGADSALVTSGRVATSQTVGGSGALRVGADLLKKLLPTATIAISNPSWENHRAVFGAAGFEVVDYTYFDAAIHGLNF
DGMLADLAKLEPGTVVLLHACCHNPTGADLSKEQWKQVAGLLKERNLFPFVDIAYQGFDKGIEADAYAVRLLAAEGIDSY
VVASSYSKSFSLYGERVGALSVVSATAAEAKAVQSQVKRIIRTIYSSPSTHGAALVAGVLTSPELRDLWEQELTEMRERI
HSLRAGLVEKLATLGAPEFDFIQRQAGMFSYSGLTKTQVDRLRDEFAIYAVGTGRICVAALSQRNLDYVAQAVATVSRV

Specific function: Unknown

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=400, Percent_Identity=43.75, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI4504067, Length=402, Percent_Identity=42.5373134328358, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=29.1338582677165, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=48.4848484848485, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1790488, Length=400, Percent_Identity=50.25, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71981858, Length=401, Percent_Identity=40.6483790523691, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI25147133, Length=400, Percent_Identity=41.25, Blast_Score=328, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17569539, Length=403, Percent_Identity=40.9429280397022, Blast_Score=311, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI17569537, Length=402, Percent_Identity=32.3383084577114, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17550384, Length=270, Percent_Identity=37.7777777777778, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI25147136, Length=213, Percent_Identity=41.7840375586854, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6323055, Length=407, Percent_Identity=36.6093366093366, Blast_Score=286, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6322743, Length=439, Percent_Identity=32.5740318906606, Blast_Score=238, Evalue=2e-63,
Organism=Drosophila melanogaster, GI19922362, Length=398, Percent_Identity=43.21608040201, Blast_Score=328, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24654046, Length=398, Percent_Identity=43.21608040201, Blast_Score=328, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24580972, Length=401, Percent_Identity=39.4014962593516, Blast_Score=314, Evalue=8e-86,
Organism=Drosophila melanogaster, GI24580970, Length=401, Percent_Identity=39.4014962593516, Blast_Score=314, Evalue=9e-86,
Organism=Drosophila melanogaster, GI19920542, Length=392, Percent_Identity=39.7959183673469, Blast_Score=308, Evalue=3e-84,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 43138; Mature: 43007

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFANVEQVPGDPILGLTEAYNADSRPNKVNLGVGIYYDENGRIPLLRAVHKIEQQLAQ
CCCCCCHHHCCCCCCCCCHHHCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHH
DAKPRGYLPIDGLAAYDKATQELLFGADSALVTSGRVATSQTVGGSGALRVGADLLKKLL
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEECCCCEECCCCCCCCHHHHHHHHHHHHC
PTATIAISNPSWENHRAVFGAAGFEVVDYTYFDAAIHGLNFDGMLADLAKLEPGTVVLLH
CCEEEEECCCCCCCCCEEEECCCCEEEEHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEE
ACCHNPTGADLSKEQWKQVAGLLKERNLFPFVDIAYQGFDKGIEADAYAVRLLAAEGIDS
EHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
YVVASSYSKSFSLYGERVGALSVVSATAAEAKAVQSQVKRIIRTIYSSPSTHGAALVAGV
EEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LTSPELRDLWEQELTEMRERIHSLRAGLVEKLATLGAPEFDFIQRQAGMFSYSGLTKTQV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHH
DRLRDEFAIYAVGTGRICVAALSQRNLDYVAQAVATVSRV
HHHHHCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFFANVEQVPGDPILGLTEAYNADSRPNKVNLGVGIYYDENGRIPLLRAVHKIEQQLAQ
CCCCCHHHCCCCCCCCCHHHCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHH
DAKPRGYLPIDGLAAYDKATQELLFGADSALVTSGRVATSQTVGGSGALRVGADLLKKLL
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEECCCCEECCCCCCCCHHHHHHHHHHHHC
PTATIAISNPSWENHRAVFGAAGFEVVDYTYFDAAIHGLNFDGMLADLAKLEPGTVVLLH
CCEEEEECCCCCCCCCEEEECCCCEEEEHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEE
ACCHNPTGADLSKEQWKQVAGLLKERNLFPFVDIAYQGFDKGIEADAYAVRLLAAEGIDS
EHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
YVVASSYSKSFSLYGERVGALSVVSATAAEAKAVQSQVKRIIRTIYSSPSTHGAALVAGV
EEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LTSPELRDLWEQELTEMRERIHSLRAGLVEKLATLGAPEFDFIQRQAGMFSYSGLTKTQV
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHH
DRLRDEFAIYAVGTGRICVAALSQRNLDYVAQAVATVSRV
HHHHHCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043; 8808952 [H]