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The map label for this gene is lldD

Identifier: 21240907

GI number: 21240907

Start: 156019

End: 157185

Strand: Reverse

Name: lldD

Synonym: XAC0133

Alternate gene names: 21240907

Gene position: 157185-156019 (Counterclockwise)

Preceding gene: 21240911

Following gene: 21240899

Centisome position: 3.04

GC content: 67.87

Gene sequence:

>1167_bases
ATGATCATTTCCGCCGCTTCCGACTACCGCGCCGCCGCCGAAGCACGCCTGCCGCCCTTCCTGTTCCATTACATCGATGG
CGGCGCGTATGCCGAGCACACCTTGCGGCGCAATGTCTCGGACCTGGCCGATGTGGCGCTGCGCCAGCGGGTGCTGCGCA
ATATGTCGGATCTGCGCCTGAGCACCGAGCTGTTCGGCGAAACCCTGGCGATGCCGGTGGCCTTGGCGCCGGTCGGCCTC
ACCGGCATGTATGCACGCCGCGGCGAAGTGCAGGCCGCGCGTGCGGCGGCCGCGCGCGGTATTCCGTTCACCCTGTCCAC
GGTGTCGGTGTGCCCGATCGAAGAAGTGGCACCGGCCATCGAACGGCCGATGTGGTTCCAGCTCTATGTGCTCAAGGACC
GTGGCTTCATGCGCAATGCGCTGGAGCGCGCCAAGGCGGCGGGCGTGACCACGCTGGTGTTCACCGTGGACATGCCCACG
CCCGGCGCGCGCTACCGCGATGCGCACTCGGGCATGAGCGGGCCCAACGCCTCGCTGCGGCGCATGCTGCAGGCGGTGAC
GCACCCGCGCTGGGCGTGGGACGTGGGCCTGCTCGGCAAACCGCACGATCTGGGCAACATCTCCGCCTACCGCGGCAGCC
CCACCGGCCTGCAGGATTACATCGGCTGGCTGGGCGCCAACTTCGACCCGTCAATCGCCTGGAAAGACCTGGAATGGATC
CGCGAATTCTGGACCGGGCCGATGGTGATCAAGGGCATCCTGGACCCGGAGGACGCACGCGATGCGGTGCGCTTCGGTGC
CGACGGCATCGTGGTCTCCAACCACGGCGGCCGTCAGCTCGACGGCGTGCTGTCCAGCGCACGCGCACTACCGGCCATTG
CCGATGCGGTGAAGGGCGAGCTGAAGATTCTGGCCGATTCGGGCATCCGCAGCGGGCTGGACGTGGTGCGCATGCTCGCG
CTCGGTGCCGATGCGGTATTGCTGGGGCGCGCGTTCGTCTACGCGTTGGCGGCCGCCGGGCAGGCCGGCGTGGAAAACCT
GCTGACCCTGATCGAAAAGGAAATGCGCGTGGCGATGACGCTGACCGGCACGCATTCCATCGCCGACATCAGCGCCGACG
CTTTGAGCCGGGTGACGCGCGAGCGTGCCGATGCGATCTCGCCATAA

Upstream 100 bases:

>100_bases
AACGCCGCGTGCAGCGCGTGCGGCCTGCCGCTGCAGCGGTCCACCTGCCACCGATGGTCTTACACTCGGCGGCTCCCCTG
CCGCTGCCGTCCCGTCTTCG

Downstream 100 bases:

>100_bases
AGCCGCTAAACCGTAACGCGTAATCGACTGCTGTGAGCGGTTAGCCAGGCAGCGGACCGAAAGTGCACCACCGGTCGCGG
CGAAGCGCGCGCCGATAGGC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MIISAASDYRAAAEARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRLSTELFGETLAMPVALAPVGL
TGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPT
PGARYRDAHSGMSGPNASLRRMLQAVTHPRWAWDVGLLGKPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWI
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLA
LGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMTLTGTHSIADISADALSRVTRERADAISP

Sequences:

>Translated_388_residues
MIISAASDYRAAAEARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRLSTELFGETLAMPVALAPVGL
TGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPT
PGARYRDAHSGMSGPNASLRRMLQAVTHPRWAWDVGLLGKPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWI
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLA
LGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMTLTGTHSIADISADALSRVTRERADAISP
>Mature_388_residues
MIISAASDYRAAAEARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRLSTELFGETLAMPVALAPVGL
TGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAIERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPT
PGARYRDAHSGMSGPNASLRRMLQAVTHPRWAWDVGLLGKPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWI
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGELKILADSGIRSGLDVVRMLA
LGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMTLTGTHSIADISADALSRVTRERADAISP

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

Homologues:

Organism=Homo sapiens, GI11068137, Length=365, Percent_Identity=35.8904109589041, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=33.9572192513369, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=33.9572192513369, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI1790033, Length=389, Percent_Identity=82.7763496143959, Blast_Score=664, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=370, Percent_Identity=34.3243243243243, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=283, Percent_Identity=33.9222614840989, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323587, Length=383, Percent_Identity=29.7650130548303, Blast_Score=172, Evalue=6e-44,
Organism=Drosophila melanogaster, GI78707188, Length=373, Percent_Identity=36.1930294906166, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI281363140, Length=373, Percent_Identity=36.1930294906166, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI78707190, Length=373, Percent_Identity=36.1930294906166, Blast_Score=214, Evalue=8e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDD_XANAC (Q8PR33)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640489.1
- ProteinModelPortal:   Q8PR33
- SMR:   Q8PR33
- GeneID:   1154204
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0133
- NMPDR:   fig|190486.1.peg.133
- HOGENOM:   HBG517781
- OMA:   WIREFWE
- ProtClustDB:   PRK11197
- BioCyc:   XAXO190486:XAC0133-MONOMER
- BRENDA:   1.1.2.3
- HAMAP:   MF_01559
- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000138

Pfam domain/function: PF01070 FMN_dh

EC number: =1.1.2.3

Molecular weight: Translated: 41831; Mature: 41831

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH_1; PS51349 FMN_HYDROXY_ACID_DH_2

Important sites: ACT_SITE 275-275 BINDING 24-24 BINDING 106-106 BINDING 127-127 BINDING 129-129 BINDING 155-155 BINDING 164-164 BINDING 251-251 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISAASDYRAAAEARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRL
CEECCCCCHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
STELFGETLAMPVALAPVGLTGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAI
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCCEEECCEEECCHHHHHHHH
ERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPTPGARYRDAHSGMSGPNASLR
CCCCEEEEEEEECCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHCCCCCCCHHHH
RMLQAVTHPRWAWDVGLLGKPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCCEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGE
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LKILADSGIRSGLDVVRMLALGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMT
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEE
LTGTHSIADISADALSRVTRERADAISP
EECCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIISAASDYRAAAEARLPPFLFHYIDGGAYAEHTLRRNVSDLADVALRQRVLRNMSDLRL
CEECCCCCHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
STELFGETLAMPVALAPVGLTGMYARRGEVQAARAAAARGIPFTLSTVSVCPIEEVAPAI
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHCCCCEEECCEEECCHHHHHHHH
ERPMWFQLYVLKDRGFMRNALERAKAAGVTTLVFTVDMPTPGARYRDAHSGMSGPNASLR
CCCCEEEEEEEECCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHCCCCCCCHHHH
RMLQAVTHPRWAWDVGLLGKPHDLGNISAYRGSPTGLQDYIGWLGANFDPSIAWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCCEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
REFWTGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGE
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
LKILADSGIRSGLDVVRMLALGADAVLLGRAFVYALAAAGQAGVENLLTLIEKEMRVAMT
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEE
LTGTHSIADISADALSRVTRERADAISP
EECCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217