Click here to switch to the map view.

The map label for this gene is fpoM [H]

Identifier: 21228583

GI number: 21228583

Start: 2960878

End: 2962365

Strand: Reverse

Name: fpoM [H]

Synonym: MM_2481

Alternate gene names: 21228583

Gene position: 2962365-2960878 (Counterclockwise)

Preceding gene: 21228584

Following gene: 21228582

Centisome position: 72.32

GC content: 49.93

Gene sequence:

>1488_bases
ATGCTGCCGGTCGCATCGTTGTTGATTCTGGTGCCGCTGATTTTCGCAGTCGTGACCTTTTTCACAAAAACAAAACAACT
GGCTGCAGGGTTTGGCTTTCTCGGGTCTCTAGCAACTCTCGGGCTTACCCTTTATGCCTATCTGAACTTTGACAGCAGTA
CTGCTGCAATGCAGTTCTATGAATCCGTAAGCTGGATACCCTTCCTCGGGGTCAACTATTCAGTCGGGATAGACGGCGTT
TCCATGCCTCTTATCCTCCTGAATGCAATAGTCATCCCGTTTATGATCCTCTTCACCTGGAAGGAGGAAATGGAATCCCC
CAACAGGTTTTACGGGCTGATCCTTACAATGCAGGCTGCGGTTATAGGAGTCTTCGTAGCCCTTGACTTCGTAGTCTTCT
ATATCTTCTGGGAGCTTACCCTTGTCCCGCTCTTCTTCATAGTAAATTTATGGGGTGGAGCAAACAGGGCTCATGCTTCC
TACAAGTTCTTTATATACACACACGTAGCCTCGCTTGTGATGCTGCTCGGGATTTTCGGGCTCTTCTATACAGCCCTGAA
CCAGACAGGCGTTCCTACATTTGACATAAGGGAGCTGATCGCACAGTTCCAGTTCTTCGAACCCGGACTGATGAAAGACG
GAATATTCCTTGCAATCCTCTTCGGGTTCCTAGCAAAACTTCCAGCCTTTCCCTTCCATTCCTGGCTCCCGGATGCATAT
TCCGAAGCCCCCACGGCAGGTAGCATACTCTTTATCCTGCTAAAAATCGGAGGTTACGGGCTTTTCAGGATCTCACTCCC
CATGCTCCCGAATACTGGCAGTCCTCAACTGATGATCATGATTCTGGGCCTGCTCGGTTCTGTAAGCATCCTCTATGGGG
CTCTTCTTGCTCTGCGGCAGAAAGACCTCAAGCGCATGATCGCGTACTCAAGCCTGAGCCACATGGGCTACGTAATCCTG
GGTTCGGCCGGCCTTGTTACCCTTTCGGTTTCAGGCGCCATGTTCCAGCAGTTTTCCCACGGGCTTATTATGAGCATTAT
GTTCATGTCTGCAGGAGCAATCCAGACTGCTGCAGGAACAAGAATCATTAACGAGCTTGGCGGGCTTGCAAAGAAAATGC
CCATGCTTACCGTAGCAATGATGGTCGGATTTATGGCATCCCTCGGCCTTCCCGGGCTTACAGGTTTTATTGCCGAGTTC
CTGGTGCTGACTTTCACCTTCACAAACCTTCCAGTCTTTGTGGTAATCGCCCTGCTGGCTATAGTGGTTACTGCAGGCTA
TCACCTCTGGGCAATGCAGAGGGCAATGTTCGGAGTGTACAATGAGAAACTTGGGGACGTGAGGGATATTAATTCCATTC
AGGTCTTTTCAATGGCCGTAATCGCACTTCTTGTGCTTTACTTCGGCCTGAACCCAAGCCCGGTGCTTGATATGATGATT
AATAATTCGGAAGCAATAGTCAGCCTTGCGGCTGGCATGGGGGTGTGA

Upstream 100 bases:

>100_bases
GGAAGATCCAGACAGGGGTTGTCCAGACCTATGCAACCGCATTAATCGCTGGTGTGAGCCTGCTGATAATACTTGTTAAA
CTGATAATGGAGGTACTCTG

Downstream 100 bases:

>100_bases
GAAATGCAGGAAATAATGTACCTCGCACCTGAACTTGTTCTGGTTGCAACCGGACTGGTCATACTTCTGACCGGAGTTTT
CCTGTCCCCCCAGTCCAAGA

Product: F420H2 dehydrogenase subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MLPVASLLILVPLIFAVVTFFTKTKQLAAGFGFLGSLATLGLTLYAYLNFDSSTAAMQFYESVSWIPFLGVNYSVGIDGV
SMPLILLNAIVIPFMILFTWKEEMESPNRFYGLILTMQAAVIGVFVALDFVVFYIFWELTLVPLFFIVNLWGGANRAHAS
YKFFIYTHVASLVMLLGIFGLFYTALNQTGVPTFDIRELIAQFQFFEPGLMKDGIFLAILFGFLAKLPAFPFHSWLPDAY
SEAPTAGSILFILLKIGGYGLFRISLPMLPNTGSPQLMIMILGLLGSVSILYGALLALRQKDLKRMIAYSSLSHMGYVIL
GSAGLVTLSVSGAMFQQFSHGLIMSIMFMSAGAIQTAAGTRIINELGGLAKKMPMLTVAMMVGFMASLGLPGLTGFIAEF
LVLTFTFTNLPVFVVIALLAIVVTAGYHLWAMQRAMFGVYNEKLGDVRDINSIQVFSMAVIALLVLYFGLNPSPVLDMMI
NNSEAIVSLAAGMGV

Sequences:

>Translated_495_residues
MLPVASLLILVPLIFAVVTFFTKTKQLAAGFGFLGSLATLGLTLYAYLNFDSSTAAMQFYESVSWIPFLGVNYSVGIDGV
SMPLILLNAIVIPFMILFTWKEEMESPNRFYGLILTMQAAVIGVFVALDFVVFYIFWELTLVPLFFIVNLWGGANRAHAS
YKFFIYTHVASLVMLLGIFGLFYTALNQTGVPTFDIRELIAQFQFFEPGLMKDGIFLAILFGFLAKLPAFPFHSWLPDAY
SEAPTAGSILFILLKIGGYGLFRISLPMLPNTGSPQLMIMILGLLGSVSILYGALLALRQKDLKRMIAYSSLSHMGYVIL
GSAGLVTLSVSGAMFQQFSHGLIMSIMFMSAGAIQTAAGTRIINELGGLAKKMPMLTVAMMVGFMASLGLPGLTGFIAEF
LVLTFTFTNLPVFVVIALLAIVVTAGYHLWAMQRAMFGVYNEKLGDVRDINSIQVFSMAVIALLVLYFGLNPSPVLDMMI
NNSEAIVSLAAGMGV
>Mature_495_residues
MLPVASLLILVPLIFAVVTFFTKTKQLAAGFGFLGSLATLGLTLYAYLNFDSSTAAMQFYESVSWIPFLGVNYSVGIDGV
SMPLILLNAIVIPFMILFTWKEEMESPNRFYGLILTMQAAVIGVFVALDFVVFYIFWELTLVPLFFIVNLWGGANRAHAS
YKFFIYTHVASLVMLLGIFGLFYTALNQTGVPTFDIRELIAQFQFFEPGLMKDGIFLAILFGFLAKLPAFPFHSWLPDAY
SEAPTAGSILFILLKIGGYGLFRISLPMLPNTGSPQLMIMILGLLGSVSILYGALLALRQKDLKRMIAYSSLSHMGYVIL
GSAGLVTLSVSGAMFQQFSHGLIMSIMFMSAGAIQTAAGTRIINELGGLAKKMPMLTVAMMVGFMASLGLPGLTGFIAEF
LVLTFTFTNLPVFVVIALLAIVVTAGYHLWAMQRAMFGVYNEKLGDVRDINSIQVFSMAVIALLVLYFGLNPSPVLDMMI
NNSEAIVSLAAGMGV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=354, Percent_Identity=30.7909604519774, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI251831117, Length=205, Percent_Identity=29.7560975609756, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1788613, Length=493, Percent_Identity=34.4827586206897, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI1788827, Length=293, Percent_Identity=29.6928327645051, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1788831, Length=287, Percent_Identity=31.0104529616725, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788829, Length=308, Percent_Identity=25.3246753246753, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI2367154, Length=238, Percent_Identity=31.9327731092437, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788614, Length=426, Percent_Identity=24.4131455399061, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693160, Length=406, Percent_Identity=27.3399014778325, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 53974; Mature: 53974

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPVASLLILVPLIFAVVTFFTKTKQLAAGFGFLGSLATLGLTLYAYLNFDSSTAAMQFY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHH
ESVSWIPFLGVNYSVGIDGVSMPLILLNAIVIPFMILFTWKEEMESPNRFYGLILTMQAA
HHCCCCEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VIGVFVALDFVVFYIFWELTLVPLFFIVNLWGGANRAHASYKFFIYTHVASLVMLLGIFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHH
LFYTALNQTGVPTFDIRELIAQFQFFEPGLMKDGIFLAILFGFLAKLPAFPFHSWLPDAY
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCHH
SEAPTAGSILFILLKIGGYGLFRISLPMLPNTGSPQLMIMILGLLGSVSILYGALLALRQ
CCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KDLKRMIAYSSLSHMGYVILGSAGLVTLSVSGAMFQQFSHGLIMSIMFMSAGAIQTAAGT
HHHHHHHHHHHHHHCCEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RIINELGGLAKKMPMLTVAMMVGFMASLGLPGLTGFIAEFLVLTFTFTNLPVFVVIALLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IVVTAGYHLWAMQRAMFGVYNEKLGDVRDINSIQVFSMAVIALLVLYFGLNPSPVLDMMI
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHC
NNSEAIVSLAAGMGV
CCCHHHHHHHHCCCC
>Mature Secondary Structure
MLPVASLLILVPLIFAVVTFFTKTKQLAAGFGFLGSLATLGLTLYAYLNFDSSTAAMQFY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHH
ESVSWIPFLGVNYSVGIDGVSMPLILLNAIVIPFMILFTWKEEMESPNRFYGLILTMQAA
HHCCCCEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VIGVFVALDFVVFYIFWELTLVPLFFIVNLWGGANRAHASYKFFIYTHVASLVMLLGIFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHH
LFYTALNQTGVPTFDIRELIAQFQFFEPGLMKDGIFLAILFGFLAKLPAFPFHSWLPDAY
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHCCCCHH
SEAPTAGSILFILLKIGGYGLFRISLPMLPNTGSPQLMIMILGLLGSVSILYGALLALRQ
CCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KDLKRMIAYSSLSHMGYVILGSAGLVTLSVSGAMFQQFSHGLIMSIMFMSAGAIQTAAGT
HHHHHHHHHHHHHHCCEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RIINELGGLAKKMPMLTVAMMVGFMASLGLPGLTGFIAEFLVLTFTFTNLPVFVVIALLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IVVTAGYHLWAMQRAMFGVYNEKLGDVRDINSIQVFSMAVIALLVLYFGLNPSPVLDMMI
HHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHC
NNSEAIVSLAAGMGV
CCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA