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The map label for this gene is aroK

Identifier: 21228464

GI number: 21228464

Start: 2818377

End: 2819258

Strand: Reverse

Name: aroK

Synonym: MM_2362

Alternate gene names: 21228464

Gene position: 2819258-2818377 (Counterclockwise)

Preceding gene: 21228472

Following gene: 21228463

Centisome position: 68.82

GC content: 48.64

Gene sequence:

>882_bases
ATGACACTTGAAGGGCACGCCTGCGCTTTCGGAGCTGGAACGATAATAAATGCGATAGCTACATGGAAAGGCGCAGCATT
TGGAATAGATCTAAAAACCTTTGCAGATGTGGAACTTTCTGAAAGCGAATCTGTGATTACCGGCTCAATCAAAGAGGTGC
CTGAAGGAGATACTCGCCTTATAGAACGCTGCGTGGAACTTGTCCTTGGGAGATTCGGGCTGGAACTTGGAGGCACGATA
AGGACATGGAGTGAAATCCCCCTTGCAGGAGGGCTTAAGAGCAGCAGTGCAGCAGCAAACGCTTCAGTCCTTGCGACCCT
TCATGCAGTGGGGGAAACAATGCCCTCTCTTGAGATCATAAAACTGGGTGTAAGGGCTGCAAAAGAAGTGGGAGTTACTG
TCACTGGAGCATTTGACGATGCCTGCGCTTCTTTTCTGGGTGGTATTGTAATTACCGATAACCGGAATATGAAACTCATC
AAACGTGAAGAAGCCGATTCAAGAGTCCTTATATTCGCCCCATCAAAAAAGGCTTTCAGCGCGGACACGAATGTAAAACG
TTCACGGCTGATAGCACCATATGTGGAAATGGCATACGAGCTTGCTCTCGCAGGAGATTATGAACGCGCAATGACGCTTA
ACGGCTTTCTTTACTGCGGAGCTCTCGGGTTTGATACGGAGTATATGCTCAGGGCTCTGGAATGCGGAGTAAAAGGGGTC
AGCCTTTCAGGGACAGGCCCTTCTTATGCAGCCCTGGTAAAAGCTGACCAGGTAAAAGAACTTAAGTCTGCGTGGGAAAG
CTGCGGCATGGAGGGAAGAGTCATAGAAACCAGTATAAATAACAGTGGCGCAATATCCTTTAACAGGGAGGGGTCCTCTT
GA

Upstream 100 bases:

>100_bases
GTCTTTCATTACGAGGAATAAATCCAGAGTCCTGTATTTAAACCTCACTTTTCTCCGGACGGAGGTAAAAAATATTAAAG
AGCAGAGCATTCTGGACGTA

Downstream 100 bases:

>100_bases
GTGAACTTGAAGCTGTCCGCAAAGAAATAGAGGAGATTGACAGGGAAATCCTTTCCCTTATTGATAAAAGGGTTAACCTT
GCTGAAAAAGTGCTTGAATC

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTLEGHACAFGAGTIINAIATWKGAAFGIDLKTFADVELSESESVITGSIKEVPEGDTRLIERCVELVLGRFGLELGGTI
RTWSEIPLAGGLKSSSAAANASVLATLHAVGETMPSLEIIKLGVRAAKEVGVTVTGAFDDACASFLGGIVITDNRNMKLI
KREEADSRVLIFAPSKKAFSADTNVKRSRLIAPYVEMAYELALAGDYERAMTLNGFLYCGALGFDTEYMLRALECGVKGV
SLSGTGPSYAALVKADQVKELKSAWESCGMEGRVIETSINNSGAISFNREGSS

Sequences:

>Translated_293_residues
MTLEGHACAFGAGTIINAIATWKGAAFGIDLKTFADVELSESESVITGSIKEVPEGDTRLIERCVELVLGRFGLELGGTI
RTWSEIPLAGGLKSSSAAANASVLATLHAVGETMPSLEIIKLGVRAAKEVGVTVTGAFDDACASFLGGIVITDNRNMKLI
KREEADSRVLIFAPSKKAFSADTNVKRSRLIAPYVEMAYELALAGDYERAMTLNGFLYCGALGFDTEYMLRALECGVKGV
SLSGTGPSYAALVKADQVKELKSAWESCGMEGRVIETSINNSGAISFNREGSS
>Mature_292_residues
TLEGHACAFGAGTIINAIATWKGAAFGIDLKTFADVELSESESVITGSIKEVPEGDTRLIERCVELVLGRFGLELGGTIR
TWSEIPLAGGLKSSSAAANASVLATLHAVGETMPSLEIIKLGVRAAKEVGVTVTGAFDDACASFLGGIVITDNRNMKLIK
REEADSRVLIFAPSKKAFSADTNVKRSRLIAPYVEMAYELALAGDYERAMTLNGFLYCGALGFDTEYMLRALECGVKGVS
LSGTGPSYAALVKADQVKELKSAWESCGMEGRVIETSINNSGAISFNREGSS

Specific function: Unknown

COG id: COG1685

COG function: function code EH; Archaeal shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROK_METMA (Q8PUH2)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_634386.1
- ProteinModelPortal:   Q8PUH2
- GeneID:   1480704
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_2362
- NMPDR:   fig|192952.1.peg.2362
- HOGENOM:   HBG646614
- OMA:   AFDDACA
- ProtClustDB:   PRK01123
- BioCyc:   MMAZ192952:MM2362-MONOMER
- BRENDA:   2.7.1.71
- GO:   GO:0005737
- HAMAP:   MF_00370
- InterPro:   IPR006204
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR010189
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF005758
- TIGRFAMs:   TIGR01920

Pfam domain/function: PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.71

Molecular weight: Translated: 30953; Mature: 30821

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEGHACAFGAGTIINAIATWKGAAFGIDLKTFADVELSESESVITGSIKEVPEGDTRL
CCCCCCEEEECHHHHHHHHHHCCCCEEEEEHHHEECCEECCCCCEEECCHHHCCCCHHHH
IERCVELVLGRFGLELGGTIRTWSEIPLAGGLKSSSAAANASVLATLHAVGETMPSLEII
HHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
KLGVRAAKEVGVTVTGAFDDACASFLGGIVITDNRNMKLIKREEADSRVLIFAPSKKAFS
HHHHHHHHHCCEEEEECCHHHHHHHHCCEEEECCCCEEEEEECCCCCEEEEEECCCCCCC
ADTNVKRSRLIAPYVEMAYELALAGDYERAMTLNGFLYCGALGFDTEYMLRALECGVKGV
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEECCEEEEEEECCCHHHHHHHHHCCCCEE
SLSGTGPSYAALVKADQVKELKSAWESCGMEGRVIETSINNSGAISFNREGSS
EECCCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCC
>Mature Secondary Structure 
TLEGHACAFGAGTIINAIATWKGAAFGIDLKTFADVELSESESVITGSIKEVPEGDTRL
CCCCCEEEECHHHHHHHHHHCCCCEEEEEHHHEECCEECCCCCEEECCHHHCCCCHHHH
IERCVELVLGRFGLELGGTIRTWSEIPLAGGLKSSSAAANASVLATLHAVGETMPSLEII
HHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
KLGVRAAKEVGVTVTGAFDDACASFLGGIVITDNRNMKLIKREEADSRVLIFAPSKKAFS
HHHHHHHHHCCEEEEECCHHHHHHHHCCEEEECCCCEEEEEECCCCCEEEEEECCCCCCC
ADTNVKRSRLIAPYVEMAYELALAGDYERAMTLNGFLYCGALGFDTEYMLRALECGVKGV
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEECCEEEEEEECCCHHHHHHHHHCCCCEE
SLSGTGPSYAALVKADQVKELKSAWESCGMEGRVIETSINNSGAISFNREGSS
EECCCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824