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The map label for this gene is pcm [C]

Identifier: 21228448

GI number: 21228448

Start: 2804059

End: 2804898

Strand: Direct

Name: pcm [C]

Synonym: MM_2346

Alternate gene names: 21228448

Gene position: 2804059-2804898 (Clockwise)

Preceding gene: 21228447

Following gene: 21228451

Centisome position: 68.45

GC content: 44.17

Gene sequence:

>840_bases
ATGGACTCACAAGGGATTGACTGGAACAAAGTTTGGAAAGATACTCTGGAAAAGCAACTGGCATTAAATAGAAATGTCGA
TTGCTCGAGTATATGGCACGGCGAGAAAAATGCCAGGCAGTTCTGGAGGATGTTTCAGGATGATAAGGCAAGGGCAGTAA
CAGAGAAGAGAATAAAGGATCTGAAACTCTCTCCTGATTCAAGAGTTCTTGATATCGGATCCGGGCCCGGAACACTTGCA
ATTCCGATTGCGAGGCAGGTGGCTCATGTAACCGCGGTTGAACCCTCGGACGGCATGATGAATGTCATGCAGGAAAATAT
CAAAGAATATGGAATCGAAAACATCGATACCGTACACAAAGATTGGGAAGCAGTCGATGTAAGGTCAGATCTTTCCGCTC
CTTATGACGTGGTTTTTGCTTCTTATTCCCTGGGCATGAAAGACATAAGGGCTTCGATACGGAAAATGATGGATGCCTCT
TCGAAGTATATTTATCTATACTGGTTCGCAGGGGAAACCTCCTGGGATATCCACTCGCGAAAACTCTGGCCATCTCTTCA
CGGATGTGAGTATCAACCGGCTCCGAAGTGCAATGTTCTCTATAATGTGTTGTATGACATGGAAATCTACCCGAATGTGA
GTGTTTTTCCCTTCGAACATATTCACAGGTATGCAAACTTTGAGGAAGCTGTTGAGGATTTTAAATCATACTACAACGTT
ACCTCAGATTCCCAGGAAACCGTTCTCAGGGACTACCTTGAAGGAATACTTGAACCAGATAACGGAAACCTTATACAAAG
GGGATGGTCCACTAGGGTAAAGATGTGGTGGGAAATATAA

Upstream 100 bases:

>100_bases
TAGTAATGCATGTATGTTAATATTTATTATTATTTTTGTATTACTGAGAATTCCAAGGTAATACTGGGTATTTCAAGATA
AAGTCTGTTGAGGTTGTAAT

Downstream 100 bases:

>100_bases
ACTTAAAGATTGTCCAGTAAAAATGGAGGCATTTTTTCTTGGTACAGCTTCTAAGCAAATGGCTTAATCATCACTTTATT
TTGAAGAAATGGGAAAAGAT

Product: methyltransferase

Products: S-adenosyl-L-homocysteine; protein L-isoaspartate alpha-methylester [C]

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MDSQGIDWNKVWKDTLEKQLALNRNVDCSSIWHGEKNARQFWRMFQDDKARAVTEKRIKDLKLSPDSRVLDIGSGPGTLA
IPIARQVAHVTAVEPSDGMMNVMQENIKEYGIENIDTVHKDWEAVDVRSDLSAPYDVVFASYSLGMKDIRASIRKMMDAS
SKYIYLYWFAGETSWDIHSRKLWPSLHGCEYQPAPKCNVLYNVLYDMEIYPNVSVFPFEHIHRYANFEEAVEDFKSYYNV
TSDSQETVLRDYLEGILEPDNGNLIQRGWSTRVKMWWEI

Sequences:

>Translated_279_residues
MDSQGIDWNKVWKDTLEKQLALNRNVDCSSIWHGEKNARQFWRMFQDDKARAVTEKRIKDLKLSPDSRVLDIGSGPGTLA
IPIARQVAHVTAVEPSDGMMNVMQENIKEYGIENIDTVHKDWEAVDVRSDLSAPYDVVFASYSLGMKDIRASIRKMMDAS
SKYIYLYWFAGETSWDIHSRKLWPSLHGCEYQPAPKCNVLYNVLYDMEIYPNVSVFPFEHIHRYANFEEAVEDFKSYYNV
TSDSQETVLRDYLEGILEPDNGNLIQRGWSTRVKMWWEI
>Mature_279_residues
MDSQGIDWNKVWKDTLEKQLALNRNVDCSSIWHGEKNARQFWRMFQDDKARAVTEKRIKDLKLSPDSRVLDIGSGPGTLA
IPIARQVAHVTAVEPSDGMMNVMQENIKEYGIENIDTVHKDWEAVDVRSDLSAPYDVVFASYSLGMKDIRASIRKMMDAS
SKYIYLYWFAGETSWDIHSRKLWPSLHGCEYQPAPKCNVLYNVLYDMEIYPNVSVFPFEHIHRYANFEEAVEDFKSYYNV
TSDSQETVLRDYLEGILEPDNGNLIQRGWSTRVKMWWEI

Specific function: Catalyzes The Methyl Esterification Of L-Isoaspartyl Residues In Peptides And Proteins That Result From Spontaneous Decomposition Of Normal L-Aspartyl And L-Asparaginyl Residues. It Plays A Role In The Repair And/Or Degradation Of Damaged Proteins. This

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: 2.1.1.77 [C]

Molecular weight: Translated: 32482; Mature: 32482

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSQGIDWNKVWKDTLEKQLALNRNVDCSSIWHGEKNARQFWRMFQDDKARAVTEKRIKD
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHH
LKLSPDSRVLDIGSGPGTLAIPIARQVAHVTAVEPSDGMMNVMQENIKEYGIENIDTVHK
CCCCCCCCEEECCCCCCEEEEHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCHHHHHHC
DWEAVDVRSDLSAPYDVVFASYSLGMKDIRASIRKMMDASSKYIYLYWFAGETSWDIHSR
CCHHEEHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCH
KLWPSLHGCEYQPAPKCNVLYNVLYDMEIYPNVSVFPFEHIHRYANFEEAVEDFKSYYNV
HCCCCCCCCCCCCCCCHHHHHHHHHCCEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHCC
TSDSQETVLRDYLEGILEPDNGNLIQRGWSTRVKMWWEI
CCCCHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEEECC
>Mature Secondary Structure
MDSQGIDWNKVWKDTLEKQLALNRNVDCSSIWHGEKNARQFWRMFQDDKARAVTEKRIKD
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHH
LKLSPDSRVLDIGSGPGTLAIPIARQVAHVTAVEPSDGMMNVMQENIKEYGIENIDTVHK
CCCCCCCCEEECCCCCCEEEEHHHHHHHHHEEECCCCHHHHHHHHHHHHHCCCHHHHHHC
DWEAVDVRSDLSAPYDVVFASYSLGMKDIRASIRKMMDASSKYIYLYWFAGETSWDIHSR
CCHHEEHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCH
KLWPSLHGCEYQPAPKCNVLYNVLYDMEIYPNVSVFPFEHIHRYANFEEAVEDFKSYYNV
HCCCCCCCCCCCCCCCHHHHHHHHHCCEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHCC
TSDSQETVLRDYLEGILEPDNGNLIQRGWSTRVKMWWEI
CCCCHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-methionine; protein L-isoaspartate [C]

Specific reaction: S-Adenosyl-L-methionine + protein L-isoaspartate =S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methylester [C]

General reaction: Methyl group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]