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The map label for this gene is divJ [H]

Identifier: 21228280

GI number: 21228280

Start: 2582321

End: 2584762

Strand: Reverse

Name: divJ [H]

Synonym: MM_2178

Alternate gene names: 21228280

Gene position: 2584762-2582321 (Counterclockwise)

Preceding gene: 21228282

Following gene: 21228276

Centisome position: 63.1

GC content: 41.89

Gene sequence:

>2442_bases
ATGGAACTTACAGCAGCATATATTAAAGCAGGCCTTGAACAGAACGAGCGCTGCATCTGGCTTGTTCCGGACTTCCAGAG
TGCAGAAAAAGCGAAAAATTTACTTTCTAACTCTGATCTGGATATCGAAAACCGTATAGAGAAATCCAGGCTTAAGATAA
TTCCCCTGAAAGAGAAAGATGACCCTTCCATCAAACAGACAGAGACCTCAAGGATCTATTTTGACTGGAAAGCAGGGAAC
CCGCAGAAAGAGATAATCAAATTCATTCACGCAGGAAACTGGAGATATCTGCGCATTAACCTTGAGGTTGGAGCCTTTGG
AAAGTCAATAACAACTTCCCTTAAGGAGCTGAGGTGCGTCCTTGCTGAGAATATGCCTGAAAAGAAAATCAGGCCACTCT
TTATGATAAAAGAGGAAGATCTTTCCGCGGAAGAGGTTTTCAACCTTATAGAAGCCGGAGAAAAACTTGTAATTAAAAGA
GAAGGTAAGTGGAAGTTTCTTAAAATAAAACAAGAAAGCCCGGACAAAAAATTTAAGACATTGATTGAGAATTCAGGTGA
CTCAATTCTTATACACGATATGAATGGAAAAGTTCTCGAAGCAAACCATGTAGCCTGTGAAACCTTTGGATATACTCGCA
GTAAAATGATCGGAAAACACATAAAAGATCTAAGGACCAGCATCCACCTTATAGAGTTCGGGCAGCAGATAGAAAAACTG
AAGCAAACAGGATATTTTACTTTTGAAATGGATTCACTGCGGAGAGACGGCACGGTTATTCCTCAAGAAGTCAATAACAG
GTTGATTGAATACGACGGGGAAACTGCCGTACTATCCATAGGCAGAGATATCAGCAAACGCAGACAGACCGAAAAAGCCC
TGAGAGATTCCGAAAGAAAATACCGCATGCTTTTTGAAGAATTCCCCGGGGGAATAGCCCAGTTCGACAAGTACGGGACT
ATCATCGTATGTAACGAAAATTTTGTAAATTTTACGGGCAGTGGTGAGAACGAAAAACTCATTTTCAATTTGCTGAACCC
TCCGGAAGAAAAGAAACAGGAGGAAAAAGGCTTCACCTGTCTCCCCGAAGTTCCCATCCATTGCGACATAAAATATATTT
CCAGCCTTGAGGACGAAATTATACCCGGTGAGATAACCTATAAGCCTCTGATTTCGGAAAATTCCAGATTTAACGGCGGC
ATTATTCTTGTGGAGGACCTGACCGAAGTAAAAAGGCTGGAAGCAGTCAGGCTTCAGCAAACAGAGACCCTCAGAAAGCT
TGTTGGTTCAATTCCTGTACCTGCATTCTGTAAGGACAGAAACGGGGTATATATTGCCTGCAATAAGGGTTTTGAAAACC
TTCTGCGGGTGCAAAAACAGGATATTATCGGAAAGCACATCTACGATTTCATCCCCCATAAAATTGCTGAAAATTACCAT
GCAATGGATATAGGACTTGTAAAACACAAAAGAAACCATGTATATGAGACCTCTTTGAAATTTCCTGACGGCTCAGTACA
CCAGGTGATGCTCAATAAATTCATATTCAGCGGCGTGACAGAAGAAGACTCGGTTCTCCTGGGGATTATGATTGACATAA
CAGAACGAAAGCAGGCTGAAGAGAGAATGCTTCAGGCGAAAATGGTTGCTGAAGCCGCAAACCGGGCGAAAACCACCTTC
ATTGTCAATATGAGCCATGAGCTGAGAACTCCTCTGAACGCAGTTATAGGGTTCTCTGATCTCCTTTTAAGTGAAACTGT
CGGTCCTCTTAATGAGAAACAGAAAAGGTACACCGAAAATATTTCAAAGAGCGGGAACCACCTTCTCGACGTAATCAATG
ACGTGCTGGACATCTCAAAGCTTGAACTGGGAAATATTGAGCTCTACTACGAAACAGTGGACGTTGCAGGGATAATTGAA
GAAGTCCAGAGGGTGCTCTCTCCCCTTTCAGCGGATAAAAATATTATAATAGAATCGTATATCGAGAAGGACCTGAAAAC
TGTAATTGCCGACAGAGTAAAACTAAAACAGATCCTTTACAATATTTTGAACAATGCCATAAAGTTCTCATCAGAAAACG
GGAAAGTAAACATTTATGCAGAACCCAGAGAAGACATGATTGAGATCAGCGTAGAGGACGAAGGCATTGGCATTCAGGAA
TCCGATTACGAAAAAGTCTTCCAGCCATTCGTGCAGATTGATGAGTCCATATCCAGAAAACATGGAGGTGTTGGACTCGG
GCTTGCACTCGTCAAAAGGTTCGTAGAGCTCCACGGAGGAAAGGTGTGGGTTAAAGCCAGCCCGGGTGGAGGAAGTATAT
TCACATTCAGGATCCCAAAAAATCCCCAGAACAAAATTAGGGAATACATGAGTCCTGTACAAATACCGTATAATCTTGAA
ATTGAAAGAGAAAAAGAGAAAATTAAGGAAGAAGCAAACTAA

Upstream 100 bases:

>100_bases
GTTAAATATTCAAAAGAGAAAAGTCAAATCAGAGTTCTGTTTCTGTTCGTCTATCCCGGCAAATGGCCTCGCTGCAGTTT
ATAAGTATCCGGAAGAAAAG

Downstream 100 bases:

>100_bases
ACTTAATTCAGTAAATGAATGTAAAGAGAAAAATGAATGATAAATGTAAAGAGAAAAATGAATGCGGTAAGGAAAAAATG
AAGTAATAGATAATAAAAAA

Product: two component system histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 813; Mature: 813

Protein sequence:

>813_residues
MELTAAYIKAGLEQNERCIWLVPDFQSAEKAKNLLSNSDLDIENRIEKSRLKIIPLKEKDDPSIKQTETSRIYFDWKAGN
PQKEIIKFIHAGNWRYLRINLEVGAFGKSITTSLKELRCVLAENMPEKKIRPLFMIKEEDLSAEEVFNLIEAGEKLVIKR
EGKWKFLKIKQESPDKKFKTLIENSGDSILIHDMNGKVLEANHVACETFGYTRSKMIGKHIKDLRTSIHLIEFGQQIEKL
KQTGYFTFEMDSLRRDGTVIPQEVNNRLIEYDGETAVLSIGRDISKRRQTEKALRDSERKYRMLFEEFPGGIAQFDKYGT
IIVCNENFVNFTGSGENEKLIFNLLNPPEEKKQEEKGFTCLPEVPIHCDIKYISSLEDEIIPGEITYKPLISENSRFNGG
IILVEDLTEVKRLEAVRLQQTETLRKLVGSIPVPAFCKDRNGVYIACNKGFENLLRVQKQDIIGKHIYDFIPHKIAENYH
AMDIGLVKHKRNHVYETSLKFPDGSVHQVMLNKFIFSGVTEEDSVLLGIMIDITERKQAEERMLQAKMVAEAANRAKTTF
IVNMSHELRTPLNAVIGFSDLLLSETVGPLNEKQKRYTENISKSGNHLLDVINDVLDISKLELGNIELYYETVDVAGIIE
EVQRVLSPLSADKNIIIESYIEKDLKTVIADRVKLKQILYNILNNAIKFSSENGKVNIYAEPREDMIEISVEDEGIGIQE
SDYEKVFQPFVQIDESISRKHGGVGLGLALVKRFVELHGGKVWVKASPGGGSIFTFRIPKNPQNKIREYMSPVQIPYNLE
IEREKEKIKEEAN

Sequences:

>Translated_813_residues
MELTAAYIKAGLEQNERCIWLVPDFQSAEKAKNLLSNSDLDIENRIEKSRLKIIPLKEKDDPSIKQTETSRIYFDWKAGN
PQKEIIKFIHAGNWRYLRINLEVGAFGKSITTSLKELRCVLAENMPEKKIRPLFMIKEEDLSAEEVFNLIEAGEKLVIKR
EGKWKFLKIKQESPDKKFKTLIENSGDSILIHDMNGKVLEANHVACETFGYTRSKMIGKHIKDLRTSIHLIEFGQQIEKL
KQTGYFTFEMDSLRRDGTVIPQEVNNRLIEYDGETAVLSIGRDISKRRQTEKALRDSERKYRMLFEEFPGGIAQFDKYGT
IIVCNENFVNFTGSGENEKLIFNLLNPPEEKKQEEKGFTCLPEVPIHCDIKYISSLEDEIIPGEITYKPLISENSRFNGG
IILVEDLTEVKRLEAVRLQQTETLRKLVGSIPVPAFCKDRNGVYIACNKGFENLLRVQKQDIIGKHIYDFIPHKIAENYH
AMDIGLVKHKRNHVYETSLKFPDGSVHQVMLNKFIFSGVTEEDSVLLGIMIDITERKQAEERMLQAKMVAEAANRAKTTF
IVNMSHELRTPLNAVIGFSDLLLSETVGPLNEKQKRYTENISKSGNHLLDVINDVLDISKLELGNIELYYETVDVAGIIE
EVQRVLSPLSADKNIIIESYIEKDLKTVIADRVKLKQILYNILNNAIKFSSENGKVNIYAEPREDMIEISVEDEGIGIQE
SDYEKVFQPFVQIDESISRKHGGVGLGLALVKRFVELHGGKVWVKASPGGGSIFTFRIPKNPQNKIREYMSPVQIPYNLE
IEREKEKIKEEAN
>Mature_813_residues
MELTAAYIKAGLEQNERCIWLVPDFQSAEKAKNLLSNSDLDIENRIEKSRLKIIPLKEKDDPSIKQTETSRIYFDWKAGN
PQKEIIKFIHAGNWRYLRINLEVGAFGKSITTSLKELRCVLAENMPEKKIRPLFMIKEEDLSAEEVFNLIEAGEKLVIKR
EGKWKFLKIKQESPDKKFKTLIENSGDSILIHDMNGKVLEANHVACETFGYTRSKMIGKHIKDLRTSIHLIEFGQQIEKL
KQTGYFTFEMDSLRRDGTVIPQEVNNRLIEYDGETAVLSIGRDISKRRQTEKALRDSERKYRMLFEEFPGGIAQFDKYGT
IIVCNENFVNFTGSGENEKLIFNLLNPPEEKKQEEKGFTCLPEVPIHCDIKYISSLEDEIIPGEITYKPLISENSRFNGG
IILVEDLTEVKRLEAVRLQQTETLRKLVGSIPVPAFCKDRNGVYIACNKGFENLLRVQKQDIIGKHIYDFIPHKIAENYH
AMDIGLVKHKRNHVYETSLKFPDGSVHQVMLNKFIFSGVTEEDSVLLGIMIDITERKQAEERMLQAKMVAEAANRAKTTF
IVNMSHELRTPLNAVIGFSDLLLSETVGPLNEKQKRYTENISKSGNHLLDVINDVLDISKLELGNIELYYETVDVAGIIE
EVQRVLSPLSADKNIIIESYIEKDLKTVIADRVKLKQILYNILNNAIKFSSENGKVNIYAEPREDMIEISVEDEGIGIQE
SDYEKVFQPFVQIDESISRKHGGVGLGLALVKRFVELHGGKVWVKASPGGGSIFTFRIPKNPQNKIREYMSPVQIPYNLE
IEREKEKIKEEAN

Specific function: Kinase required for the regulation of cell division and differentiation. Makes part of a signal transduction pathway, activating pleD by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=43.0962343096234, Blast_Score=178, Evalue=1e-45,
Organism=Escherichia coli, GI48994928, Length=365, Percent_Identity=31.2328767123288, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI145693157, Length=274, Percent_Identity=31.3868613138686, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI87081816, Length=252, Percent_Identity=32.1428571428571, Blast_Score=136, Evalue=5e-33,
Organism=Escherichia coli, GI1788549, Length=380, Percent_Identity=27.8947368421053, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788713, Length=415, Percent_Identity=26.2650602409639, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=29.646017699115, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=24.4979919678715, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=24.6861924686192, Blast_Score=94, Evalue=5e-20,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=27.027027027027, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1790861, Length=222, Percent_Identity=27.9279279279279, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1790346, Length=244, Percent_Identity=29.0983606557377, Blast_Score=87, Evalue=6e-18,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=26.2008733624454, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=28.9473684210526, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788279, Length=204, Percent_Identity=30.8823529411765, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=23.3480176211454, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=222, Percent_Identity=28.8288288288288, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=223, Percent_Identity=28.2511210762332, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790300, Length=363, Percent_Identity=22.5895316804408, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=106, Percent_Identity=37.7358490566038, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 92993; Mature: 92993

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELTAAYIKAGLEQNERCIWLVPDFQSAEKAKNLLSNSDLDIENRIEKSRLKIIPLKEKD
CCCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHCCEEEEECCCCC
DPSIKQTETSRIYFDWKAGNPQKEIIKFIHAGNWRYLRINLEVGAFGKSITTSLKELRCV
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHH
LAENMPEKKIRPLFMIKEEDLSAEEVFNLIEAGEKLVIKREGKWKFLKIKQESPDKKFKT
HHCCCCHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCCHHHHH
LIENSGDSILIHDMNGKVLEANHVACETFGYTRSKMIGKHIKDLRTSIHLIEFGQQIEKL
HHHCCCCEEEEECCCCCEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQTGYFTFEMDSLRRDGTVIPQEVNNRLIEYDGETAVLSIGRDISKRRQTEKALRDSERK
HHCCCEEEEHHCCCCCCCCCCHHHCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHH
YRMLFEEFPGGIAQFDKYGTIIVCNENFVNFTGSGENEKLIFNLLNPPEEKKQEEKGFTC
HHHHHHHCCCCHHHHCCCCEEEEECCCEEEECCCCCCCEEEEEECCCCHHHHHHHCCCEE
LPEVPIHCDIKYISSLEDEIIPGEITYKPLISENSRFNGGIILVEDLTEVKRLEAVRLQQ
CCCCCCEECHHHHHCCHHCCCCCCEEECCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHH
TETLRKLVGSIPVPAFCKDRNGVYIACNKGFENLLRVQKQDIIGKHIYDFIPHKIAENYH
HHHHHHHHCCCCCCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AMDIGLVKHKRNHVYETSLKFPDGSVHQVMLNKFIFSGVTEEDSVLLGIMIDITERKQAE
EEEEHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEEHHHHHHH
ERMLQAKMVAEAANRAKTTFIVNMSHELRTPLNAVIGFSDLLLSETVGPLNEKQKRYTEN
HHHHHHHHHHHHHCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ISKSGNHLLDVINDVLDISKLELGNIELYYETVDVAGIIEEVQRVLSPLSADKNIIIESY
HHCCCHHHHHHHHHHHHHHHEEECCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IEKDLKTVIADRVKLKQILYNILNNAIKFSSENGKVNIYAEPREDMIEISVEDEGIGIQE
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCC
SDYEKVFQPFVQIDESISRKHGGVGLGLALVKRFVELHGGKVWVKASPGGGSIFTFRIPK
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCC
NPQNKIREYMSPVQIPYNLEIEREKEKIKEEAN
CHHHHHHHHHCCCCCCCCEEECHHHHHHHHCCC
>Mature Secondary Structure
MELTAAYIKAGLEQNERCIWLVPDFQSAEKAKNLLSNSDLDIENRIEKSRLKIIPLKEKD
CCCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHCCEEEEECCCCC
DPSIKQTETSRIYFDWKAGNPQKEIIKFIHAGNWRYLRINLEVGAFGKSITTSLKELRCV
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHHHH
LAENMPEKKIRPLFMIKEEDLSAEEVFNLIEAGEKLVIKREGKWKFLKIKQESPDKKFKT
HHCCCCHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCCHHHHH
LIENSGDSILIHDMNGKVLEANHVACETFGYTRSKMIGKHIKDLRTSIHLIEFGQQIEKL
HHHCCCCEEEEECCCCCEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQTGYFTFEMDSLRRDGTVIPQEVNNRLIEYDGETAVLSIGRDISKRRQTEKALRDSERK
HHCCCEEEEHHCCCCCCCCCCHHHCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHH
YRMLFEEFPGGIAQFDKYGTIIVCNENFVNFTGSGENEKLIFNLLNPPEEKKQEEKGFTC
HHHHHHHCCCCHHHHCCCCEEEEECCCEEEECCCCCCCEEEEEECCCCHHHHHHHCCCEE
LPEVPIHCDIKYISSLEDEIIPGEITYKPLISENSRFNGGIILVEDLTEVKRLEAVRLQQ
CCCCCCEECHHHHHCCHHCCCCCCEEECCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHH
TETLRKLVGSIPVPAFCKDRNGVYIACNKGFENLLRVQKQDIIGKHIYDFIPHKIAENYH
HHHHHHHHCCCCCCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AMDIGLVKHKRNHVYETSLKFPDGSVHQVMLNKFIFSGVTEEDSVLLGIMIDITERKQAE
EEEEHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEEHHHHHHH
ERMLQAKMVAEAANRAKTTFIVNMSHELRTPLNAVIGFSDLLLSETVGPLNEKQKRYTEN
HHHHHHHHHHHHHCCCEEEEEEECCHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
ISKSGNHLLDVINDVLDISKLELGNIELYYETVDVAGIIEEVQRVLSPLSADKNIIIESY
HHCCCHHHHHHHHHHHHHHHEEECCEEEEEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IEKDLKTVIADRVKLKQILYNILNNAIKFSSENGKVNIYAEPREDMIEISVEDEGIGIQE
HHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCEEEEEECCCCCCCCC
SDYEKVFQPFVQIDESISRKHGGVGLGLALVKRFVELHGGKVWVKASPGGGSIFTFRIPK
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCC
NPQNKIREYMSPVQIPYNLEIEREKEKIKEEAN
CHHHHHHHHHCCCCCCCCEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1438215; 11259647 [H]