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The map label for this gene is cdhA1

Identifier: 21228191

GI number: 21228191

Start: 2489804

End: 2492224

Strand: Reverse

Name: cdhA1

Synonym: MM_2089

Alternate gene names: 21228191

Gene position: 2492224-2489804 (Counterclockwise)

Preceding gene: 21228193

Following gene: 21228190

Centisome position: 60.84

GC content: 51.22

Gene sequence:

>2421_bases
ATGAGCAAATTAACTACTGGGAGTTTTTCAATAGAAGATCTTGAATCCGTTCAGATCACTATCAATAATATTGTAGGGGC
AGCAAAGGAGGCTGCAGAAGAAAAAACAAAAGAGCTCGGTCATATGGGCCCAACTCCGTTCCCAGGTCTTGAAACCTACA
GGGACGACTGGAACCTCAAATTGCTCGACCGCTATGAGCCTGTTGTCACCCCTATGTGTGATCAGTGCTGTTACTGCACA
TACGGTCCCTGTGACCTCTCAAACAACAAGAGAGGTGCCTGTGGTATCGACATGCTTGGCCACAACGGAAGGGAATTCTT
CCTCCGTGTAATTACAGGTACTGCCTGTCACGCAGCCCATGGCCGCCACCTGCTTGACCATCTGATTGAAGTCTTTGGAG
AAGAGTTACCTCTCAACCTCGGGCAATCCGATGTCCTGACCCCCAATATCACAATTACCACCGGGCAGAGACCACAGACC
CTTGGAGAAATCAAACCTGCAATGGAACATGTTGAAGAGCAGCTAACCCAGCTCCTTGCAACCGTCCACGCAGGGCAGGA
ATCCGCAGAGATCGACTACGACTCAAAGGCTCTTTTCAGTGGAAGCCTGGACCACGTAGGAATGGAAATTTCCGATATAG
TCCAGATCGCAGCCCTCGACTTCCCGAAGGCCGACCCAGAAGCCCCCCTCATTGAAATGGGTATGGGAACAATTGACAAG
GACAAGCCATTCCTCTGTGTGATCGGACACAATGTAGGCGGTGTAACCTACATGATGGACTACATGGAAGAACACGAATT
GACCGACAAGGTAGAACTCGGTGGGCTCTGCTGTACCGCAATCGACCTTACAAGGTACAAGGAAGCCGACAGGAGACCAC
CATACACCAAAGTCGTTGGTTCCATGTCCAAAGAGCTCAAGATCATCCGCTCTGGAATGCCTGATGTCATTGTCGTTGAC
GAACAGTGCGTCCGTGGTGACATTGTACCCGAAGCCCAGAAACTCAAGATTCCGGTCATCGCATCAAATGCAAAGATTAT
GTATGGTCTTCCCAACAGGACCGATGCCGGCGTTGAAGAGACAATTGAGGAACTCAAGTCCGGAGCAATTCCCGGTGCAG
TGATCCTTGACTACGAAAAGCTTGGGGAAATCTCCGTAAGGCTCGCTCAGGAAATGCACCCGATCCGCGAAGCTGCTGGA
GTCAGGGAAATCCCATCCGATGAACAGCTAAAGGAATGGGTTGACAAGTGTGCCGACTGTGGAGCCTGCTATCTGGCATG
CCCGATTGAGCTGGACATTCCGGAAGCCATGAAGTTCGCCAAGCAGGGAGATTTCAGCTATCTTGAAGACCTCCACGATG
CATGTATCGGCTGCCGCCGCTGCGAACAGGTCTGTAAGAAGGAAATCCCAATCCTTAGTGTCATCGAAAAGGCATCACAG
AAGATTATCGCTGAGGAAAAAGGCTGGATGAGAGCCGGCAGAGGTCAGGTATCTGACGCTGAAATCCGTGCAGAAGGTCT
TAACCTCGTCATGGGTACAACCCCCGGTATCATCGCAATCATCGGATGTCCGAACTATTCTGATTGTGCAAAAGCCGTTT
ACTACATTGCAGAGGAGTTCCTGAAGAGAAACTACATCGTTGTTGGTACCGGCTGTGGGTCCATGGACATGGGTATGTAC
AAGGACGAAGACGGCAAGACGCTTTATGAGAGATTCCCGGGAGGTTTCCAGTCCGGAGGACTTGTCAACATAGGATCATG
TGTCTCGAACGCCCATATCACCGGAGCCGCTCAGAAAGTAGCCGGAATTTTCGGTGGCAGAACCATGGAAGGCAACCTGG
CGGAAATTGCGGACTATGTCCTTAACCGTGTTGGTGCCTGCGGACTTGCATGGGGTGCATTCTCTCAGAAAGCTTCCTCA
ATTGGTACAGGATGTAACATCTACGGTATCCCTGCCGTGCTCGGTGCTCACAGCTCCAAGTACAGGAGAGCCCTGATTGC
AAAGAACTATGATGAGTCCAAGTGGAAAGTCTACGACGCCAGAAACGGCGAGGAGATGCCAATCCCACCAGCGCCAGAAT
TCCTTCTGACCACAGCAGAGACCTGGCAGGAAGCAATCCCGATGATGGCAAAAGCCTGTCTCCGCCCGTCCGACAACAGC
CTGGGCAGATCTATTAAGCTGACTCACTGGATGGAACTCCACGACAAATACATCGGCGGACTGCCCGAGGACTGGTGGAA
GTTTATCAGGACAGAAGCCGACCTTCCACTTGCCAAACGTGCAGATCTCATGAAAAAACTCGAAGCAGAACGCGGATGGG
AAATTGACTGGAAGAAGAAGAAGATCATATCTGGTCCGAAGATCAAGTTCGACGTATCGGCACAGCCCACTAACCTCAAG
AGACTCTGTAAGGGGGCCTGA

Upstream 100 bases:

>100_bases
AAAGTCAAAAACGATCTCTAAAAAAAGTCATTTAAGTAGCTGAAGCTTTCAAGAATCGTCGGTAAAGTGACTTTAAGTAT
ATTTAGGAGGTAAAGCTAAA

Downstream 100 bases:

>100_bases
AAATGGTTGACACAACAAAGAACACCAAGCTCTTTACCAGCTACGGGGTGACTACCTCCAAAGCAGTCAACCCTGACATG
GTAGCTAAGATGATCTCCAA

Product: acetyl-CoA decarbonylase/synthase complex subunit alpha

Products: NA

Alternate protein names: ACDS complex subunit alpha 1; ACDS complex carbon monoxide dehydrogenase 1; ACDS CODH 1

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MSKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKTKELGHMGPTPFPGLETYRDDWNLKLLDRYEPVVTPMCDQCCYCT
YGPCDLSNNKRGACGIDMLGHNGREFFLRVITGTACHAAHGRHLLDHLIEVFGEELPLNLGQSDVLTPNITITTGQRPQT
LGEIKPAMEHVEEQLTQLLATVHAGQESAEIDYDSKALFSGSLDHVGMEISDIVQIAALDFPKADPEAPLIEMGMGTIDK
DKPFLCVIGHNVGGVTYMMDYMEEHELTDKVELGGLCCTAIDLTRYKEADRRPPYTKVVGSMSKELKIIRSGMPDVIVVD
EQCVRGDIVPEAQKLKIPVIASNAKIMYGLPNRTDAGVEETIEELKSGAIPGAVILDYEKLGEISVRLAQEMHPIREAAG
VREIPSDEQLKEWVDKCADCGACYLACPIELDIPEAMKFAKQGDFSYLEDLHDACIGCRRCEQVCKKEIPILSVIEKASQ
KIIAEEKGWMRAGRGQVSDAEIRAEGLNLVMGTTPGIIAIIGCPNYSDCAKAVYYIAEEFLKRNYIVVGTGCGSMDMGMY
KDEDGKTLYERFPGGFQSGGLVNIGSCVSNAHITGAAQKVAGIFGGRTMEGNLAEIADYVLNRVGACGLAWGAFSQKASS
IGTGCNIYGIPAVLGAHSSKYRRALIAKNYDESKWKVYDARNGEEMPIPPAPEFLLTTAETWQEAIPMMAKACLRPSDNS
LGRSIKLTHWMELHDKYIGGLPEDWWKFIRTEADLPLAKRADLMKKLEAERGWEIDWKKKKIISGPKIKFDVSAQPTNLK
RLCKGA

Sequences:

>Translated_806_residues
MSKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKTKELGHMGPTPFPGLETYRDDWNLKLLDRYEPVVTPMCDQCCYCT
YGPCDLSNNKRGACGIDMLGHNGREFFLRVITGTACHAAHGRHLLDHLIEVFGEELPLNLGQSDVLTPNITITTGQRPQT
LGEIKPAMEHVEEQLTQLLATVHAGQESAEIDYDSKALFSGSLDHVGMEISDIVQIAALDFPKADPEAPLIEMGMGTIDK
DKPFLCVIGHNVGGVTYMMDYMEEHELTDKVELGGLCCTAIDLTRYKEADRRPPYTKVVGSMSKELKIIRSGMPDVIVVD
EQCVRGDIVPEAQKLKIPVIASNAKIMYGLPNRTDAGVEETIEELKSGAIPGAVILDYEKLGEISVRLAQEMHPIREAAG
VREIPSDEQLKEWVDKCADCGACYLACPIELDIPEAMKFAKQGDFSYLEDLHDACIGCRRCEQVCKKEIPILSVIEKASQ
KIIAEEKGWMRAGRGQVSDAEIRAEGLNLVMGTTPGIIAIIGCPNYSDCAKAVYYIAEEFLKRNYIVVGTGCGSMDMGMY
KDEDGKTLYERFPGGFQSGGLVNIGSCVSNAHITGAAQKVAGIFGGRTMEGNLAEIADYVLNRVGACGLAWGAFSQKASS
IGTGCNIYGIPAVLGAHSSKYRRALIAKNYDESKWKVYDARNGEEMPIPPAPEFLLTTAETWQEAIPMMAKACLRPSDNS
LGRSIKLTHWMELHDKYIGGLPEDWWKFIRTEADLPLAKRADLMKKLEAERGWEIDWKKKKIISGPKIKFDVSAQPTNLK
RLCKGA
>Mature_805_residues
SKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKTKELGHMGPTPFPGLETYRDDWNLKLLDRYEPVVTPMCDQCCYCTY
GPCDLSNNKRGACGIDMLGHNGREFFLRVITGTACHAAHGRHLLDHLIEVFGEELPLNLGQSDVLTPNITITTGQRPQTL
GEIKPAMEHVEEQLTQLLATVHAGQESAEIDYDSKALFSGSLDHVGMEISDIVQIAALDFPKADPEAPLIEMGMGTIDKD
KPFLCVIGHNVGGVTYMMDYMEEHELTDKVELGGLCCTAIDLTRYKEADRRPPYTKVVGSMSKELKIIRSGMPDVIVVDE
QCVRGDIVPEAQKLKIPVIASNAKIMYGLPNRTDAGVEETIEELKSGAIPGAVILDYEKLGEISVRLAQEMHPIREAAGV
REIPSDEQLKEWVDKCADCGACYLACPIELDIPEAMKFAKQGDFSYLEDLHDACIGCRRCEQVCKKEIPILSVIEKASQK
IIAEEKGWMRAGRGQVSDAEIRAEGLNLVMGTTPGIIAIIGCPNYSDCAKAVYYIAEEFLKRNYIVVGTGCGSMDMGMYK
DEDGKTLYERFPGGFQSGGLVNIGSCVSNAHITGAAQKVAGIFGGRTMEGNLAEIADYVLNRVGACGLAWGAFSQKASSI
GTGCNIYGIPAVLGAHSSKYRRALIAKNYDESKWKVYDARNGEEMPIPPAPEFLLTTAETWQEAIPMMAKACLRPSDNSL
GRSIKLTHWMELHDKYIGGLPEDWWKFIRTEADLPLAKRADLMKKLEAERGWEIDWKKKKIISGPKIKFDVSAQPTNLKR
LCKGA

Specific function: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy

COG id: COG1152

COG function: function code C; CO dehydrogenase/acetyl-CoA synthase alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDA1_METMA (Q49161)

Other databases:

- EMBL:   L26487
- EMBL:   AE008384
- RefSeq:   NP_634113.1
- ProteinModelPortal:   Q49161
- SMR:   Q49161
- GeneID:   1480431
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_2089
- NMPDR:   fig|192952.1.peg.2089
- HOGENOM:   HBG539676
- OMA:   PNITITT
- ProtClustDB:   PRK00941
- BioCyc:   MMAZ192952:MM2089-MONOMER
- BRENDA:   1.2.99.2
- GO:   GO:0005737
- GO:   GO:0015948
- HAMAP:   MF_01137
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR004460
- InterPro:   IPR016101
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004137
- InterPro:   IPR011254
- InterPro:   IPR016099
- Gene3D:   G3DSA:1.20.1270.30
- Gene3D:   G3DSA:1.10.1060.10
- Gene3D:   G3DSA:3.40.50.2030
- TIGRFAMs:   TIGR00314

Pfam domain/function: PF03063 Prismane; SSF46548 Helical_ferredxn; SSF56821 Prismane_like

EC number: =1.2.99.2

Molecular weight: Translated: 88584; Mature: 88453

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKTKELGHMGPTPFPGLETYRDDWNLK
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCEE
LLDRYEPVVTPMCDQCCYCTYGPCDLSNNKRGACGIDMLGHNGREFFLRVITGTACHAAH
EECCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHCCHHHHHH
GRHLLDHLIEVFGEELPLNLGQSDVLTPNITITTGQRPQTLGEIKPAMEHVEEQLTQLLA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
TVHAGQESAEIDYDSKALFSGSLDHVGMEISDIVQIAALDFPKADPEAPLIEMGMGTIDK
HHHCCCCCCCCCCCCHHHHCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCC
DKPFLCVIGHNVGGVTYMMDYMEEHELTDKVELGGLCCTAIDLTRYKEADRRPPYTKVVG
CCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCEEEHHHHHHHHHHHCCCCCHHHHHH
SMSKELKIIRSGMPDVIVVDEQCVRGDIVPEAQKLKIPVIASNAKIMYGLPNRTDAGVEE
HHHHHHHHHHCCCCCEEEECCHHHCCCCCCCHHHEEEEEEECCCEEEEECCCCCCCCHHH
TIEELKSGAIPGAVILDYEKLGEISVRLAQEMHPIREAAGVREIPSDEQLKEWVDKCADC
HHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
GACYLACPIELDIPEAMKFAKQGDFSYLEDLHDACIGCRRCEQVCKKEIPILSVIEKASQ
CCEEEECCEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KIIAEEKGWMRAGRGQVSDAEIRAEGLNLVMGTTPGIIAIIGCPNYSDCAKAVYYIAEEF
HHHHHHCCHHHCCCCCCCCHHHHHCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHH
LKRNYIVVGTGCGSMDMGMYKDEDGKTLYERFPGGFQSGGLVNIGSCVSNAHITGAAQKV
HHCCCEEEEECCCCCCCCCEECCCCCHHHHHCCCCCCCCCEEEHHHHHCCCCCCHHHHHH
AGIFGGRTMEGNLAEIADYVLNRVGACGLAWGAFSQKASSIGTGCNIYGIPAVLGAHSSK
HHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECHHHHCCCCHH
YRRALIAKNYDESKWKVYDARNGEEMPIPPAPEFLLTTAETWQEAIPMMAKACLRPSDNS
HHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHEEECHHHHHHHHHHHHHHHCCCCCCC
LGRSIKLTHWMELHDKYIGGLPEDWWKFIRTEADLPLAKRADLMKKLEAERGWEIDWKKK
CCCEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
KIISGPKIKFDVSAQPTNLKRLCKGA
HHCCCCCEEEECCCCCHHHHHHHCCC
>Mature Secondary Structure 
SKLTTGSFSIEDLESVQITINNIVGAAKEAAEEKTKELGHMGPTPFPGLETYRDDWNLK
CCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCEE
LLDRYEPVVTPMCDQCCYCTYGPCDLSNNKRGACGIDMLGHNGREFFLRVITGTACHAAH
EECCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHCCHHHHHH
GRHLLDHLIEVFGEELPLNLGQSDVLTPNITITTGQRPQTLGEIKPAMEHVEEQLTQLLA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
TVHAGQESAEIDYDSKALFSGSLDHVGMEISDIVQIAALDFPKADPEAPLIEMGMGTIDK
HHHCCCCCCCCCCCCHHHHCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCC
DKPFLCVIGHNVGGVTYMMDYMEEHELTDKVELGGLCCTAIDLTRYKEADRRPPYTKVVG
CCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCEEEHHHHHHHHHHHCCCCCHHHHHH
SMSKELKIIRSGMPDVIVVDEQCVRGDIVPEAQKLKIPVIASNAKIMYGLPNRTDAGVEE
HHHHHHHHHHCCCCCEEEECCHHHCCCCCCCHHHEEEEEEECCCEEEEECCCCCCCCHHH
TIEELKSGAIPGAVILDYEKLGEISVRLAQEMHPIREAAGVREIPSDEQLKEWVDKCADC
HHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
GACYLACPIELDIPEAMKFAKQGDFSYLEDLHDACIGCRRCEQVCKKEIPILSVIEKASQ
CCEEEECCEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KIIAEEKGWMRAGRGQVSDAEIRAEGLNLVMGTTPGIIAIIGCPNYSDCAKAVYYIAEEF
HHHHHHCCHHHCCCCCCCCHHHHHCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHH
LKRNYIVVGTGCGSMDMGMYKDEDGKTLYERFPGGFQSGGLVNIGSCVSNAHITGAAQKV
HHCCCEEEEECCCCCCCCCEECCCCCHHHHHCCCCCCCCCEEEHHHHHCCCCCCHHHHHH
AGIFGGRTMEGNLAEIADYVLNRVGACGLAWGAFSQKASSIGTGCNIYGIPAVLGAHSSK
HHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEECHHHHCCCCHH
YRRALIAKNYDESKWKVYDARNGEEMPIPPAPEFLLTTAETWQEAIPMMAKACLRPSDNS
HHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHEEECHHHHHHHHHHHHHHHCCCCCCC
LGRSIKLTHWMELHDKYIGGLPEDWWKFIRTEADLPLAKRADLMKKLEAERGWEIDWKKK
CCCEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHH
KIISGPKIKFDVSAQPTNLKRLCKGA
HHCCCCCEEEECCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8662887; 12125824