Click here to switch to the map view.

The map label for this gene is cdhB1

Identifier: 21228190

GI number: 21228190

Start: 2489289

End: 2489801

Strand: Reverse

Name: cdhB1

Synonym: MM_2088

Alternate gene names: 21228190

Gene position: 2489801-2489289 (Counterclockwise)

Preceding gene: 21228191

Following gene: 21228189

Centisome position: 60.78

GC content: 46.2

Gene sequence:

>513_bases
ATGGTTGACACAACAAAGAACACCAAGCTCTTTACCAGCTACGGGGTGACTACCTCCAAAGCAGTCAACCCTGACATGGT
AGCTAAGATGATCTCCAAGGCAAAGAGGCCGCTTTTTGTGGTCGGGACCGGAGTTCTTAGACCAGAAGTTCTGGACCGTG
CAGTCAAGATTGCACAGAAAGCAAACATTCCGATTGCAGCTACCGGAAGCTCCCTCAAGGGATTCTTAGACAAGGGTGTA
GATGCTAAATACATCAATTTGCACCAGCTAGGGTTCTATTTAACCGATCCTGCATGGCCCGGGCTTGACGGAAAAGGCAA
CTACGACACCATAATCGTCCTGGAATTCAAAAAATATTACATCAACCAGGTACTGTCCGGAACTAAGAACTTCTCCAATG
TAAAAGCAATTTCAATCGGCAGAGATTACATCCAGAACGCAACAATGTCCTTCGGGAACATAAGCAGGGAAGACCACTAC
GCTGCCCTGGATGAACTAATTGACAACTTATAA

Upstream 100 bases:

>100_bases
TTGACTGGAAGAAGAAGAAGATCATATCTGGTCCGAAGATCAAGTTCGACGTATCGGCACAGCCCACTAACCTCAAGAGA
CTCTGTAAGGGGGCCTGAAA

Downstream 100 bases:

>100_bases
ATTTGATTTAGGAGGCGAAAAATAAATGGCAGATGAATTCCCATTTGAGATTTCCCCAATGTTTGAAGGAGAAAGAGTAA
GGAAAGAAGGAATGTTCGTT

Product: acetyl-CoA decarbonylase/synthase complex subunit epsilon

Products: CO2; AH2

Alternate protein names: ACDS complex subunit epsilon 1

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MVDTTKNTKLFTSYGVTTSKAVNPDMVAKMISKAKRPLFVVGTGVLRPEVLDRAVKIAQKANIPIAATGSSLKGFLDKGV
DAKYINLHQLGFYLTDPAWPGLDGKGNYDTIIVLEFKKYYINQVLSGTKNFSNVKAISIGRDYIQNATMSFGNISREDHY
AALDELIDNL

Sequences:

>Translated_170_residues
MVDTTKNTKLFTSYGVTTSKAVNPDMVAKMISKAKRPLFVVGTGVLRPEVLDRAVKIAQKANIPIAATGSSLKGFLDKGV
DAKYINLHQLGFYLTDPAWPGLDGKGNYDTIIVLEFKKYYINQVLSGTKNFSNVKAISIGRDYIQNATMSFGNISREDHY
AALDELIDNL
>Mature_170_residues
MVDTTKNTKLFTSYGVTTSKAVNPDMVAKMISKAKRPLFVVGTGVLRPEVLDRAVKIAQKANIPIAATGSSLKGFLDKGV
DAKYINLHQLGFYLTDPAWPGLDGKGNYDTIIVLEFKKYYINQVLSGTKNFSNVKAISIGRDYIQNATMSFGNISREDHY
AALDELIDNL

Specific function: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably has a structural role in stabilizing the alpha-epsilon subcomponent of the ACDS complex by forming a structura

COG id: COG1880

COG function: function code C; CO dehydrogenase/acetyl-CoA synthase epsilon subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CdhB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDE1_METMA (Q49162)

Other databases:

- EMBL:   L26487
- EMBL:   AE008384
- RefSeq:   NP_634112.1
- ProteinModelPortal:   Q49162
- SMR:   Q49162
- GeneID:   1480430
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_2088
- NMPDR:   fig|192952.1.peg.2088
- HOGENOM:   HBG541140
- OMA:   IAQKANI
- ProtClustDB:   PRK00945
- BioCyc:   MMAZ192952:MM2088-MONOMER
- HAMAP:   MF_01134
- InterPro:   IPR003704
- PIRSF:   PIRSF006035
- TIGRFAMs:   TIGR00315

Pfam domain/function: PF02552 CO_dh

EC number: 1.2.99.2

Molecular weight: Translated: 18697; Mature: 18697

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDTTKNTKLFTSYGVTTSKAVNPDMVAKMISKAKRPLFVVGTGVLRPEVLDRAVKIAQK
CCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
ANIPIAATGSSLKGFLDKGVDAKYINLHQLGFYLTDPAWPGLDGKGNYDTIIVLEFKKYY
CCCCEEECCCHHHHHHHCCCCCEEEEHHHCCEEEECCCCCCCCCCCCCCEEEEEHHHHHH
INQVLSGTKNFSNVKAISIGRDYIQNATMSFGNISREDHYAALDELIDNL
HHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDTTKNTKLFTSYGVTTSKAVNPDMVAKMISKAKRPLFVVGTGVLRPEVLDRAVKIAQK
CCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
ANIPIAATGSSLKGFLDKGVDAKYINLHQLGFYLTDPAWPGLDGKGNYDTIIVLEFKKYY
CCCCEEECCCHHHHHHHCCCCCEEEEHHHCCEEEECCCCCCCCCCCCCCEEEEEHHHHHH
INQVLSGTKNFSNVKAISIGRDYIQNATMSFGNISREDHYAALDELIDNL
HHHHHHCCCCCCCEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CO; H2O; A

Specific reaction: CO + H2O + A = CO2 + AH2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8662887; 12125824