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The map label for this gene is tfb [H]

Identifier: 21227874

GI number: 21227874

Start: 2115751

End: 2116764

Strand: Direct

Name: tfb [H]

Synonym: MM_1772

Alternate gene names: 21227874

Gene position: 2115751-2116764 (Clockwise)

Preceding gene: 21227873

Following gene: 21227875

Centisome position: 51.65

GC content: 50.0

Gene sequence:

>1014_bases
ATGGTAGAAGTCGAAAGAGTTCGCTATTCGGACACCCTTGAAAGGGAAAAAATACGTGCCATGATTAAAGCTCGCAAAGA
AAAACAAAAAGAGCAAACTGTTGAGAATGAAAAGGCCGTGTGTCCAGAATGCGGTAGCAGAAACCTAGTGCACGACTATG
AGAGAGCGGAGCTCGTGTGTGGGGACTGCGGACTTGTCATTGATGCCGACTTTGTTGATGAAGGACCGGAATGGCGAGCT
TTCGATCACGATCAGCGCATGAAGCGTTCCCGTGTGGGCGCGCCCATGACATATACAATCCACGACAAAGGGCTTTCCAC
AATGATTGACTGGAGAAACCGTGACTCCTACGGAAAGTCTATCTCCTCCAAAAACCGTGCCCAGCTTTACCGTTTAAGAA
AATGGCAGCGTAGAATCCGTGTAAGTAACGCAACCGAAAGAAACCTGGCTTTTGCACTTTCAGAACTTGACAGGATGGCT
TCGGCTCTCGGTCTTCCGAGGACTGTCAGGGAGACAGCAGCAGTTGTCTATAGAAAAGCTGTGGACAAGAACCTCATCCG
TGGAAGAAGCATTGAAGGTGTAGCCGCAGCAGCACTATATGCAGCCTGCCGCCAGTGCAGTGTCCCGAGGACCCTTGACG
AGATCGAAGAGGTTTCCAGGGTAAGCAGGAAAGAAATCGGAAGAACTTACCGTTTTATTTCCAGAGAACTTGCCTTGAAG
CTCATGCCCACCTCTCCAATCGACTATGTCCCAAGGTTCTGCTCCGGGCTTAACCTGAAAGGAGAAGTCCAGTCCAAGAG
CGTTGAGATCCTCAGGCAGGCTTCGGAAAAAGAACTCACAAGCGGAAGAGGCCCCACAGGAGTTGCCGCAGCAGCAATTT
ACATTGCATCCATTCTTTGCGGAGAGCGCAGGACTCAGCGTGAAGTTGCAGATGTTGCCGGGGTCACGGAAGTCACCATC
AGGAACAGGTATAAAGAGCTTGCAGAAGAACTGGATATCGAGATTATCCTCTAA

Upstream 100 bases:

>100_bases
TTCTTCTCCCTTCTTTTATATATATTCTGTGATTTATATCGTACAGGCTTGAAATTCAGGGATAGACATATGGTCATGTT
AATTTGTAAGGTGATATAAT

Downstream 100 bases:

>100_bases
ATCTTTCTTCTTTTTTTTCAGCCAGGCTGATTGATGTTCTTCAGGCAGACAGAGGGTTGAATGTGCCCTCTTTTTCTTCC
CTTTTTCATGGAACTTTATT

Product: transcription initiation factor IIB

Products: NA

Alternate protein names: TFIIB [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MVEVERVRYSDTLEREKIRAMIKARKEKQKEQTVENEKAVCPECGSRNLVHDYERAELVCGDCGLVIDADFVDEGPEWRA
FDHDQRMKRSRVGAPMTYTIHDKGLSTMIDWRNRDSYGKSISSKNRAQLYRLRKWQRRIRVSNATERNLAFALSELDRMA
SALGLPRTVRETAAVVYRKAVDKNLIRGRSIEGVAAAALYAACRQCSVPRTLDEIEEVSRVSRKEIGRTYRFISRELALK
LMPTSPIDYVPRFCSGLNLKGEVQSKSVEILRQASEKELTSGRGPTGVAAAAIYIASILCGERRTQREVADVAGVTEVTI
RNRYKELAEELDIEIIL

Sequences:

>Translated_337_residues
MVEVERVRYSDTLEREKIRAMIKARKEKQKEQTVENEKAVCPECGSRNLVHDYERAELVCGDCGLVIDADFVDEGPEWRA
FDHDQRMKRSRVGAPMTYTIHDKGLSTMIDWRNRDSYGKSISSKNRAQLYRLRKWQRRIRVSNATERNLAFALSELDRMA
SALGLPRTVRETAAVVYRKAVDKNLIRGRSIEGVAAAALYAACRQCSVPRTLDEIEEVSRVSRKEIGRTYRFISRELALK
LMPTSPIDYVPRFCSGLNLKGEVQSKSVEILRQASEKELTSGRGPTGVAAAAIYIASILCGERRTQREVADVAGVTEVTI
RNRYKELAEELDIEIIL
>Mature_337_residues
MVEVERVRYSDTLEREKIRAMIKARKEKQKEQTVENEKAVCPECGSRNLVHDYERAELVCGDCGLVIDADFVDEGPEWRA
FDHDQRMKRSRVGAPMTYTIHDKGLSTMIDWRNRDSYGKSISSKNRAQLYRLRKWQRRIRVSNATERNLAFALSELDRMA
SALGLPRTVRETAAVVYRKAVDKNLIRGRSIEGVAAAALYAACRQCSVPRTLDEIEEVSRVSRKEIGRTYRFISRELALK
LMPTSPIDYVPRFCSGLNLKGEVQSKSVEILRQASEKELTSGRGPTGVAAAAIYIASILCGERRTQREVADVAGVTEVTI
RNRYKELAEELDIEIIL

Specific function: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) [H]

COG id: COG1405

COG function: function code K; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TFIIB-type zinc finger [H]

Homologues:

Organism=Homo sapiens, GI4504193, Length=289, Percent_Identity=38.0622837370242, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI22035556, Length=291, Percent_Identity=26.4604810996564, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17564892, Length=288, Percent_Identity=37.5, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17531397, Length=294, Percent_Identity=24.1496598639456, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325343, Length=308, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321685, Length=186, Percent_Identity=29.0322580645161, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136758, Length=293, Percent_Identity=35.8361774744027, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI281361961, Length=295, Percent_Identity=26.4406779661017, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24647658, Length=295, Percent_Identity=26.4406779661017, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006670
- InterPro:   IPR011028
- InterPro:   IPR013763
- InterPro:   IPR000812
- InterPro:   IPR013150
- InterPro:   IPR013137 [H]

Pfam domain/function: PF00382 TFIIB; PF08271 TFIIB_Zn_Ribbon [H]

EC number: NA

Molecular weight: Translated: 38290; Mature: 38290

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS51134 ZF_TFIIB ; PS00782 TFIIB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEVERVRYSDTLEREKIRAMIKARKEKQKEQTVENEKAVCPECGSRNLVHDYERAELVC
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEEE
GDCGLVIDADFVDEGPEWRAFDHDQRMKRSRVGAPMTYTIHDKGLSTMIDWRNRDSYGKS
CCCCEEEECHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCHHCCC
ISSKNRAQLYRLRKWQRRIRVSNATERNLAFALSELDRMASALGLPRTVRETAAVVYRKA
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VDKNLIRGRSIEGVAAAALYAACRQCSVPRTLDEIEEVSRVSRKEIGRTYRFISRELALK
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
LMPTSPIDYVPRFCSGLNLKGEVQSKSVEILRQASEKELTSGRGPTGVAAAAIYIASILC
ECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GERRTQREVADVAGVTEVTIRNRYKELAEELDIEIIL
CCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEC
>Mature Secondary Structure
MVEVERVRYSDTLEREKIRAMIKARKEKQKEQTVENEKAVCPECGSRNLVHDYERAELVC
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEEE
GDCGLVIDADFVDEGPEWRAFDHDQRMKRSRVGAPMTYTIHDKGLSTMIDWRNRDSYGKS
CCCCEEEECHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCHHCCC
ISSKNRAQLYRLRKWQRRIRVSNATERNLAFALSELDRMASALGLPRTVRETAAVVYRKA
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VDKNLIRGRSIEGVAAAALYAACRQCSVPRTLDEIEEVSRVSRKEIGRTYRFISRELALK
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
LMPTSPIDYVPRFCSGLNLKGEVQSKSVEILRQASEKELTSGRGPTGVAAAAIYIASILC
ECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GERRTQREVADVAGVTEVTIRNRYKELAEELDIEIIL
CCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]