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The map label for this gene is serA [H]

Identifier: 21227855

GI number: 21227855

Start: 2095657

End: 2097279

Strand: Direct

Name: serA [H]

Synonym: MM_1753

Alternate gene names: 21227855

Gene position: 2095657-2097279 (Clockwise)

Preceding gene: 21227854

Following gene: 21227856

Centisome position: 51.16

GC content: 48.18

Gene sequence:

>1623_bases
TTGTTAAAATTTAGCATCTCATGTTTATCGTATTTATCTGGAGAAATTGACATGAAAGTATTGGTCAGCGACTCACTCTC
CAACGAAGGGTTGGAGATCCTAAAAGAACATTTTGATATTGATGTCTGCACCGGGCTCTGTGAAGATGAGCTGGTGGAAA
AGATCAAAGGCTACGACGCCCTTGTAATACGCAGCGGTACCCAGGTTACTCAGAGAATAATCGAGGCTGCTGACAACCTG
AAGATTATCGGAAGGGCAGGGGTCGGAGTCGACAATGTGGATGTGGATGCAGCCACAAAGAAAGGTATCATCGTGGCCAA
CGCTCCCGAAGGGAACATGATCTCGGCAGCAGAGCACACAATTGCCATGATGATGTCAATGTCGAGGAATATCCCTCAGG
CCAACGCTTCCCTGAAAGCCAGGGAATGGAAGCGCAATAAGTTCATGGGCGTTGAGGTCAAGGGAAAGACCCTGGGAGTT
ATAGGTCTCGGAAGAATTGGGTCTGAAGTCGCAAAGAGAGCTGCAGGGCTTGAAATGAACCTCATGGGATATGACCCCTT
CATCTCCGAGAAGCGGGCTATGGAACTTGGAGTCAAGCTGGCTACAGTTAACGAAATCGCAAAAGAGGCTGACTACATAA
CAGTACATACCCCACTTATCAAGGAAACCAGAAACATTCTTGACGACGAGCAGTTCGCCCTTATGAAGAAAGGAGTCCGG
GTTCTTAACTGCGCCCGCGGAGGCATTATCAACGAAGAAGCCCTTGCAAGAGCCCTTGAAAGCGGCAAGGTAGGCGGCGC
AGCCATTGACGTTTTTGTCGAAGAGCCTCCTTTCTCCAGCCCTCTTCTTAACTTTGACAATGTTATCGTAACTCCCCACC
TCGGTGCCTCTACACAGGAAGCTCAGGTTAATGTTGCAATCGACATTGCAAAGGAAGTTGTTTCCGTCCTTACAGGCGGG
TCTGCAAAGAACGCAATCAATATCCCCTCCGTAAAGCCTGAAGCTATGGCAGTCCTTGCCCCGTATATAAGGCTTTCAGA
ACTCATGGGCAAAATTGCAGGGCAGCTTGTGGACAGCAATTATGAAAAGGTAGAAATTGCATACAACGGGGAAATCTCCG
GAAAAGATACCAGACCACTTACAGTTTCTGCTCTCAAAGGGCTGCTTGAAATGGCTGTTGGGTCCGGGGTAAATTATGTC
AACGCTCCAATCCTTGCGAAGTCCAGAAAAATCGCAGTGGTAGAAAGCAAGTCTGAATCTGCGGAAGAGTATTCTTCCAC
TGTCAGTATCAGGCTCTCCAGCGGAGAATCTACAAAAATGGTCGCAGGAACCGTTGTTGGGGATGAGCCCAAGATAGTTT
CCATCGATGATGACAAGGTAGATATCTTCCCGGCTGGTCGTATGATTTTTGCCAAACATATAAACAAACCGAACGTTATC
GGTCCCTGTTGCATGGTCCTTGGGAAAAACAATATCAACATTTCAGGCATGCAGGTTGGCAGGTCGGAAGTCGGAGGCGT
GACCATGATGGTTCTTAATGTCGACACCGATGTTTCCGATGCTATCCTTGATGAGGTCAGGCAGGTTCCGGGCATCCTTA
ATGCCAAGCTTGTAACCCTCTGA

Upstream 100 bases:

>100_bases
GGTTAACCTGGAGAAAAGACTTTACAGGCTTTAGAAGTGAAGAATTCAGGTCTAAAAACATGTGATAACGCTTAAGTGTG
ATTAAGTTGATTGGTATTCT

Downstream 100 bases:

>100_bases
ATCCATTGAGAAAATGCAGTAAGGATAATTCCAGAAAAATGCTTCATTCCGGTACGGGTTTAATGAGTCTGTGCCGGAGA
CTTTTACTTTTTCCCGGAAT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MLKFSISCLSYLSGEIDMKVLVSDSLSNEGLEILKEHFDIDVCTGLCEDELVEKIKGYDALVIRSGTQVTQRIIEAADNL
KIIGRAGVGVDNVDVDAATKKGIIVANAPEGNMISAAEHTIAMMMSMSRNIPQANASLKAREWKRNKFMGVEVKGKTLGV
IGLGRIGSEVAKRAAGLEMNLMGYDPFISEKRAMELGVKLATVNEIAKEADYITVHTPLIKETRNILDDEQFALMKKGVR
VLNCARGGIINEEALARALESGKVGGAAIDVFVEEPPFSSPLLNFDNVIVTPHLGASTQEAQVNVAIDIAKEVVSVLTGG
SAKNAINIPSVKPEAMAVLAPYIRLSELMGKIAGQLVDSNYEKVEIAYNGEISGKDTRPLTVSALKGLLEMAVGSGVNYV
NAPILAKSRKIAVVESKSESAEEYSSTVSIRLSSGESTKMVAGTVVGDEPKIVSIDDDKVDIFPAGRMIFAKHINKPNVI
GPCCMVLGKNNINISGMQVGRSEVGGVTMMVLNVDTDVSDAILDEVRQVPGILNAKLVTL

Sequences:

>Translated_540_residues
MLKFSISCLSYLSGEIDMKVLVSDSLSNEGLEILKEHFDIDVCTGLCEDELVEKIKGYDALVIRSGTQVTQRIIEAADNL
KIIGRAGVGVDNVDVDAATKKGIIVANAPEGNMISAAEHTIAMMMSMSRNIPQANASLKAREWKRNKFMGVEVKGKTLGV
IGLGRIGSEVAKRAAGLEMNLMGYDPFISEKRAMELGVKLATVNEIAKEADYITVHTPLIKETRNILDDEQFALMKKGVR
VLNCARGGIINEEALARALESGKVGGAAIDVFVEEPPFSSPLLNFDNVIVTPHLGASTQEAQVNVAIDIAKEVVSVLTGG
SAKNAINIPSVKPEAMAVLAPYIRLSELMGKIAGQLVDSNYEKVEIAYNGEISGKDTRPLTVSALKGLLEMAVGSGVNYV
NAPILAKSRKIAVVESKSESAEEYSSTVSIRLSSGESTKMVAGTVVGDEPKIVSIDDDKVDIFPAGRMIFAKHINKPNVI
GPCCMVLGKNNINISGMQVGRSEVGGVTMMVLNVDTDVSDAILDEVRQVPGILNAKLVTL
>Mature_540_residues
MLKFSISCLSYLSGEIDMKVLVSDSLSNEGLEILKEHFDIDVCTGLCEDELVEKIKGYDALVIRSGTQVTQRIIEAADNL
KIIGRAGVGVDNVDVDAATKKGIIVANAPEGNMISAAEHTIAMMMSMSRNIPQANASLKAREWKRNKFMGVEVKGKTLGV
IGLGRIGSEVAKRAAGLEMNLMGYDPFISEKRAMELGVKLATVNEIAKEADYITVHTPLIKETRNILDDEQFALMKKGVR
VLNCARGGIINEEALARALESGKVGGAAIDVFVEEPPFSSPLLNFDNVIVTPHLGASTQEAQVNVAIDIAKEVVSVLTGG
SAKNAINIPSVKPEAMAVLAPYIRLSELMGKIAGQLVDSNYEKVEIAYNGEISGKDTRPLTVSALKGLLEMAVGSGVNYV
NAPILAKSRKIAVVESKSESAEEYSSTVSIRLSSGESTKMVAGTVVGDEPKIVSIDDDKVDIFPAGRMIFAKHINKPNVI
GPCCMVLGKNNINISGMQVGRSEVGGVTMMVLNVDTDVSDAILDEVRQVPGILNAKLVTL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=405, Percent_Identity=43.9506172839506, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI61743967, Length=314, Percent_Identity=31.8471337579618, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI4557497, Length=314, Percent_Identity=31.8471337579618, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI145580578, Length=315, Percent_Identity=30.7936507936508, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI4557499, Length=315, Percent_Identity=30.7936507936508, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI145580575, Length=315, Percent_Identity=30.7936507936508, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI6912396, Length=315, Percent_Identity=30.1587301587302, Blast_Score=140, Evalue=4e-33,
Organism=Escherichia coli, GI1789279, Length=322, Percent_Identity=36.0248447204969, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI87082289, Length=320, Percent_Identity=30.3125, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1787645, Length=334, Percent_Identity=28.7425149700599, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI87081824, Length=256, Percent_Identity=25.78125, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788660, Length=287, Percent_Identity=25.4355400696864, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=303, Percent_Identity=47.1947194719472, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI25147481, Length=302, Percent_Identity=31.1258278145695, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320925, Length=380, Percent_Identity=32.1052631578947, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322116, Length=380, Percent_Identity=31.8421052631579, Blast_Score=203, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6324055, Length=250, Percent_Identity=31.6, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=264, Percent_Identity=28.030303030303, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6325144, Length=188, Percent_Identity=28.7234042553192, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324980, Length=185, Percent_Identity=26.4864864864865, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19921140, Length=324, Percent_Identity=45.679012345679, Blast_Score=274, Evalue=9e-74,
Organism=Drosophila melanogaster, GI28574286, Length=313, Percent_Identity=30.0319488817891, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24585516, Length=311, Percent_Identity=27.0096463022508, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI62472511, Length=300, Percent_Identity=30.6666666666667, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24646446, Length=300, Percent_Identity=30.6666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24646448, Length=300, Percent_Identity=30.6666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24646452, Length=300, Percent_Identity=30.6666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24646450, Length=300, Percent_Identity=30.6666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=29.903536977492, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28574284, Length=317, Percent_Identity=27.7602523659306, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI45551003, Length=317, Percent_Identity=27.7602523659306, Blast_Score=132, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24585514, Length=317, Percent_Identity=27.7602523659306, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574282, Length=317, Percent_Identity=27.7602523659306, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45552429, Length=317, Percent_Identity=27.7602523659306, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57659; Mature: 57659

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3 ; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKFSISCLSYLSGEIDMKVLVSDSLSNEGLEILKEHFDIDVCTGLCEDELVEKIKGYDA
CEEEEHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCHHHHHCCCHHHHHHHHCCCCE
LVIRSGTQVTQRIIEAADNLKIIGRAGVGVDNVDVDAATKKGIIVANAPEGNMISAAEHT
EEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHH
IAMMMSMSRNIPQANASLKAREWKRNKFMGVEVKGKTLGVIGLGRIGSEVAKRAAGLEMN
HHHHHHHHCCCCCCCCCCCHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHCCCEEE
LMGYDPFISEKRAMELGVKLATVNEIAKEADYITVHTPLIKETRNILDDEQFALMKKGVR
EECCCCCCCHHHHHHHCEEEEHHHHHHHHCCEEEEECHHHHHHHHHCCCHHHHHHHCCCC
VLNCARGGIINEEALARALESGKVGGAAIDVFVEEPPFSSPLLNFDNVIVTPHLGASTQE
EEEHHCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCC
AQVNVAIDIAKEVVSVLTGGSAKNAINIPSVKPEAMAVLAPYIRLSELMGKIAGQLVDSN
CEEEEEHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YEKVEIAYNGEISGKDTRPLTVSALKGLLEMAVGSGVNYVNAPILAKSRKIAVVESKSES
CCEEEEEECCEECCCCCCCEEHHHHHHHHHHHHCCCCCEECCCEEECCCEEEEEECCCCC
AEEYSSTVSIRLSSGESTKMVAGTVVGDEPKIVSIDDDKVDIFPAGRMIFAKHINKPNVI
HHHHCCEEEEEEECCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCEEEEHHCCCCCCC
GPCCMVLGKNNINISGMQVGRSEVGGVTMMVLNVDTDVSDAILDEVRQVPGILNAKLVTL
CCEEHEECCCCCEEEEEECCCHHCCCEEEEEEEECCCHHHHHHHHHHHCCCHHCEEEEEC
>Mature Secondary Structure
MLKFSISCLSYLSGEIDMKVLVSDSLSNEGLEILKEHFDIDVCTGLCEDELVEKIKGYDA
CEEEEHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHCCHHHHHCCCHHHHHHHHCCCCE
LVIRSGTQVTQRIIEAADNLKIIGRAGVGVDNVDVDAATKKGIIVANAPEGNMISAAEHT
EEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCEEHHHHHH
IAMMMSMSRNIPQANASLKAREWKRNKFMGVEVKGKTLGVIGLGRIGSEVAKRAAGLEMN
HHHHHHHHCCCCCCCCCCCHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHCCCEEE
LMGYDPFISEKRAMELGVKLATVNEIAKEADYITVHTPLIKETRNILDDEQFALMKKGVR
EECCCCCCCHHHHHHHCEEEEHHHHHHHHCCEEEEECHHHHHHHHHCCCHHHHHHHCCCC
VLNCARGGIINEEALARALESGKVGGAAIDVFVEEPPFSSPLLNFDNVIVTPHLGASTQE
EEEHHCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCC
AQVNVAIDIAKEVVSVLTGGSAKNAINIPSVKPEAMAVLAPYIRLSELMGKIAGQLVDSN
CEEEEEHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
YEKVEIAYNGEISGKDTRPLTVSALKGLLEMAVGSGVNYVNAPILAKSRKIAVVESKSES
CCEEEEEECCEECCCCCCCEEHHHHHHHHHHHHCCCCCEECCCEEECCCEEEEEECCCCC
AEEYSSTVSIRLSSGESTKMVAGTVVGDEPKIVSIDDDKVDIFPAGRMIFAKHINKPNVI
HHHHCCEEEEEEECCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCEEEEHHCCCCCCC
GPCCMVLGKNNINISGMQVGRSEVGGVTMMVLNVDTDVSDAILDEVRQVPGILNAKLVTL
CCEEHEECCCCCEEEEEECCCHHCCCEEEEEEEECCCHHHHHHHHHHHCCCHHCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]