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The map label for this gene is aroC

Identifier: 21227814

GI number: 21227814

Start: 2054237

End: 2055334

Strand: Direct

Name: aroC

Synonym: MM_1712

Alternate gene names: 21227814

Gene position: 2054237-2055334 (Clockwise)

Preceding gene: 21227813

Following gene: 21227815

Centisome position: 50.15

GC content: 54.19

Gene sequence:

>1098_bases
ATGGCTGGAAACGTTTTCGGGCAGATGTTTCGAATCACGACCTGGGGGGAGTCCCACGGCAGGGCTGTCGGAGTTGTTGT
TGACGGGCTGCCTGCAGGGCTTCCTTTTTCCGAAGCCGACATCCAGAAAGAGCTGGACAGGCGGCGTCCGGGACAGAGCG
AGGTCTCCACACCTCGAAGCGAGGCTGACAGTGTGGAAATACTCTCCGGAATTTTCGAGGGCAAGAGCACGGGGACTCCC
ATCTCCATGCTTGTCTGGAACTCGGATGCCAGGTCTTCTTCTTATGATGCCATTAAAAATACTCCCCGCCCGGGACATGC
TGATTTTACCTACATTGCCCGCTACGGAATTCGGGACCACCGCGGAGGAGGCAGGTCTTCAGCTCGCGAAACTATAGGAA
GGGTTGCAGGCGGTGCCCTTGCAAAGCTTTTACTTTCCCATTACGGAATCCGGATTGTTGGACACGTTCTCGAACTCGGC
GGGATCCGGGCAAAATCACTCTCTTTTGAAGAAATCCTTGAAAATGTTGAAAGAACTCCTGTTCGCTGCGCAGACCCCGA
AGCTGCAAAGAAAATGCTTGAAAAGGTTTCAGCCCTCCGGCAGGAAGGAGACAGCGCGGGCGGAATTGTCGAGGTAATGG
TGAAAGGAGTCCCCGCAGGTCTCGGAGAACCCGTTTTTGACAGGCTTGATGCAGACCTTGCAAAAGCTCTTATGAGCATT
CCCGCAGTCAAAGGCTTTGAAATCGGAGCCGGGTTTGAGGCTGCCCGTATGCGCGGAAGTGAAATGAACGATTCCTTCCT
CATGGAAGACGGAAAAGTTACCTGTTCGAGCAATAACGCAGGCGGCATCCTCGGAGGGATTTCCTCGGGCCTGGACATCG
TCTGCCGTGTAGCAGTAAAGCCCACCCCTTCCATAAGTAAACTTCAGCAAACGGTTGATCTCACAACCCGGGAAAATGCC
GAAATAGCGATTAAAGGACGGCATGACCCCACGATTCCTCCGCGCATGGTGCCGGTTGCAGAAGCCATGGTTGCCCTCGT
GTTTGCCGACCATATGCTCAGAAGCGGCTTTATCAATCCCAGGACCCTGTTAGGGTGA

Upstream 100 bases:

>100_bases
AAATGCTGAAAGCCGAATATAATGATGTTACTGATGTGGTTGTGCACCTTGAACCTGCCTTACCCCAAGGATCATATAGC
AAAAAAACCACTTAAGATGC

Downstream 100 bases:

>100_bases
AGAAATAAGCATAATTTAGCTTGTATCCTCCGGTTTGCTTCGATAATAAACACTCCAAACCACAAATCATCTTTCTTAGC
ATGAAAGTACTTCCGGATAC

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MAGNVFGQMFRITTWGESHGRAVGVVVDGLPAGLPFSEADIQKELDRRRPGQSEVSTPRSEADSVEILSGIFEGKSTGTP
ISMLVWNSDARSSSYDAIKNTPRPGHADFTYIARYGIRDHRGGGRSSARETIGRVAGGALAKLLLSHYGIRIVGHVLELG
GIRAKSLSFEEILENVERTPVRCADPEAAKKMLEKVSALRQEGDSAGGIVEVMVKGVPAGLGEPVFDRLDADLAKALMSI
PAVKGFEIGAGFEAARMRGSEMNDSFLMEDGKVTCSSNNAGGILGGISSGLDIVCRVAVKPTPSISKLQQTVDLTTRENA
EIAIKGRHDPTIPPRMVPVAEAMVALVFADHMLRSGFINPRTLLG

Sequences:

>Translated_365_residues
MAGNVFGQMFRITTWGESHGRAVGVVVDGLPAGLPFSEADIQKELDRRRPGQSEVSTPRSEADSVEILSGIFEGKSTGTP
ISMLVWNSDARSSSYDAIKNTPRPGHADFTYIARYGIRDHRGGGRSSARETIGRVAGGALAKLLLSHYGIRIVGHVLELG
GIRAKSLSFEEILENVERTPVRCADPEAAKKMLEKVSALRQEGDSAGGIVEVMVKGVPAGLGEPVFDRLDADLAKALMSI
PAVKGFEIGAGFEAARMRGSEMNDSFLMEDGKVTCSSNNAGGILGGISSGLDIVCRVAVKPTPSISKLQQTVDLTTRENA
EIAIKGRHDPTIPPRMVPVAEAMVALVFADHMLRSGFINPRTLLG
>Mature_364_residues
AGNVFGQMFRITTWGESHGRAVGVVVDGLPAGLPFSEADIQKELDRRRPGQSEVSTPRSEADSVEILSGIFEGKSTGTPI
SMLVWNSDARSSSYDAIKNTPRPGHADFTYIARYGIRDHRGGGRSSARETIGRVAGGALAKLLLSHYGIRIVGHVLELGG
IRAKSLSFEEILENVERTPVRCADPEAAKKMLEKVSALRQEGDSAGGIVEVMVKGVPAGLGEPVFDRLDADLAKALMSIP
AVKGFEIGAGFEAARMRGSEMNDSFLMEDGKVTCSSNNAGGILGGISSGLDIVCRVAVKPTPSISKLQQTVDLTTRENAE
IAIKGRHDPTIPPRMVPVAEAMVALVFADHMLRSGFINPRTLLG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=356, Percent_Identity=54.4943820224719, Blast_Score=344, Evalue=4e-96,
Organism=Saccharomyces cerevisiae, GI6321290, Length=363, Percent_Identity=47.3829201101928, Blast_Score=336, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_METMA (Q8PW84)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633736.1
- ProteinModelPortal:   Q8PW84
- GeneID:   1480054
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1712
- NMPDR:   fig|192952.1.peg.1712
- HOGENOM:   HBG292336
- OMA:   SRFTTQR
- ProtClustDB:   PRK05382
- BioCyc:   MMAZ192952:MM1712-MONOMER
- BRENDA:   4.2.3.5
- HAMAP:   MF_00300_A
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 38878; Mature: 38747

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGNVFGQMFRITTWGESHGRAVGVVVDGLPAGLPFSEADIQKELDRRRPGQSEVSTPRS
CCCCHHHHEEEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
EADSVEILSGIFEGKSTGTPISMLVWNSDARSSSYDAIKNTPRPGHADFTYIARYGIRDH
CHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCHHHHHHHCCCCC
RGGGRSSARETIGRVAGGALAKLLLSHYGIRIVGHVLELGGIRAKSLSFEEILENVERTP
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
VRCADPEAAKKMLEKVSALRQEGDSAGGIVEVMVKGVPAGLGEPVFDRLDADLAKALMSI
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHC
PAVKGFEIGAGFEAARMRGSEMNDSFLMEDGKVTCSSNNAGGILGGISSGLDIVCRVAVK
CCCCCEECCCCCHHHHHCCCCCCCCEEECCCEEEECCCCCCCCHHCHHCCCEEEEEEECC
PTPSISKLQQTVDLTTRENAEIAIKGRHDPTIPPRMVPVAEAMVALVFADHMLRSGFINP
CCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
RTLLG
HHCCC
>Mature Secondary Structure 
AGNVFGQMFRITTWGESHGRAVGVVVDGLPAGLPFSEADIQKELDRRRPGQSEVSTPRS
CCCHHHHEEEEEECCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
EADSVEILSGIFEGKSTGTPISMLVWNSDARSSSYDAIKNTPRPGHADFTYIARYGIRDH
CHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCHHHHHHHCCCCC
RGGGRSSARETIGRVAGGALAKLLLSHYGIRIVGHVLELGGIRAKSLSFEEILENVERTP
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
VRCADPEAAKKMLEKVSALRQEGDSAGGIVEVMVKGVPAGLGEPVFDRLDADLAKALMSI
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHC
PAVKGFEIGAGFEAARMRGSEMNDSFLMEDGKVTCSSNNAGGILGGISSGLDIVCRVAVK
CCCCCEECCCCCHHHHHCCCCCCCCEEECCCEEEECCCCCCCCHHCHHCCCEEEEEEECC
PTPSISKLQQTVDLTTRENAEIAIKGRHDPTIPPRMVPVAEAMVALVFADHMLRSGFINP
CCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
RTLLG
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824