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The map label for this gene is hisA

Identifier: 21227606

GI number: 21227606

Start: 1793554

End: 1794294

Strand: Direct

Name: hisA

Synonym: MM_1504

Alternate gene names: 21227606

Gene position: 1793554-1794294 (Clockwise)

Preceding gene: 21227605

Following gene: 21227607

Centisome position: 43.78

GC content: 48.04

Gene sequence:

>741_bases
ATGGTCTTTGAAGTAATACCTGCGGTGGACATGAGAGGAGGGAAGTGTGTACAGCTGGTACAGGGAGTGCCTGGCAGCGA
GATTGTGTCCATTGATGACCCACTCGCAGTCGCCCTTGACTGGGTGAGTAAAGGAGCAAAAACCCTTCATCTTGTGGATC
TTGACGGAGCAATAGAAGGGGAAAGAAAAAATTCCCCAATTATTGAAAAGATCGTCAACACCTGCAAGGAAAAAGGCGTG
AGTATCCAGGTCGGAGGGGGCATACGGAGCTTTGAAGATGCAGCCTCGCTTCTTGAGATCGGTGTCTCAAGGATAATTCT
CGGAACAGCCGCCCTCCAGAACCCAGAACTTGTAAAGCAGCTTTCCAGTTCTTTTGGAAGTTCACATGTAAACGTTGCCC
TGGATGCAAAGAATGGGAAAATCTCAATTAAAGGCTGGACCGAAGAATGCGCTCAAACTCCTGTTGAAATGGGCAGGAAA
TTTGAAGAGCTTGGAGCCGGGAGCCTTCTTTTTACCAACATTGACACCGAAGGCTTGATGCAGGGGGTAAACCCTGTTCC
TACAAAAGAGCTTGTAGAATCCGTCAGCATTCCTGTAATCGCATCCGGTGGGGTAAGCACCCTGGAAGATATAAAAACCC
TGAAAAAGACCGGAGCTGCGGGTGTTGTTGTAGGCAGTGCCCTTTATATGGGCAGGTTTACTCTGGAAGAAGCAATTAAT
GCTGCCCTTGGAGATATTTAA

Upstream 100 bases:

>100_bases
AGGATCATGCCCTGAATGAAAAATCTGAATAGCATACATAAAATACATAAATCACTGAAGTGAAAAAATATTCCTGTAAA
ATATGGAGATGTAGCTTTTT

Downstream 100 bases:

>100_bases
TTATTTTAAAGAAAAGTGTGATGCTGTATGAGAATTAGCAAAATTTCCCGCAAGACGAAGGAAACCGACATTCAGCTCGA
AATTAACCTTGACGGTAAAG

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MVFEVIPAVDMRGGKCVQLVQGVPGSEIVSIDDPLAVALDWVSKGAKTLHLVDLDGAIEGERKNSPIIEKIVNTCKEKGV
SIQVGGGIRSFEDAASLLEIGVSRIILGTAALQNPELVKQLSSSFGSSHVNVALDAKNGKISIKGWTEECAQTPVEMGRK
FEELGAGSLLFTNIDTEGLMQGVNPVPTKELVESVSIPVIASGGVSTLEDIKTLKKTGAAGVVVGSALYMGRFTLEEAIN
AALGDI

Sequences:

>Translated_246_residues
MVFEVIPAVDMRGGKCVQLVQGVPGSEIVSIDDPLAVALDWVSKGAKTLHLVDLDGAIEGERKNSPIIEKIVNTCKEKGV
SIQVGGGIRSFEDAASLLEIGVSRIILGTAALQNPELVKQLSSSFGSSHVNVALDAKNGKISIKGWTEECAQTPVEMGRK
FEELGAGSLLFTNIDTEGLMQGVNPVPTKELVESVSIPVIASGGVSTLEDIKTLKKTGAAGVVVGSALYMGRFTLEEAIN
AALGDI
>Mature_246_residues
MVFEVIPAVDMRGGKCVQLVQGVPGSEIVSIDDPLAVALDWVSKGAKTLHLVDLDGAIEGERKNSPIIEKIVNTCKEKGV
SIQVGGGIRSFEDAASLLEIGVSRIILGTAALQNPELVKQLSSSFGSSHVNVALDAKNGKISIKGWTEECAQTPVEMGRK
FEELGAGSLLFTNIDTEGLMQGVNPVPTKELVESVSIPVIASGGVSTLEDIKTLKKTGAAGVVVGSALYMGRFTLEEAIN
AALGDI

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=241, Percent_Identity=34.8547717842324, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1788336, Length=237, Percent_Identity=25.7383966244726, Blast_Score=89, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_METMA (Q8PWS2)

Other databases:

- EMBL:   AE008384
- RefSeq:   NP_633528.1
- ProteinModelPortal:   Q8PWS2
- SMR:   Q8PWS2
- GeneID:   1479846
- GenomeReviews:   AE008384_GR
- KEGG:   mma:MM_1504
- NMPDR:   fig|192952.1.peg.1504
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK13585
- BioCyc:   MMAZ192952:MM1504-MONOMER
- BRENDA:   5.3.1.16
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25713; Mature: 25713

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: ACT_SITE 10-10 ACT_SITE 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFEVIPAVDMRGGKCVQLVQGVPGSEIVSIDDPLAVALDWVSKGAKTLHLVDLDGAIEG
CCEEEECCCCCCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCC
ERKNSPIIEKIVNTCKEKGVSIQVGGGIRSFEDAASLLEIGVSRIILGTAALQNPELVKQ
CCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LSSSFGSSHVNVALDAKNGKISIKGWTEECAQTPVEMGRKFEELGAGSLLFTNIDTEGLM
HHHHCCCCCEEEEEECCCCEEEEECCHHHHHCCHHHHHHHHHHHCCCCEEEECCCHHHHH
QGVNPVPTKELVESVSIPVIASGGVSTLEDIKTLKKTGAAGVVVGSALYMGRFTLEEAIN
CCCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AALGDI
HHHCCC
>Mature Secondary Structure
MVFEVIPAVDMRGGKCVQLVQGVPGSEIVSIDDPLAVALDWVSKGAKTLHLVDLDGAIEG
CCEEEECCCCCCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCC
ERKNSPIIEKIVNTCKEKGVSIQVGGGIRSFEDAASLLEIGVSRIILGTAALQNPELVKQ
CCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LSSSFGSSHVNVALDAKNGKISIKGWTEECAQTPVEMGRKFEELGAGSLLFTNIDTEGLM
HHHHCCCCCEEEEEECCCCEEEEECCHHHHHCCHHHHHHHHHHHCCCCEEEECCCHHHHH
QGVNPVPTKELVESVSIPVIASGGVSTLEDIKTLKKTGAAGVVVGSALYMGRFTLEEAIN
CCCCCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AALGDI
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824