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The map label for this gene is hisB [H]

Identifier: 21227607

GI number: 21227607

Start: 1794322

End: 1794897

Strand: Direct

Name: hisB [H]

Synonym: MM_1505

Alternate gene names: 21227607

Gene position: 1794322-1794897 (Clockwise)

Preceding gene: 21227606

Following gene: 21227613

Centisome position: 43.8

GC content: 48.96

Gene sequence:

>576_bases
ATGAGAATTAGCAAAATTTCCCGCAAGACGAAGGAAACCGACATTCAGCTCGAAATTAACCTTGACGGTAAAGGCACTGC
AGATGTCAGTACAGGGATCGGGTTTTTTGACCACATGCTTTCTTCTTTCGCAAGGCACGCCGAGTTTGACCTTAAAGTGC
GTGCCGAAGGTGATCTTTATGTGGACGAGCACCACCTCATTGAGGATACGGGAATAGTCCTCGGAAAAGCTCTTGCCGAA
GCCCTTGGAGATATGGCAGGAATCGCCCGTTTCGGGGAAGCCAGAATCCCTATGGACGAGGCTCTTGCTGAAGTTGCCCT
GGATGTAGGAGGCCGCAGCTATCTTGTCATGAAAGCTGACTTTATCGCTCCCCAGGTAGGGCAGTTCAGTACCCAGCTGG
TAAAGCACTTCTTTGAGACTGTCGCCTCAAATGCAAAGATTACCATACACGCCAGCGTTTACGGGGACAATGACCACCAT
AAAATAGAGGCTCTCTTCAAGGCTTTTGCTTATGCGATGAAAAGGGCTGTAAAAATCGAGGGCAAAGAAGTAAAGAGCAC
GAAAGGCACCCTCTAA

Upstream 100 bases:

>100_bases
TGTAGGCAGTGCCCTTTATATGGGCAGGTTTACTCTGGAAGAAGCAATTAATGCTGCCCTTGGAGATATTTAATTATTTT
AAAGAAAAGTGTGATGCTGT

Downstream 100 bases:

>100_bases
TTATTTTTAAACTCAGGTGTTTTTAAATTCCGGTTTTCTTTCCCATTAGCGGGAACTGCACGCTTAAATCCTGACTCGCC
ACTCATTCGTAAAGACGAGC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MRISKISRKTKETDIQLEINLDGKGTADVSTGIGFFDHMLSSFARHAEFDLKVRAEGDLYVDEHHLIEDTGIVLGKALAE
ALGDMAGIARFGEARIPMDEALAEVALDVGGRSYLVMKADFIAPQVGQFSTQLVKHFFETVASNAKITIHASVYGDNDHH
KIEALFKAFAYAMKRAVKIEGKEVKSTKGTL

Sequences:

>Translated_191_residues
MRISKISRKTKETDIQLEINLDGKGTADVSTGIGFFDHMLSSFARHAEFDLKVRAEGDLYVDEHHLIEDTGIVLGKALAE
ALGDMAGIARFGEARIPMDEALAEVALDVGGRSYLVMKADFIAPQVGQFSTQLVKHFFETVASNAKITIHASVYGDNDHH
KIEALFKAFAYAMKRAVKIEGKEVKSTKGTL
>Mature_191_residues
MRISKISRKTKETDIQLEINLDGKGTADVSTGIGFFDHMLSSFARHAEFDLKVRAEGDLYVDEHHLIEDTGIVLGKALAE
ALGDMAGIARFGEARIPMDEALAEVALDVGGRSYLVMKADFIAPQVGQFSTQLVKHFFETVASNAKITIHASVYGDNDHH
KIEALFKAFAYAMKRAVKIEGKEVKSTKGTL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=190, Percent_Identity=46.3157894736842, Blast_Score=199, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324776, Length=212, Percent_Identity=38.6792452830189, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 20942; Mature: 20942

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISKISRKTKETDIQLEINLDGKGTADVSTGIGFFDHMLSSFARHAEFDLKVRAEGDLY
CCCHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEE
VDEHHLIEDTGIVLGKALAEALGDMAGIARFGEARIPMDEALAEVALDVGGRSYLVMKAD
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEC
FIAPQVGQFSTQLVKHFFETVASNAKITIHASVYGDNDHHKIEALFKAFAYAMKRAVKIE
CCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
GKEVKSTKGTL
CCCCCCCCCCC
>Mature Secondary Structure
MRISKISRKTKETDIQLEINLDGKGTADVSTGIGFFDHMLSSFARHAEFDLKVRAEGDLY
CCCHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEE
VDEHHLIEDTGIVLGKALAEALGDMAGIARFGEARIPMDEALAEVALDVGGRSYLVMKAD
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEC
FIAPQVGQFSTQLVKHFFETVASNAKITIHASVYGDNDHHKIEALFKAFAYAMKRAVKIE
CCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
GKEVKSTKGTL
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA